PhosphoNET

           
Protein Info 
   
Short Name:  PRPSAP2
Full Name:  Phosphoribosyl pyrophosphate synthase-associated protein 2
Alias:  41 kDa phosphoribosypyrophosphate synthetase-associated protein; KPRB; PAP41; Phosphoribosyl pyrophosphate synthetase-associated protein 2; PRPP synthetase-associated protein 2
Type:  Inhibitor protein
Mass (Da):  40926
Number AA:  369
UniProt ID:  O60256
International Prot ID:  IPI00003168
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:  GO:0004857  GO:0000287  GO:0004749 PhosphoSite+ KinaseNET
Biological Process:  GO:0009116  GO:0009165   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T5___MFCVTPPELETK
Site 2S27LVLFSANSNSSCMEL
Site 3S29LFSANSNSSCMELSK
Site 4S30FSANSNSSCMELSKK
Site 5Y52EMGKVQVYQEPNRET
Site 6T59YQEPNRETRVQIQES
Site 7S66TRVQIQESVRGKDVF
Site 8T77KDVFIIQTVSKDVNT
Site 9S124CKMRKRGSIVSKLLA
Site 10S127RKRGSIVSKLLASMM
Site 11T144AGLTHLITMDLHQKE
Site 12Y172ASPFLLQYIQEEIPD
Site 13S192IVAKSPASAKRAQSF
Site 14S198ASAKRAQSFAERLRL
Site 15S219GEAQDAESDLVDGRH
Site 16S227DLVDGRHSPPMVRSV
Site 17S233HSPPMVRSVAAIHPS
Site 18T255PKEKPPITVVGDVGG
Site 19T284SFLAAAETLKERGAY
Site 20S304ATHGLLSSDAPRRIE
Site 21S313APRRIEESAIDEVVV
Site 22S346VDISMILSEAIRRIH
Site 23Y360HNGESMSYLFRNIGL
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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