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Updated November 2019
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Protein Info
Short Name:
PHLPP
Full Name:
PH domain leucine-rich repeat-containing protein phosphatase 1
Alias:
KIAA0606; pleckstrin homology domain containing family E protein; PLEKHEI, SCOP
Type:
Protein-serine phosphatase
Mass (Da):
184672
Number AA:
1717
UniProt ID:
O60346
International Prot ID:
IPI00297617
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0019898
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0030145
GO:0005515
GO:0004722
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
L
G
R
E
D
R
A
S
A
P
A
A
A
A
A
Site 2
S50
A
A
A
G
G
G
R
S
P
E
P
A
L
T
P
Site 3
T56
R
S
P
E
P
A
L
T
P
A
A
P
S
G
G
Site 4
S61
A
L
T
P
A
A
P
S
G
G
N
G
S
G
S
Site 5
S66
A
P
S
G
G
N
G
S
G
S
G
A
R
E
E
Site 6
S68
S
G
G
N
G
S
G
S
G
A
R
E
E
A
P
Site 7
S118
G
A
G
G
G
A
N
S
L
L
L
R
R
G
R
Site 8
S131
G
R
L
K
R
N
L
S
A
A
A
A
A
A
S
Site 9
S138
S
A
A
A
A
A
A
S
S
S
S
S
S
S
A
Site 10
S142
A
A
A
S
S
S
S
S
S
S
A
A
A
A
S
Site 11
S143
A
A
S
S
S
S
S
S
S
A
A
A
A
S
H
Site 12
S144
A
S
S
S
S
S
S
S
A
A
A
A
S
H
S
Site 13
S149
S
S
S
A
A
A
A
S
H
S
P
G
A
A
G
Site 14
S171
S
A
S
L
C
T
R
S
L
D
R
K
T
L
L
Site 15
T176
T
R
S
L
D
R
K
T
L
L
L
K
H
R
Q
Site 16
T184
L
L
L
K
H
R
Q
T
L
Q
L
Q
P
S
D
Site 17
S190
Q
T
L
Q
L
Q
P
S
D
R
D
W
V
R
H
Site 18
T214
F
D
R
H
M
A
S
T
Y
L
R
P
V
L
C
Site 19
Y215
D
R
H
M
A
S
T
Y
L
R
P
V
L
C
T
Site 20
S279
A
P
P
E
P
R
D
S
E
V
P
P
A
R
S
Site 21
S286
S
E
V
P
P
A
R
S
A
P
G
A
F
G
G
Site 22
S313
V
G
G
P
G
G
W
S
R
R
A
S
P
A
P
Site 23
S317
G
G
W
S
R
R
A
S
P
A
P
S
D
S
S
Site 24
S321
R
R
A
S
P
A
P
S
D
S
S
P
G
E
P
Site 25
S323
A
S
P
A
P
S
D
S
S
P
G
E
P
F
V
Site 26
S324
S
P
A
P
S
D
S
S
P
G
E
P
F
V
G
Site 27
S335
P
F
V
G
G
P
V
S
S
P
R
A
P
R
P
Site 28
S336
F
V
G
G
P
V
S
S
P
R
A
P
R
P
V
Site 29
S345
R
A
P
R
P
V
V
S
D
T
E
S
F
S
L
Site 30
T347
P
R
P
V
V
S
D
T
E
S
F
S
L
S
P
Site 31
S349
P
V
V
S
D
T
E
S
F
S
L
S
P
S
A
Site 32
S351
V
S
D
T
E
S
F
S
L
S
P
S
A
E
S
Site 33
S353
D
T
E
S
F
S
L
S
P
S
A
E
S
V
S
Site 34
S355
E
S
F
S
L
S
P
S
A
E
S
V
S
D
R
Site 35
S358
S
L
S
P
S
A
E
S
V
S
D
R
L
D
P
Site 36
S360
S
P
S
A
E
S
V
S
D
R
L
D
P
Y
S
Site 37
Y366
V
S
D
R
L
D
P
Y
S
S
G
G
G
S
S
Site 38
S367
S
D
R
L
D
P
Y
S
S
G
G
G
S
S
S
Site 39
S368
D
R
L
D
P
Y
S
S
G
G
G
S
S
S
S
Site 40
S372
P
Y
S
S
G
G
G
S
S
S
S
S
E
E
L
Site 41
S374
S
S
G
G
G
S
S
S
S
S
E
E
L
E
A
Site 42
S375
S
G
G
G
S
S
S
S
S
E
E
L
E
A
D
Site 43
S376
G
G
G
S
S
S
S
S
E
E
L
E
A
D
A
Site 44
S385
E
L
E
A
D
A
A
S
A
P
T
G
V
P
G
Site 45
T409
Q
P
L
P
L
P
Q
T
A
S
S
P
Q
P
Q
Site 46
S411
L
P
L
P
Q
T
A
S
S
P
Q
P
Q
Q
K
Site 47
S412
P
L
P
Q
T
A
S
S
P
Q
P
Q
Q
K
A
Site 48
S425
K
A
P
R
A
I
D
S
P
G
G
A
V
R
E
Site 49
S434
G
G
A
V
R
E
G
S
C
E
E
K
A
A
A
Site 50
S450
V
A
P
G
G
L
Q
S
T
P
G
R
S
G
V
Site 51
T451
A
P
G
G
L
Q
S
T
P
G
R
S
G
V
T
Site 52
T470
P
P
P
P
P
P
P
T
L
Y
V
Q
L
H
G
Site 53
Y472
P
P
P
P
P
T
L
Y
V
Q
L
H
G
E
T
Site 54
Y496
P
L
Q
I
Q
N
D
Y
L
F
Q
L
G
F
G
Site 55
S515
V
Q
E
E
G
M
D
S
E
I
G
C
L
I
R
Site 56
S530
F
Y
A
G
K
P
H
S
T
G
S
S
E
R
I
Site 57
T531
Y
A
G
K
P
H
S
T
G
S
S
E
R
I
Q
Site 58
S533
G
K
P
H
S
T
G
S
S
E
R
I
Q
L
S
Site 59
S534
K
P
H
S
T
G
S
S
E
R
I
Q
L
S
G
Site 60
S540
S
S
E
R
I
Q
L
S
G
M
Y
N
V
R
K
Site 61
Y543
R
I
Q
L
S
G
M
Y
N
V
R
K
G
K
M
Site 62
T558
Q
L
P
V
N
R
W
T
R
R
Q
V
I
L
C
Site 63
T579
S
S
V
K
D
S
L
T
G
K
M
H
V
L
P
Site 64
S605
H
Q
H
C
L
A
F
S
S
S
G
P
Q
S
Q
Site 65
S606
Q
H
C
L
A
F
S
S
S
G
P
Q
S
Q
T
Site 66
S607
H
C
L
A
F
S
S
S
G
P
Q
S
Q
T
Y
Site 67
S611
F
S
S
S
G
P
Q
S
Q
T
Y
Y
I
C
F
Site 68
Y614
S
G
P
Q
S
Q
T
Y
Y
I
C
F
D
T
F
Site 69
Y615
G
P
Q
S
Q
T
Y
Y
I
C
F
D
T
F
T
Site 70
Y624
C
F
D
T
F
T
E
Y
L
R
W
L
R
Q
V
Site 71
S632
L
R
W
L
R
Q
V
S
K
V
A
S
Q
R
I
Site 72
S636
R
Q
V
S
K
V
A
S
Q
R
I
S
S
V
D
Site 73
S659
L
P
A
N
L
F
Y
S
Q
D
L
T
H
L
N
Site 74
T663
L
F
Y
S
Q
D
L
T
H
L
N
L
K
Q
N
Site 75
S677
N
F
L
R
Q
N
P
S
L
P
A
A
R
G
L
Site 76
T691
L
N
E
L
Q
R
F
T
K
L
K
S
L
N
L
Site 77
S695
Q
R
F
T
K
L
K
S
L
N
L
S
N
N
H
Site 78
S699
K
L
K
S
L
N
L
S
N
N
H
L
G
D
F
Site 79
S751
L
D
G
N
F
L
Q
S
L
P
A
E
L
E
N
Site 80
Y764
E
N
M
K
Q
L
S
Y
L
G
L
S
F
N
E
Site 81
T797
M
S
G
N
C
V
E
T
L
R
L
Q
A
L
R
Site 82
Y895
D
V
Y
P
V
P
N
Y
L
S
Y
M
D
V
S
Site 83
Y898
P
V
P
N
Y
L
S
Y
M
D
V
S
R
N
R
Site 84
S963
P
E
R
L
E
R
T
S
V
E
V
L
D
V
Q
Site 85
S994
S
L
R
F
L
N
A
S
A
N
K
L
E
S
L
Site 86
S1000
A
S
A
N
K
L
E
S
L
P
P
A
T
L
S
Site 87
T1005
L
E
S
L
P
P
A
T
L
S
E
E
T
N
S
Site 88
S1007
S
L
P
P
A
T
L
S
E
E
T
N
S
I
L
Site 89
S1012
T
L
S
E
E
T
N
S
I
L
Q
E
L
Y
L
Site 90
Y1018
N
S
I
L
Q
E
L
Y
L
T
N
N
S
L
T
Site 91
T1020
I
L
Q
E
L
Y
L
T
N
N
S
L
T
D
K
Site 92
S1023
E
L
Y
L
T
N
N
S
L
T
D
K
C
V
P
Site 93
Y1045
L
K
I
L
H
M
A
Y
N
R
L
Q
S
F
P
Site 94
S1050
M
A
Y
N
R
L
Q
S
F
P
A
S
K
M
A
Site 95
S1054
R
L
Q
S
F
P
A
S
K
M
A
K
L
E
E
Site 96
S1068
E
L
E
E
I
D
L
S
G
N
K
L
K
A
I
Site 97
S1118
D
L
S
C
N
E
L
S
E
V
T
L
P
E
N
Site 98
T1136
K
L
Q
E
L
D
L
T
G
N
P
R
L
V
L
Site 99
S1163
C
F
K
I
D
Q
P
S
T
G
D
A
S
G
A
Site 100
T1164
F
K
I
D
Q
P
S
T
G
D
A
S
G
A
P
Site 101
S1168
Q
P
S
T
G
D
A
S
G
A
P
A
V
W
S
Site 102
S1175
S
G
A
P
A
V
W
S
H
G
Y
T
E
A
S
Site 103
Y1178
P
A
V
W
S
H
G
Y
T
E
A
S
G
V
K
Site 104
T1179
A
V
W
S
H
G
Y
T
E
A
S
G
V
K
N
Site 105
S1182
S
H
G
Y
T
E
A
S
G
V
K
N
K
L
C
Site 106
Y1206
C
D
N
R
E
A
L
Y
G
V
F
D
G
D
R
Site 107
Y1219
D
R
N
V
E
V
P
Y
L
L
Q
C
T
M
S
Site 108
T1236
L
A
E
E
L
Q
K
T
K
N
E
E
E
Y
M
Site 109
Y1242
K
T
K
N
E
E
E
Y
M
V
N
T
F
I
V
Site 110
S1280
D
P
V
D
P
G
G
S
F
T
L
T
S
A
N
Site 111
T1284
P
G
G
S
F
T
L
T
S
A
N
V
G
K
C
Site 112
S1285
G
G
S
F
T
L
T
S
A
N
V
G
K
C
Q
Site 113
T1293
A
N
V
G
K
C
Q
T
V
L
C
R
N
G
K
Site 114
S1305
N
G
K
P
L
P
L
S
R
S
Y
I
M
S
C
Site 115
S1307
K
P
L
P
L
S
R
S
Y
I
M
S
C
E
E
Site 116
Y1308
P
L
P
L
S
R
S
Y
I
M
S
C
E
E
E
Site 117
S1311
L
S
R
S
Y
I
M
S
C
E
E
E
L
K
R
Site 118
S1338
K
V
N
G
V
T
E
S
T
R
I
L
G
Y
T
Site 119
Y1344
E
S
T
R
I
L
G
Y
T
F
L
H
P
S
V
Site 120
S1350
G
Y
T
F
L
H
P
S
V
V
P
R
P
H
V
Site 121
S1359
V
P
R
P
H
V
Q
S
V
L
L
T
P
Q
D
Site 122
T1363
H
V
Q
S
V
L
L
T
P
Q
D
E
F
F
I
Site 123
S1379
G
S
K
G
L
W
D
S
L
S
V
E
E
A
V
Site 124
S1381
K
G
L
W
D
S
L
S
V
E
E
A
V
E
A
Site 125
S1444
G
G
A
V
P
P
P
S
P
G
I
F
P
P
S
Site 126
S1461
M
V
I
K
D
R
P
S
D
G
L
G
V
P
S
Site 127
S1468
S
D
G
L
G
V
P
S
S
S
S
G
M
A
S
Site 128
S1469
D
G
L
G
V
P
S
S
S
S
G
M
A
S
E
Site 129
S1475
S
S
S
S
G
M
A
S
E
I
S
S
E
L
S
Site 130
S1478
S
G
M
A
S
E
I
S
S
E
L
S
T
S
E
Site 131
S1479
G
M
A
S
E
I
S
S
E
L
S
T
S
E
M
Site 132
S1482
S
E
I
S
S
E
L
S
T
S
E
M
S
S
E
Site 133
T1483
E
I
S
S
E
L
S
T
S
E
M
S
S
E
V
Site 134
S1484
I
S
S
E
L
S
T
S
E
M
S
S
E
V
G
Site 135
S1488
L
S
T
S
E
M
S
S
E
V
G
S
T
A
S
Site 136
S1492
E
M
S
S
E
V
G
S
T
A
S
D
E
P
P
Site 137
T1493
M
S
S
E
V
G
S
T
A
S
D
E
P
P
P
Site 138
S1495
S
E
V
G
S
T
A
S
D
E
P
P
P
G
A
Site 139
S1504
E
P
P
P
G
A
L
S
E
N
S
P
A
Y
P
Site 140
S1507
P
G
A
L
S
E
N
S
P
A
Y
P
S
E
Q
Site 141
Y1510
L
S
E
N
S
P
A
Y
P
S
E
Q
R
C
M
Site 142
S1512
E
N
S
P
A
Y
P
S
E
Q
R
C
M
L
H
Site 143
S1526
H
P
I
C
L
S
N
S
F
Q
R
Q
L
S
S
Site 144
S1532
N
S
F
Q
R
Q
L
S
S
A
T
F
S
S
A
Site 145
S1533
S
F
Q
R
Q
L
S
S
A
T
F
S
S
A
F
Site 146
T1535
Q
R
Q
L
S
S
A
T
F
S
S
A
F
S
D
Site 147
S1537
Q
L
S
S
A
T
F
S
S
A
F
S
D
N
G
Site 148
S1541
A
T
F
S
S
A
F
S
D
N
G
L
D
S
D
Site 149
S1547
F
S
D
N
G
L
D
S
D
D
E
E
P
I
E
Site 150
T1558
E
P
I
E
G
V
F
T
N
G
S
R
V
E
V
Site 151
S1561
E
G
V
F
T
N
G
S
R
V
E
V
E
V
D
Site 152
S1598
S
D
E
G
I
V
I
S
A
N
E
D
E
P
G
Site 153
S1613
L
P
R
K
A
D
F
S
A
V
G
T
I
G
R
Site 154
T1617
A
D
F
S
A
V
G
T
I
G
R
R
R
A
N
Site 155
S1626
G
R
R
R
A
N
G
S
V
A
P
Q
E
R
S
Site 156
Y1651
P
L
R
K
P
G
G
Y
F
A
A
P
A
Q
P
Site 157
Y1704
Q
P
Q
L
P
R
H
Y
Q
L
D
Q
L
P
D
Site 158
Y1712
Q
L
D
Q
L
P
D
Y
Y
D
T
P
L
_
_
Site 159
Y1713
L
D
Q
L
P
D
Y
Y
D
T
P
L
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation