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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
URB1
Full Name:
Nucleolar pre-ribosomal-associated protein 1
Alias:
C21orf108; KIAA0539; NPA1; Nucleolar preribosomal-associated protein 1; Protein URB1; URB1 ribosome biogenesis 1
Type:
Mass (Da):
254389
Number AA:
2271
UniProt ID:
O60287
International Prot ID:
IPI00297241
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0005730
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
G
V
P
K
R
K
A
S
G
G
Q
D
G
A
A
Site 2
S17
G
G
Q
D
G
A
A
S
S
A
G
A
A
K
R
Site 3
T31
R
A
R
K
E
E
L
T
G
V
R
F
K
A
Q
Site 4
S54
P
G
L
E
A
F
V
S
A
A
K
K
L
P
R
Site 5
Y65
K
L
P
R
E
D
V
Y
D
V
V
E
G
Y
I
Site 6
S86
V
E
I
F
Q
L
L
S
G
E
K
R
P
E
S
Site 7
S93
S
G
E
K
R
P
E
S
E
T
M
L
I
F
Q
Site 8
T95
E
K
R
P
E
S
E
T
M
L
I
F
Q
V
F
Site 9
T121
S
H
F
H
V
V
G
T
N
I
V
K
K
L
M
Site 10
S170
E
A
A
R
D
V
C
S
H
F
D
L
N
K
K
Site 11
Y180
D
L
N
K
K
T
L
Y
T
L
V
T
K
R
D
Site 12
T184
K
T
L
Y
T
L
V
T
K
R
D
S
K
G
V
Site 13
S188
T
L
V
T
K
R
D
S
K
G
V
Y
D
V
R
Site 14
Y192
K
R
D
S
K
G
V
Y
D
V
R
Q
A
Y
V
Site 15
S229
E
F
I
P
C
I
F
S
S
G
I
K
E
D
R
Site 16
T249
I
L
L
S
T
L
K
T
K
V
V
H
N
K
N
Site 17
T260
H
N
K
N
I
T
K
T
Q
K
V
R
F
F
T
Site 18
T267
T
Q
K
V
R
F
F
T
G
Q
L
L
N
H
I
Site 19
Y278
L
N
H
I
A
S
L
Y
N
W
N
G
I
T
D
Site 20
T301
S
A
E
E
A
G
K
T
M
V
R
E
L
V
H
Site 21
S328
G
I
N
F
Y
D
A
S
L
G
T
F
G
R
G
Site 22
T331
F
Y
D
A
S
L
G
T
F
G
R
G
G
N
L
Site 23
Y374
C
P
D
L
L
N
K
Y
F
K
E
V
T
F
S
Site 24
T379
N
K
Y
F
K
E
V
T
F
S
F
I
P
R
A
Site 25
S381
Y
F
K
E
V
T
F
S
F
I
P
R
A
K
S
Site 26
S388
S
F
I
P
R
A
K
S
T
W
L
N
N
I
K
Site 27
Y401
I
K
L
L
N
K
I
Y
E
A
Q
P
E
I
S
Site 28
T429
L
L
A
M
V
M
V
T
T
V
P
L
V
C
N
Site 29
T430
L
A
M
V
M
V
T
T
V
P
L
V
C
N
K
Site 30
S448
T
Q
A
L
N
L
D
S
T
S
V
R
H
T
A
Site 31
T449
Q
A
L
N
L
D
S
T
S
V
R
H
T
A
L
Site 32
S450
A
L
N
L
D
S
T
S
V
R
H
T
A
L
S
Site 33
T469
I
L
K
R
A
L
K
T
V
D
H
C
L
N
K
Site 34
Y485
V
W
Q
E
S
G
V
Y
T
A
V
M
M
E
E
Site 35
S517
T
V
V
W
V
W
Q
S
L
K
K
Q
E
T
K
Site 36
S534
D
K
K
G
Q
K
R
S
D
G
P
P
A
A
C
Site 37
S589
K
L
L
K
G
V
I
S
E
Q
G
L
R
E
E
Site 38
T695
T
M
E
E
D
K
E
T
V
I
Q
F
L
E
R
Site 39
S713
T
L
V
A
N
P
Y
S
Y
T
D
K
A
S
D
Site 40
S719
Y
S
Y
T
D
K
A
S
D
F
V
Q
E
A
S
Site 41
S741
K
Q
E
A
D
D
M
S
I
P
I
S
H
I
D
Site 42
S745
D
D
M
S
I
P
I
S
H
I
D
D
V
L
D
Site 43
Y859
L
S
R
F
N
R
Y
Y
S
L
W
I
P
E
Q
Site 44
S860
S
R
F
N
R
Y
Y
S
L
W
I
P
E
Q
A
Site 45
S878
W
L
L
Q
A
Q
G
S
P
S
P
P
A
L
P
Site 46
S880
L
Q
A
Q
G
S
P
S
P
P
A
L
P
L
A
Site 47
Y898
T
A
L
L
Q
A
A
Y
E
S
Q
A
L
R
D
Site 48
Y934
A
A
K
Q
V
L
L
Y
L
R
S
T
V
E
N
Site 49
S937
Q
V
L
L
Y
L
R
S
T
V
E
N
F
G
Q
Site 50
S948
N
F
G
Q
L
G
R
S
V
G
P
P
L
L
Q
Site 51
S997
L
D
M
E
S
V
A
S
L
E
L
A
N
D
Q
Site 52
T1035
Q
Q
A
L
P
P
H
T
L
S
P
V
L
V
K
Site 53
Y1075
Q
L
G
L
L
A
R
Y
S
E
A
I
T
Q
S
Site 54
T1080
A
R
Y
S
E
A
I
T
Q
S
V
L
K
E
L
Site 55
T1096
N
R
R
A
G
P
A
T
S
P
P
K
T
P
P
Site 56
S1097
R
R
A
G
P
A
T
S
P
P
K
T
P
P
Q
Site 57
T1101
P
A
T
S
P
P
K
T
P
P
Q
L
E
A
L
Site 58
Y1114
A
L
Q
E
L
H
P
Y
M
E
G
A
Q
L
R
Site 59
T1137
L
P
E
T
H
L
V
T
Q
Q
P
T
K
S
P
Site 60
T1141
H
L
V
T
Q
Q
P
T
K
S
P
G
K
E
R
Site 61
S1143
V
T
Q
Q
P
T
K
S
P
G
K
E
R
H
L
Site 62
T1162
K
T
L
V
Q
L
L
T
C
S
P
Q
D
Q
L
Site 63
S1164
L
V
Q
L
L
T
C
S
P
Q
D
Q
L
Q
S
Site 64
S1171
S
P
Q
D
Q
L
Q
S
G
E
L
L
W
S
S
Site 65
S1177
Q
S
G
E
L
L
W
S
S
E
Y
V
R
G
L
Site 66
S1178
S
G
E
L
L
W
S
S
E
Y
V
R
G
L
G
Site 67
Y1221
V
G
A
D
L
L
D
Y
C
L
A
R
R
T
Q
Site 68
S1282
Y
L
Q
C
R
T
R
S
H
F
T
R
P
A
G
Site 69
T1301
V
I
P
V
L
R
K
T
L
W
R
Q
L
Q
S
Site 70
S1308
T
L
W
R
Q
L
Q
S
R
L
L
S
T
D
S
Site 71
S1312
Q
L
Q
S
R
L
L
S
T
D
S
P
P
A
S
Site 72
T1313
L
Q
S
R
L
L
S
T
D
S
P
P
A
S
G
Site 73
S1315
S
R
L
L
S
T
D
S
P
P
A
S
G
L
Y
Site 74
S1319
S
T
D
S
P
P
A
S
G
L
Y
Q
E
I
L
Site 75
Y1322
S
P
P
A
S
G
L
Y
Q
E
I
L
A
Q
L
Site 76
T1351
R
L
P
S
L
L
H
T
P
S
S
H
K
R
W
Site 77
S1353
P
S
L
L
H
T
P
S
S
H
K
R
W
I
V
Site 78
S1354
S
L
L
H
T
P
S
S
H
K
R
W
I
V
A
Site 79
S1363
K
R
W
I
V
A
D
S
I
S
A
A
L
E
G
Site 80
S1365
W
I
V
A
D
S
I
S
A
A
L
E
G
S
A
Site 81
S1371
I
S
A
A
L
E
G
S
A
E
E
L
C
A
W
Site 82
T1381
E
L
C
A
W
R
R
T
L
L
E
S
C
V
K
Site 83
S1395
K
W
L
I
V
S
F
S
G
G
Q
Q
D
D
D
Site 84
T1404
G
Q
Q
D
D
D
N
T
Q
N
Q
E
K
E
M
Site 85
Y1442
K
K
G
L
K
F
R
Y
Q
D
H
T
F
L
K
Site 86
T1446
K
F
R
Y
Q
D
H
T
F
L
K
M
L
L
T
Site 87
S1460
T
A
V
Q
L
L
Y
S
P
E
S
S
V
R
T
Site 88
S1463
Q
L
L
Y
S
P
E
S
S
V
R
T
K
L
I
Site 89
S1464
L
L
Y
S
P
E
S
S
V
R
T
K
L
I
Q
Site 90
T1467
S
P
E
S
S
V
R
T
K
L
I
Q
L
P
V
Site 91
T1491
L
F
L
P
T
L
L
T
S
D
G
E
E
S
P
Site 92
S1492
F
L
P
T
L
L
T
S
D
G
E
E
S
P
D
Site 93
S1497
L
T
S
D
G
E
E
S
P
D
S
Q
V
K
E
Site 94
S1500
D
G
E
E
S
P
D
S
Q
V
K
E
A
L
V
Site 95
T1576
A
A
V
E
H
H
K
T
C
R
S
L
G
R
S
Site 96
S1579
E
H
H
K
T
C
R
S
L
G
R
S
L
W
Q
Site 97
S1583
T
C
R
S
L
G
R
S
L
W
Q
Q
P
S
V
Site 98
S1589
R
S
L
W
Q
Q
P
S
V
G
D
I
L
R
L
Site 99
T1621
R
L
L
P
P
E
D
T
Q
E
L
I
F
K
D
Site 100
S1630
E
L
I
F
K
D
K
S
R
V
D
L
D
G
L
Site 101
S1676
G
L
T
V
T
A
L
S
S
Y
D
P
Q
M
R
Site 102
S1706
G
A
R
F
Q
E
Q
S
Q
L
L
Y
L
L
D
Site 103
Y1710
Q
E
Q
S
Q
L
L
Y
L
L
D
V
V
R
N
Site 104
T1721
V
V
R
N
G
I
R
T
Q
D
M
R
L
T
F
Site 105
Y1749
L
K
P
E
E
H
M
Y
L
K
V
S
N
F
L
Site 106
S1758
K
V
S
N
F
L
L
S
H
E
Y
L
N
M
D
Site 107
Y1775
P
G
F
Y
Q
F
F
Y
S
S
D
F
E
Q
K
Site 108
T1783
S
S
D
F
E
Q
K
T
E
Q
K
W
V
F
G
Site 109
Y1802
G
I
R
D
K
Q
C
Y
E
L
C
A
R
R
G
Site 110
Y1846
A
Q
V
A
R
S
A
Y
E
I
I
R
D
Y
S
Site 111
S1896
D
K
A
V
E
W
E
S
Q
R
L
C
Q
P
S
Site 112
S1903
S
Q
R
L
C
Q
P
S
S
Q
E
P
A
K
R
Site 113
S1904
Q
R
L
C
Q
P
S
S
Q
E
P
A
K
R
L
Site 114
S1948
N
F
F
G
T
L
D
S
V
L
R
Y
R
A
T
Site 115
T1955
S
V
L
R
Y
R
A
T
V
I
Q
A
F
R
D
Site 116
T1967
F
R
D
M
N
R
F
T
V
N
E
T
V
L
S
Site 117
S1986
L
V
L
L
H
K
W
S
L
I
E
R
D
L
K
Site 118
S2050
A
D
P
E
L
M
A
S
T
L
E
T
C
K
G
Site 119
S2061
T
C
K
G
L
L
R
S
I
L
T
Y
W
R
P
Site 120
T2076
V
I
P
G
P
D
P
T
Q
E
P
V
D
S
A
Site 121
S2082
P
T
Q
E
P
V
D
S
A
S
P
E
S
D
A
Site 122
S2084
Q
E
P
V
D
S
A
S
P
E
S
D
A
P
G
Site 123
S2087
V
D
S
A
S
P
E
S
D
A
P
G
P
V
Y
Site 124
S2114
S
V
A
E
H
P
L
S
R
A
E
A
A
G
L
Site 125
S2147
L
K
D
S
A
V
R
S
S
I
F
R
L
Y
S
Site 126
S2148
K
D
S
A
V
R
S
S
I
F
R
L
Y
S
R
Site 127
Y2153
R
S
S
I
F
R
L
Y
S
R
L
C
G
A
E
Site 128
S2154
S
S
I
F
R
L
Y
S
R
L
C
G
A
E
G
Site 129
S2189
A
A
Q
G
R
A
G
S
P
F
H
P
A
M
E
Site 130
S2199
H
P
A
M
E
A
L
S
L
S
S
L
S
E
K
Site 131
S2201
A
M
E
A
L
S
L
S
S
L
S
E
K
D
E
Site 132
T2234
L
G
A
Q
R
P
D
T
L
L
T
H
V
R
M
Site 133
T2237
Q
R
P
D
T
L
L
T
H
V
R
M
V
C
E
Site 134
S2251
E
A
A
D
D
A
P
S
S
E
E
E
A
I
V
Site 135
S2252
A
A
D
D
A
P
S
S
E
E
E
A
I
V
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation