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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
mahogunin
Full Name:
E3 ubiquitin-protein ligase MGRN1
Alias:
EC 6.3.2.-; Mahogunin ring finger 1; MGRN1; RING finger protein 156
Type:
Protein degradation, putative E3 ubiquitin-protein ligase
Mass (Da):
60753
Number AA:
552
UniProt ID:
O60291
International Prot ID:
IPI00643212
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0016874
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y23
D
I
Q
A
N
S
A
Y
R
Y
P
P
K
S
G
Site 2
Y25
Q
A
N
S
A
Y
R
Y
P
P
K
S
G
N
Y
Site 3
S29
A
Y
R
Y
P
P
K
S
G
N
Y
F
A
S
H
Site 4
Y32
Y
P
P
K
S
G
N
Y
F
A
S
H
F
F
M
Site 5
T46
M
G
G
E
K
F
D
T
P
H
P
E
G
Y
L
Site 6
Y52
D
T
P
H
P
E
G
Y
L
F
G
E
N
M
D
Site 7
S65
M
D
L
N
F
L
G
S
R
P
V
Q
F
P
Y
Site 8
Y72
S
R
P
V
Q
F
P
Y
V
T
P
A
P
H
E
Site 9
T74
P
V
Q
F
P
Y
V
T
P
A
P
H
E
P
V
Site 10
T83
A
P
H
E
P
V
K
T
L
R
S
L
V
N
I
Site 11
S86
E
P
V
K
T
L
R
S
L
V
N
I
R
K
D
Site 12
S94
L
V
N
I
R
K
D
S
L
R
L
V
R
Y
K
Site 13
Y100
D
S
L
R
L
V
R
Y
K
D
D
A
D
S
P
Site 14
S106
R
Y
K
D
D
A
D
S
P
T
E
D
G
D
K
Site 15
T108
K
D
D
A
D
S
P
T
E
D
G
D
K
P
R
Site 16
Y118
G
D
K
P
R
V
L
Y
S
L
E
F
T
F
D
Site 17
S119
D
K
P
R
V
L
Y
S
L
E
F
T
F
D
A
Site 18
Y149
F
L
N
G
R
A
V
Y
S
P
K
S
P
S
L
Site 19
S150
L
N
G
R
A
V
Y
S
P
K
S
P
S
L
Q
Site 20
S153
R
A
V
Y
S
P
K
S
P
S
L
Q
S
E
T
Site 21
S155
V
Y
S
P
K
S
P
S
L
Q
S
E
T
V
H
Site 22
S158
P
K
S
P
S
L
Q
S
E
T
V
H
Y
K
R
Site 23
Y163
L
Q
S
E
T
V
H
Y
K
R
G
V
S
Q
Q
Site 24
S168
V
H
Y
K
R
G
V
S
Q
Q
F
S
L
P
S
Site 25
S172
R
G
V
S
Q
Q
F
S
L
P
S
F
K
I
D
Site 26
S175
S
Q
Q
F
S
L
P
S
F
K
I
D
F
S
E
Site 27
S181
P
S
F
K
I
D
F
S
E
W
K
D
D
E
L
Site 28
S231
F
E
K
H
M
D
G
S
F
S
V
K
P
L
K
Site 29
S233
K
H
M
D
G
S
F
S
V
K
P
L
K
Q
K
Site 30
S247
K
Q
I
V
D
R
V
S
Y
L
L
Q
E
I
Y
Site 31
Y254
S
Y
L
L
Q
E
I
Y
G
I
E
N
K
N
N
Site 32
S267
N
N
Q
E
T
K
P
S
D
D
E
N
S
D
N
Site 33
S272
K
P
S
D
D
E
N
S
D
N
S
N
E
C
V
Site 34
Y308
S
C
A
D
T
L
R
Y
Q
A
N
N
C
P
I
Site 35
S337
R
K
K
P
G
A
L
S
P
V
S
F
S
P
V
Site 36
S348
F
S
P
V
L
A
Q
S
L
E
H
D
E
H
S
Site 37
S355
S
L
E
H
D
E
H
S
C
P
F
K
K
S
K
Site 38
S361
H
S
C
P
F
K
K
S
K
P
H
P
A
S
L
Site 39
S367
K
S
K
P
H
P
A
S
L
A
S
K
K
P
K
Site 40
T377
S
K
K
P
K
R
E
T
N
S
D
S
V
P
P
Site 41
S379
K
P
K
R
E
T
N
S
D
S
V
P
P
G
Y
Site 42
S381
K
R
E
T
N
S
D
S
V
P
P
G
Y
E
P
Site 43
Y386
S
D
S
V
P
P
G
Y
E
P
I
S
L
L
E
Site 44
S390
P
P
G
Y
E
P
I
S
L
L
E
A
L
N
G
Site 45
S407
A
V
S
P
A
I
P
S
A
P
L
Y
E
E
I
Site 46
Y411
A
I
P
S
A
P
L
Y
E
E
I
T
Y
S
G
Site 47
T415
A
P
L
Y
E
E
I
T
Y
S
G
I
S
D
G
Site 48
Y416
P
L
Y
E
E
I
T
Y
S
G
I
S
D
G
L
Site 49
S417
L
Y
E
E
I
T
Y
S
G
I
S
D
G
L
S
Site 50
S439
A
I
D
H
I
L
D
S
S
R
Q
K
G
R
P
Site 51
S448
R
Q
K
G
R
P
Q
S
K
A
P
D
S
T
L
Site 52
S453
P
Q
S
K
A
P
D
S
T
L
R
S
P
S
S
Site 53
T454
Q
S
K
A
P
D
S
T
L
R
S
P
S
S
P
Site 54
S457
A
P
D
S
T
L
R
S
P
S
S
P
I
H
E
Site 55
S459
D
S
T
L
R
S
P
S
S
P
I
H
E
E
D
Site 56
S460
S
T
L
R
S
P
S
S
P
I
H
E
E
D
E
Site 57
S471
E
E
D
E
E
K
L
S
E
D
V
D
A
P
P
Site 58
S490
A
E
L
A
L
R
E
S
S
S
P
E
S
F
I
Site 59
S491
E
L
A
L
R
E
S
S
S
P
E
S
F
I
T
Site 60
S492
L
A
L
R
E
S
S
S
P
E
S
F
I
T
E
Site 61
S495
R
E
S
S
S
P
E
S
F
I
T
E
E
V
D
Site 62
T498
S
S
P
E
S
F
I
T
E
E
V
D
E
S
S
Site 63
S504
I
T
E
E
V
D
E
S
S
S
P
Q
Q
G
T
Site 64
S505
T
E
E
V
D
E
S
S
S
P
Q
Q
G
T
R
Site 65
S506
E
E
V
D
E
S
S
S
P
Q
Q
G
T
R
A
Site 66
S515
Q
Q
G
T
R
A
A
S
I
E
N
V
L
Q
D
Site 67
S524
E
N
V
L
Q
D
S
S
P
E
H
C
G
R
G
Site 68
Y537
R
G
P
P
A
D
I
Y
L
P
A
L
G
P
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation