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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NPHS1
Full Name:
Nephrin
Alias:
CNF; nephrin; nephrosis 1, congenital, Finnish type; NPHN; renal glomerulus-specific cell adhesion receptor
Type:
Adhesion; Membrane protein, integral; Immunoglobulin superfamily
Mass (Da):
134742
Number AA:
1241
UniProt ID:
O60500
International Prot ID:
IPI00472109
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0007588
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T414
R
R
E
D
N
G
L
T
L
T
C
E
A
F
S
Site 2
T416
E
D
N
G
L
T
L
T
C
E
A
F
S
E
A
Site 3
S421
T
L
T
C
E
A
F
S
E
A
F
T
K
E
T
Site 4
S432
T
K
E
T
F
K
K
S
L
I
L
N
V
K
Y
Site 5
Y439
S
L
I
L
N
V
K
Y
P
A
Q
K
L
W
I
Site 6
Y638
R
E
T
V
S
S
F
Y
R
L
N
V
L
Y
R
Site 7
S700
G
P
R
H
R
I
L
S
S
G
A
L
H
L
W
Site 8
S701
P
R
H
R
I
L
S
S
G
A
L
H
L
W
N
Site 9
T710
A
L
H
L
W
N
V
T
R
A
D
D
G
L
Y
Site 10
S1058
T
E
P
P
S
G
P
S
G
L
P
L
L
P
V
Site 11
S1098
R
R
L
A
E
G
I
S
E
K
T
E
A
G
S
Site 12
T1101
A
E
G
I
S
E
K
T
E
A
G
S
E
E
D
Site 13
Y1114
E
D
R
V
R
N
E
Y
E
E
S
Q
W
T
G
Site 14
S1117
V
R
N
E
Y
E
E
S
Q
W
T
G
E
R
D
Site 15
T1120
E
Y
E
E
S
Q
W
T
G
E
R
D
T
Q
S
Site 16
T1125
Q
W
T
G
E
R
D
T
Q
S
S
T
V
S
T
Site 17
S1127
T
G
E
R
D
T
Q
S
S
T
V
S
T
T
E
Site 18
S1128
G
E
R
D
T
Q
S
S
T
V
S
T
T
E
A
Site 19
T1129
E
R
D
T
Q
S
S
T
V
S
T
T
E
A
E
Site 20
S1131
D
T
Q
S
S
T
V
S
T
T
E
A
E
P
Y
Site 21
T1132
T
Q
S
S
T
V
S
T
T
E
A
E
P
Y
Y
Site 22
Y1138
S
T
T
E
A
E
P
Y
Y
R
S
L
R
D
F
Site 23
Y1139
T
T
E
A
E
P
Y
Y
R
S
L
R
D
F
S
Site 24
S1141
E
A
E
P
Y
Y
R
S
L
R
D
F
S
P
Q
Site 25
S1146
Y
R
S
L
R
D
F
S
P
Q
L
P
P
T
Q
Site 26
T1152
F
S
P
Q
L
P
P
T
Q
E
E
V
S
Y
S
Site 27
S1157
P
P
T
Q
E
E
V
S
Y
S
R
G
F
T
G
Site 28
Y1158
P
T
Q
E
E
V
S
Y
S
R
G
F
T
G
E
Site 29
S1159
T
Q
E
E
V
S
Y
S
R
G
F
T
G
E
D
Site 30
T1163
V
S
Y
S
R
G
F
T
G
E
D
E
D
M
A
Site 31
Y1176
M
A
F
P
G
H
L
Y
D
E
V
E
R
T
Y
Site 32
T1182
L
Y
D
E
V
E
R
T
Y
P
P
S
G
A
W
Site 33
Y1183
Y
D
E
V
E
R
T
Y
P
P
S
G
A
W
G
Site 34
S1186
V
E
R
T
Y
P
P
S
G
A
W
G
P
L
Y
Site 35
Y1193
S
G
A
W
G
P
L
Y
D
E
V
Q
M
G
P
Site 36
Y1210
L
H
W
P
E
D
T
Y
Q
D
P
R
G
I
Y
Site 37
Y1217
Y
Q
D
P
R
G
I
Y
D
Q
V
A
G
D
L
Site 38
T1226
Q
V
A
G
D
L
D
T
L
E
P
D
S
L
P
Site 39
S1231
L
D
T
L
E
P
D
S
L
P
F
E
L
R
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation