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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ST18
Full Name:
Suppression of tumorigenicity 18 protein
Alias:
Zinc finger protein 387
Type:
Mass (Da):
115155
Number AA:
1047
UniProt ID:
O60284
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
D
A
E
A
E
D
K
T
L
R
T
R
S
K
G
Site 2
T12
A
E
D
K
T
L
R
T
R
S
K
G
T
E
V
Site 3
S14
D
K
T
L
R
T
R
S
K
G
T
E
V
P
M
Site 4
S23
G
T
E
V
P
M
D
S
L
I
Q
E
L
S
V
Site 5
S29
D
S
L
I
Q
E
L
S
V
A
Y
D
C
S
M
Site 6
Y32
I
Q
E
L
S
V
A
Y
D
C
S
M
A
K
K
Site 7
S35
L
S
V
A
Y
D
C
S
M
A
K
K
R
T
A
Site 8
S56
V
P
V
N
K
R
K
S
L
L
M
K
P
R
H
Site 9
Y64
L
L
M
K
P
R
H
Y
S
P
K
A
D
C
Q
Site 10
S65
L
M
K
P
R
H
Y
S
P
K
A
D
C
Q
E
Site 11
S75
A
D
C
Q
E
D
R
S
D
R
T
E
D
D
G
Site 12
T78
Q
E
D
R
S
D
R
T
E
D
D
G
P
L
E
Site 13
S103
M
I
K
P
M
D
E
S
L
L
S
T
A
Q
E
Site 14
S106
P
M
D
E
S
L
L
S
T
A
Q
E
N
S
S
Site 15
T107
M
D
E
S
L
L
S
T
A
Q
E
N
S
S
R
Site 16
S112
L
S
T
A
Q
E
N
S
S
R
K
E
D
R
Y
Site 17
S113
S
T
A
Q
E
N
S
S
R
K
E
D
R
Y
S
Site 18
Y119
S
S
R
K
E
D
R
Y
S
C
Y
Q
E
L
M
Site 19
S120
S
R
K
E
D
R
Y
S
C
Y
Q
E
L
M
V
Site 20
Y122
K
E
D
R
Y
S
C
Y
Q
E
L
M
V
K
S
Site 21
S141
G
K
F
E
K
N
V
S
V
Q
T
V
S
E
N
Site 22
T144
E
K
N
V
S
V
Q
T
V
S
E
N
L
N
D
Site 23
S152
V
S
E
N
L
N
D
S
G
I
Q
S
L
K
A
Site 24
S156
L
N
D
S
G
I
Q
S
L
K
A
E
S
D
E
Site 25
S172
D
E
C
F
L
I
H
S
D
D
G
R
D
K
I
Site 26
S182
G
R
D
K
I
D
D
S
Q
P
P
F
C
S
S
Site 27
S188
D
S
Q
P
P
F
C
S
S
D
D
N
E
S
N
Site 28
S189
S
Q
P
P
F
C
S
S
D
D
N
E
S
N
S
Site 29
S194
C
S
S
D
D
N
E
S
N
S
E
S
A
E
N
Site 30
S196
S
D
D
N
E
S
N
S
E
S
A
E
N
G
W
Site 31
S198
D
N
E
S
N
S
E
S
A
E
N
G
W
D
S
Site 32
S205
S
A
E
N
G
W
D
S
G
S
N
F
S
E
E
Site 33
S207
E
N
G
W
D
S
G
S
N
F
S
E
E
T
K
Site 34
S210
W
D
S
G
S
N
F
S
E
E
T
K
P
P
R
Site 35
Y221
K
P
P
R
V
P
K
Y
V
L
T
D
H
K
K
Site 36
T224
R
V
P
K
Y
V
L
T
D
H
K
K
D
L
L
Site 37
S252
P
C
E
N
R
C
D
S
E
T
E
R
K
D
P
Site 38
T254
E
N
R
C
D
S
E
T
E
R
K
D
P
Q
N
Site 39
S274
L
D
G
N
A
Q
P
S
F
P
D
V
E
E
E
Site 40
S283
P
D
V
E
E
E
D
S
E
S
L
A
V
M
T
Site 41
S285
V
E
E
E
D
S
E
S
L
A
V
M
T
E
E
Site 42
T342
L
A
G
E
R
R
Q
T
K
V
I
D
M
G
G
Site 43
S358
Q
I
F
N
N
K
H
S
P
R
P
E
K
R
E
Site 44
T366
P
R
P
E
K
R
E
T
K
C
P
I
P
G
C
Site 45
Y383
T
G
H
V
T
G
L
Y
P
H
H
R
S
L
S
Site 46
S388
G
L
Y
P
H
H
R
S
L
S
G
C
P
H
K
Site 47
S390
Y
P
H
H
R
S
L
S
G
C
P
H
K
V
R
Site 48
T414
E
N
V
L
K
C
P
T
P
G
C
T
G
R
G
Site 49
S425
T
G
R
G
H
V
N
S
N
R
N
T
H
R
S
Site 50
T429
H
V
N
S
N
R
N
T
H
R
S
L
S
G
C
Site 51
S432
S
N
R
N
T
H
R
S
L
S
G
C
P
I
A
Site 52
S434
R
N
T
H
R
S
L
S
G
C
P
I
A
A
A
Site 53
S447
A
A
E
K
L
A
M
S
Q
D
K
N
Q
L
D
Site 54
S455
Q
D
K
N
Q
L
D
S
P
Q
T
G
Q
C
P
Site 55
S469
P
D
Q
A
H
R
T
S
L
V
K
Q
I
E
F
Site 56
S480
Q
I
E
F
N
F
P
S
Q
A
I
T
S
P
R
Site 57
T484
N
F
P
S
Q
A
I
T
S
P
R
A
T
V
S
Site 58
S485
F
P
S
Q
A
I
T
S
P
R
A
T
V
S
K
Site 59
T489
A
I
T
S
P
R
A
T
V
S
K
E
Q
E
K
Site 60
T520
G
K
R
P
L
I
Q
T
V
Q
G
R
K
T
P
Site 61
T526
Q
T
V
Q
G
R
K
T
P
P
F
P
E
S
K
Site 62
S532
K
T
P
P
F
P
E
S
K
H
F
P
N
P
V
Site 63
S547
K
F
P
N
R
L
P
S
A
G
A
H
T
Q
S
Site 64
T552
L
P
S
A
G
A
H
T
Q
S
P
G
R
A
S
Site 65
S554
S
A
G
A
H
T
Q
S
P
G
R
A
S
S
Y
Site 66
S559
T
Q
S
P
G
R
A
S
S
Y
S
Y
G
Q
C
Site 67
S560
Q
S
P
G
R
A
S
S
Y
S
Y
G
Q
C
S
Site 68
Y561
S
P
G
R
A
S
S
Y
S
Y
G
Q
C
S
E
Site 69
S562
P
G
R
A
S
S
Y
S
Y
G
Q
C
S
E
D
Site 70
Y563
G
R
A
S
S
Y
S
Y
G
Q
C
S
E
D
T
Site 71
T589
S
T
R
C
R
E
A
T
D
I
L
S
N
K
P
Site 72
S593
R
E
A
T
D
I
L
S
N
K
P
Q
S
L
H
Site 73
S598
I
L
S
N
K
P
Q
S
L
H
A
K
G
A
E
Site 74
S617
E
N
G
T
L
D
L
S
M
K
K
N
R
I
L
Site 75
S627
K
N
R
I
L
D
K
S
A
P
L
T
S
S
N
Site 76
T631
L
D
K
S
A
P
L
T
S
S
N
T
S
I
P
Site 77
S632
D
K
S
A
P
L
T
S
S
N
T
S
I
P
T
Site 78
S633
K
S
A
P
L
T
S
S
N
T
S
I
P
T
P
Site 79
T635
A
P
L
T
S
S
N
T
S
I
P
T
P
S
S
Site 80
S636
P
L
T
S
S
N
T
S
I
P
T
P
S
S
S
Site 81
T639
S
S
N
T
S
I
P
T
P
S
S
S
P
F
K
Site 82
S641
N
T
S
I
P
T
P
S
S
S
P
F
K
T
S
Site 83
S642
T
S
I
P
T
P
S
S
S
P
F
K
T
S
S
Site 84
S643
S
I
P
T
P
S
S
S
P
F
K
T
S
S
I
Site 85
T647
P
S
S
S
P
F
K
T
S
S
I
L
V
N
A
Site 86
Y672
G
W
D
T
P
I
N
Y
S
K
T
H
G
K
T
Site 87
S689
E
K
E
K
D
P
V
S
S
L
E
N
L
E
E
Site 88
S690
K
E
K
D
P
V
S
S
L
E
N
L
E
E
K
Site 89
S704
K
K
F
P
G
E
A
S
I
P
S
P
K
P
K
Site 90
S707
P
G
E
A
S
I
P
S
P
K
P
K
L
H
A
Site 91
T726
K
E
L
I
T
C
P
T
P
G
C
D
G
S
G
Site 92
S732
P
T
P
G
C
D
G
S
G
H
V
T
G
N
Y
Site 93
T736
C
D
G
S
G
H
V
T
G
N
Y
A
S
H
R
Site 94
Y739
S
G
H
V
T
G
N
Y
A
S
H
R
S
V
S
Site 95
S741
H
V
T
G
N
Y
A
S
H
R
S
V
S
G
C
Site 96
S744
G
N
Y
A
S
H
R
S
V
S
G
C
P
L
A
Site 97
S746
Y
A
S
H
R
S
V
S
G
C
P
L
A
D
K
Site 98
S757
L
A
D
K
T
L
K
S
L
M
A
A
N
S
Q
Site 99
S763
K
S
L
M
A
A
N
S
Q
E
L
K
C
P
T
Site 100
T770
S
Q
E
L
K
C
P
T
P
G
C
D
G
S
G
Site 101
Y783
S
G
H
V
T
G
N
Y
A
S
H
R
S
L
S
Site 102
S785
H
V
T
G
N
Y
A
S
H
R
S
L
S
G
C
Site 103
S788
G
N
Y
A
S
H
R
S
L
S
G
C
P
R
A
Site 104
S790
Y
A
S
H
R
S
L
S
G
C
P
R
A
R
K
Site 105
T803
R
K
G
G
V
K
M
T
P
T
K
E
E
K
E
Site 106
Y831
Q
G
H
I
S
G
K
Y
T
S
H
R
T
A
S
Site 107
T832
G
H
I
S
G
K
Y
T
S
H
R
T
A
S
G
Site 108
S833
H
I
S
G
K
Y
T
S
H
R
T
A
S
G
C
Site 109
S838
Y
T
S
H
R
T
A
S
G
C
P
L
A
A
K
Site 110
S856
E
N
P
L
N
G
A
S
L
S
W
K
L
N
K
Site 111
S858
P
L
N
G
A
S
L
S
W
K
L
N
K
Q
E
Site 112
S891
F
V
T
H
R
S
L
S
G
C
P
L
N
A
Q
Site 113
T911
K
V
S
E
E
L
M
T
I
K
L
K
A
T
G
Site 114
S922
K
A
T
G
G
I
E
S
D
E
E
I
R
H
L
Site 115
S939
E
I
K
E
L
N
E
S
N
L
K
I
E
A
D
Site 116
T952
A
D
M
M
K
L
Q
T
Q
I
T
S
M
E
S
Site 117
T955
M
K
L
Q
T
Q
I
T
S
M
E
S
N
L
K
Site 118
T963
S
M
E
S
N
L
K
T
I
E
E
E
N
K
L
Site 119
S977
L
I
E
Q
N
N
E
S
L
L
K
E
L
A
G
Site 120
S1005
L
P
Q
M
G
P
I
S
E
Q
N
F
E
A
Y
Site 121
Y1012
S
E
Q
N
F
E
A
Y
V
N
T
L
T
D
M
Site 122
T1017
E
A
Y
V
N
T
L
T
D
M
Y
S
N
L
E
Site 123
Y1020
V
N
T
L
T
D
M
Y
S
N
L
E
R
D
Y
Site 124
S1021
N
T
L
T
D
M
Y
S
N
L
E
R
D
Y
S
Site 125
Y1027
Y
S
N
L
E
R
D
Y
S
P
E
C
K
A
L
Site 126
S1028
S
N
L
E
R
D
Y
S
P
E
C
K
A
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation