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Updated November 2019
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Protein Info
Short Name:
MAPKBP1
Full Name:
Mitogen-activated protein kinase-binding protein 1
Alias:
JNK-binding protein 1
Type:
Uncharacterized protein
Mass (Da):
163818
Number AA:
1514
UniProt ID:
O60336
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
A
V
E
G
S
T
I
T
S
R
I
K
N
L
L
Site 2
S10
V
E
G
S
T
I
T
S
R
I
K
N
L
L
R
Site 3
S18
R
I
K
N
L
L
R
S
P
S
I
K
L
R
R
Site 4
S20
K
N
L
L
R
S
P
S
I
K
L
R
R
S
K
Site 5
S26
P
S
I
K
L
R
R
S
K
A
G
N
R
R
E
Site 6
S36
G
N
R
R
E
D
L
S
S
K
V
T
L
E
K
Site 7
S37
N
R
R
E
D
L
S
S
K
V
T
L
E
K
V
Site 8
S88
K
Q
H
H
I
L
N
S
S
R
K
T
I
T
A
Site 9
Y104
A
F
S
P
D
G
K
Y
L
V
T
G
E
S
G
Site 10
S125
V
W
D
V
A
E
H
S
Q
V
A
E
L
Q
E
Site 11
S173
K
K
N
I
V
V
A
S
N
K
V
S
S
R
V
Site 12
T181
N
K
V
S
S
R
V
T
A
V
S
F
S
E
D
Site 13
S184
S
S
R
V
T
A
V
S
F
S
E
D
C
S
Y
Site 14
Y191
S
F
S
E
D
C
S
Y
F
V
T
A
G
N
R
Site 15
Y204
N
R
H
I
K
F
W
Y
L
D
D
S
K
T
S
Site 16
S208
K
F
W
Y
L
D
D
S
K
T
S
K
V
N
A
Site 17
T210
W
Y
L
D
D
S
K
T
S
K
V
N
A
T
V
Site 18
T235
E
L
R
N
N
L
F
T
D
V
A
C
G
R
G
Site 19
S247
G
R
G
K
K
A
D
S
T
F
C
I
T
S
S
Site 20
T248
R
G
K
K
A
D
S
T
F
C
I
T
S
S
G
Site 21
S261
S
G
L
L
C
E
F
S
D
R
R
L
L
D
K
Site 22
S277
V
E
L
R
N
I
D
S
F
T
T
T
V
A
H
Site 23
S308
T
V
R
L
F
N
P
S
N
L
H
F
L
S
T
Site 24
S314
P
S
N
L
H
F
L
S
T
L
P
R
P
H
A
Site 25
T315
S
N
L
H
F
L
S
T
L
P
R
P
H
A
L
Site 26
T324
P
R
P
H
A
L
G
T
D
I
A
S
V
T
E
Site 27
S337
T
E
A
S
R
L
F
S
G
V
A
N
A
R
Y
Site 28
Y344
S
G
V
A
N
A
R
Y
P
D
T
I
A
L
T
Site 29
T347
A
N
A
R
Y
P
D
T
I
A
L
T
F
D
P
Site 30
Y369
V
Y
N
D
H
S
I
Y
V
W
D
V
R
D
P
Site 31
S384
K
K
V
G
K
V
Y
S
A
L
Y
H
S
S
C
Site 32
Y387
G
K
V
Y
S
A
L
Y
H
S
S
C
V
W
S
Site 33
Y398
C
V
W
S
V
E
V
Y
P
E
V
K
D
S
N
Site 34
S404
V
Y
P
E
V
K
D
S
N
Q
A
C
L
P
P
Site 35
T416
L
P
P
S
S
F
I
T
C
S
S
D
N
T
I
Site 36
S419
S
S
F
I
T
C
S
S
D
N
T
I
R
L
W
Site 37
T428
N
T
I
R
L
W
N
T
E
S
S
G
V
H
G
Site 38
S430
I
R
L
W
N
T
E
S
S
G
V
H
G
S
T
Site 39
S431
R
L
W
N
T
E
S
S
G
V
H
G
S
T
L
Site 40
S436
E
S
S
G
V
H
G
S
T
L
H
R
N
I
L
Site 41
T437
S
S
G
V
H
G
S
T
L
H
R
N
I
L
S
Site 42
T463
N
T
Q
A
L
L
D
T
E
L
P
G
G
D
K
Site 43
S474
G
G
D
K
A
D
A
S
L
L
D
P
R
V
G
Site 44
S484
D
P
R
V
G
I
R
S
V
C
V
S
P
N
G
Site 45
S488
G
I
R
S
V
C
V
S
P
N
G
Q
H
L
A
Site 46
S496
P
N
G
Q
H
L
A
S
G
D
R
M
G
T
L
Site 47
T502
A
S
G
D
R
M
G
T
L
R
V
H
E
L
Q
Site 48
S510
L
R
V
H
E
L
Q
S
L
S
E
M
L
K
V
Site 49
S512
V
H
E
L
Q
S
L
S
E
M
L
K
V
E
A
Site 50
S522
L
K
V
E
A
H
D
S
E
I
L
C
L
E
Y
Site 51
Y529
S
E
I
L
C
L
E
Y
S
K
P
D
T
G
L
Site 52
S530
E
I
L
C
L
E
Y
S
K
P
D
T
G
L
K
Site 53
T534
L
E
Y
S
K
P
D
T
G
L
K
L
L
A
S
Site 54
Y557
V
L
D
A
G
R
E
Y
S
L
Q
Q
T
L
D
Site 55
S558
L
D
A
G
R
E
Y
S
L
Q
Q
T
L
D
E
Site 56
T562
R
E
Y
S
L
Q
Q
T
L
D
E
H
S
S
S
Site 57
S569
T
L
D
E
H
S
S
S
I
T
A
V
K
F
A
Site 58
T571
D
E
H
S
S
S
I
T
A
V
K
F
A
A
S
Site 59
S586
D
G
Q
V
R
M
I
S
C
G
A
D
K
S
I
Site 60
Y594
C
G
A
D
K
S
I
Y
F
R
T
A
Q
K
S
Site 61
T597
D
K
S
I
Y
F
R
T
A
Q
K
S
G
D
G
Site 62
S601
Y
F
R
T
A
Q
K
S
G
D
G
V
Q
F
T
Site 63
T617
T
H
H
V
V
R
K
T
T
L
Y
D
M
D
V
Site 64
T618
H
H
V
V
R
K
T
T
L
Y
D
M
D
V
E
Site 65
Y620
V
V
R
K
T
T
L
Y
D
M
D
V
E
P
S
Site 66
Y630
D
V
E
P
S
W
K
Y
T
A
I
G
C
Q
D
Site 67
S646
N
I
R
I
F
N
I
S
S
G
K
Q
K
K
L
Site 68
T663
G
S
Q
G
E
D
G
T
L
I
K
V
Q
T
D
Site 69
Y675
Q
T
D
P
S
G
I
Y
I
A
T
S
C
S
D
Site 70
S679
S
G
I
Y
I
A
T
S
C
S
D
K
N
L
S
Site 71
S686
S
C
S
D
K
N
L
S
I
F
D
F
S
S
G
Site 72
T707
F
G
H
S
E
I
V
T
G
M
K
F
S
N
D
Site 73
S720
N
D
C
K
H
L
I
S
V
S
G
D
S
C
I
Site 74
T737
W
R
L
S
S
E
M
T
I
S
M
R
Q
R
L
Site 75
S739
L
S
S
E
M
T
I
S
M
R
Q
R
L
A
E
Site 76
S760
G
G
K
Q
Q
G
P
S
S
P
Q
R
A
S
G
Site 77
S761
G
K
Q
Q
G
P
S
S
P
Q
R
A
S
G
P
Site 78
S766
P
S
S
P
Q
R
A
S
G
P
N
R
H
Q
A
Site 79
S775
P
N
R
H
Q
A
P
S
M
L
S
P
G
P
A
Site 80
S778
H
Q
A
P
S
M
L
S
P
G
P
A
L
S
S
Site 81
S784
L
S
P
G
P
A
L
S
S
D
S
D
K
E
G
Site 82
S785
S
P
G
P
A
L
S
S
D
S
D
K
E
G
E
Site 83
S787
G
P
A
L
S
S
D
S
D
K
E
G
E
D
E
Site 84
T796
K
E
G
E
D
E
G
T
E
E
E
L
P
A
L
Site 85
S816
S
T
K
K
A
L
A
S
V
P
S
P
A
L
P
Site 86
S819
K
A
L
A
S
V
P
S
P
A
L
P
R
S
L
Site 87
S825
P
S
P
A
L
P
R
S
L
S
H
W
E
M
S
Site 88
S827
P
A
L
P
R
S
L
S
H
W
E
M
S
R
A
Site 89
S832
S
L
S
H
W
E
M
S
R
A
Q
E
S
V
G
Site 90
S837
E
M
S
R
A
Q
E
S
V
G
F
L
D
P
A
Site 91
S865
V
Q
P
G
V
E
L
S
V
R
S
M
L
D
L
Site 92
T877
L
D
L
R
Q
L
E
T
L
A
P
S
L
Q
D
Site 93
S881
Q
L
E
T
L
A
P
S
L
Q
D
P
S
Q
D
Site 94
S886
A
P
S
L
Q
D
P
S
Q
D
S
L
A
I
I
Site 95
S889
L
Q
D
P
S
Q
D
S
L
A
I
I
P
S
G
Site 96
S895
D
S
L
A
I
I
P
S
G
P
R
K
H
G
Q
Site 97
T907
H
G
Q
E
A
L
E
T
S
L
T
S
Q
N
E
Site 98
S908
G
Q
E
A
L
E
T
S
L
T
S
Q
N
E
K
Site 99
T910
E
A
L
E
T
S
L
T
S
Q
N
E
K
P
P
Site 100
S911
A
L
E
T
S
L
T
S
Q
N
E
K
P
P
R
Site 101
S922
K
P
P
R
P
Q
A
S
Q
P
C
S
Y
P
H
Site 102
S926
P
Q
A
S
Q
P
C
S
Y
P
H
I
I
R
L
Site 103
Y927
Q
A
S
Q
P
C
S
Y
P
H
I
I
R
L
L
Site 104
S935
P
H
I
I
R
L
L
S
Q
E
E
G
V
F
A
Site 105
Y956
P
I
E
D
G
I
V
Y
P
E
P
S
D
N
P
Site 106
S960
G
I
V
Y
P
E
P
S
D
N
P
T
M
D
T
Site 107
T964
P
E
P
S
D
N
P
T
M
D
T
S
E
F
Q
Site 108
T979
V
Q
A
P
A
R
G
T
L
G
R
V
Y
P
G
Site 109
Y984
R
G
T
L
G
R
V
Y
P
G
S
R
S
S
E
Site 110
S987
L
G
R
V
Y
P
G
S
R
S
S
E
K
H
S
Site 111
S989
R
V
Y
P
G
S
R
S
S
E
K
H
S
P
D
Site 112
S990
V
Y
P
G
S
R
S
S
E
K
H
S
P
D
S
Site 113
S994
S
R
S
S
E
K
H
S
P
D
S
A
C
S
V
Site 114
S997
S
E
K
H
S
P
D
S
A
C
S
V
D
Y
S
Site 115
S1000
H
S
P
D
S
A
C
S
V
D
Y
S
S
S
C
Site 116
Y1003
D
S
A
C
S
V
D
Y
S
S
S
C
L
S
S
Site 117
S1004
S
A
C
S
V
D
Y
S
S
S
C
L
S
S
P
Site 118
S1005
A
C
S
V
D
Y
S
S
S
C
L
S
S
P
E
Site 119
S1006
C
S
V
D
Y
S
S
S
C
L
S
S
P
E
H
Site 120
S1009
D
Y
S
S
S
C
L
S
S
P
E
H
P
T
E
Site 121
S1010
Y
S
S
S
C
L
S
S
P
E
H
P
T
E
D
Site 122
S1018
P
E
H
P
T
E
D
S
E
S
T
E
P
L
S
Site 123
S1020
H
P
T
E
D
S
E
S
T
E
P
L
S
V
D
Site 124
S1025
S
E
S
T
E
P
L
S
V
D
G
I
S
S
D
Site 125
S1031
L
S
V
D
G
I
S
S
D
L
E
E
P
A
E
Site 126
Y1053
E
E
G
G
M
G
P
Y
G
L
Q
E
G
S
P
Site 127
S1059
P
Y
G
L
Q
E
G
S
P
Q
T
P
D
Q
E
Site 128
T1062
L
Q
E
G
S
P
Q
T
P
D
Q
E
Q
F
L
Site 129
S1078
Q
H
F
E
T
L
A
S
G
A
A
P
G
A
P
Site 130
S1092
P
V
Q
V
P
E
R
S
E
S
R
S
I
S
S
Site 131
S1094
Q
V
P
E
R
S
E
S
R
S
I
S
S
R
F
Site 132
S1096
P
E
R
S
E
S
R
S
I
S
S
R
F
L
L
Site 133
S1098
R
S
E
S
R
S
I
S
S
R
F
L
L
Q
V
Site 134
S1114
T
R
P
L
R
E
P
S
P
S
S
S
S
L
A
Site 135
S1116
P
L
R
E
P
S
P
S
S
S
S
L
A
L
M
Site 136
S1117
L
R
E
P
S
P
S
S
S
S
L
A
L
M
S
Site 137
S1118
R
E
P
S
P
S
S
S
S
L
A
L
M
S
R
Site 138
S1119
E
P
S
P
S
S
S
S
L
A
L
M
S
R
P
Site 139
S1124
S
S
S
L
A
L
M
S
R
P
A
Q
V
P
Q
Site 140
S1154
A
P
P
E
V
E
P
S
S
G
N
P
S
P
Q
Site 141
S1155
P
P
E
V
E
P
S
S
G
N
P
S
P
Q
Q
Site 142
S1159
E
P
S
S
G
N
P
S
P
Q
Q
A
A
S
V
Site 143
S1165
P
S
P
Q
Q
A
A
S
V
L
L
P
R
C
R
Site 144
S1177
R
C
R
L
N
P
D
S
S
W
A
P
K
R
V
Site 145
S1178
C
R
L
N
P
D
S
S
W
A
P
K
R
V
A
Site 146
T1186
W
A
P
K
R
V
A
T
A
S
P
F
S
G
L
Site 147
S1188
P
K
R
V
A
T
A
S
P
F
S
G
L
Q
K
Site 148
S1198
S
G
L
Q
K
A
Q
S
V
H
S
L
V
P
Q
Site 149
S1201
Q
K
A
Q
S
V
H
S
L
V
P
Q
E
R
H
Site 150
S1211
P
Q
E
R
H
E
A
S
L
Q
A
P
S
P
G
Site 151
S1216
E
A
S
L
Q
A
P
S
P
G
A
L
L
S
R
Site 152
S1222
P
S
P
G
A
L
L
S
R
E
I
E
A
Q
D
Site 153
S1233
E
A
Q
D
G
L
G
S
L
P
P
A
D
G
R
Site 154
S1242
P
P
A
D
G
R
P
S
R
P
H
S
Y
Q
N
Site 155
S1246
G
R
P
S
R
P
H
S
Y
Q
N
P
T
T
S
Site 156
Y1247
R
P
S
R
P
H
S
Y
Q
N
P
T
T
S
S
Site 157
S1253
S
Y
Q
N
P
T
T
S
S
M
A
K
I
S
R
Site 158
S1254
Y
Q
N
P
T
T
S
S
M
A
K
I
S
R
S
Site 159
S1259
T
S
S
M
A
K
I
S
R
S
I
S
V
G
E
Site 160
S1261
S
M
A
K
I
S
R
S
I
S
V
G
E
N
L
Site 161
S1263
A
K
I
S
R
S
I
S
V
G
E
N
L
G
L
Site 162
S1286
P
I
R
V
S
P
L
S
K
L
A
L
P
S
R
Site 163
T1309
K
P
L
P
D
R
P
T
L
A
A
F
S
P
V
Site 164
S1314
R
P
T
L
A
A
F
S
P
V
T
K
G
R
A
Site 165
S1339
V
G
L
G
K
A
H
S
T
T
E
R
W
A
C
Site 166
T1341
L
G
K
A
H
S
T
T
E
R
W
A
C
L
G
Site 167
T1352
A
C
L
G
E
G
T
T
P
K
P
R
T
E
C
Site 168
T1357
G
T
T
P
K
P
R
T
E
C
Q
A
H
P
G
Site 169
S1367
Q
A
H
P
G
P
S
S
P
C
A
Q
Q
L
P
Site 170
S1376
C
A
Q
Q
L
P
V
S
S
L
F
Q
G
P
E
Site 171
T1393
Q
P
P
P
P
E
K
T
P
N
P
M
E
C
T
Site 172
S1407
T
K
P
G
A
A
L
S
Q
D
S
E
P
A
V
Site 173
S1410
G
A
A
L
S
Q
D
S
E
P
A
V
S
L
E
Site 174
S1415
Q
D
S
E
P
A
V
S
L
E
Q
C
E
Q
L
Site 175
Y1437
V
R
Q
A
V
R
L
Y
H
S
V
A
G
C
K
Site 176
S1439
Q
A
V
R
L
Y
H
S
V
A
G
C
K
M
P
Site 177
S1451
K
M
P
S
A
E
Q
S
R
I
A
Q
L
L
R
Site 178
T1460
I
A
Q
L
L
R
D
T
F
S
S
V
R
Q
E
Site 179
S1462
Q
L
L
R
D
T
F
S
S
V
R
Q
E
L
E
Site 180
S1463
L
L
R
D
T
F
S
S
V
R
Q
E
L
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation