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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPL
Full Name:
Periplakin
Alias:
190 kDa paraneoplastic pemphigus antigen; 195 kDa cornified envelope precursor; 195 kDa cornified envelope precursor protein; KIAA0568; PEPL
Type:
Cytoskeletal protein
Mass (Da):
204678
Number AA:
1756
UniProt ID:
O60437
International Prot ID:
IPI00298057
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0030057
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005200
PhosphoSite+
KinaseNET
Biological Process:
GO:0031424
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
R
K
R
N
K
G
K
Y
S
P
T
V
Q
T
R
Site 2
S14
K
R
N
K
G
K
Y
S
P
T
V
Q
T
R
S
Site 3
T16
N
K
G
K
Y
S
P
T
V
Q
T
R
S
I
S
Site 4
S21
S
P
T
V
Q
T
R
S
I
S
N
K
E
L
S
Site 5
S23
T
V
Q
T
R
S
I
S
N
K
E
L
S
E
L
Site 6
S28
S
I
S
N
K
E
L
S
E
L
I
E
Q
L
Q
Site 7
T48
V
E
K
N
I
V
D
T
E
A
K
M
Q
S
D
Site 8
T71
Q
P
E
H
R
D
V
T
L
Q
K
V
L
D
S
Site 9
T115
R
Q
L
K
E
R
V
T
N
L
R
G
K
H
K
Site 10
Y125
R
G
K
H
K
Q
I
Y
R
L
A
V
K
E
V
Site 11
S153
L
D
K
L
N
N
Q
S
F
G
T
D
L
P
L
Site 12
S192
D
G
D
K
E
Q
N
S
E
L
R
A
K
Y
Q
Site 13
Y198
N
S
E
L
R
A
K
Y
Q
K
L
L
A
A
S
Site 14
S205
Y
Q
K
L
L
A
A
S
Q
A
R
Q
Q
H
L
Site 15
S213
Q
A
R
Q
Q
H
L
S
S
L
Q
D
Y
M
Q
Site 16
S214
A
R
Q
Q
H
L
S
S
L
Q
D
Y
M
Q
R
Site 17
Y218
H
L
S
S
L
Q
D
Y
M
Q
R
C
T
N
E
Site 18
Y227
Q
R
C
T
N
E
L
Y
W
L
D
Q
Q
A
K
Site 19
Y239
Q
A
K
G
R
M
Q
Y
D
W
S
D
R
N
L
Site 20
Y248
W
S
D
R
N
L
D
Y
P
S
R
R
R
Q
Y
Site 21
S250
D
R
N
L
D
Y
P
S
R
R
R
Q
Y
E
N
Site 22
Y255
Y
P
S
R
R
R
Q
Y
E
N
F
I
N
R
N
Site 23
S290
A
E
H
P
G
R
N
S
I
E
A
H
M
E
A
Site 24
Y318
C
E
E
S
H
L
K
Y
M
E
D
Y
H
Q
F
Site 25
Y322
H
L
K
Y
M
E
D
Y
H
Q
F
H
E
D
V
Site 26
S341
E
L
L
R
K
V
D
S
D
L
N
Q
K
Y
G
Site 27
Y347
D
S
D
L
N
Q
K
Y
G
P
D
F
K
D
R
Site 28
Y355
G
P
D
F
K
D
R
Y
Q
I
E
L
L
L
R
Site 29
Y374
Q
E
K
V
L
D
K
Y
E
D
V
V
Q
G
L
Site 30
Y393
Q
Q
V
V
P
L
K
Y
R
R
E
T
P
L
K
Site 31
T397
P
L
K
Y
R
R
E
T
P
L
K
P
I
P
V
Site 32
S418
E
G
E
Q
G
L
I
S
R
G
Y
S
Y
T
L
Site 33
Y421
Q
G
L
I
S
R
G
Y
S
Y
T
L
Q
K
N
Site 34
S422
G
L
I
S
R
G
Y
S
Y
T
L
Q
K
N
N
Site 35
T424
I
S
R
G
Y
S
Y
T
L
Q
K
N
N
G
E
Site 36
S438
E
S
W
E
L
M
D
S
A
G
N
K
L
I
A
Site 37
S465
E
A
L
A
L
A
D
S
L
G
S
Q
Y
R
S
Site 38
S468
A
L
A
D
S
L
G
S
Q
Y
R
S
V
R
Q
Site 39
S472
S
L
G
S
Q
Y
R
S
V
R
Q
K
A
A
G
Site 40
S480
V
R
Q
K
A
A
G
S
K
R
T
L
Q
Q
R
Site 41
Y488
K
R
T
L
Q
Q
R
Y
E
V
L
K
T
E
N
Site 42
T493
Q
R
Y
E
V
L
K
T
E
N
P
G
D
A
S
Site 43
S500
T
E
N
P
G
D
A
S
D
L
Q
G
R
Q
L
Site 44
S516
A
G
L
D
K
V
A
S
D
L
D
R
Q
E
K
Site 45
T526
D
R
Q
E
K
A
I
T
G
I
L
R
P
P
L
Site 46
S542
Q
G
R
A
V
Q
D
S
A
E
R
A
K
D
L
Site 47
T564
L
R
I
E
P
E
K
T
R
S
T
A
E
G
E
Site 48
S566
I
E
P
E
K
T
R
S
T
A
E
G
E
A
F
Site 49
T567
E
P
E
K
T
R
S
T
A
E
G
E
A
F
I
Site 50
T593
L
R
T
R
V
E
D
T
N
R
K
Y
E
H
L
Site 51
Y597
V
E
D
T
N
R
K
Y
E
H
L
L
Q
L
L
Site 52
S620
V
A
N
R
L
E
K
S
L
Q
Q
S
W
E
L
Site 53
S624
L
E
K
S
L
Q
Q
S
W
E
L
L
A
T
H
Site 54
T630
Q
S
W
E
L
L
A
T
H
E
N
H
L
N
Q
Site 55
T640
N
H
L
N
Q
D
D
T
V
P
E
S
S
R
V
Site 56
S644
Q
D
D
T
V
P
E
S
S
R
V
L
D
S
K
Site 57
S650
E
S
S
R
V
L
D
S
K
G
Q
E
L
A
A
Site 58
S667
C
E
L
Q
A
Q
K
S
L
L
G
E
V
E
Q
Site 59
S684
Q
A
A
K
Q
C
S
S
T
L
A
S
R
F
Q
Site 60
S688
Q
C
S
S
T
L
A
S
R
F
Q
E
H
C
P
Site 61
S724
Q
V
E
R
R
A
Q
S
L
Q
S
A
K
A
A
Site 62
Y732
L
Q
S
A
K
A
A
Y
E
H
F
H
R
G
H
Site 63
S751
Q
F
L
V
S
I
P
S
Y
E
P
Q
E
T
D
Site 64
Y752
F
L
V
S
I
P
S
Y
E
P
Q
E
T
D
S
Site 65
T757
P
S
Y
E
P
Q
E
T
D
S
L
S
Q
M
E
Site 66
S759
Y
E
P
Q
E
T
D
S
L
S
Q
M
E
T
K
Site 67
S761
P
Q
E
T
D
S
L
S
Q
M
E
T
K
L
K
Site 68
T765
D
S
L
S
Q
M
E
T
K
L
K
N
Q
K
N
Site 69
S779
N
L
L
D
E
I
A
S
R
E
Q
E
V
Q
K
Site 70
Y801
Y
Q
Q
A
V
K
D
Y
E
L
E
A
E
K
L
Site 71
S810
L
E
A
E
K
L
R
S
L
L
D
L
E
N
G
Site 72
S819
L
D
L
E
N
G
R
S
S
H
V
S
K
R
A
Site 73
S820
D
L
E
N
G
R
S
S
H
V
S
K
R
A
R
Site 74
S823
N
G
R
S
S
H
V
S
K
R
A
R
L
Q
S
Site 75
S830
S
K
R
A
R
L
Q
S
P
A
T
K
V
K
E
Site 76
Y850
A
A
K
F
T
E
V
Y
A
I
N
R
Q
R
L
Site 77
T876
Q
Q
P
E
V
E
V
T
H
E
T
L
Q
R
N
Site 78
S887
L
Q
R
N
R
P
D
S
G
V
E
E
A
W
K
Site 79
T903
R
K
E
L
D
E
E
T
E
R
R
R
Q
L
E
Site 80
S915
Q
L
E
N
E
V
K
S
T
Q
E
E
I
W
T
Site 81
T916
L
E
N
E
V
K
S
T
Q
E
E
I
W
T
L
Site 82
T922
S
T
Q
E
E
I
W
T
L
R
N
Q
G
P
Q
Site 83
S931
R
N
Q
G
P
Q
E
S
V
V
R
K
E
V
L
Site 84
S949
P
D
P
V
L
E
E
S
F
Q
Q
L
Q
R
T
Site 85
T956
S
F
Q
Q
L
Q
R
T
L
A
E
E
Q
H
K
Site 86
Y992
T
R
D
G
G
Q
E
Y
V
V
K
E
V
L
R
Site 87
S1046
A
A
L
A
E
E
K
S
R
A
Q
E
K
V
T
Site 88
Y1070
D
P
Q
L
E
A
E
Y
Q
Q
L
Q
E
D
H
Site 89
S1092
E
K
Q
E
E
E
L
S
F
L
Q
D
K
L
K
Site 90
T1126
K
V
E
K
D
A
A
T
E
R
E
V
S
D
L
Site 91
S1131
A
A
T
E
R
E
V
S
D
L
T
R
Q
Y
E
Site 92
T1134
E
R
E
V
S
D
L
T
R
Q
Y
E
D
E
A
Site 93
Y1137
V
S
D
L
T
R
Q
Y
E
D
E
A
A
K
A
Site 94
S1147
E
A
A
K
A
R
A
S
Q
R
E
K
T
E
L
Site 95
T1152
R
A
S
Q
R
E
K
T
E
L
L
R
K
I
W
Site 96
S1186
R
P
D
P
K
A
E
S
E
V
A
N
L
R
L
Site 97
Y1202
L
V
E
Q
E
R
K
Y
R
G
A
E
E
Q
L
Site 98
S1211
G
A
E
E
Q
L
R
S
Y
Q
S
E
L
E
A
Site 99
Y1212
A
E
E
Q
L
R
S
Y
Q
S
E
L
E
A
L
Site 100
Y1238
V
T
K
E
V
I
K
Y
K
T
D
P
E
M
E
Site 101
T1259
R
E
E
I
V
D
K
T
R
L
I
E
R
C
D
Site 102
Y1270
E
R
C
D
L
E
I
Y
Q
L
K
K
E
I
Q
Site 103
T1304
Q
F
Q
E
D
P
Q
T
K
E
E
V
A
S
L
Site 104
S1310
Q
T
K
E
E
V
A
S
L
R
A
K
L
S
E
Site 105
S1316
A
S
L
R
A
K
L
S
E
E
Q
K
K
Q
V
Site 106
S1331
D
L
E
R
E
R
A
S
Q
E
E
Q
I
A
R
Site 107
S1344
A
R
K
E
E
E
L
S
R
V
K
E
R
V
V
Site 108
Y1358
V
Q
Q
E
V
V
R
Y
E
E
E
P
G
L
R
Site 109
S1369
P
G
L
R
A
E
A
S
A
F
A
E
S
I
D
Site 110
S1374
E
A
S
A
F
A
E
S
I
D
V
E
L
R
Q
Site 111
T1397
R
R
L
Q
R
R
R
T
E
L
E
R
Q
L
E
Site 112
T1482
L
L
E
G
E
L
E
T
L
R
R
K
L
A
A
Site 113
S1502
V
K
E
K
V
V
L
S
E
S
V
Q
V
E
K
Site 114
S1504
E
K
V
V
L
S
E
S
V
Q
V
E
K
G
D
Site 115
T1512
V
Q
V
E
K
G
D
T
E
Q
E
I
Q
R
L
Site 116
S1521
Q
E
I
Q
R
L
K
S
S
L
E
E
E
S
R
Site 117
S1522
E
I
Q
R
L
K
S
S
L
E
E
E
S
R
S
Site 118
S1527
K
S
S
L
E
E
E
S
R
S
K
R
E
L
D
Site 119
S1529
S
L
E
E
E
S
R
S
K
R
E
L
D
V
E
Site 120
S1545
S
R
L
E
A
R
L
S
E
L
E
F
H
N
S
Site 121
S1552
S
E
L
E
F
H
N
S
K
S
S
K
E
L
D
Site 122
S1554
L
E
F
H
N
S
K
S
S
K
E
L
D
F
L
Site 123
T1579
R
Q
N
L
Q
L
E
T
R
R
L
Q
S
E
I
Site 124
S1584
L
E
T
R
R
L
Q
S
E
I
N
M
A
A
T
Site 125
T1600
T
R
D
L
R
N
M
T
V
A
D
S
G
T
N
Site 126
S1604
R
N
M
T
V
A
D
S
G
T
N
H
D
S
R
Site 127
T1606
M
T
V
A
D
S
G
T
N
H
D
S
R
L
W
Site 128
S1610
D
S
G
T
N
H
D
S
R
L
W
S
L
E
R
Site 129
S1614
N
H
D
S
R
L
W
S
L
E
R
E
L
D
D
Site 130
S1626
L
D
D
L
K
R
L
S
K
D
K
D
L
E
I
Site 131
S1642
E
L
Q
K
R
L
G
S
V
A
V
K
R
E
Q
Site 132
S1657
R
E
N
H
L
R
R
S
I
V
V
I
H
P
D
Site 133
T1665
I
V
V
I
H
P
D
T
G
R
E
L
S
P
E
Site 134
S1670
P
D
T
G
R
E
L
S
P
E
E
A
H
R
A
Site 135
S1708
K
G
P
N
G
E
S
S
V
I
H
D
R
K
S
Site 136
S1715
S
V
I
H
D
R
K
S
G
K
K
F
S
I
E
Site 137
S1720
R
K
S
G
K
K
F
S
I
E
E
A
L
Q
S
Site 138
S1727
S
I
E
E
A
L
Q
S
G
R
L
T
P
A
Q
Site 139
T1731
A
L
Q
S
G
R
L
T
P
A
Q
Y
D
R
Y
Site 140
Y1735
G
R
L
T
P
A
Q
Y
D
R
Y
V
N
K
D
Site 141
Y1738
T
P
A
Q
Y
D
R
Y
V
N
K
D
M
S
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
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2019 Kinexus Bioinformatics Corporation