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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FAM189A1
Full Name:
Protein FAM189A1
Alias:
Transmembrane protein 228
Type:
Mass (Da):
56544
Number AA:
539
UniProt ID:
O60320
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
R
P
A
A
L
P
R
S
L
S
R
L
R
E
C
Site 2
S20
A
A
L
P
R
S
L
S
R
L
R
E
C
P
G
Site 3
S148
C
E
L
Q
H
Q
S
S
G
C
S
N
L
G
E
Site 4
S151
Q
H
Q
S
S
G
C
S
N
L
G
E
T
L
K
Site 5
T225
P
A
N
P
T
C
V
T
P
H
G
T
V
L
H
Site 6
T229
T
C
V
T
P
H
G
T
V
L
H
Q
T
L
D
Site 7
T234
H
G
T
V
L
H
Q
T
L
D
F
D
E
F
I
Site 8
Y249
P
P
L
P
P
P
P
Y
Y
P
P
E
Y
T
C
Site 9
Y250
P
L
P
P
P
P
Y
Y
P
P
E
Y
T
C
T
Site 10
Y254
P
P
Y
Y
P
P
E
Y
T
C
T
P
S
T
E
Site 11
T255
P
Y
Y
P
P
E
Y
T
C
T
P
S
T
E
A
Site 12
T257
Y
P
P
E
Y
T
C
T
P
S
T
E
A
Q
R
Site 13
T260
E
Y
T
C
T
P
S
T
E
A
Q
R
G
L
H
Site 14
Y279
P
S
P
F
G
T
L
Y
D
V
A
I
N
S
P
Site 15
Y290
I
N
S
P
G
L
L
Y
P
A
E
L
P
P
P
Site 16
Y298
P
A
E
L
P
P
P
Y
E
A
V
V
G
Q
P
Site 17
S308
V
V
G
Q
P
P
A
S
Q
V
T
S
I
G
Q
Site 18
S312
P
P
A
S
Q
V
T
S
I
G
Q
Q
V
A
E
Site 19
S320
I
G
Q
Q
V
A
E
S
S
S
G
D
P
N
T
Site 20
S322
Q
Q
V
A
E
S
S
S
G
D
P
N
T
S
A
Site 21
T327
S
S
S
G
D
P
N
T
S
A
G
F
S
T
P
Site 22
S328
S
S
G
D
P
N
T
S
A
G
F
S
T
P
V
Site 23
S332
P
N
T
S
A
G
F
S
T
P
V
P
A
D
S
Site 24
T333
N
T
S
A
G
F
S
T
P
V
P
A
D
S
T
Site 25
S339
S
T
P
V
P
A
D
S
T
S
L
L
V
S
E
Site 26
S345
D
S
T
S
L
L
V
S
E
G
T
A
T
P
G
Site 27
T348
S
L
L
V
S
E
G
T
A
T
P
G
S
S
P
Site 28
T350
L
V
S
E
G
T
A
T
P
G
S
S
P
S
P
Site 29
S353
E
G
T
A
T
P
G
S
S
P
S
P
D
G
P
Site 30
S354
G
T
A
T
P
G
S
S
P
S
P
D
G
P
V
Site 31
S356
A
T
P
G
S
S
P
S
P
D
G
P
V
G
A
Site 32
S367
P
V
G
A
P
A
P
S
E
P
A
L
P
P
G
Site 33
S377
A
L
P
P
G
R
V
S
P
E
D
P
G
M
G
Site 34
S385
P
E
D
P
G
M
G
S
Q
V
Q
P
G
P
G
Site 35
S395
Q
P
G
P
G
H
V
S
R
S
T
S
D
P
T
Site 36
S397
G
P
G
H
V
S
R
S
T
S
D
P
T
L
C
Site 37
T398
P
G
H
V
S
R
S
T
S
D
P
T
L
C
T
Site 38
S399
G
H
V
S
R
S
T
S
D
P
T
L
C
T
S
Site 39
T402
S
R
S
T
S
D
P
T
L
C
T
S
S
M
A
Site 40
S407
D
P
T
L
C
T
S
S
M
A
G
D
A
S
S
Site 41
S413
S
S
M
A
G
D
A
S
S
H
R
P
S
C
S
Site 42
S414
S
M
A
G
D
A
S
S
H
R
P
S
C
S
Q
Site 43
S418
D
A
S
S
H
R
P
S
C
S
Q
D
L
E
A
Site 44
S420
S
S
H
R
P
S
C
S
Q
D
L
E
A
G
L
Site 45
S428
Q
D
L
E
A
G
L
S
E
A
V
P
G
S
A
Site 46
S434
L
S
E
A
V
P
G
S
A
S
M
S
R
S
A
Site 47
S436
E
A
V
P
G
S
A
S
M
S
R
S
A
T
A
Site 48
S440
G
S
A
S
M
S
R
S
A
T
A
A
C
R
A
Site 49
T442
A
S
M
S
R
S
A
T
A
A
C
R
A
Q
L
Site 50
S450
A
A
C
R
A
Q
L
S
P
A
G
D
P
D
T
Site 51
T457
S
P
A
G
D
P
D
T
W
K
T
D
Q
R
P
Site 52
T460
G
D
P
D
T
W
K
T
D
Q
R
P
T
P
E
Site 53
T465
W
K
T
D
Q
R
P
T
P
E
P
F
P
A
T
Site 54
S473
P
E
P
F
P
A
T
S
K
E
R
P
R
S
L
Site 55
S479
T
S
K
E
R
P
R
S
L
V
D
S
K
A
Y
Site 56
S483
R
P
R
S
L
V
D
S
K
A
Y
A
D
A
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation