KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SMARCA5
Full Name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
Alias:
HSNF2H; ISWI; SMCA5; Sucrose nonfermenting protein 2 homologue; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a5
Type:
Helicase; Transcription factor; Histone-binding protein; EC 3.6.1.-
Mass (Da):
121905
Number AA:
1052
UniProt ID:
O60264
International Prot ID:
IPI00297211
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031213
GO:0000793
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016887
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0043044
GO:0006334
GO:0016584
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
S
A
A
E
P
P
P
Site 2
S15
P
P
P
P
P
P
E
S
A
P
S
K
P
A
A
Site 3
S18
P
P
P
E
S
A
P
S
K
P
A
A
S
I
A
Site 4
S23
A
P
S
K
P
A
A
S
I
A
S
G
G
S
N
Site 5
S26
K
P
A
A
S
I
A
S
G
G
S
N
S
S
N
Site 6
S29
A
S
I
A
S
G
G
S
N
S
S
N
K
G
G
Site 7
S31
I
A
S
G
G
S
N
S
S
N
K
G
G
P
E
Site 8
S32
A
S
G
G
S
N
S
S
N
K
G
G
P
E
G
Site 9
S66
E
E
I
F
D
D
A
S
P
G
K
Q
K
E
I
Site 10
T79
E
I
Q
E
P
D
P
T
Y
E
E
K
M
Q
T
Site 11
Y80
I
Q
E
P
D
P
T
Y
E
E
K
M
Q
T
D
Site 12
T86
T
Y
E
E
K
M
Q
T
D
R
A
N
R
F
E
Site 13
Y94
D
R
A
N
R
F
E
Y
L
L
K
Q
T
E
L
Site 14
T99
F
E
Y
L
L
K
Q
T
E
L
F
A
H
F
I
Site 15
T113
I
Q
P
A
A
Q
K
T
P
T
S
P
L
K
M
Site 16
T115
P
A
A
Q
K
T
P
T
S
P
L
K
M
K
P
Site 17
S116
A
A
Q
K
T
P
T
S
P
L
K
M
K
P
G
Site 18
S137
D
E
K
Q
N
L
L
S
V
G
D
Y
R
H
R
Site 19
Y141
N
L
L
S
V
G
D
Y
R
H
R
R
T
E
Q
Site 20
T146
G
D
Y
R
H
R
R
T
E
Q
E
E
D
E
E
Site 21
T156
E
E
D
E
E
L
L
T
E
S
S
K
A
T
N
Site 22
S159
E
E
L
L
T
E
S
S
K
A
T
N
V
C
T
Site 23
S171
V
C
T
R
F
E
D
S
P
S
Y
V
K
W
G
Site 24
S173
T
R
F
E
D
S
P
S
Y
V
K
W
G
K
L
Site 25
Y174
R
F
E
D
S
P
S
Y
V
K
W
G
K
L
R
Site 26
Y183
K
W
G
K
L
R
D
Y
Q
V
R
G
L
N
W
Site 27
S193
R
G
L
N
W
L
I
S
L
Y
E
N
G
I
N
Site 28
S217
G
K
T
L
Q
T
I
S
L
L
G
Y
M
K
H
Site 29
Y221
Q
T
I
S
L
L
G
Y
M
K
H
Y
R
N
I
Site 30
Y225
L
L
G
Y
M
K
H
Y
R
N
I
P
G
P
H
Site 31
T254
E
F
K
R
W
V
P
T
L
R
S
V
C
L
I
Site 32
S257
R
W
V
P
T
L
R
S
V
C
L
I
G
D
K
Site 33
Y304
F
K
K
F
N
W
R
Y
L
V
I
D
E
A
H
Site 34
S318
H
R
I
K
N
E
K
S
K
L
S
E
I
V
R
Site 35
S321
K
N
E
K
S
K
L
S
E
I
V
R
E
F
K
Site 36
T329
E
I
V
R
E
F
K
T
T
N
R
L
L
L
T
Site 37
T330
I
V
R
E
F
K
T
T
N
R
L
L
L
T
G
Site 38
T336
T
T
N
R
L
L
L
T
G
T
P
L
Q
N
N
Site 39
T338
N
R
L
L
L
T
G
T
P
L
Q
N
N
L
H
Site 40
S361
L
L
P
D
V
F
N
S
A
D
D
F
D
S
W
Site 41
S403
I
K
A
D
V
E
K
S
L
P
P
K
K
E
V
Site 42
Y413
P
K
K
E
V
K
I
Y
V
G
L
S
K
M
Q
Site 43
Y424
S
K
M
Q
R
E
W
Y
T
R
I
L
M
K
D
Site 44
Y461
R
K
C
C
N
H
P
Y
L
F
D
G
A
E
P
Site 45
Y472
G
A
E
P
G
P
P
Y
T
T
D
M
H
L
V
Site 46
T473
A
E
P
G
P
P
Y
T
T
D
M
H
L
V
T
Site 47
S500
P
K
L
K
E
Q
G
S
R
V
L
I
F
S
Q
Site 48
Y518
V
L
D
I
L
E
D
Y
C
M
W
R
N
Y
E
Site 49
T533
Y
C
R
L
D
G
Q
T
P
H
D
E
R
Q
D
Site 50
S541
P
H
D
E
R
Q
D
S
I
N
A
Y
N
E
P
Site 51
Y545
R
Q
D
S
I
N
A
Y
N
E
P
N
S
T
K
Site 52
T551
A
Y
N
E
P
N
S
T
K
F
V
F
M
L
S
Site 53
Y577
T
A
D
V
V
I
L
Y
D
S
D
W
N
P
Q
Site 54
T601
H
R
I
G
Q
T
K
T
V
R
V
F
R
F
I
Site 55
T609
V
R
V
F
R
F
I
T
D
N
T
V
E
E
R
Site 56
T612
F
R
F
I
T
D
N
T
V
E
E
R
I
V
E
Site 57
S629
E
M
K
L
R
L
D
S
I
V
I
Q
Q
G
R
Site 58
S664
G
A
T
H
V
F
A
S
K
E
S
E
I
T
D
Site 59
T670
A
S
K
E
S
E
I
T
D
E
D
I
D
G
I
Site 60
T685
L
E
R
G
A
K
K
T
A
E
M
N
E
K
L
Site 61
S693
A
E
M
N
E
K
L
S
K
M
G
E
S
S
L
Site 62
S698
K
L
S
K
M
G
E
S
S
L
R
N
F
T
M
Site 63
S699
L
S
K
M
G
E
S
S
L
R
N
F
T
M
D
Site 64
T704
E
S
S
L
R
N
F
T
M
D
T
E
S
S
V
Site 65
T707
L
R
N
F
T
M
D
T
E
S
S
V
Y
N
F
Site 66
S710
F
T
M
D
T
E
S
S
V
Y
N
F
E
G
E
Site 67
Y712
M
D
T
E
S
S
V
Y
N
F
E
G
E
D
Y
Site 68
Y719
Y
N
F
E
G
E
D
Y
R
E
K
Q
K
I
A
Site 69
Y747
A
N
Y
A
V
D
A
Y
F
R
E
A
L
R
V
Site 70
S755
F
R
E
A
L
R
V
S
E
P
K
A
P
K
A
Site 71
Y792
L
E
K
E
I
L
F
Y
R
K
T
I
G
Y
K
Site 72
T795
E
I
L
F
Y
R
K
T
I
G
Y
K
V
P
R
Site 73
Y798
F
Y
R
K
T
I
G
Y
K
V
P
R
N
P
E
Site 74
S825
L
K
I
D
E
A
E
S
L
N
D
E
E
L
E
Site 75
T839
E
E
K
E
K
L
L
T
Q
G
F
T
N
W
N
Site 76
T876
A
R
E
V
E
G
K
T
P
E
E
V
I
E
Y
Site 77
Y883
T
P
E
E
V
I
E
Y
S
A
V
F
W
E
R
Site 78
S916
A
R
I
Q
R
R
I
S
I
K
K
A
L
D
T
Site 79
T923
S
I
K
K
A
L
D
T
K
I
G
R
Y
K
A
Site 80
Y928
L
D
T
K
I
G
R
Y
K
A
P
F
H
Q
L
Site 81
S938
P
F
H
Q
L
R
I
S
Y
G
T
N
K
G
K
Site 82
Y939
F
H
Q
L
R
I
S
Y
G
T
N
K
G
K
N
Site 83
T941
Q
L
R
I
S
Y
G
T
N
K
G
K
N
Y
T
Site 84
Y970
G
F
D
K
E
N
V
Y
D
E
L
R
Q
C
I
Site 85
T1003
E
L
Q
R
R
C
N
T
L
I
T
L
I
E
R
Site 86
S1031
K
K
R
G
P
K
P
S
T
Q
K
R
K
M
D
Site 87
T1032
K
R
G
P
K
P
S
T
Q
K
R
K
M
D
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation