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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZFHX1B
Full Name:
Zinc finger E-box-binding homeobox 2
Alias:
KIAA0569; SIP1; SIP-1; Smad interacting-protein 1; Smad-interacting 1; Smad-interacting protein 1; SMADIP1; ZEB2; ZFX1B; Zinc finger E-box binding homeobox 2; Zinc finger E-box-binding 2; Zinc finger homeobox 1b; Zinc finger homeobox protein 1b
Type:
Transcription, coactivator/corepressor
Mass (Da):
136447
Number AA:
1214
UniProt ID:
O60315
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0046332
GO:0019208
GO:0043565
PhosphoSite+
KinaseNET
Biological Process:
GO:0016481
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y28
R
R
K
N
V
V
N
Y
D
N
V
V
D
T
G
Site 2
S36
D
N
V
V
D
T
G
S
E
T
D
E
E
D
K
Site 3
T38
V
V
D
T
G
S
E
T
D
E
E
D
K
L
H
Site 4
T60
A
N
P
L
D
Q
E
T
S
P
A
S
V
P
N
Site 5
S61
N
P
L
D
Q
E
T
S
P
A
S
V
P
N
H
Site 6
S64
D
Q
E
T
S
P
A
S
V
P
N
H
E
S
S
Site 7
S71
S
V
P
N
H
E
S
S
P
H
V
S
Q
A
L
Site 8
S75
H
E
S
S
P
H
V
S
Q
A
L
L
P
R
E
Site 9
S106
N
N
E
I
L
Q
A
S
V
D
G
P
E
E
M
Site 10
Y117
P
E
E
M
K
E
D
Y
D
T
M
G
P
E
A
Site 11
T119
E
M
K
E
D
Y
D
T
M
G
P
E
A
T
I
Site 12
Y147
C
T
S
D
F
E
E
Y
F
A
K
R
K
L
E
Site 13
S162
E
R
D
G
H
A
V
S
I
E
E
Y
L
Q
R
Site 14
Y166
H
A
V
S
I
E
E
Y
L
Q
R
S
D
T
A
Site 15
S170
I
E
E
Y
L
Q
R
S
D
T
A
I
I
Y
P
Site 16
T172
E
Y
L
Q
R
S
D
T
A
I
I
Y
P
E
A
Site 17
Y176
R
S
D
T
A
I
I
Y
P
E
A
P
E
E
L
Site 18
S184
P
E
A
P
E
E
L
S
R
L
G
T
P
E
A
Site 19
T188
E
E
L
S
R
L
G
T
P
E
A
N
G
Q
E
Site 20
T203
E
N
D
L
P
P
G
T
P
D
A
F
A
Q
L
Site 21
Y215
A
Q
L
L
T
C
P
Y
C
D
R
G
Y
K
R
Site 22
Y220
C
P
Y
C
D
R
G
Y
K
R
L
T
S
L
K
Site 23
T224
D
R
G
Y
K
R
L
T
S
L
K
E
H
I
K
Site 24
S225
R
G
Y
K
R
L
T
S
L
K
E
H
I
K
Y
Site 25
Y232
S
L
K
E
H
I
K
Y
R
H
E
K
N
E
E
Site 26
T249
S
C
P
L
C
S
Y
T
F
A
Y
R
T
Q
L
Site 27
T254
S
Y
T
F
A
Y
R
T
Q
L
E
R
H
M
V
Site 28
T262
Q
L
E
R
H
M
V
T
H
K
P
G
T
D
Q
Site 29
T274
T
D
Q
H
Q
M
L
T
Q
G
A
G
N
R
K
Site 30
T285
G
N
R
K
F
K
C
T
E
C
G
K
A
F
K
Site 31
Y293
E
C
G
K
A
F
K
Y
K
H
H
L
K
E
H
Site 32
S305
K
E
H
L
R
I
H
S
G
E
K
P
Y
E
C
Site 33
Y310
I
H
S
G
E
K
P
Y
E
C
P
N
C
K
K
Site 34
S320
P
N
C
K
K
R
F
S
H
S
G
S
Y
S
S
Site 35
S322
C
K
K
R
F
S
H
S
G
S
Y
S
S
H
I
Site 36
S324
K
R
F
S
H
S
G
S
Y
S
S
H
I
S
S
Site 37
Y325
R
F
S
H
S
G
S
Y
S
S
H
I
S
S
K
Site 38
S326
F
S
H
S
G
S
Y
S
S
H
I
S
S
K
K
Site 39
S327
S
H
S
G
S
Y
S
S
H
I
S
S
K
K
C
Site 40
S330
G
S
Y
S
S
H
I
S
S
K
K
C
I
G
L
Site 41
S331
S
Y
S
S
H
I
S
S
K
K
C
I
G
L
I
Site 42
T350
R
M
R
N
N
I
K
T
G
S
S
P
N
S
V
Site 43
S352
R
N
N
I
K
T
G
S
S
P
N
S
V
S
S
Site 44
S353
N
N
I
K
T
G
S
S
P
N
S
V
S
S
S
Site 45
S356
K
T
G
S
S
P
N
S
V
S
S
S
P
T
N
Site 46
S358
G
S
S
P
N
S
V
S
S
S
P
T
N
S
A
Site 47
S359
S
S
P
N
S
V
S
S
S
P
T
N
S
A
I
Site 48
S360
S
P
N
S
V
S
S
S
P
T
N
S
A
I
T
Site 49
T362
N
S
V
S
S
S
P
T
N
S
A
I
T
Q
L
Site 50
S364
V
S
S
S
P
T
N
S
A
I
T
Q
L
R
N
Site 51
S380
L
E
N
G
K
P
L
S
M
S
E
Q
T
G
L
Site 52
S382
N
G
K
P
L
S
M
S
E
Q
T
G
L
L
K
Site 53
T392
T
G
L
L
K
I
K
T
E
P
L
D
F
N
D
Site 54
Y400
E
P
L
D
F
N
D
Y
K
V
L
M
A
T
H
Site 55
T406
D
Y
K
V
L
M
A
T
H
G
F
S
G
T
S
Site 56
S410
L
M
A
T
H
G
F
S
G
T
S
P
F
M
N
Site 57
S413
T
H
G
F
S
G
T
S
P
F
M
N
G
G
L
Site 58
S424
N
G
G
L
G
A
T
S
P
L
G
V
H
P
S
Site 59
S431
S
P
L
G
V
H
P
S
A
Q
S
P
M
Q
H
Site 60
S434
G
V
H
P
S
A
Q
S
P
M
Q
H
L
G
V
Site 61
T452
A
P
L
L
G
F
P
T
M
N
S
N
L
S
E
Site 62
S458
P
T
M
N
S
N
L
S
E
V
Q
K
V
L
Q
Site 63
T470
V
L
Q
I
V
D
N
T
V
S
R
Q
K
M
D
Site 64
Y489
E
I
S
K
L
K
G
Y
H
M
K
D
P
C
S
Site 65
S496
Y
H
M
K
D
P
C
S
Q
P
E
E
Q
G
V
Site 66
T504
Q
P
E
E
Q
G
V
T
S
P
N
I
P
P
V
Site 67
S505
P
E
E
Q
G
V
T
S
P
N
I
P
P
V
G
Site 68
S517
P
V
G
L
P
V
V
S
H
N
G
A
T
K
S
Site 69
S524
S
H
N
G
A
T
K
S
I
I
D
Y
T
L
E
Site 70
Y528
A
T
K
S
I
I
D
Y
T
L
E
K
V
N
E
Site 71
T529
T
K
S
I
I
D
Y
T
L
E
K
V
N
E
A
Site 72
S542
E
A
K
A
C
L
Q
S
L
T
T
D
S
R
R
Site 73
T545
A
C
L
Q
S
L
T
T
D
S
R
R
Q
I
S
Site 74
S547
L
Q
S
L
T
T
D
S
R
R
Q
I
S
N
I
Site 75
S552
T
D
S
R
R
Q
I
S
N
I
K
K
E
K
L
Site 76
T561
I
K
K
E
K
L
R
T
L
I
D
L
V
T
D
Site 77
T567
R
T
L
I
D
L
V
T
D
D
K
M
I
E
N
Site 78
T579
I
E
N
H
N
I
S
T
P
F
S
C
Q
F
C
Site 79
S589
S
C
Q
F
C
K
E
S
F
P
G
P
I
P
L
Site 80
Y602
P
L
H
Q
H
E
R
Y
L
C
K
M
N
E
E
Site 81
S637
D
N
K
A
L
L
L
S
S
V
L
S
E
K
G
Site 82
T646
V
L
S
E
K
G
M
T
S
P
I
N
P
Y
K
Site 83
S647
L
S
E
K
G
M
T
S
P
I
N
P
Y
K
D
Site 84
S671
A
M
N
M
E
P
N
S
D
E
L
L
K
I
S
Site 85
Y698
W
F
E
Q
R
K
V
Y
Q
Y
S
N
S
R
S
Site 86
Y700
E
Q
R
K
V
Y
Q
Y
S
N
S
R
S
P
S
Site 87
S701
Q
R
K
V
Y
Q
Y
S
N
S
R
S
P
S
L
Site 88
S703
K
V
Y
Q
Y
S
N
S
R
S
P
S
L
E
R
Site 89
S705
Y
Q
Y
S
N
S
R
S
P
S
L
E
R
S
S
Site 90
S707
Y
S
N
S
R
S
P
S
L
E
R
S
S
K
P
Site 91
S711
R
S
P
S
L
E
R
S
S
K
P
L
A
P
N
Site 92
S712
S
P
S
L
E
R
S
S
K
P
L
A
P
N
S
Site 93
S719
S
K
P
L
A
P
N
S
N
P
P
T
K
D
S
Site 94
T723
A
P
N
S
N
P
P
T
K
D
S
L
L
P
R
Site 95
S726
S
N
P
P
T
K
D
S
L
L
P
R
S
P
V
Site 96
S731
K
D
S
L
L
P
R
S
P
V
K
P
M
D
S
Site 97
S738
S
P
V
K
P
M
D
S
I
T
S
P
S
I
A
Site 98
T740
V
K
P
M
D
S
I
T
S
P
S
I
A
E
L
Site 99
S741
K
P
M
D
S
I
T
S
P
S
I
A
E
L
H
Site 100
S750
S
I
A
E
L
H
N
S
V
T
N
C
D
P
P
Site 101
T752
A
E
L
H
N
S
V
T
N
C
D
P
P
L
R
Site 102
T761
C
D
P
P
L
R
L
T
K
P
S
H
F
T
N
Site 103
S764
P
L
R
L
T
K
P
S
H
F
T
N
I
K
P
Site 104
S778
P
V
E
K
L
D
H
S
R
S
N
T
P
S
P
Site 105
S780
E
K
L
D
H
S
R
S
N
T
P
S
P
L
N
Site 106
T782
L
D
H
S
R
S
N
T
P
S
P
L
N
L
S
Site 107
S784
H
S
R
S
N
T
P
S
P
L
N
L
S
S
T
Site 108
S789
T
P
S
P
L
N
L
S
S
T
S
S
K
N
S
Site 109
S790
P
S
P
L
N
L
S
S
T
S
S
K
N
S
H
Site 110
T791
S
P
L
N
L
S
S
T
S
S
K
N
S
H
S
Site 111
S792
P
L
N
L
S
S
T
S
S
K
N
S
H
S
S
Site 112
S793
L
N
L
S
S
T
S
S
K
N
S
H
S
S
S
Site 113
S796
S
S
T
S
S
K
N
S
H
S
S
S
Y
T
P
Site 114
S798
T
S
S
K
N
S
H
S
S
S
Y
T
P
N
S
Site 115
S799
S
S
K
N
S
H
S
S
S
Y
T
P
N
S
F
Site 116
S800
S
K
N
S
H
S
S
S
Y
T
P
N
S
F
S
Site 117
Y801
K
N
S
H
S
S
S
Y
T
P
N
S
F
S
S
Site 118
T802
N
S
H
S
S
S
Y
T
P
N
S
F
S
S
E
Site 119
S805
S
S
S
Y
T
P
N
S
F
S
S
E
E
L
Q
Site 120
S807
S
Y
T
P
N
S
F
S
S
E
E
L
Q
A
E
Site 121
S819
Q
A
E
P
L
D
L
S
L
P
K
Q
M
K
E
Site 122
S829
K
Q
M
K
E
P
K
S
I
I
A
T
K
N
K
Site 123
T833
E
P
K
S
I
I
A
T
K
N
K
T
K
A
S
Site 124
T837
I
I
A
T
K
N
K
T
K
A
S
S
I
S
L
Site 125
S840
T
K
N
K
T
K
A
S
S
I
S
L
D
H
N
Site 126
S841
K
N
K
T
K
A
S
S
I
S
L
D
H
N
S
Site 127
S843
K
T
K
A
S
S
I
S
L
D
H
N
S
V
S
Site 128
S848
S
I
S
L
D
H
N
S
V
S
S
S
S
E
N
Site 129
S850
S
L
D
H
N
S
V
S
S
S
S
E
N
S
D
Site 130
S852
D
H
N
S
V
S
S
S
S
E
N
S
D
E
P
Site 131
S853
H
N
S
V
S
S
S
S
E
N
S
D
E
P
L
Site 132
S856
V
S
S
S
S
E
N
S
D
E
P
L
N
L
T
Site 133
T863
S
D
E
P
L
N
L
T
F
I
K
K
E
F
S
Site 134
S870
T
F
I
K
K
E
F
S
N
S
N
N
L
D
N
Site 135
S872
I
K
K
E
F
S
N
S
N
N
L
D
N
K
S
Site 136
S879
S
N
N
L
D
N
K
S
T
N
P
V
F
S
M
Site 137
T880
N
N
L
D
N
K
S
T
N
P
V
F
S
M
N
Site 138
S885
K
S
T
N
P
V
F
S
M
N
P
F
S
A
K
Site 139
Y895
P
F
S
A
K
P
L
Y
T
A
L
P
P
Q
S
Site 140
T908
Q
S
A
F
P
P
A
T
F
M
P
P
V
Q
T
Site 141
S916
F
M
P
P
V
Q
T
S
I
P
G
L
R
P
Y
Site 142
Y923
S
I
P
G
L
R
P
Y
P
G
L
D
Q
M
S
Site 143
T945
T
Y
P
T
G
A
A
T
F
A
D
M
Q
Q
R
Site 144
Y955
D
M
Q
Q
R
R
K
Y
Q
R
K
Q
G
F
Q
Site 145
Y972
L
L
D
G
A
Q
D
Y
M
S
G
L
D
D
M
Site 146
S974
D
G
A
Q
D
Y
M
S
G
L
D
D
M
T
D
Site 147
T980
M
S
G
L
D
D
M
T
D
S
D
S
C
L
S
Site 148
S982
G
L
D
D
M
T
D
S
D
S
C
L
S
R
K
Site 149
S984
D
D
M
T
D
S
D
S
C
L
S
R
K
K
I
Site 150
T994
S
R
K
K
I
K
K
T
E
S
G
M
Y
A
C
Site 151
S996
K
K
I
K
K
T
E
S
G
M
Y
A
C
D
L
Site 152
Y999
K
K
T
E
S
G
M
Y
A
C
D
L
C
D
K
Site 153
T1007
A
C
D
L
C
D
K
T
F
Q
K
S
S
S
L
Site 154
S1011
C
D
K
T
F
Q
K
S
S
S
L
L
R
H
K
Site 155
S1013
K
T
F
Q
K
S
S
S
L
L
R
H
K
Y
E
Site 156
Y1019
S
S
L
L
R
H
K
Y
E
H
T
G
K
R
P
Site 157
S1046
K
H
H
L
I
E
H
S
R
L
H
S
G
E
K
Site 158
S1050
I
E
H
S
R
L
H
S
G
E
K
P
Y
Q
C
Site 159
Y1055
L
H
S
G
E
K
P
Y
Q
C
D
K
C
G
K
Site 160
S1065
D
K
C
G
K
R
F
S
H
S
G
S
Y
S
Q
Site 161
S1067
C
G
K
R
F
S
H
S
G
S
Y
S
Q
H
M
Site 162
S1069
K
R
F
S
H
S
G
S
Y
S
Q
H
M
N
H
Site 163
Y1080
H
M
N
H
R
Y
S
Y
C
K
R
E
A
E
E
Site 164
Y1112
E
L
L
M
N
R
A
Y
L
Q
S
I
T
P
Q
Site 165
S1115
M
N
R
A
Y
L
Q
S
I
T
P
Q
G
Y
S
Site 166
T1117
R
A
Y
L
Q
S
I
T
P
Q
G
Y
S
D
S
Site 167
S1122
S
I
T
P
Q
G
Y
S
D
S
E
E
R
E
S
Site 168
S1124
T
P
Q
G
Y
S
D
S
E
E
R
E
S
M
P
Site 169
S1129
S
D
S
E
E
R
E
S
M
P
R
D
G
E
S
Site 170
S1136
S
M
P
R
D
G
E
S
E
K
E
H
E
K
E
Site 171
Y1148
E
K
E
G
E
D
G
Y
G
K
L
G
R
Q
D
Site 172
S1167
F
E
E
E
E
E
E
S
E
N
K
S
M
D
T
Site 173
S1171
E
E
E
S
E
N
K
S
M
D
T
D
P
E
T
Site 174
T1174
S
E
N
K
S
M
D
T
D
P
E
T
I
R
D
Site 175
T1178
S
M
D
T
D
P
E
T
I
R
D
E
E
E
T
Site 176
T1185
T
I
R
D
E
E
E
T
G
D
H
S
M
D
D
Site 177
S1189
E
E
E
T
G
D
H
S
M
D
D
S
S
E
D
Site 178
S1193
G
D
H
S
M
D
D
S
S
E
D
G
K
M
E
Site 179
S1194
D
H
S
M
D
D
S
S
E
D
G
K
M
E
T
Site 180
S1203
D
G
K
M
E
T
K
S
D
H
E
E
D
N
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation