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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ECE2
Full Name:
Endothelin-converting enzyme 2
Alias:
ECE-2; Endothelin converting enzyme 2; Endothelin-converting enzyme 2 region; KIAA0604; MGC2408
Type:
EC 3.4.24.71; Vesicle protein; Methyltransferase; EC 2.1.1.-; Protease
Mass (Da):
99773
Number AA:
883
UniProt ID:
O60344
International Prot ID:
IPI00218597
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0030659
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0004222
GO:0008168
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007420
GO:0010002
GO:0007267
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
L
P
E
R
N
C
G
Y
R
E
V
E
Y
W
D
Site 2
Y25
C
G
Y
R
E
V
E
Y
W
D
Q
R
Y
Q
G
Site 3
Y30
V
E
Y
W
D
Q
R
Y
Q
G
A
A
D
S
A
Site 4
Y39
G
A
A
D
S
A
P
Y
D
W
F
G
D
F
S
Site 5
S46
Y
D
W
F
G
D
F
S
S
F
R
A
L
L
E
Site 6
S47
D
W
F
G
D
F
S
S
F
R
A
L
L
E
P
Site 7
T111
V
P
Q
L
R
W
E
T
M
D
V
R
K
L
D
Site 8
S123
K
L
D
F
P
S
A
S
F
D
V
V
L
E
K
Site 9
T145
A
G
E
R
D
P
W
T
V
S
S
E
G
V
H
Site 10
S147
E
R
D
P
W
T
V
S
S
E
G
V
H
T
V
Site 11
S148
R
D
P
W
T
V
S
S
E
G
V
H
T
V
D
Site 12
T153
V
S
S
E
G
V
H
T
V
D
Q
V
L
S
E
Site 13
S159
H
T
V
D
Q
V
L
S
E
V
G
F
Q
K
G
Site 14
S173
G
T
R
Q
L
L
G
S
R
T
Q
L
E
L
V
Site 15
Y203
L
V
A
L
G
V
Q
Y
H
R
D
P
S
H
S
Site 16
S208
V
Q
Y
H
R
D
P
S
H
S
T
C
L
T
E
Site 17
S210
Y
H
R
D
P
S
H
S
T
C
L
T
E
A
C
Site 18
S233
E
S
L
D
R
G
V
S
P
C
E
D
F
Y
Q
Site 19
Y239
V
S
P
C
E
D
F
Y
Q
F
S
C
G
G
W
Site 20
S257
N
P
L
P
D
G
R
S
R
W
N
T
F
N
S
Site 21
T280
L
K
H
L
L
E
N
T
T
F
N
S
S
S
E
Site 22
T281
K
H
L
L
E
N
T
T
F
N
S
S
S
E
A
Site 23
S286
N
T
T
F
N
S
S
S
E
A
E
Q
K
T
Q
Site 24
T292
S
S
E
A
E
Q
K
T
Q
R
F
Y
L
S
C
Site 25
Y296
E
Q
K
T
Q
R
F
Y
L
S
C
L
Q
V
E
Site 26
S356
P
F
F
T
V
Y
I
S
A
D
S
K
S
S
N
Site 27
S359
T
V
Y
I
S
A
D
S
K
S
S
N
S
N
V
Site 28
S361
Y
I
S
A
D
S
K
S
S
N
S
N
V
I
Q
Site 29
S372
N
V
I
Q
V
D
Q
S
G
L
F
L
P
S
R
Site 30
Y381
L
F
L
P
S
R
D
Y
Y
L
N
R
T
A
N
Site 31
Y382
F
L
P
S
R
D
Y
Y
L
N
R
T
A
N
E
Site 32
T386
R
D
Y
Y
L
N
R
T
A
N
E
K
V
L
T
Site 33
T393
T
A
N
E
K
V
L
T
A
Y
L
D
Y
M
E
Site 34
Y395
N
E
K
V
L
T
A
Y
L
D
Y
M
E
E
L
Site 35
T411
M
L
L
G
G
R
P
T
S
T
R
E
Q
M
Q
Site 36
S412
L
L
G
G
R
P
T
S
T
R
E
Q
M
Q
Q
Site 37
Y444
R
R
D
E
E
K
I
Y
H
K
M
S
I
S
E
Site 38
S448
E
K
I
Y
H
K
M
S
I
S
E
L
Q
A
L
Site 39
S477
S
P
L
E
L
S
D
S
E
P
V
V
V
Y
G
Site 40
S518
L
V
Q
K
T
T
S
S
L
D
R
R
F
E
S
Site 41
S525
S
L
D
R
R
F
E
S
A
Q
E
K
L
L
E
Site 42
Y535
E
K
L
L
E
T
L
Y
G
T
K
K
S
C
V
Site 43
T568
G
S
L
F
V
K
A
T
F
D
R
Q
S
K
E
Site 44
S573
K
A
T
F
D
R
Q
S
K
E
I
A
E
G
M
Site 45
Y614
K
E
K
A
D
A
I
Y
D
M
I
G
F
P
D
Site 46
Y633
P
K
E
L
D
D
V
Y
D
G
Y
E
I
S
E
Site 47
Y636
L
D
D
V
Y
D
G
Y
E
I
S
E
D
S
F
Site 48
S654
M
L
N
L
Y
N
F
S
A
K
V
M
A
D
Q
Site 49
S667
D
Q
L
R
K
P
P
S
R
D
Q
W
S
M
T
Site 50
S672
P
P
S
R
D
Q
W
S
M
T
P
Q
T
V
N
Site 51
T674
S
R
D
Q
W
S
M
T
P
Q
T
V
N
A
Y
Site 52
T677
Q
W
S
M
T
P
Q
T
V
N
A
Y
Y
L
P
Site 53
Y681
T
P
Q
T
V
N
A
Y
Y
L
P
T
K
N
E
Site 54
Y682
P
Q
T
V
N
A
Y
Y
L
P
T
K
N
E
I
Site 55
Y701
G
I
L
Q
A
P
F
Y
A
R
N
H
P
K
A
Site 56
Y733
F
D
D
Q
G
R
E
Y
D
K
E
G
N
L
R
Site 57
T755
L
A
A
F
R
N
H
T
A
C
M
E
E
Q
Y
Site 58
Y765
M
E
E
Q
Y
N
Q
Y
Q
V
N
G
E
R
L
Site 59
T777
E
R
L
N
G
R
Q
T
L
G
E
N
I
A
D
Site 60
Y792
N
G
G
L
K
A
A
Y
N
A
Y
K
A
W
L
Site 61
S829
G
F
A
Q
V
W
C
S
V
R
T
P
E
S
S
Site 62
T832
Q
V
W
C
S
V
R
T
P
E
S
S
H
E
G
Site 63
S835
C
S
V
R
T
P
E
S
S
H
E
G
L
V
T
Site 64
S836
S
V
R
T
P
E
S
S
H
E
G
L
V
T
D
Site 65
T842
S
S
H
E
G
L
V
T
D
P
H
S
P
A
R
Site 66
S846
G
L
V
T
D
P
H
S
P
A
R
F
R
V
L
Site 67
T855
A
R
F
R
V
L
G
T
L
S
N
S
R
D
F
Site 68
S857
F
R
V
L
G
T
L
S
N
S
R
D
F
L
R
Site 69
S859
V
L
G
T
L
S
N
S
R
D
F
L
R
H
F
Site 70
S872
H
F
G
C
P
V
G
S
P
M
N
P
G
Q
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation