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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FZD6
Full Name:
Frizzled-6
Alias:
Frizzled 6; Fz-6; Hfz6
Type:
Receptor, GPCR
Mass (Da):
79274
Number AA:
706
UniProt ID:
O60353
International Prot ID:
IPI00020228
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0004930
GO:0042813
GO:0004926
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0016055
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
L
R
G
H
S
L
F
T
C
E
P
I
T
V
P
Site 2
Y103
R
K
L
C
E
K
V
Y
S
D
C
K
K
L
I
Site 3
S104
K
L
C
E
K
V
Y
S
D
C
K
K
L
I
D
Site 4
T112
D
C
K
K
L
I
D
T
F
G
I
R
W
P
E
Site 5
Y128
L
E
C
D
R
L
Q
Y
C
D
E
T
V
P
V
Site 6
T132
R
L
Q
Y
C
D
E
T
V
P
V
T
F
D
P
Site 7
T136
C
D
E
T
V
P
V
T
F
D
P
H
T
E
F
Site 8
T141
P
V
T
F
D
P
H
T
E
F
L
G
P
Q
K
Site 9
T167
W
C
P
R
H
L
K
T
S
G
G
Q
G
Y
K
Site 10
S168
C
P
R
H
L
K
T
S
G
G
Q
G
Y
K
F
Site 11
Y189
A
P
P
C
P
N
M
Y
F
K
S
D
E
L
E
Site 12
Y229
I
D
V
R
R
F
R
Y
P
E
R
P
I
I
Y
Site 13
T258
G
F
L
L
G
D
S
T
A
C
N
K
A
D
E
Site 14
T272
E
K
L
E
L
G
D
T
V
V
L
G
S
Q
N
Site 15
S316
L
A
A
G
R
K
W
S
C
E
A
I
E
Q
K
Site 16
T501
V
G
S
K
K
T
C
T
E
W
A
G
F
F
K
Site 17
S517
N
R
K
R
D
P
I
S
E
S
R
R
V
L
Q
Site 18
S519
K
R
D
P
I
S
E
S
R
R
V
L
Q
E
S
Site 19
S526
S
R
R
V
L
Q
E
S
C
E
F
F
L
K
H
Site 20
S535
E
F
F
L
K
H
N
S
K
V
K
H
K
K
K
Site 21
Y544
V
K
H
K
K
K
H
Y
K
P
S
S
H
K
L
Site 22
S548
K
K
H
Y
K
P
S
S
H
K
L
K
V
I
S
Site 23
S555
S
H
K
L
K
V
I
S
K
S
M
G
T
S
T
Site 24
S557
K
L
K
V
I
S
K
S
M
G
T
S
T
G
A
Site 25
S561
I
S
K
S
M
G
T
S
T
G
A
T
A
N
H
Site 26
T562
S
K
S
M
G
T
S
T
G
A
T
A
N
H
G
Site 27
T565
M
G
T
S
T
G
A
T
A
N
H
G
T
S
A
Site 28
Y580
V
A
I
T
S
H
D
Y
L
G
Q
E
T
L
T
Site 29
S592
T
L
T
E
I
Q
T
S
P
E
T
S
M
R
E
Site 30
S596
I
Q
T
S
P
E
T
S
M
R
E
V
K
A
D
Site 31
S606
E
V
K
A
D
G
A
S
T
P
R
L
R
E
Q
Site 32
T607
V
K
A
D
G
A
S
T
P
R
L
R
E
Q
D
Site 33
S620
Q
D
C
G
E
P
A
S
P
A
A
S
I
S
R
Site 34
S624
E
P
A
S
P
A
A
S
I
S
R
L
S
G
E
Site 35
S626
A
S
P
A
A
S
I
S
R
L
S
G
E
Q
V
Site 36
S629
A
A
S
I
S
R
L
S
G
E
Q
V
D
G
K
Site 37
S641
D
G
K
G
Q
A
G
S
V
S
E
S
A
R
S
Site 38
S643
K
G
Q
A
G
S
V
S
E
S
A
R
S
E
G
Site 39
S645
Q
A
G
S
V
S
E
S
A
R
S
E
G
R
I
Site 40
S648
S
V
S
E
S
A
R
S
E
G
R
I
S
P
K
Site 41
S653
A
R
S
E
G
R
I
S
P
K
S
D
I
T
D
Site 42
S656
E
G
R
I
S
P
K
S
D
I
T
D
T
G
L
Site 43
T659
I
S
P
K
S
D
I
T
D
T
G
L
A
Q
S
Site 44
T661
P
K
S
D
I
T
D
T
G
L
A
Q
S
N
N
Site 45
S673
S
N
N
L
Q
V
P
S
S
S
E
P
S
S
L
Site 46
S674
N
N
L
Q
V
P
S
S
S
E
P
S
S
L
K
Site 47
S675
N
L
Q
V
P
S
S
S
E
P
S
S
L
K
G
Site 48
S678
V
P
S
S
S
E
P
S
S
L
K
G
S
T
S
Site 49
S679
P
S
S
S
E
P
S
S
L
K
G
S
T
S
L
Site 50
S683
E
P
S
S
L
K
G
S
T
S
L
L
V
H
P
Site 51
S692
S
L
L
V
H
P
V
S
G
V
R
K
E
Q
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation