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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KDM1
Full Name:
Lysine-specific histone demethylase 1A
Alias:
Amine oxidase flavin containing domain protein 2; AOF2; BHC110; BRAF35-HDAC complex protein BHC110; KIAA0601; LSD1; Lysine (K)-specific demethylase 1A; Lysine-specific histone demethylase 1
Type:
Demethylase; EC 1.-.-.-; Transcription factor; Oxidoreductase
Mass (Da):
92903
Number AA:
852
UniProt ID:
O60341
International Prot ID:
IPI00456631
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0050660
GO:0032452
GO:0016491
PhosphoSite+
KinaseNET
Biological Process:
GO:0016577
GO:0007275
GO:0010553
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T27
G
T
E
A
G
P
G
T
A
G
G
S
E
N
G
Site 2
S31
G
P
G
T
A
G
G
S
E
N
G
S
E
V
A
Site 3
S35
A
G
G
S
E
N
G
S
E
V
A
A
Q
P
A
Site 4
T59
P
G
A
V
G
E
R
T
P
R
K
K
E
P
P
Site 5
S69
K
K
E
P
P
R
A
S
P
P
G
G
L
A
E
Site 6
S80
G
L
A
E
P
P
G
S
A
G
P
Q
A
G
P
Site 7
T88
A
G
P
Q
A
G
P
T
V
V
P
G
S
A
T
Site 8
S93
G
P
T
V
V
P
G
S
A
T
P
M
E
T
G
Site 9
T95
T
V
V
P
G
S
A
T
P
M
E
T
G
I
A
Site 10
T99
G
S
A
T
P
M
E
T
G
I
A
E
T
P
E
Site 11
T104
M
E
T
G
I
A
E
T
P
E
G
R
R
T
S
Site 12
T110
E
T
P
E
G
R
R
T
S
R
R
K
R
A
K
Site 13
S111
T
P
E
G
R
R
T
S
R
R
K
R
A
K
V
Site 14
Y120
R
K
R
A
K
V
E
Y
R
E
M
D
E
S
L
Site 15
S126
E
Y
R
E
M
D
E
S
L
A
N
L
S
E
D
Site 16
S131
D
E
S
L
A
N
L
S
E
D
E
Y
Y
S
E
Site 17
Y135
A
N
L
S
E
D
E
Y
Y
S
E
E
E
R
N
Site 18
Y136
N
L
S
E
D
E
Y
Y
S
E
E
E
R
N
A
Site 19
S137
L
S
E
D
E
Y
Y
S
E
E
E
R
N
A
K
Site 20
S166
P
P
E
E
E
N
E
S
E
P
E
E
P
S
G
Site 21
S172
E
S
E
P
E
E
P
S
G
V
E
G
A
A
F
Site 22
T189
R
L
P
H
D
R
M
T
S
Q
E
A
A
C
F
Site 23
S190
L
P
H
D
R
M
T
S
Q
E
A
A
C
F
P
Site 24
S201
A
C
F
P
D
I
I
S
G
P
Q
Q
T
Q
K
Site 25
T230
D
N
P
K
I
Q
L
T
F
E
A
T
L
Q
Q
Site 26
T246
E
A
P
Y
N
S
D
T
V
L
V
H
R
V
H
Site 27
S254
V
L
V
H
R
V
H
S
Y
L
E
R
H
G
L
Site 28
Y255
L
V
H
R
V
H
S
Y
L
E
R
H
G
L
I
Site 29
T278
K
P
L
P
T
K
K
T
G
K
V
I
I
I
G
Site 30
T319
R
V
G
G
R
V
A
T
F
R
K
G
N
Y
V
Site 31
Y325
A
T
F
R
K
G
N
Y
V
A
D
L
G
A
M
Site 32
T335
D
L
G
A
M
V
V
T
G
L
G
G
N
P
M
Site 33
S346
G
N
P
M
A
V
V
S
K
Q
V
N
M
E
L
Site 34
Y363
I
K
Q
K
C
P
L
Y
E
A
N
G
Q
A
V
Site 35
T389
F
N
R
L
L
E
A
T
S
Y
L
S
H
Q
L
Site 36
S390
N
R
L
L
E
A
T
S
Y
L
S
H
Q
L
D
Site 37
Y391
R
L
L
E
A
T
S
Y
L
S
H
Q
L
D
F
Site 38
T475
V
K
P
P
R
D
I
T
A
E
F
L
V
K
S
Site 39
S482
T
A
E
F
L
V
K
S
K
H
R
D
L
T
A
Site 40
T488
K
S
K
H
R
D
L
T
A
L
C
K
E
Y
D
Site 41
T500
E
Y
D
E
L
A
E
T
Q
G
K
L
E
E
K
Site 42
S517
E
L
E
A
N
P
P
S
D
V
Y
L
S
S
R
Site 43
Y520
A
N
P
P
S
D
V
Y
L
S
S
R
D
R
Q
Site 44
S522
P
P
S
D
V
Y
L
S
S
R
D
R
Q
I
L
Site 45
S523
P
S
D
V
Y
L
S
S
R
D
R
Q
I
L
D
Site 46
S545
F
A
N
A
T
P
L
S
T
L
S
L
K
H
W
Site 47
T546
A
N
A
T
P
L
S
T
L
S
L
K
H
W
D
Site 48
S548
A
T
P
L
S
T
L
S
L
K
H
W
D
Q
D
Site 49
S563
D
D
F
E
F
T
G
S
H
L
T
V
R
N
G
Site 50
T566
E
F
T
G
S
H
L
T
V
R
N
G
Y
S
C
Site 51
T610
I
A
V
N
T
R
S
T
S
Q
T
F
I
Y
K
Site 52
S611
A
V
N
T
R
S
T
S
Q
T
F
I
Y
K
C
Site 53
T613
N
T
R
S
T
S
Q
T
F
I
Y
K
C
D
A
Site 54
T648
P
P
L
P
E
W
K
T
S
A
V
Q
R
M
G
Site 55
S649
P
L
P
E
W
K
T
S
A
V
Q
R
M
G
F
Site 56
S683
N
L
F
G
H
V
G
S
T
T
A
S
R
G
E
Site 57
T685
F
G
H
V
G
S
T
T
A
S
R
G
E
L
F
Site 58
T746
A
V
P
Q
P
K
E
T
V
V
S
R
W
R
A
Site 59
S749
Q
P
K
E
T
V
V
S
R
W
R
A
D
P
W
Site 60
S760
A
D
P
W
A
R
G
S
Y
S
Y
V
A
A
G
Site 61
Y761
D
P
W
A
R
G
S
Y
S
Y
V
A
A
G
S
Site 62
S762
P
W
A
R
G
S
Y
S
Y
V
A
A
G
S
S
Site 63
Y763
W
A
R
G
S
Y
S
Y
V
A
A
G
S
S
G
Site 64
Y773
A
G
S
S
G
N
D
Y
D
L
M
A
Q
P
I
Site 65
T781
D
L
M
A
Q
P
I
T
P
G
P
S
I
P
G
Site 66
S785
Q
P
I
T
P
G
P
S
I
P
G
A
P
Q
P
Site 67
T803
L
F
F
A
G
E
H
T
I
R
N
Y
P
A
T
Site 68
Y807
G
E
H
T
I
R
N
Y
P
A
T
V
H
G
A
Site 69
T810
T
I
R
N
Y
P
A
T
V
H
G
A
L
L
S
Site 70
S817
T
V
H
G
A
L
L
S
G
L
R
E
A
G
R
Site 71
Y834
D
Q
F
L
G
A
M
Y
T
L
P
R
Q
A
T
Site 72
T835
Q
F
L
G
A
M
Y
T
L
P
R
Q
A
T
P
Site 73
T841
Y
T
L
P
R
Q
A
T
P
G
V
P
A
Q
Q
Site 74
S849
P
G
V
P
A
Q
Q
S
P
S
M
_
_
_
_
Site 75
S851
V
P
A
Q
Q
S
P
S
M
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation