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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPP1R12B
Full Name:
Protein phosphatase 1 regulatory subunit 12B
Alias:
Myosin phosphatase regulatory subunit; Myosin phosphatase target 2; Myosin phosphatase-targeting 2; Myosin phosphatase-targeting subunit 2; MYPT2
Type:
Regulatory protein - Protein phosphatase targeting protein
Mass (Da):
110404
Number AA:
982
UniProt ID:
O60237
International Prot ID:
IPI00329075
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0008047
PhosphoSite+
KinaseNET
Biological Process:
GO:0006937
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
L
G
G
K
R
A
E
S
A
R
M
R
R
A
E
Site 2
S29
Q
L
R
R
W
R
G
S
L
T
E
Q
E
P
A
Site 3
T31
R
R
W
R
G
S
L
T
E
Q
E
P
A
E
R
Site 4
T47
G
A
G
R
Q
P
L
T
R
R
G
S
P
R
V
Site 5
S51
Q
P
L
T
R
R
G
S
P
R
V
R
F
E
D
Site 6
T71
A
A
C
S
S
G
D
T
D
E
V
R
K
L
L
Site 7
T86
A
R
G
A
D
I
N
T
V
N
V
D
G
L
T
Site 8
T126
Q
Q
D
N
E
G
W
T
P
L
H
A
A
A
S
Site 9
Y142
G
Y
L
N
I
A
E
Y
F
I
N
H
G
A
S
Site 10
S155
A
S
V
G
I
V
N
S
E
G
E
V
P
S
D
Site 11
S205
D
A
R
Q
W
L
N
S
G
K
I
E
D
V
R
Site 12
Y241
R
L
L
I
Q
A
G
Y
E
L
N
V
Q
D
Y
Site 13
Y248
Y
E
L
N
V
Q
D
Y
D
G
W
T
P
L
H
Site 14
T285
I
R
N
K
L
G
Q
T
P
F
D
V
A
D
E
Site 15
T314
V
L
R
S
E
K
E
T
R
N
K
L
I
E
S
Site 16
S325
L
I
E
S
D
L
N
S
K
I
Q
S
G
F
F
Site 17
S329
D
L
N
S
K
I
Q
S
G
F
F
K
N
K
E
Site 18
Y340
K
N
K
E
K
M
L
Y
E
E
E
T
P
K
S
Site 19
T344
K
M
L
Y
E
E
E
T
P
K
S
Q
E
M
E
Site 20
S347
Y
E
E
E
T
P
K
S
Q
E
M
E
E
E
N
Site 21
S357
M
E
E
E
N
K
E
S
S
S
S
S
S
E
E
Site 22
S358
E
E
E
N
K
E
S
S
S
S
S
S
E
E
E
Site 23
S359
E
E
N
K
E
S
S
S
S
S
S
E
E
E
E
Site 24
S360
E
N
K
E
S
S
S
S
S
S
E
E
E
E
G
Site 25
S361
N
K
E
S
S
S
S
S
S
E
E
E
E
G
E
Site 26
S362
K
E
S
S
S
S
S
S
E
E
E
E
G
E
D
Site 27
S372
E
E
G
E
D
E
A
S
E
S
E
T
E
K
E
Site 28
S374
G
E
D
E
A
S
E
S
E
T
E
K
E
A
D
Site 29
S391
P
E
A
F
V
N
H
S
N
S
E
S
K
S
S
Site 30
S393
A
F
V
N
H
S
N
S
E
S
K
S
S
I
T
Site 31
S395
V
N
H
S
N
S
E
S
K
S
S
I
T
E
Q
Site 32
S397
H
S
N
S
E
S
K
S
S
I
T
E
Q
I
P
Site 33
S398
S
N
S
E
S
K
S
S
I
T
E
Q
I
P
A
Site 34
T410
I
P
A
P
A
Q
N
T
F
S
A
S
S
A
R
Site 35
S412
A
P
A
Q
N
T
F
S
A
S
S
A
R
R
F
Site 36
S414
A
Q
N
T
F
S
A
S
S
A
R
R
F
S
S
Site 37
S415
Q
N
T
F
S
A
S
S
A
R
R
F
S
S
G
Site 38
S420
A
S
S
A
R
R
F
S
S
G
L
F
N
K
P
Site 39
S421
S
S
A
R
R
F
S
S
G
L
F
N
K
P
E
Site 40
S434
P
E
E
P
K
D
E
S
P
S
S
W
R
L
G
Site 41
S436
E
P
K
D
E
S
P
S
S
W
R
L
G
L
R
Site 42
S437
P
K
D
E
S
P
S
S
W
R
L
G
L
R
K
Site 43
T445
W
R
L
G
L
R
K
T
G
S
H
N
M
L
S
Site 44
S447
L
G
L
R
K
T
G
S
H
N
M
L
S
E
V
Site 45
S452
T
G
S
H
N
M
L
S
E
V
A
N
S
R
E
Site 46
S457
M
L
S
E
V
A
N
S
R
E
P
I
R
D
R
Site 47
S466
E
P
I
R
D
R
G
S
S
I
Y
R
S
S
S
Site 48
S467
P
I
R
D
R
G
S
S
I
Y
R
S
S
S
S
Site 49
Y469
R
D
R
G
S
S
I
Y
R
S
S
S
S
P
R
Site 50
S471
R
G
S
S
I
Y
R
S
S
S
S
P
R
I
S
Site 51
S472
G
S
S
I
Y
R
S
S
S
S
P
R
I
S
A
Site 52
S473
S
S
I
Y
R
S
S
S
S
P
R
I
S
A
L
Site 53
S474
S
I
Y
R
S
S
S
S
P
R
I
S
A
L
L
Site 54
S478
S
S
S
S
P
R
I
S
A
L
L
D
N
K
D
Site 55
S492
D
K
E
R
E
N
K
S
Y
I
S
S
L
A
P
Site 56
Y493
K
E
R
E
N
K
S
Y
I
S
S
L
A
P
R
Site 57
S496
E
N
K
S
Y
I
S
S
L
A
P
R
K
L
N
Site 58
S504
L
A
P
R
K
L
N
S
T
S
D
I
E
E
K
Site 59
T505
A
P
R
K
L
N
S
T
S
D
I
E
E
K
E
Site 60
S506
P
R
K
L
N
S
T
S
D
I
E
E
K
E
N
Site 61
S516
E
E
K
E
N
R
E
S
A
V
N
L
V
R
S
Site 62
S525
V
N
L
V
R
S
G
S
Y
T
R
Q
L
W
R
Site 63
T527
L
V
R
S
G
S
Y
T
R
Q
L
W
R
D
E
Site 64
T543
K
G
N
E
I
P
Q
T
I
A
P
S
T
Y
V
Site 65
T548
P
Q
T
I
A
P
S
T
Y
V
S
T
Y
L
K
Site 66
Y549
Q
T
I
A
P
S
T
Y
V
S
T
Y
L
K
R
Site 67
S551
I
A
P
S
T
Y
V
S
T
Y
L
K
R
T
P
Site 68
Y553
P
S
T
Y
V
S
T
Y
L
K
R
T
P
H
K
Site 69
T557
V
S
T
Y
L
K
R
T
P
H
K
S
Q
A
D
Site 70
S561
L
K
R
T
P
H
K
S
Q
A
D
T
T
A
E
Site 71
T565
P
H
K
S
Q
A
D
T
T
A
E
K
T
A
D
Site 72
T570
A
D
T
T
A
E
K
T
A
D
N
V
S
S
S
Site 73
T591
T
N
R
P
L
P
S
T
A
N
G
V
T
A
T
Site 74
T606
P
V
L
S
I
T
G
T
D
S
S
V
E
A
R
Site 75
S609
S
I
T
G
T
D
S
S
V
E
A
R
E
K
R
Site 76
S618
E
A
R
E
K
R
R
S
Y
L
T
P
V
R
D
Site 77
Y619
A
R
E
K
R
R
S
Y
L
T
P
V
R
D
E
Site 78
T621
E
K
R
R
S
Y
L
T
P
V
R
D
E
E
A
Site 79
S630
V
R
D
E
E
A
E
S
L
R
K
A
R
S
R
Site 80
S636
E
S
L
R
K
A
R
S
R
Q
A
R
Q
T
R
Site 81
T642
R
S
R
Q
A
R
Q
T
R
R
S
T
Q
G
V
Site 82
S645
Q
A
R
Q
T
R
R
S
T
Q
G
V
T
L
T
Site 83
T646
A
R
Q
T
R
R
S
T
Q
G
V
T
L
T
D
Site 84
T652
S
T
Q
G
V
T
L
T
D
L
Q
E
A
E
R
Site 85
T660
D
L
Q
E
A
E
R
T
F
S
R
S
R
A
E
Site 86
S662
Q
E
A
E
R
T
F
S
R
S
R
A
E
R
Q
Site 87
S664
A
E
R
T
F
S
R
S
R
A
E
R
Q
A
Q
Site 88
T681
P
R
E
K
P
T
D
T
E
G
L
E
G
S
P
Site 89
S687
D
T
E
G
L
E
G
S
P
E
K
H
E
P
S
Site 90
S711
G
Q
Q
P
W
G
R
S
L
D
E
E
P
I
C
Site 91
T731
P
A
Q
P
D
K
P
T
T
P
A
S
P
S
T
Site 92
T732
A
Q
P
D
K
P
T
T
P
A
S
P
S
T
S
Site 93
S735
D
K
P
T
T
P
A
S
P
S
T
S
R
P
S
Site 94
S737
P
T
T
P
A
S
P
S
T
S
R
P
S
L
Y
Site 95
T738
T
T
P
A
S
P
S
T
S
R
P
S
L
Y
T
Site 96
S739
T
P
A
S
P
S
T
S
R
P
S
L
Y
T
S
Site 97
S742
S
P
S
T
S
R
P
S
L
Y
T
S
S
H
L
Site 98
Y744
S
T
S
R
P
S
L
Y
T
S
S
H
L
L
W
Site 99
T745
T
S
R
P
S
L
Y
T
S
S
H
L
L
W
T
Site 100
S746
S
R
P
S
L
Y
T
S
S
H
L
L
W
T
N
Site 101
T752
T
S
S
H
L
L
W
T
N
R
F
S
V
P
D
Site 102
S756
L
L
W
T
N
R
F
S
V
P
D
S
E
S
S
Site 103
S760
N
R
F
S
V
P
D
S
E
S
S
E
T
T
T
Site 104
S762
F
S
V
P
D
S
E
S
S
E
T
T
T
N
T
Site 105
T765
P
D
S
E
S
S
E
T
T
T
N
T
T
T
A
Site 106
T766
D
S
E
S
S
E
T
T
T
N
T
T
T
A
K
Site 107
T767
S
E
S
S
E
T
T
T
N
T
T
T
A
K
E
Site 108
S789
E
A
D
L
D
E
Q
S
S
K
R
L
S
I
R
Site 109
S790
A
D
L
D
E
Q
S
S
K
R
L
S
I
R
E
Site 110
S794
E
Q
S
S
K
R
L
S
I
R
E
R
R
R
P
Site 111
T808
P
K
E
R
R
R
G
T
G
I
N
F
W
T
K
Site 112
S823
D
E
D
E
T
D
G
S
E
E
V
K
E
T
W
Site 113
T829
G
S
E
E
V
K
E
T
W
H
E
R
L
S
R
Site 114
S835
E
T
W
H
E
R
L
S
R
L
E
S
G
G
S
Site 115
S839
E
R
L
S
R
L
E
S
G
G
S
N
P
T
T
Site 116
S842
S
R
L
E
S
G
G
S
N
P
T
T
S
D
S
Site 117
T845
E
S
G
G
S
N
P
T
T
S
D
S
Y
G
D
Site 118
T846
S
G
G
S
N
P
T
T
S
D
S
Y
G
D
R
Site 119
S847
G
G
S
N
P
T
T
S
D
S
Y
G
D
R
A
Site 120
S849
S
N
P
T
T
S
D
S
Y
G
D
R
A
S
A
Site 121
Y850
N
P
T
T
S
D
S
Y
G
D
R
A
S
A
R
Site 122
S855
D
S
Y
G
D
R
A
S
A
R
A
R
R
E
A
Site 123
T869
A
R
E
A
R
L
A
T
L
T
S
R
V
E
E
Site 124
T871
E
A
R
L
A
T
L
T
S
R
V
E
E
D
S
Site 125
S872
A
R
L
A
T
L
T
S
R
V
E
E
D
S
N
Site 126
S878
T
S
R
V
E
E
D
S
N
R
D
Y
K
K
L
Site 127
Y882
E
E
D
S
N
R
D
Y
K
K
L
Y
E
S
A
Site 128
Y886
N
R
D
Y
K
K
L
Y
E
S
A
L
T
E
N
Site 129
T891
K
L
Y
E
S
A
L
T
E
N
Q
K
L
K
T
Site 130
S912
L
E
L
A
D
I
K
S
K
L
E
K
V
A
Q
Site 131
T925
A
Q
Q
K
Q
E
K
T
S
D
R
S
S
V
L
Site 132
S926
Q
Q
K
Q
E
K
T
S
D
R
S
S
V
L
E
Site 133
S930
E
K
T
S
D
R
S
S
V
L
E
M
E
K
R
Site 134
S947
R
A
L
E
R
K
M
S
E
M
E
E
E
M
K
Site 135
T957
E
E
E
M
K
V
L
T
E
L
K
S
D
N
Q
Site 136
S961
K
V
L
T
E
L
K
S
D
N
Q
R
L
K
D
Site 137
S981
I
R
V
I
S
K
L
S
K
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation