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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HS6ST1
Full Name:
Heparan-sulfate 6-O-sulfotransferase 1
Alias:
H6ST1; Heparan sulfate 6-O-sulfotransferase; Heparan sulfate 6-O-sulfotransferase 1; Heparan-sulfate 6-sulfotransferase; HS6ST; HS6ST-1
Type:
Glycan Metabolism - heparan sulfate biosynthesis; Transferase; EC 2.8.2.-
Mass (Da):
47028
Number AA:
410
UniProt ID:
O60243
International Prot ID:
IPI00028449
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0008146
PhosphoSite+
KinaseNET
Biological Process:
GO:0015015
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
R
R
R
A
G
G
R
T
M
V
E
R
A
S
K
Site 2
S41
Q
Y
A
G
P
G
L
S
L
G
A
P
G
G
R
Site 3
T59
D
D
L
D
L
F
P
T
P
D
P
H
Y
E
K
Site 4
Y64
F
P
T
P
D
P
H
Y
E
K
K
Y
Y
F
P
Site 5
Y68
D
P
H
Y
E
K
K
Y
Y
F
P
V
R
E
L
Site 6
Y69
P
H
Y
E
K
K
Y
Y
F
P
V
R
E
L
E
Site 7
S78
P
V
R
E
L
E
R
S
L
R
F
D
M
K
G
Site 8
T97
V
F
L
H
I
Q
K
T
G
G
T
T
F
G
R
Site 9
T101
I
Q
K
T
G
G
T
T
F
G
R
H
L
V
Q
Site 10
T126
R
P
G
Q
K
K
C
T
C
Y
R
P
N
R
R
Site 11
T135
Y
R
P
N
R
R
E
T
W
L
F
S
R
F
S
Site 12
S139
R
R
E
T
W
L
F
S
R
F
S
T
G
W
S
Site 13
S169
G
V
L
D
R
R
D
S
A
A
L
R
T
P
R
Site 14
T174
R
D
S
A
A
L
R
T
P
R
K
F
Y
Y
I
Site 15
Y179
L
R
T
P
R
K
F
Y
Y
I
T
L
L
R
D
Site 16
Y180
R
T
P
R
K
F
Y
Y
I
T
L
L
R
D
P
Site 17
T182
P
R
K
F
Y
Y
I
T
L
L
R
D
P
V
S
Site 18
S189
T
L
L
R
D
P
V
S
R
Y
L
S
E
W
R
Site 19
Y191
L
R
D
P
V
S
R
Y
L
S
E
W
R
H
V
Site 20
S193
D
P
V
S
R
Y
L
S
E
W
R
H
V
Q
R
Site 21
T203
R
H
V
Q
R
G
A
T
W
K
T
S
L
H
M
Site 22
T215
L
H
M
C
D
G
R
T
P
T
P
E
E
L
P
Site 23
T217
M
C
D
G
R
T
P
T
P
E
E
L
P
P
C
Site 24
Y225
P
E
E
L
P
P
C
Y
E
G
T
D
W
S
G
Site 25
Y243
Q
E
F
M
D
C
P
Y
N
L
A
N
N
R
Q
Site 26
T300
L
T
E
F
Q
R
K
T
Q
Y
L
F
E
R
T
Site 27
Y302
E
F
Q
R
K
T
Q
Y
L
F
E
R
T
F
N
Site 28
Y319
F
I
R
P
F
M
Q
Y
N
S
T
R
A
G
G
Site 29
S321
R
P
F
M
Q
Y
N
S
T
R
A
G
G
V
E
Site 30
T333
G
V
E
V
D
E
D
T
I
R
R
I
E
E
L
Site 31
Y348
N
D
L
D
M
Q
L
Y
D
Y
A
K
D
L
F
Site 32
Y350
L
D
M
Q
L
Y
D
Y
A
K
D
L
F
Q
Q
Site 33
Y361
L
F
Q
Q
R
Y
Q
Y
K
R
Q
L
E
R
R
Site 34
S374
R
R
E
Q
R
L
R
S
R
E
E
R
L
L
H
Site 35
T400
D
E
P
G
R
V
P
T
E
D
Y
M
S
H
I
Site 36
Y403
G
R
V
P
T
E
D
Y
M
S
H
I
I
E
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation