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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATP8B3
Full Name:
Probable phospholipid-transporting ATPase IK
Alias:
Aminophospholipid translocase ATP8B3; AT8B3; ATPase, Class I, type 8B, member 3; ATPIK; EC 3.6.3.1; Potential phospholipid-transporting ATPase IK
Type:
EC 3.6.3.1; Transporter; Hydrolase; Membrane protein, integral
Mass (Da):
148031
Number AA:
1310
UniProt ID:
O60423
International Prot ID:
IPI00216974
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0015662
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006754
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
G
T
G
P
A
Q
T
P
R
S
T
R
A
G
Site 2
S11
G
P
A
Q
T
P
R
S
T
R
A
G
P
E
P
Site 3
T12
P
A
Q
T
P
R
S
T
R
A
G
P
E
P
S
Site 4
S19
T
R
A
G
P
E
P
S
P
A
P
P
G
P
G
Site 5
S31
G
P
G
D
T
G
D
S
D
V
T
Q
E
G
S
Site 6
T34
D
T
G
D
S
D
V
T
Q
E
G
S
G
P
A
Site 7
S38
S
D
V
T
Q
E
G
S
G
P
A
G
I
R
G
Site 8
S57
I
R
A
G
M
G
D
S
P
G
R
G
A
P
E
Site 9
Y77
Q
P
G
R
A
R
K
Y
E
W
R
P
E
G
P
Site 10
T85
E
W
R
P
E
G
P
T
S
M
G
S
L
G
Q
Site 11
S86
W
R
P
E
G
P
T
S
M
G
S
L
G
Q
R
Site 12
S89
E
G
P
T
S
M
G
S
L
G
Q
R
E
D
L
Site 13
S103
L
Q
D
E
D
R
N
S
A
F
T
W
K
V
Q
Site 14
Y116
V
Q
A
N
N
R
A
Y
N
G
Q
F
K
E
K
Site 15
Y133
L
C
W
Q
R
K
K
Y
K
T
N
V
I
R
T
Site 16
T135
W
Q
R
K
K
Y
K
T
N
V
I
R
T
A
K
Site 17
Y143
N
V
I
R
T
A
K
Y
N
F
Y
S
F
L
P
Site 18
Y154
S
F
L
P
L
N
L
Y
E
Q
F
H
R
V
S
Site 19
S210
D
D
M
G
R
H
K
S
D
R
A
I
N
N
R
Site 20
Y266
T
E
P
S
S
L
C
Y
V
E
T
V
D
I
D
Site 21
T269
S
S
L
C
Y
V
E
T
V
D
I
D
G
E
T
Site 22
S299
A
T
I
K
K
M
A
S
F
Q
G
T
V
T
C
Site 23
T303
K
M
A
S
F
Q
G
T
V
T
C
E
A
P
N
Site 24
Y327
L
E
W
N
D
K
K
Y
S
L
D
I
G
N
L
Site 25
Y348
I
R
N
T
D
T
C
Y
G
L
V
I
Y
A
G
Site 26
T372
G
K
I
H
L
K
R
T
K
L
D
L
L
M
N
Site 27
Y412
K
E
F
K
D
H
H
Y
Y
L
S
G
V
H
G
Site 28
Y413
E
F
K
D
H
H
Y
Y
L
S
G
V
H
G
S
Site 29
S415
K
D
H
H
Y
Y
L
S
G
V
H
G
S
S
V
Site 30
Y467
I
D
W
D
V
Q
M
Y
Y
K
P
Q
D
V
P
Site 31
T480
V
P
A
K
A
R
S
T
S
L
N
D
H
L
G
Site 32
S481
P
A
K
A
R
S
T
S
L
N
D
H
L
G
Q
Site 33
S494
G
Q
V
E
Y
I
F
S
D
K
T
G
T
L
T
Site 34
T497
E
Y
I
F
S
D
K
T
G
T
L
T
Q
N
I
Site 35
T501
S
D
K
T
G
T
L
T
Q
N
I
L
T
F
N
Site 36
Y517
C
C
I
S
G
R
V
Y
G
P
D
S
E
A
T
Site 37
S521
G
R
V
Y
G
P
D
S
E
A
T
T
R
P
K
Site 38
T524
Y
G
P
D
S
E
A
T
T
R
P
K
E
N
P
Site 39
T525
G
P
D
S
E
A
T
T
R
P
K
E
N
P
Y
Site 40
Y532
T
R
P
K
E
N
P
Y
L
W
N
K
F
A
D
Site 41
S579
H
T
V
M
V
R
E
S
P
R
E
R
P
D
Q
Site 42
Y589
E
R
P
D
Q
L
L
Y
Q
A
A
S
P
D
E
Site 43
Y608
T
A
A
R
N
F
G
Y
V
F
L
S
R
T
Q
Site 44
S612
N
F
G
Y
V
F
L
S
R
T
Q
D
T
V
T
Site 45
T619
S
R
T
Q
D
T
V
T
I
M
E
L
G
E
E
Site 46
Y629
E
L
G
E
E
R
V
Y
Q
V
L
A
I
M
D
Site 47
S639
L
A
I
M
D
F
N
S
T
R
K
R
M
S
V
Site 48
S645
N
S
T
R
K
R
M
S
V
L
V
R
K
P
E
Site 49
T664
L
Y
T
K
G
A
D
T
V
I
F
E
R
L
H
Site 50
T694
F
A
Q
E
T
L
R
T
L
C
L
A
Y
R
E
Site 51
Y707
R
E
V
A
E
D
I
Y
E
D
W
Q
Q
R
H
Site 52
S718
Q
Q
R
H
Q
E
A
S
L
L
L
Q
N
R
A
Site 53
S803
I
L
E
E
K
E
I
S
R
I
L
E
T
Y
W
Site 54
Y809
I
S
R
I
L
E
T
Y
W
E
N
S
N
N
L
Site 55
T818
E
N
S
N
N
L
L
T
R
E
S
L
S
Q
V
Site 56
S821
N
N
L
L
T
R
E
S
L
S
Q
V
K
L
A
Site 57
S842
F
L
D
K
L
L
V
S
L
R
K
E
P
R
A
Site 58
S866
A
W
Q
E
L
G
Q
S
R
R
D
F
L
Y
A
Site 59
Y872
Q
S
R
R
D
F
L
Y
A
R
R
L
S
L
L
Site 60
S895
A
A
P
P
A
Q
D
S
R
A
R
R
S
S
E
Site 61
S900
Q
D
S
R
A
R
R
S
S
E
V
L
Q
E
R
Site 62
S901
D
S
R
A
R
R
S
S
E
V
L
Q
E
R
A
Site 63
S1064
G
L
F
E
Q
D
V
S
A
E
Q
S
L
E
K
Site 64
S1068
Q
D
V
S
A
E
Q
S
L
E
K
P
E
L
Y
Site 65
Y1075
S
L
E
K
P
E
L
Y
V
V
G
Q
K
D
E
Site 66
Y1086
Q
K
D
E
L
F
N
Y
W
V
F
V
Q
A
I
Site 67
T1114
T
L
W
I
S
R
D
T
A
G
P
A
S
F
S
Site 68
S1119
R
D
T
A
G
P
A
S
F
S
D
H
Q
S
F
Site 69
S1121
T
A
G
P
A
S
F
S
D
H
Q
S
F
A
V
Site 70
S1239
E
K
V
E
E
G
P
S
E
E
I
F
T
M
E
Site 71
T1244
G
P
S
E
E
I
F
T
M
E
P
L
P
H
V
Site 72
S1255
L
P
H
V
H
R
E
S
R
A
R
R
S
S
Y
Site 73
S1260
R
E
S
R
A
R
R
S
S
Y
A
F
S
H
R
Site 74
S1261
E
S
R
A
R
R
S
S
Y
A
F
S
H
R
E
Site 75
Y1262
S
R
A
R
R
S
S
Y
A
F
S
H
R
E
G
Site 76
S1265
R
R
S
S
Y
A
F
S
H
R
E
G
Y
A
N
Site 77
Y1270
A
F
S
H
R
E
G
Y
A
N
L
I
T
Q
G
Site 78
T1275
E
G
Y
A
N
L
I
T
Q
G
T
I
L
R
R
Site 79
T1278
A
N
L
I
T
Q
G
T
I
L
R
R
G
P
G
Site 80
S1287
L
R
R
G
P
G
V
S
S
D
I
A
S
E
S
Site 81
S1288
R
R
G
P
G
V
S
S
D
I
A
S
E
S
L
Site 82
S1292
G
V
S
S
D
I
A
S
E
S
L
D
P
S
D
Site 83
S1294
S
S
D
I
A
S
E
S
L
D
P
S
D
E
E
Site 84
S1298
A
S
E
S
L
D
P
S
D
E
E
A
A
S
S
Site 85
S1304
P
S
D
E
E
A
A
S
S
P
K
E
S
Q
_
Site 86
S1305
S
D
E
E
A
A
S
S
P
K
E
S
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation