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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRPSAP2
Full Name:
Phosphoribosyl pyrophosphate synthase-associated protein 2
Alias:
41 kDa phosphoribosypyrophosphate synthetase-associated protein; KPRB; PAP41; Phosphoribosyl pyrophosphate synthetase-associated protein 2; PRPP synthetase-associated protein 2
Type:
Inhibitor protein
Mass (Da):
40926
Number AA:
369
UniProt ID:
O60256
International Prot ID:
IPI00003168
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0004857
GO:0000287
GO:0004749
PhosphoSite+
KinaseNET
Biological Process:
GO:0009116
GO:0009165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
F
C
V
T
P
P
E
L
E
T
K
Site 2
S27
L
V
L
F
S
A
N
S
N
S
S
C
M
E
L
Site 3
S29
L
F
S
A
N
S
N
S
S
C
M
E
L
S
K
Site 4
S30
F
S
A
N
S
N
S
S
C
M
E
L
S
K
K
Site 5
Y52
E
M
G
K
V
Q
V
Y
Q
E
P
N
R
E
T
Site 6
T59
Y
Q
E
P
N
R
E
T
R
V
Q
I
Q
E
S
Site 7
S66
T
R
V
Q
I
Q
E
S
V
R
G
K
D
V
F
Site 8
T77
K
D
V
F
I
I
Q
T
V
S
K
D
V
N
T
Site 9
S124
C
K
M
R
K
R
G
S
I
V
S
K
L
L
A
Site 10
S127
R
K
R
G
S
I
V
S
K
L
L
A
S
M
M
Site 11
T144
A
G
L
T
H
L
I
T
M
D
L
H
Q
K
E
Site 12
Y172
A
S
P
F
L
L
Q
Y
I
Q
E
E
I
P
D
Site 13
S192
I
V
A
K
S
P
A
S
A
K
R
A
Q
S
F
Site 14
S198
A
S
A
K
R
A
Q
S
F
A
E
R
L
R
L
Site 15
S219
G
E
A
Q
D
A
E
S
D
L
V
D
G
R
H
Site 16
S227
D
L
V
D
G
R
H
S
P
P
M
V
R
S
V
Site 17
S233
H
S
P
P
M
V
R
S
V
A
A
I
H
P
S
Site 18
T255
P
K
E
K
P
P
I
T
V
V
G
D
V
G
G
Site 19
T284
S
F
L
A
A
A
E
T
L
K
E
R
G
A
Y
Site 20
S304
A
T
H
G
L
L
S
S
D
A
P
R
R
I
E
Site 21
S313
A
P
R
R
I
E
E
S
A
I
D
E
V
V
V
Site 22
S346
V
D
I
S
M
I
L
S
E
A
I
R
R
I
H
Site 23
Y360
H
N
G
E
S
M
S
Y
L
F
R
N
I
G
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation