KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
MARCH-VI
Full Name:
E3 ubiquitin-protein ligase MARCH6
Alias:
Doa10 homolog; EC 6.3.2.-; MARCH-VI; MARH6; Membrane-associated ring finger (C3HC4) 6; Membrane-associated RING finger protein 6; Membrane-associated RING-CH protein VI; RING finger protein 176; RNF176; TEB4; TEB-4
Type:
Ubiquitin ligase; Ligase; EC 6.3.2.-; Ubiquitin conjugating system
Mass (Da):
Number AA:
910
UniProt ID:
O60337
International Prot ID:
IPI00105518
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0016874
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
R
V
C
R
S
E
G
T
P
E
K
P
L
Y
H
Site 2
Y23
G
T
P
E
K
P
L
Y
H
P
C
V
C
T
G
Site 3
Y51
L
K
H
S
R
K
E
Y
C
E
L
C
K
H
R
Site 4
T62
C
K
H
R
F
A
F
T
P
I
Y
S
P
D
M
Site 5
Y65
R
F
A
F
T
P
I
Y
S
P
D
M
P
S
R
Site 6
S66
F
A
F
T
P
I
Y
S
P
D
M
P
S
R
L
Site 7
S71
I
Y
S
P
D
M
P
S
R
L
P
I
Q
D
I
Site 8
T273
D
R
A
A
E
E
L
T
W
E
R
M
L
G
L
Site 9
T405
S
L
E
M
F
D
A
T
L
K
D
R
E
L
S
Site 10
S412
T
L
K
D
R
E
L
S
F
Q
S
A
P
G
T
Site 11
S437
V
Y
V
F
Y
F
A
S
F
I
L
L
L
R
E
Site 12
Y474
E
M
I
H
L
P
I
Y
R
H
L
R
R
F
I
Site 13
S518
P
Y
N
V
M
L
Y
S
D
A
P
V
S
E
L
Site 14
T545
A
L
L
E
Q
G
H
T
R
Q
W
L
K
G
L
Site 15
S568
G
Y
L
L
D
L
H
S
Y
L
L
G
D
Q
E
Site 16
S580
D
Q
E
E
N
E
N
S
A
N
Q
Q
V
N
N
Site 17
Y623
G
P
V
G
F
Q
P
Y
R
R
P
L
N
F
P
Site 18
T754
L
R
V
P
L
D
Q
T
P
L
F
Y
P
W
Q
Site 19
Y850
N
L
V
H
R
R
I
Y
P
F
L
L
M
V
V
Site 20
Y874
V
R
Q
F
K
R
L
Y
E
H
I
K
N
D
K
Site 21
Y882
E
H
I
K
N
D
K
Y
L
V
G
Q
R
L
V
Site 22
Y891
V
G
Q
R
L
V
N
Y
E
R
K
S
G
K
Q
Site 23
S895
L
V
N
Y
E
R
K
S
G
K
Q
G
S
S
P
Site 24
S900
R
K
S
G
K
Q
G
S
S
P
P
P
P
Q
S
Site 25
S901
K
S
G
K
Q
G
S
S
P
P
P
P
Q
S
S
Site 26
S907
S
S
P
P
P
P
Q
S
S
Q
E
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation