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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Parkin
Full Name:
E3 ubiquitin-protein ligase parkin
Alias:
E3 ubiquitin-protein ligase parkin; EC 6.3.2.-; PARK2; Parkinson disease protein 2; PRKN; PRKN2; Ubiquitin E3 ligase PRKN
Type:
Ubiquitin conjugating protein
Mass (Da):
51641
Number AA:
465
UniProt ID:
O60260
International Prot ID:
IPI00005254
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005634
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004842
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007417
GO:0042787
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
I
V
F
V
R
F
N
S
S
H
G
F
P
V
E
Site 2
S19
G
F
P
V
E
V
D
S
D
T
S
I
F
Q
L
Site 3
T21
P
V
E
V
D
S
D
T
S
I
F
Q
L
K
E
Site 4
S65
N
C
D
L
D
Q
Q
S
I
V
H
I
V
Q
R
Site 5
T83
K
G
Q
E
M
N
A
T
G
G
D
D
P
R
N
Site 6
S101
G
C
E
R
E
P
Q
S
L
T
R
V
D
L
S
Site 7
T103
E
R
E
P
Q
S
L
T
R
V
D
L
S
S
S
Site 8
S108
S
L
T
R
V
D
L
S
S
S
V
L
P
G
D
Site 9
S109
L
T
R
V
D
L
S
S
S
V
L
P
G
D
S
Site 10
S110
T
R
V
D
L
S
S
S
V
L
P
G
D
S
V
Site 11
S116
S
S
V
L
P
G
D
S
V
G
L
A
V
I
L
Site 12
T125
G
L
A
V
I
L
H
T
D
S
R
K
D
S
P
Site 13
S127
A
V
I
L
H
T
D
S
R
K
D
S
P
P
A
Site 14
S131
H
T
D
S
R
K
D
S
P
P
A
G
S
P
A
Site 15
S136
K
D
S
P
P
A
G
S
P
A
G
R
S
I
Y
Site 16
S141
A
G
S
P
A
G
R
S
I
Y
N
S
F
Y
V
Site 17
Y143
S
P
A
G
R
S
I
Y
N
S
F
Y
V
Y
C
Site 18
Y147
R
S
I
Y
N
S
F
Y
V
Y
C
K
G
P
C
Site 19
Y149
I
Y
N
S
F
Y
V
Y
C
K
G
P
C
Q
R
Site 20
S167
G
K
L
R
V
Q
C
S
T
C
R
Q
A
T
L
Site 21
T168
K
L
R
V
Q
C
S
T
C
R
Q
A
T
L
T
Site 22
T173
C
S
T
C
R
Q
A
T
L
T
L
T
Q
G
P
Site 23
T175
T
C
R
Q
A
T
L
T
L
T
Q
G
P
S
C
Site 24
T177
R
Q
A
T
L
T
L
T
Q
G
P
S
C
W
D
Site 25
S193
V
L
I
P
N
R
M
S
G
E
C
Q
S
P
H
Site 26
S198
R
M
S
G
E
C
Q
S
P
H
C
P
G
T
S
Site 27
T204
Q
S
P
H
C
P
G
T
S
A
E
F
F
F
K
Site 28
S218
K
C
G
A
H
P
T
S
D
K
E
T
S
V
A
Site 29
T222
H
P
T
S
D
K
E
T
S
V
A
L
H
L
I
Site 30
S223
P
T
S
D
K
E
T
S
V
A
L
H
L
I
A
Site 31
Y285
V
H
D
P
Q
L
G
Y
S
L
P
C
V
A
G
Site 32
S296
C
V
A
G
C
P
N
S
L
I
K
E
L
H
H
Site 33
Y312
R
I
L
G
E
E
Q
Y
N
R
Y
Q
Q
Y
G
Site 34
Y315
G
E
E
Q
Y
N
R
Y
Q
Q
Y
G
A
E
E
Site 35
T351
E
P
D
Q
R
K
V
T
C
E
G
G
N
G
L
Site 36
Y372
C
R
E
C
K
E
A
Y
H
E
G
E
C
S
A
Site 37
S378
A
Y
H
E
G
E
C
S
A
V
F
E
A
S
G
Site 38
T386
A
V
F
E
A
S
G
T
T
T
Q
A
Y
R
V
Site 39
T388
F
E
A
S
G
T
T
T
Q
A
Y
R
V
D
E
Site 40
Y391
S
G
T
T
T
Q
A
Y
R
V
D
E
R
A
A
Site 41
S407
Q
A
R
W
E
A
A
S
K
E
T
I
K
K
T
Site 42
T414
S
K
E
T
I
K
K
T
T
K
P
C
P
R
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation