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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LCMT2
Full Name:
Leucine carboxyl methyltransferase 2
Alias:
p21WAF1/CIP1 promoter-interacting protein;tRNA wybutosine-synthesizing protein 4 homolog
Type:
Mass (Da):
75602
Number AA:
686
UniProt ID:
O60294
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
R
A
G
A
V
Q
N
T
N
D
S
S
A
L
S
Site 2
S19
A
V
Q
N
T
N
D
S
S
A
L
S
K
R
S
Site 3
S20
V
Q
N
T
N
D
S
S
A
L
S
K
R
S
L
Site 4
S23
T
N
D
S
S
A
L
S
K
R
S
L
A
A
R
Site 5
S26
S
S
A
L
S
K
R
S
L
A
A
R
G
Y
V
Site 6
Y32
R
S
L
A
A
R
G
Y
V
Q
D
P
F
A
A
Site 7
Y57
P
L
I
H
R
G
Y
Y
V
R
A
R
A
V
R
Site 8
Y96
G
A
G
F
D
S
L
Y
F
R
L
K
T
A
G
Site 9
T101
S
L
Y
F
R
L
K
T
A
G
R
L
A
R
A
Site 10
T129
K
A
E
R
I
G
E
T
P
E
L
C
A
L
T
Site 11
S146
F
E
R
G
E
P
A
S
A
L
C
F
E
S
A
Site 12
Y218
P
N
A
L
F
V
V
Y
E
Q
M
R
P
Q
D
Site 13
S240
Q
H
F
R
Q
L
N
S
P
L
H
G
L
E
R
Site 14
S312
H
Y
F
I
L
A
A
S
R
G
D
T
L
S
H
Site 15
T316
L
A
A
S
R
G
D
T
L
S
H
T
L
V
F
Site 16
S318
A
S
R
G
D
T
L
S
H
T
L
V
F
P
S
Site 17
T320
R
G
D
T
L
S
H
T
L
V
F
P
S
S
E
Site 18
S325
S
H
T
L
V
F
P
S
S
E
A
F
P
R
V
Site 19
S326
H
T
L
V
F
P
S
S
E
A
F
P
R
V
N
Site 20
S336
F
P
R
V
N
P
A
S
P
S
G
V
F
P
A
Site 21
S344
P
S
G
V
F
P
A
S
V
V
S
S
E
G
Q
Site 22
S362
L
K
R
Y
G
H
A
S
V
F
L
S
P
D
V
Site 23
S387
E
G
R
H
C
R
V
S
Q
F
H
L
L
S
R
Site 24
S393
V
S
Q
F
H
L
L
S
R
D
C
D
S
E
W
Site 25
S398
L
L
S
R
D
C
D
S
E
W
K
G
S
Q
I
Site 26
S403
C
D
S
E
W
K
G
S
Q
I
G
S
C
G
T
Site 27
Y419
V
Q
W
D
G
R
L
Y
H
T
M
T
R
L
S
Site 28
T421
W
D
G
R
L
Y
H
T
M
T
R
L
S
E
S
Site 29
T423
G
R
L
Y
H
T
M
T
R
L
S
E
S
R
V
Site 30
S426
Y
H
T
M
T
R
L
S
E
S
R
V
L
V
L
Site 31
S428
T
M
T
R
L
S
E
S
R
V
L
V
L
G
G
Site 32
S438
L
V
L
G
G
R
L
S
P
V
S
P
A
L
G
Site 33
S441
G
G
R
L
S
P
V
S
P
A
L
G
V
L
Q
Site 34
S454
L
Q
L
H
F
F
K
S
E
D
N
N
T
E
D
Site 35
T459
F
K
S
E
D
N
N
T
E
D
L
K
V
T
I
Site 36
T467
E
D
L
K
V
T
I
T
K
A
G
R
K
D
D
Site 37
S488
R
H
S
T
T
E
V
S
C
Q
N
Q
E
Y
L
Site 38
Y494
V
S
C
Q
N
Q
E
Y
L
F
V
Y
G
G
R
Site 39
Y498
N
Q
E
Y
L
F
V
Y
G
G
R
S
V
V
E
Site 40
S536
E
V
P
E
A
R
H
S
H
S
A
C
T
W
Q
Site 41
S538
P
E
A
R
H
S
H
S
A
C
T
W
Q
G
G
Site 42
T584
V
D
I
Q
P
P
I
T
P
R
Y
S
H
T
A
Site 43
Y587
Q
P
P
I
T
P
R
Y
S
H
T
A
H
V
L
Site 44
S588
P
P
I
T
P
R
Y
S
H
T
A
H
V
L
N
Site 45
S624
I
N
L
T
T
G
L
S
S
E
Y
Q
I
D
T
Site 46
T631
S
S
E
Y
Q
I
D
T
T
Y
V
P
W
P
L
Site 47
Y633
E
Y
Q
I
D
T
T
Y
V
P
W
P
L
M
L
Site 48
Y669
N
C
F
S
F
G
T
Y
F
N
P
H
T
V
T
Site 49
T674
G
T
Y
F
N
P
H
T
V
T
L
D
L
S
S
Site 50
T676
Y
F
N
P
H
T
V
T
L
D
L
S
S
L
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation