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Updated November 2019
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Protein Info
Short Name:
ATP10A
Full Name:
Probable phospholipid-transporting ATPase VA
Alias:
aminophospholipid translocase VA; AT10A; ATP10C; ATPase type IV, phospholipid transporting (P-type); ATPase, Class V, type 10A; ATPase, Class V, type 10C; ATPVA; ATPVC; KIAA0566; phospholipid-transporting ATPase VA
Type:
Hydrolase; Transporter; EC 3.6.3.1
Mass (Da):
167690
Number AA:
UniProt ID:
O60312
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0015662
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006754
GO:0015914
GO:0008360
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
E
R
E
P
A
G
T
E
E
P
G
P
P
G
Site 2
T24
R
R
R
R
E
G
R
T
R
T
V
R
S
N
L
Site 3
T26
R
R
E
G
R
T
R
T
V
R
S
N
L
L
P
Site 4
S29
G
R
T
R
T
V
R
S
N
L
L
P
P
P
G
Site 5
T66
L
A
D
N
R
L
K
T
T
K
Y
T
L
L
S
Site 6
Y69
N
R
L
K
T
T
K
Y
T
L
L
S
F
L
P
Site 7
T70
R
L
K
T
T
K
Y
T
L
L
S
F
L
P
K
Site 8
Y131
F
R
D
L
W
E
D
Y
S
R
H
R
S
D
H
Site 9
S132
R
D
L
W
E
D
Y
S
R
H
R
S
D
H
K
Site 10
S136
E
D
Y
S
R
H
R
S
D
H
K
I
N
H
L
Site 11
S149
H
L
G
C
L
V
F
S
R
E
E
K
K
Y
V
Site 12
Y155
F
S
R
E
E
K
K
Y
V
N
R
F
W
K
E
Site 13
T197
D
G
L
C
H
I
E
T
A
N
L
D
G
E
T
Site 14
S216
R
Q
V
V
R
G
F
S
E
L
V
S
E
F
N
Site 15
S220
R
G
F
S
E
L
V
S
E
F
N
P
L
T
F
Site 16
S229
F
N
P
L
T
F
T
S
V
I
E
C
E
K
P
Site 17
S241
E
K
P
N
N
D
L
S
R
F
R
G
C
I
I
Site 18
Y258
N
G
K
K
A
G
L
Y
K
E
N
L
L
L
R
Site 19
Y281
A
V
V
G
I
V
I
Y
A
G
H
E
T
K
A
Site 20
S293
T
K
A
L
L
N
N
S
G
P
R
Y
K
R
S
Site 21
Y297
L
N
N
S
G
P
R
Y
K
R
S
K
L
E
R
Site 22
S300
S
G
P
R
Y
K
R
S
K
L
E
R
Q
M
N
Site 23
S340
W
R
Y
Q
E
K
K
S
L
F
Y
V
P
K
S
Site 24
Y343
Q
E
K
K
S
L
F
Y
V
P
K
S
D
G
S
Site 25
S347
S
L
F
Y
V
P
K
S
D
G
S
S
L
S
P
Site 26
S351
V
P
K
S
D
G
S
S
L
S
P
V
T
A
A
Site 27
S353
K
S
D
G
S
S
L
S
P
V
T
A
A
V
Y
Site 28
Y399
I
N
Q
D
M
Q
L
Y
D
E
E
T
D
S
Q
Site 29
T403
M
Q
L
Y
D
E
E
T
D
S
Q
L
Q
C
R
Site 30
S405
L
Y
D
E
E
T
D
S
Q
L
Q
C
R
A
L
Site 31
T415
Q
C
R
A
L
N
I
T
E
D
L
G
Q
I
Q
Site 32
Y423
E
D
L
G
Q
I
Q
Y
I
F
S
D
K
T
G
Site 33
T429
Q
Y
I
F
S
D
K
T
G
T
L
T
E
N
K
Site 34
T433
S
D
K
T
G
T
L
T
E
N
K
M
V
F
R
Site 35
T443
K
M
V
F
R
R
C
T
V
S
G
V
E
Y
S
Site 36
S445
V
F
R
R
C
T
V
S
G
V
E
Y
S
H
D
Site 37
Y449
C
T
V
S
G
V
E
Y
S
H
D
A
N
A
Q
Site 38
S466
A
R
Y
Q
E
A
D
S
E
E
E
E
V
V
P
Site 39
S477
E
V
V
P
R
G
G
S
V
S
Q
R
G
S
I
Site 40
S479
V
P
R
G
G
S
V
S
Q
R
G
S
I
G
S
Site 41
S483
G
S
V
S
Q
R
G
S
I
G
S
H
Q
S
V
Site 42
S486
S
Q
R
G
S
I
G
S
H
Q
S
V
R
V
V
Site 43
S489
G
S
I
G
S
H
Q
S
V
R
V
V
H
R
T
Site 44
T496
S
V
R
V
V
H
R
T
Q
S
T
K
S
H
R
Site 45
S498
R
V
V
H
R
T
Q
S
T
K
S
H
R
R
T
Site 46
S501
H
R
T
Q
S
T
K
S
H
R
R
T
G
S
R
Site 47
T505
S
T
K
S
H
R
R
T
G
S
R
A
E
A
K
Site 48
S507
K
S
H
R
R
T
G
S
R
A
E
A
K
R
A
Site 49
S515
R
A
E
A
K
R
A
S
M
L
S
K
H
T
A
Site 50
S518
A
K
R
A
S
M
L
S
K
H
T
A
F
S
S
Site 51
T521
A
S
M
L
S
K
H
T
A
F
S
S
P
M
E
Site 52
S525
S
K
H
T
A
F
S
S
P
M
E
K
D
I
T
Site 53
T532
S
P
M
E
K
D
I
T
P
D
P
K
L
L
E
Site 54
S542
P
K
L
L
E
K
V
S
E
C
D
K
S
L
A
Site 55
S547
K
V
S
E
C
D
K
S
L
A
V
A
R
H
Q
Site 56
S585
C
N
T
V
V
V
T
S
P
D
Q
P
R
T
K
Site 57
T591
T
S
P
D
Q
P
R
T
K
V
R
V
R
F
E
Site 58
S601
R
V
R
F
E
L
K
S
P
V
K
T
I
E
D
Site 59
T605
E
L
K
S
P
V
K
T
I
E
D
F
L
R
R
Site 60
T614
E
D
F
L
R
R
F
T
P
S
C
L
T
S
G
Site 61
S627
S
G
C
S
S
I
G
S
L
A
A
N
K
S
S
Site 62
S633
G
S
L
A
A
N
K
S
S
H
K
L
G
S
S
Site 63
S639
K
S
S
H
K
L
G
S
S
F
P
S
T
P
S
Site 64
S640
S
S
H
K
L
G
S
S
F
P
S
T
P
S
S
Site 65
S643
K
L
G
S
S
F
P
S
T
P
S
S
D
G
M
Site 66
T644
L
G
S
S
F
P
S
T
P
S
S
D
G
M
L
Site 67
S646
S
S
F
P
S
T
P
S
S
D
G
M
L
L
R
Site 68
S647
S
F
P
S
T
P
S
S
D
G
M
L
L
R
L
Site 69
T662
E
E
R
L
G
Q
P
T
S
A
I
A
S
N
G
Site 70
S663
E
R
L
G
Q
P
T
S
A
I
A
S
N
G
Y
Site 71
S667
Q
P
T
S
A
I
A
S
N
G
Y
S
S
Q
A
Site 72
S671
A
I
A
S
N
G
Y
S
S
Q
A
D
N
W
A
Site 73
S672
I
A
S
N
G
Y
S
S
Q
A
D
N
W
A
S
Site 74
Y693
E
S
E
R
E
L
R
Y
E
A
E
S
P
D
E
Site 75
S697
E
L
R
Y
E
A
E
S
P
D
E
A
A
L
V
Site 76
Y705
P
D
E
A
A
L
V
Y
A
A
R
A
Y
N
C
Site 77
S723
E
R
L
H
D
Q
V
S
V
E
L
P
H
L
G
Site 78
S744
L
H
T
L
G
F
D
S
V
R
K
R
M
S
V
Site 79
S750
D
S
V
R
K
R
M
S
V
V
I
R
H
P
L
Site 80
Y764
L
T
D
E
I
N
V
Y
T
K
G
A
D
S
V
Site 81
S780
M
D
L
L
Q
P
C
S
S
V
D
A
R
G
R
Site 82
S781
D
L
L
Q
P
C
S
S
V
D
A
R
G
R
H
Site 83
T796
Q
K
K
I
R
S
K
T
Q
N
Y
L
N
V
Y
Site 84
Y799
I
R
S
K
T
Q
N
Y
L
N
V
Y
A
A
E
Site 85
Y803
T
Q
N
Y
L
N
V
Y
A
A
E
G
L
R
T
Site 86
Y823
R
V
L
S
K
E
E
Y
A
C
W
L
Q
S
H
Site 87
S829
E
Y
A
C
W
L
Q
S
H
L
E
A
E
S
S
Site 88
S836
S
H
L
E
A
E
S
S
L
E
N
S
E
E
L
Site 89
S840
A
E
S
S
L
E
N
S
E
E
L
L
F
Q
S
Site 90
S876
D
G
V
P
E
T
I
S
K
L
R
Q
A
G
L
Site 91
T914
D
H
D
E
E
V
I
T
L
N
A
T
S
Q
E
Site 92
T946
L
Q
R
A
P
E
K
T
K
G
K
V
S
M
R
Site 93
S951
E
K
T
K
G
K
V
S
M
R
F
S
S
L
C
Site 94
S955
G
K
V
S
M
R
F
S
S
L
C
P
P
S
T
Site 95
S956
K
V
S
M
R
F
S
S
L
C
P
P
S
T
S
Site 96
S961
F
S
S
L
C
P
P
S
T
S
T
A
S
G
R
Site 97
T962
S
S
L
C
P
P
S
T
S
T
A
S
G
R
R
Site 98
S963
S
L
C
P
P
S
T
S
T
A
S
G
R
R
P
Site 99
S966
P
P
S
T
S
T
A
S
G
R
R
P
S
L
V
Site 100
S971
T
A
S
G
R
R
P
S
L
V
I
D
G
R
S
Site 101
S1006
R
S
V
L
C
C
R
S
T
P
L
Q
K
S
M
Site 102
S1012
R
S
T
P
L
Q
K
S
M
V
V
K
L
V
R
Site 103
S1049
A
D
V
G
V
G
I
S
G
Q
E
G
M
Q
A
Site 104
S1060
G
M
Q
A
V
M
A
S
D
F
A
V
P
K
F
Site 105
Y1157
L
L
T
N
P
Q
L
Y
K
S
G
Q
N
M
E
Site 106
S1159
T
N
P
Q
L
Y
K
S
G
Q
N
M
E
E
Y
Site 107
Y1166
S
G
Q
N
M
E
E
Y
R
P
R
T
F
W
F
Site 108
T1311
L
Q
L
A
R
Q
L
T
R
K
S
P
R
R
C
Site 109
S1314
A
R
Q
L
T
R
K
S
P
R
R
C
S
A
P
Site 110
S1319
R
K
S
P
R
R
C
S
A
P
K
E
T
F
A
Site 111
S1334
Q
G
R
L
P
K
D
S
G
T
E
H
S
S
G
Site 112
T1336
R
L
P
K
D
S
G
T
E
H
S
S
G
R
T
Site 113
S1340
D
S
G
T
E
H
S
S
G
R
T
V
K
T
S
Site 114
T1343
T
E
H
S
S
G
R
T
V
K
T
S
V
P
L
Site 115
T1346
S
S
G
R
T
V
K
T
S
V
P
L
S
Q
P
Site 116
S1347
S
G
R
T
V
K
T
S
V
P
L
S
Q
P
S
Site 117
S1351
V
K
T
S
V
P
L
S
Q
P
S
W
H
T
Q
Site 118
S1354
S
V
P
L
S
Q
P
S
W
H
T
Q
Q
P
V
Site 119
T1357
L
S
Q
P
S
W
H
T
Q
Q
P
V
C
S
L
Site 120
S1363
H
T
Q
Q
P
V
C
S
L
E
A
S
G
E
P
Site 121
S1367
P
V
C
S
L
E
A
S
G
E
P
S
T
V
D
Site 122
S1371
L
E
A
S
G
E
P
S
T
V
D
M
S
M
P
Site 123
T1372
E
A
S
G
E
P
S
T
V
D
M
S
M
P
V
Site 124
S1376
E
P
S
T
V
D
M
S
M
P
V
R
E
H
T
Site 125
T1383
S
M
P
V
R
E
H
T
L
L
E
G
L
S
A
Site 126
S1405
P
G
E
A
V
L
R
S
P
G
G
C
P
E
E
Site 127
S1413
P
G
G
C
P
E
E
S
K
V
R
A
A
S
T
Site 128
S1419
E
S
K
V
R
A
A
S
T
G
R
V
T
P
L
Site 129
T1420
S
K
V
R
A
A
S
T
G
R
V
T
P
L
S
Site 130
S1457
L
G
S
V
L
Q
F
S
R
T
E
Q
L
A
D
Site 131
S1477
G
L
P
V
Q
P
H
S
G
R
S
G
L
Q
G
Site 132
S1494
H
R
L
L
I
G
A
S
S
R
R
S
Q
_
_
Site 133
S1495
R
L
L
I
G
A
S
S
R
R
S
Q
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation