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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DSCAM
Full Name:
Down syndrome cell adhesion molecule
Alias:
CHD2; CHD2-42; CHD2-52; CHD2-52 down syndrome cell adhesion molecule; Down syndrome cell adhesion molecule
Type:
Adhesion
Mass (Da):
222260
Number AA:
2012
UniProt ID:
O60469
International Prot ID:
IPI00029700
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005887
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0007399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
Q
S
F
A
N
V
F
S
E
D
L
H
S
S
L
Site 2
S113
N
P
S
G
K
I
R
S
Q
D
V
H
I
K
A
Site 3
T135
V
R
V
E
D
Q
K
T
M
R
G
N
V
A
V
Site 4
T274
L
S
G
R
F
Q
K
T
V
T
G
L
L
I
E
Site 5
T276
G
R
F
Q
K
T
V
T
G
L
L
I
E
N
I
Site 6
Y299
V
C
E
V
S
N
R
Y
G
T
A
K
V
I
G
Site 7
Y468
S
E
G
N
V
V
S
Y
L
N
I
S
S
S
Q
Site 8
Y703
P
R
D
Q
D
G
I
Y
G
K
A
V
I
L
N
Site 9
S769
G
Y
Y
L
C
K
V
S
N
D
V
G
A
D
V
Site 10
S848
E
V
G
E
E
V
I
S
T
L
Q
I
L
P
T
Site 11
S860
L
P
T
V
R
E
D
S
G
F
F
S
C
H
A
Site 12
S931
N
K
S
D
S
W
D
S
A
Q
R
T
K
D
V
Site 13
T935
S
W
D
S
A
Q
R
T
K
D
V
S
P
Q
L
Site 14
S1633
K
R
L
R
D
A
K
S
L
A
E
M
L
M
S
Site 15
S1640
S
L
A
E
M
L
M
S
K
N
T
R
T
S
D
Site 16
S1646
M
S
K
N
T
R
T
S
D
T
L
S
K
Q
Q
Site 17
T1648
K
N
T
R
T
S
D
T
L
S
K
Q
Q
Q
T
Site 18
S1650
T
R
T
S
D
T
L
S
K
Q
Q
Q
T
L
R
Site 19
T1674
L
L
I
E
E
R
D
T
M
E
T
I
D
D
R
Site 20
T1677
E
E
R
D
T
M
E
T
I
D
D
R
S
T
V
Site 21
T1683
E
T
I
D
D
R
S
T
V
L
L
T
D
A
D
Site 22
T1687
D
R
S
T
V
L
L
T
D
A
D
F
G
E
A
Site 23
S1699
G
E
A
A
K
Q
K
S
L
T
V
T
H
T
V
Site 24
T1701
A
A
K
Q
K
S
L
T
V
T
H
T
V
H
Y
Site 25
T1703
K
Q
K
S
L
T
V
T
H
T
V
H
Y
Q
S
Site 26
T1705
K
S
L
T
V
T
H
T
V
H
Y
Q
S
V
S
Site 27
Y1708
T
V
T
H
T
V
H
Y
Q
S
V
S
Q
A
T
Site 28
S1712
T
V
H
Y
Q
S
V
S
Q
A
T
G
P
L
V
Site 29
S1722
T
G
P
L
V
D
V
S
D
A
R
P
G
T
N
Site 30
T1728
V
S
D
A
R
P
G
T
N
P
T
T
R
R
N
Site 31
T1731
A
R
P
G
T
N
P
T
T
R
R
N
A
K
A
Site 32
T1732
R
P
G
T
N
P
T
T
R
R
N
A
K
A
G
Site 33
Y1746
G
P
T
A
R
N
R
Y
A
S
Q
W
T
L
N
Site 34
S1748
T
A
R
N
R
Y
A
S
Q
W
T
L
N
R
P
Site 35
T1772
T
T
D
W
R
L
P
T
P
R
A
A
G
S
V
Site 36
S1778
P
T
P
R
A
A
G
S
V
D
K
E
S
D
S
Site 37
S1783
A
G
S
V
D
K
E
S
D
S
Y
S
V
S
P
Site 38
S1785
S
V
D
K
E
S
D
S
Y
S
V
S
P
S
Q
Site 39
Y1786
V
D
K
E
S
D
S
Y
S
V
S
P
S
Q
D
Site 40
S1787
D
K
E
S
D
S
Y
S
V
S
P
S
Q
D
T
Site 41
S1789
E
S
D
S
Y
S
V
S
P
S
Q
D
T
D
R
Site 42
S1791
D
S
Y
S
V
S
P
S
Q
D
T
D
R
A
R
Site 43
T1794
S
V
S
P
S
Q
D
T
D
R
A
R
S
S
M
Site 44
S1799
Q
D
T
D
R
A
R
S
S
M
V
S
T
E
S
Site 45
S1800
D
T
D
R
A
R
S
S
M
V
S
T
E
S
A
Site 46
S1803
R
A
R
S
S
M
V
S
T
E
S
A
S
S
T
Site 47
T1804
A
R
S
S
M
V
S
T
E
S
A
S
S
T
Y
Site 48
S1806
S
S
M
V
S
T
E
S
A
S
S
T
Y
E
E
Site 49
S1809
V
S
T
E
S
A
S
S
T
Y
E
E
L
A
R
Site 50
T1810
S
T
E
S
A
S
S
T
Y
E
E
L
A
R
A
Site 51
Y1811
T
E
S
A
S
S
T
Y
E
E
L
A
R
A
Y
Site 52
Y1818
Y
E
E
L
A
R
A
Y
E
H
A
K
M
E
E
Site 53
T1835
R
H
A
K
F
T
I
T
E
C
F
I
S
D
T
Site 54
S1840
T
I
T
E
C
F
I
S
D
T
S
S
E
Q
L
Site 55
T1842
T
E
C
F
I
S
D
T
S
S
E
Q
L
T
A
Site 56
S1844
C
F
I
S
D
T
S
S
E
Q
L
T
A
G
T
Site 57
T1848
D
T
S
S
E
Q
L
T
A
G
T
N
E
Y
T
Site 58
T1855
T
A
G
T
N
E
Y
T
D
S
L
T
S
S
T
Site 59
S1857
G
T
N
E
Y
T
D
S
L
T
S
S
T
P
S
Site 60
T1859
N
E
Y
T
D
S
L
T
S
S
T
P
S
E
S
Site 61
S1860
E
Y
T
D
S
L
T
S
S
T
P
S
E
S
G
Site 62
S1861
Y
T
D
S
L
T
S
S
T
P
S
E
S
G
I
Site 63
T1862
T
D
S
L
T
S
S
T
P
S
E
S
G
I
C
Site 64
S1864
S
L
T
S
S
T
P
S
E
S
G
I
C
R
F
Site 65
T1872
E
S
G
I
C
R
F
T
A
S
P
P
K
P
Q
Site 66
S1874
G
I
C
R
F
T
A
S
P
P
K
P
Q
D
G
Site 67
T1918
L
N
R
G
G
P
G
T
S
R
D
L
S
L
G
Site 68
S1919
N
R
G
G
P
G
T
S
R
D
L
S
L
G
Q
Site 69
S1923
P
G
T
S
R
D
L
S
L
G
Q
A
C
L
E
Site 70
S1934
A
C
L
E
P
Q
K
S
R
T
L
K
R
P
T
Site 71
T1936
L
E
P
Q
K
S
R
T
L
K
R
P
T
V
L
Site 72
T1941
S
R
T
L
K
R
P
T
V
L
E
P
I
P
M
Site 73
S1952
P
I
P
M
E
A
A
S
S
A
S
S
T
R
E
Site 74
S1953
I
P
M
E
A
A
S
S
A
S
S
T
R
E
G
Site 75
S1956
E
A
A
S
S
A
S
S
T
R
E
G
Q
S
W
Site 76
T1957
A
A
S
S
A
S
S
T
R
E
G
Q
S
W
Q
Site 77
S1986
L
G
Q
A
A
K
M
S
S
S
Q
E
S
L
L
Site 78
S1987
G
Q
A
A
K
M
S
S
S
Q
E
S
L
L
D
Site 79
S1988
Q
A
A
K
M
S
S
S
Q
E
S
L
L
D
S
Site 80
S1991
K
M
S
S
S
Q
E
S
L
L
D
S
R
G
H
Site 81
S1995
S
Q
E
S
L
L
D
S
R
G
H
L
K
G
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation