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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRAD
Full Name:
Kalirin
Alias:
Duet; Duo; EC 2.7.11.1; HAPIP; Hs.8004; Kalirin; Kalirin, RhoGEF kinase; KALRN; Serine/threonine kinase with Dbl- and pleckstrin homology domains; Serine/threonine kinase with Dbl and pleckstriny domains
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; CAMK group; Trio family
Mass (Da):
340174
Number AA:
2985
UniProt ID:
O60229
International Prot ID:
IPI00028382
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005089
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
L
R
L
L
D
R
G
S
F
R
N
D
G
L
K
Site 2
S33
R
N
D
G
L
K
A
S
D
V
L
P
I
L
K
Site 3
T59
K
R
G
G
P
I
L
T
F
P
A
R
S
N
H
Site 4
T79
E
D
L
R
K
L
V
T
Y
L
A
S
V
P
S
Site 5
Y80
D
L
R
K
L
V
T
Y
L
A
S
V
P
S
E
Site 6
S86
T
Y
L
A
S
V
P
S
E
D
V
C
K
R
G
Site 7
T95
D
V
C
K
R
G
F
T
V
I
I
D
M
R
G
Site 8
S103
V
I
I
D
M
R
G
S
K
W
D
L
I
K
P
Site 9
T140
N
F
W
Q
K
Q
K
T
N
F
G
S
S
K
F
Site 10
S145
Q
K
T
N
F
G
S
S
K
F
I
F
E
T
S
Site 11
S166
L
T
K
L
V
D
P
S
Q
L
T
E
E
F
D
Site 12
S175
L
T
E
E
F
D
G
S
L
D
Y
N
H
E
E
Site 13
Y178
E
F
D
G
S
L
D
Y
N
H
E
E
W
I
E
Site 14
S189
E
W
I
E
L
R
L
S
L
E
E
F
F
N
S
Site 15
S196
S
L
E
E
F
F
N
S
A
V
H
L
L
S
R
Site 16
S223
F
P
V
D
V
E
G
S
R
R
L
I
D
E
H
Site 17
T231
R
R
L
I
D
E
H
T
Q
L
K
K
K
V
L
Site 18
S259
L
L
Q
C
I
R
C
S
D
G
F
S
G
R
N
Site 19
S263
I
R
C
S
D
G
F
S
G
R
N
C
I
P
G
Site 20
S271
G
R
N
C
I
P
G
S
A
D
F
Q
S
L
V
Site 21
S276
P
G
S
A
D
F
Q
S
L
V
P
K
I
T
S
Site 22
S290
S
L
L
D
K
L
H
S
T
R
Q
H
L
H
Q
Site 23
S336
N
K
E
L
F
L
Q
S
H
T
E
I
G
V
S
Site 24
S343
S
H
T
E
I
G
V
S
Y
Q
Y
A
L
D
L
Site 25
S379
M
S
V
A
S
R
L
S
E
A
G
H
Y
A
S
Site 26
Y384
R
L
S
E
A
G
H
Y
A
S
Q
Q
I
K
Q
Site 27
S386
S
E
A
G
H
Y
A
S
Q
Q
I
K
Q
I
S
Site 28
S402
Q
L
D
Q
E
W
K
S
F
A
A
A
L
D
E
Site 29
S429
Q
K
A
E
Q
F
L
S
G
V
D
A
W
C
K
Site 30
Y461
I
H
H
H
Q
T
L
Y
E
Q
V
T
Q
A
Y
Site 31
S472
T
Q
A
Y
T
E
V
S
Q
D
G
K
A
L
L
Site 32
S487
D
V
L
Q
R
P
L
S
P
G
N
S
E
S
L
Site 33
S491
R
P
L
S
P
G
N
S
E
S
L
T
A
T
A
Site 34
S493
L
S
P
G
N
S
E
S
L
T
A
T
A
N
Y
Site 35
T495
P
G
N
S
E
S
L
T
A
T
A
N
Y
S
K
Site 36
T497
N
S
E
S
L
T
A
T
A
N
Y
S
K
A
V
Site 37
S561
N
H
G
E
A
F
L
S
K
H
T
G
V
G
K
Site 38
S569
K
H
T
G
V
G
K
S
L
H
R
A
R
A
L
Site 39
S643
R
K
L
L
L
D
M
S
V
S
F
H
T
H
T
Site 40
S645
L
L
L
D
M
S
V
S
F
H
T
H
T
K
E
Site 41
T694
Q
T
A
T
L
D
A
T
L
N
V
I
K
E
G
Site 42
S710
D
L
I
Q
Q
L
R
S
A
P
P
S
L
G
E
Site 43
S714
Q
L
R
S
A
P
P
S
L
G
E
P
S
E
A
Site 44
S719
P
P
S
L
G
E
P
S
E
A
R
D
S
A
V
Site 45
S724
E
P
S
E
A
R
D
S
A
V
S
N
N
K
T
Site 46
S727
E
A
R
D
S
A
V
S
N
N
K
T
P
H
S
Site 47
T731
S
A
V
S
N
N
K
T
P
H
S
S
S
I
S
Site 48
S734
S
N
N
K
T
P
H
S
S
S
I
S
H
I
E
Site 49
S736
N
K
T
P
H
S
S
S
I
S
H
I
E
S
V
Site 50
S738
T
P
H
S
S
S
I
S
H
I
E
S
V
L
Q
Site 51
S742
S
S
I
S
H
I
E
S
V
L
Q
Q
L
D
D
Site 52
Y777
Q
L
R
I
F
E
Q
Y
T
I
E
V
T
A
E
Site 53
T801
R
Q
M
N
D
F
N
T
E
D
L
T
L
A
E
Site 54
T805
D
F
N
T
E
D
L
T
L
A
E
Q
R
L
Q
Site 55
T815
E
Q
R
L
Q
R
H
T
E
R
K
L
A
M
N
Site 56
T825
K
L
A
M
N
N
M
T
F
E
V
I
Q
Q
G
Site 57
Y838
Q
G
Q
D
L
H
Q
Y
I
T
E
V
Q
A
S
Site 58
S924
L
V
N
A
S
S
L
S
E
A
E
Q
L
Q
R
Site 59
S948
E
S
L
F
H
A
T
S
L
Q
K
T
H
Q
S
Site 60
T952
H
A
T
S
L
Q
K
T
H
Q
S
A
L
Q
V
Site 61
S1017
K
T
S
E
Q
V
C
S
V
L
E
S
L
E
Q
Site 62
S1021
Q
V
C
S
V
L
E
S
L
E
Q
E
Y
R
R
Site 63
Y1026
L
E
S
L
E
Q
E
Y
R
R
D
E
D
W
C
Site 64
Y1079
N
A
E
V
F
L
K
Y
I
H
R
N
N
V
S
Site 65
S1086
Y
I
H
R
N
N
V
S
M
P
S
V
A
S
H
Site 66
S1089
R
N
N
V
S
M
P
S
V
A
S
H
T
R
G
Site 67
S1092
V
S
M
P
S
V
A
S
H
T
R
G
P
E
Q
Site 68
T1120
N
R
V
L
H
F
W
T
L
K
K
R
R
L
D
Site 69
Y1132
R
L
D
Q
C
Q
Q
Y
V
V
F
E
R
S
A
Site 70
Y1153
I
Q
E
T
G
E
F
Y
L
S
T
H
T
S
T
Site 71
S1155
E
T
G
E
F
Y
L
S
T
H
T
S
T
G
E
Site 72
T1156
T
G
E
F
Y
L
S
T
H
T
S
T
G
E
T
Site 73
S1159
F
Y
L
S
T
H
T
S
T
G
E
T
T
E
E
Site 74
T1215
E
I
R
K
W
V
T
T
V
D
K
H
Y
R
D
Site 75
Y1220
V
T
T
V
D
K
H
Y
R
D
F
S
L
R
M
Site 76
S1224
D
K
H
Y
R
D
F
S
L
R
M
G
K
Y
R
Site 77
Y1230
F
S
L
R
M
G
K
Y
R
Y
S
L
E
K
A
Site 78
S1233
R
M
G
K
Y
R
Y
S
L
E
K
A
L
G
V
Site 79
S1256
E
L
D
I
I
P
A
S
L
S
D
R
E
V
K
Site 80
S1258
D
I
I
P
A
S
L
S
D
R
E
V
K
L
R
Site 81
S1278
V
N
E
E
K
R
K
S
A
R
K
K
E
F
I
Site 82
T1292
I
M
A
E
L
L
Q
T
E
K
A
Y
V
R
D
Site 83
Y1296
L
L
Q
T
E
K
A
Y
V
R
D
L
H
E
C
Site 84
T1306
D
L
H
E
C
L
E
T
Y
L
W
E
M
T
S
Site 85
Y1307
L
H
E
C
L
E
T
Y
L
W
E
M
T
S
G
Site 86
S1313
T
Y
L
W
E
M
T
S
G
V
E
E
I
P
P
Site 87
Y1337
F
G
N
I
Q
E
I
Y
D
F
H
N
N
I
F
Site 88
Y1351
F
L
K
E
L
E
K
Y
E
Q
L
P
E
D
V
Site 89
Y1372
W
A
D
K
F
Q
M
Y
V
T
Y
C
K
N
K
Site 90
Y1375
K
F
Q
M
Y
V
T
Y
C
K
N
K
P
D
S
Site 91
S1406
Q
R
H
G
L
A
N
S
I
S
S
Y
L
I
K
Site 92
Y1410
L
A
N
S
I
S
S
Y
L
I
K
P
V
Q
R
Site 93
T1419
I
K
P
V
Q
R
I
T
K
Y
Q
L
L
L
K
Site 94
Y1421
P
V
Q
R
I
T
K
Y
Q
L
L
L
K
E
L
Site 95
S1448
D
G
L
E
V
M
L
S
V
P
K
K
A
N
D
Site 96
S1488
F
Q
V
W
D
P
K
S
L
I
R
K
G
R
E
Site 97
S1508
F
E
I
S
L
V
F
S
K
E
I
K
D
S
S
Site 98
S1514
F
S
K
E
I
K
D
S
S
G
H
T
K
Y
V
Site 99
S1515
S
K
E
I
K
D
S
S
G
H
T
K
Y
V
Y
Site 100
Y1520
D
S
S
G
H
T
K
Y
V
Y
K
N
K
L
L
Site 101
Y1522
S
G
H
T
K
Y
V
Y
K
N
K
L
L
T
S
Site 102
S1529
Y
K
N
K
L
L
T
S
E
L
G
V
T
E
H
Site 103
T1534
L
T
S
E
L
G
V
T
E
H
V
E
G
D
P
Site 104
S1548
P
C
K
F
A
L
W
S
G
R
T
P
S
S
D
Site 105
T1551
F
A
L
W
S
G
R
T
P
S
S
D
N
K
T
Site 106
S1553
L
W
S
G
R
T
P
S
S
D
N
K
T
V
L
Site 107
S1554
W
S
G
R
T
P
S
S
D
N
K
T
V
L
K
Site 108
T1558
T
P
S
S
D
N
K
T
V
L
K
A
S
N
I
Site 109
T1599
E
P
L
Q
L
P
K
T
P
A
K
Q
R
N
N
Site 110
S1607
P
A
K
Q
R
N
N
S
K
R
D
G
V
E
D
Site 111
S1617
D
G
V
E
D
I
D
S
Q
G
D
G
S
S
Q
Site 112
S1622
I
D
S
Q
G
D
G
S
S
Q
P
D
T
I
S
Site 113
S1623
D
S
Q
G
D
G
S
S
Q
P
D
T
I
S
I
Site 114
T1627
D
G
S
S
Q
P
D
T
I
S
I
A
S
R
T
Site 115
S1629
S
S
Q
P
D
T
I
S
I
A
S
R
T
S
Q
Site 116
S1632
P
D
T
I
S
I
A
S
R
T
S
Q
N
T
V
Site 117
S1635
I
S
I
A
S
R
T
S
Q
N
T
V
D
S
D
Site 118
T1638
A
S
R
T
S
Q
N
T
V
D
S
D
K
L
S
Site 119
S1641
T
S
Q
N
T
V
D
S
D
K
L
S
G
G
C
Site 120
S1645
T
V
D
S
D
K
L
S
G
G
C
E
L
T
V
Site 121
S1662
Q
D
F
S
A
G
H
S
S
E
L
T
I
Q
V
Site 122
T1666
A
G
H
S
S
E
L
T
I
Q
V
G
Q
T
V
Site 123
S1680
V
E
L
L
E
R
P
S
E
R
P
G
W
C
L
Site 124
T1690
P
G
W
C
L
V
R
T
T
E
R
S
P
P
L
Site 125
T1691
G
W
C
L
V
R
T
T
E
R
S
P
P
L
E
Site 126
S1694
L
V
R
T
T
E
R
S
P
P
L
E
G
L
V
Site 127
S1709
P
S
S
A
L
C
I
S
H
S
R
S
S
V
E
Site 128
S1711
S
A
L
C
I
S
H
S
R
S
S
V
E
M
D
Site 129
Y1728
F
P
L
V
K
D
A
Y
S
H
S
S
S
E
N
Site 130
S1729
P
L
V
K
D
A
Y
S
H
S
S
S
E
N
G
Site 131
S1731
V
K
D
A
Y
S
H
S
S
S
E
N
G
G
K
Site 132
S1733
D
A
Y
S
H
S
S
S
E
N
G
G
K
S
E
Site 133
S1739
S
S
E
N
G
G
K
S
E
S
V
A
N
L
Q
Site 134
S1741
E
N
G
G
K
S
E
S
V
A
N
L
Q
A
Q
Site 135
S1750
A
N
L
Q
A
Q
P
S
L
N
S
I
H
S
S
Site 136
S1753
Q
A
Q
P
S
L
N
S
I
H
S
S
P
G
P
Site 137
S1756
P
S
L
N
S
I
H
S
S
P
G
P
K
R
S
Site 138
S1757
S
L
N
S
I
H
S
S
P
G
P
K
R
S
T
Site 139
S1763
S
S
P
G
P
K
R
S
T
N
T
L
K
K
W
Site 140
T1764
S
P
G
P
K
R
S
T
N
T
L
K
K
W
L
Site 141
T1766
G
P
K
R
S
T
N
T
L
K
K
W
L
T
S
Site 142
T1772
N
T
L
K
K
W
L
T
S
P
V
R
R
L
N
Site 143
S1773
T
L
K
K
W
L
T
S
P
V
R
R
L
N
S
Site 144
S1780
S
P
V
R
R
L
N
S
G
K
A
D
G
N
I
Site 145
S1799
K
V
R
D
G
R
K
S
F
D
L
G
S
P
K
Site 146
S1804
R
K
S
F
D
L
G
S
P
K
P
G
D
E
T
Site 147
T1811
S
P
K
P
G
D
E
T
T
P
Q
G
D
S
A
Site 148
T1812
P
K
P
G
D
E
T
T
P
Q
G
D
S
A
D
Site 149
S1817
E
T
T
P
Q
G
D
S
A
D
E
K
S
K
K
Site 150
S1822
G
D
S
A
D
E
K
S
K
K
G
W
G
E
D
Site 151
S1835
E
D
E
P
D
E
E
S
H
T
P
L
P
P
P
Site 152
T1837
E
P
D
E
E
S
H
T
P
L
P
P
P
M
K
Site 153
T1851
K
I
F
D
N
D
P
T
Q
D
E
M
S
S
L
Site 154
S1857
P
T
Q
D
E
M
S
S
L
L
A
A
R
Q
A
Site 155
S1887
K
L
V
K
N
K
L
S
L
E
G
S
S
Y
R
Site 156
S1891
N
K
L
S
L
E
G
S
S
Y
R
G
S
L
K
Site 157
S1892
K
L
S
L
E
G
S
S
Y
R
G
S
L
K
D
Site 158
Y1893
L
S
L
E
G
S
S
Y
R
G
S
L
K
D
P
Site 159
S1896
E
G
S
S
Y
R
G
S
L
K
D
P
A
G
C
Site 160
T1912
N
E
G
M
A
P
P
T
P
P
K
N
P
E
E
Site 161
T1939
V
L
N
E
L
V
Q
T
E
K
D
Y
V
K
D
Site 162
Y1943
L
V
Q
T
E
K
D
Y
V
K
D
L
G
I
V
Site 163
Y2029
Q
N
K
P
R
S
E
Y
I
V
A
E
Y
D
A
Site 164
Y2034
S
E
Y
I
V
A
E
Y
D
A
Y
F
E
E
V
Site 165
Y2037
I
V
A
E
Y
D
A
Y
F
E
E
V
K
Q
E
Site 166
T2050
Q
E
I
N
Q
R
L
T
L
S
D
F
L
I
K
Site 167
T2063
I
K
P
I
Q
R
I
T
K
Y
Q
L
L
L
K
Site 168
Y2065
P
I
Q
R
I
T
K
Y
Q
L
L
L
K
D
F
Site 169
S2076
L
K
D
F
L
R
Y
S
E
K
A
G
L
E
C
Site 170
T2117
Q
G
F
E
G
T
L
T
A
Q
G
K
L
L
Q
Site 171
T2127
G
K
L
L
Q
Q
D
T
F
Y
V
I
E
L
D
Site 172
S2163
S
E
L
L
R
K
G
S
L
T
P
G
Y
M
F
Site 173
T2165
L
L
R
K
G
S
L
T
P
G
Y
M
F
K
R
Site 174
Y2168
K
G
S
L
T
P
G
Y
M
F
K
R
S
I
K
Site 175
Y2178
K
R
S
I
K
M
N
Y
L
V
L
E
E
N
V
Site 176
T2199
F
A
L
M
N
R
E
T
S
E
R
V
V
L
Q
Site 177
S2200
A
L
M
N
R
E
T
S
E
R
V
V
L
Q
A
Site 178
T2226
D
I
N
Q
V
L
E
T
Q
R
D
F
L
N
A
Site 179
S2236
D
F
L
N
A
L
Q
S
P
I
E
Y
Q
R
K
Site 180
Y2240
A
L
Q
S
P
I
E
Y
Q
R
K
E
R
S
T
Site 181
T2247
Y
Q
R
K
E
R
S
T
A
V
M
R
S
Q
P
Site 182
S2252
R
S
T
A
V
M
R
S
Q
P
A
R
L
P
Q
Site 183
S2261
P
A
R
L
P
Q
A
S
P
R
P
Y
S
S
V
Site 184
Y2265
P
Q
A
S
P
R
P
Y
S
S
V
P
A
G
S
Site 185
S2266
Q
A
S
P
R
P
Y
S
S
V
P
A
G
S
E
Site 186
S2267
A
S
P
R
P
Y
S
S
V
P
A
G
S
E
K
Site 187
S2272
Y
S
S
V
P
A
G
S
E
K
P
P
K
G
S
Site 188
S2279
S
E
K
P
P
K
G
S
S
Y
N
P
P
L
P
Site 189
S2280
E
K
P
P
K
G
S
S
Y
N
P
P
L
P
P
Site 190
Y2281
K
P
P
K
G
S
S
Y
N
P
P
L
P
P
L
Site 191
S2291
P
L
P
P
L
K
I
S
T
S
N
G
S
P
G
Site 192
T2292
L
P
P
L
K
I
S
T
S
N
G
S
P
G
F
Site 193
S2293
P
P
L
K
I
S
T
S
N
G
S
P
G
F
E
Site 194
S2296
K
I
S
T
S
N
G
S
P
G
F
E
Y
H
Q
Site 195
Y2301
N
G
S
P
G
F
E
Y
H
Q
P
G
D
K
F
Site 196
S2311
P
G
D
K
F
E
A
S
K
Q
N
D
L
G
G
Site 197
S2324
G
G
C
N
G
T
S
S
M
A
V
I
K
D
Y
Site 198
Y2331
S
M
A
V
I
K
D
Y
Y
A
L
K
E
N
E
Site 199
Y2332
M
A
V
I
K
D
Y
Y
A
L
K
E
N
E
I
Site 200
S2342
K
E
N
E
I
C
V
S
Q
G
E
V
V
Q
V
Site 201
Y2361
Q
Q
N
M
C
L
V
Y
Q
P
A
S
D
H
S
Site 202
S2365
C
L
V
Y
Q
P
A
S
D
H
S
P
A
A
E
Site 203
S2368
Y
Q
P
A
S
D
H
S
P
A
A
E
G
W
V
Site 204
S2391
T
K
A
T
A
A
E
S
S
D
G
S
I
K
K
Site 205
S2395
A
A
E
S
S
D
G
S
I
K
K
S
C
S
W
Site 206
S2399
S
D
G
S
I
K
K
S
C
S
W
H
T
L
R
Site 207
S2401
G
S
I
K
K
S
C
S
W
H
T
L
R
M
R
Site 208
T2404
K
K
S
C
S
W
H
T
L
R
M
R
K
R
A
Site 209
T2416
K
R
A
E
V
E
N
T
G
K
N
E
A
T
G
Site 210
S2436
D
I
L
G
N
K
V
S
V
K
E
T
N
S
S
Site 211
T2440
N
K
V
S
V
K
E
T
N
S
S
E
E
S
E
Site 212
S2442
V
S
V
K
E
T
N
S
S
E
E
S
E
C
D
Site 213
S2443
S
V
K
E
T
N
S
S
E
E
S
E
C
D
D
Site 214
S2446
E
T
N
S
S
E
E
S
E
C
D
D
L
D
P
Site 215
T2455
C
D
D
L
D
P
N
T
S
M
E
I
L
N
P
Site 216
S2456
D
D
L
D
P
N
T
S
M
E
I
L
N
P
N
Site 217
T2513
P
D
Q
N
I
L
D
T
D
N
S
S
A
T
Y
Site 218
S2516
N
I
L
D
T
D
N
S
S
A
T
Y
T
V
S
Site 219
S2517
I
L
D
T
D
N
S
S
A
T
Y
T
V
S
S
Site 220
T2519
D
T
D
N
S
S
A
T
Y
T
V
S
S
C
D
Site 221
Y2520
T
D
N
S
S
A
T
Y
T
V
S
S
C
D
S
Site 222
T2521
D
N
S
S
A
T
Y
T
V
S
S
C
D
S
G
Site 223
S2523
S
S
A
T
Y
T
V
S
S
C
D
S
G
E
I
Site 224
S2524
S
A
T
Y
T
V
S
S
C
D
S
G
E
I
T
Site 225
T2555
I
A
T
N
D
H
G
T
T
S
T
S
A
T
V
Site 226
S2557
T
N
D
H
G
T
T
S
T
S
A
T
V
K
V
Site 227
T2561
G
T
T
S
T
S
A
T
V
K
V
Q
G
V
P
Site 228
S2593
L
R
W
L
P
P
S
S
T
G
N
C
T
I
S
Site 229
T2594
R
W
L
P
P
S
S
T
G
N
C
T
I
S
G
Site 230
S2600
S
T
G
N
C
T
I
S
G
Y
T
V
E
Y
R
Site 231
Y2606
I
S
G
Y
T
V
E
Y
R
E
E
G
S
Q
I
Site 232
S2611
V
E
Y
R
E
E
G
S
Q
I
W
Q
Q
S
V
Site 233
S2617
G
S
Q
I
W
Q
Q
S
V
A
S
T
L
D
T
Site 234
Y2637
D
L
S
P
G
C
P
Y
Q
F
R
V
S
A
S
Site 235
S2644
Y
Q
F
R
V
S
A
S
N
P
W
G
I
S
L
Site 236
S2650
A
S
N
P
W
G
I
S
L
P
S
E
P
S
E
Site 237
S2653
P
W
G
I
S
L
P
S
E
P
S
E
F
V
R
Site 238
S2656
I
S
L
P
S
E
P
S
E
F
V
R
L
P
E
Site 239
Y2664
E
F
V
R
L
P
E
Y
D
A
A
A
D
G
A
Site 240
S2674
A
A
D
G
A
T
I
S
W
K
E
N
F
D
S
Site 241
S2681
S
W
K
E
N
F
D
S
A
Y
T
E
L
N
E
Site 242
Y2683
K
E
N
F
D
S
A
Y
T
E
L
N
E
I
G
Site 243
S2695
E
I
G
R
G
R
F
S
I
V
K
K
C
I
H
Site 244
S2715
D
V
A
V
K
F
V
S
K
K
M
K
K
K
E
Site 245
Y2739
Q
H
L
Q
H
P
Q
Y
I
T
L
H
D
T
Y
Site 246
T2745
Q
Y
I
T
L
H
D
T
Y
E
S
P
T
S
Y
Site 247
Y2746
Y
I
T
L
H
D
T
Y
E
S
P
T
S
Y
I
Site 248
S2748
T
L
H
D
T
Y
E
S
P
T
S
Y
I
L
I
Site 249
Y2767
D
D
G
R
L
L
D
Y
L
M
N
H
D
E
L
Site 250
Y2782
M
E
E
K
V
A
F
Y
I
R
D
I
M
E
A
Site 251
S2883
V
S
P
F
L
D
E
S
K
E
E
T
C
I
N
Site 252
T2887
L
D
E
S
K
E
E
T
C
I
N
V
C
R
V
Site 253
Y2902
D
F
S
F
P
H
E
Y
F
C
G
V
S
N
A
Site 254
T2927
E
D
F
R
R
R
P
T
A
A
T
C
L
Q
H
Site 255
T2930
R
R
R
P
T
A
A
T
C
L
Q
H
P
W
L
Site 256
S2943
W
L
Q
P
H
N
G
S
Y
S
K
I
P
L
D
Site 257
S2945
Q
P
H
N
G
S
Y
S
K
I
P
L
D
T
S
Site 258
S2975
R
P
I
P
N
V
K
S
Y
I
V
N
R
V
N
Site 259
Y2976
P
I
P
N
V
K
S
Y
I
V
N
R
V
N
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation