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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADCY9
Full Name:
Adenylate cyclase type 9
Alias:
AC9; Adenylate cyclase 9; Adenylyl cyclase 9; ATP pyrophosphate-lyase 9; KIAA0520
Type:
Nucleotide Metabolism - purine; Membrane protein, integral; Adenylyl cyclase; EC 4.6.1.1; Lyase
Mass (Da):
150701
Number AA:
1353
UniProt ID:
O60503
International Prot ID:
IPI00030099
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004016
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0007189
GO:0034199
GO:0006171
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
Q
Q
L
L
H
H
H
S
T
E
V
S
C
D
S
Site 2
T15
Q
L
L
H
H
H
S
T
E
V
S
C
D
S
S
Site 3
S18
H
H
H
S
T
E
V
S
C
D
S
S
G
D
S
Site 4
S21
S
T
E
V
S
C
D
S
S
G
D
S
N
S
V
Site 5
S22
T
E
V
S
C
D
S
S
G
D
S
N
S
V
R
Site 6
S25
S
C
D
S
S
G
D
S
N
S
V
R
V
K
I
Site 7
S27
D
S
S
G
D
S
N
S
V
R
V
K
I
N
P
Site 8
S38
K
I
N
P
K
Q
L
S
S
N
S
H
P
K
H
Site 9
S39
I
N
P
K
Q
L
S
S
N
S
H
P
K
H
C
Site 10
S41
P
K
Q
L
S
S
N
S
H
P
K
H
C
K
Y
Site 11
Y48
S
H
P
K
H
C
K
Y
S
I
S
S
S
C
S
Site 12
S49
H
P
K
H
C
K
Y
S
I
S
S
S
C
S
S
Site 13
S51
K
H
C
K
Y
S
I
S
S
S
C
S
S
S
G
Site 14
S52
H
C
K
Y
S
I
S
S
S
C
S
S
S
G
D
Site 15
S53
C
K
Y
S
I
S
S
S
C
S
S
S
G
D
S
Site 16
S55
Y
S
I
S
S
S
C
S
S
S
G
D
S
G
G
Site 17
S56
S
I
S
S
S
C
S
S
S
G
D
S
G
G
V
Site 18
S57
I
S
S
S
C
S
S
S
G
D
S
G
G
V
P
Site 19
S60
S
C
S
S
S
G
D
S
G
G
V
P
R
R
V
Site 20
S87
P
Q
L
F
E
R
A
S
S
R
W
W
D
P
K
Site 21
S88
Q
L
F
E
R
A
S
S
R
W
W
D
P
K
F
Site 22
T112
L
E
R
C
F
P
Q
T
Q
R
R
F
R
Y
A
Site 23
Y118
Q
T
Q
R
R
F
R
Y
A
L
F
Y
I
G
F
Site 24
Y122
R
F
R
Y
A
L
F
Y
I
G
F
A
C
L
L
Site 25
Y133
A
C
L
L
W
S
I
Y
F
A
V
H
M
R
S
Site 26
Y168
L
F
T
F
T
K
L
Y
A
R
H
Y
A
W
T
Site 27
Y172
T
K
L
Y
A
R
H
Y
A
W
T
S
L
A
L
Site 28
T196
A
A
Q
F
Q
V
L
T
P
V
S
G
R
G
D
Site 29
S199
F
Q
V
L
T
P
V
S
G
R
G
D
S
S
N
Site 30
S204
P
V
S
G
R
G
D
S
S
N
L
T
A
T
A
Site 31
S205
V
S
G
R
G
D
S
S
N
L
T
A
T
A
R
Site 32
T208
R
G
D
S
S
N
L
T
A
T
A
R
P
T
D
Site 33
T210
D
S
S
N
L
T
A
T
A
R
P
T
D
T
C
Site 34
T214
L
T
A
T
A
R
P
T
D
T
C
L
S
Q
V
Site 35
S219
R
P
T
D
T
C
L
S
Q
V
G
S
F
S
M
Site 36
Y261
V
L
F
E
T
F
G
Y
H
F
R
D
E
A
C
Site 37
S271
R
D
E
A
C
F
P
S
P
G
A
G
A
L
H
Site 38
S302
G
V
H
L
F
V
M
S
Q
V
R
S
R
S
T
Site 39
S308
M
S
Q
V
R
S
R
S
T
F
L
K
V
G
Q
Site 40
T309
S
Q
V
R
S
R
S
T
F
L
K
V
G
Q
S
Site 41
S316
T
F
L
K
V
G
Q
S
I
M
H
G
K
D
L
Site 42
S354
M
K
Q
G
D
E
E
S
E
N
S
V
K
R
H
Site 43
S357
G
D
E
E
S
E
N
S
V
K
R
H
A
T
S
Site 44
T363
N
S
V
K
R
H
A
T
S
S
P
K
N
R
K
Site 45
S364
S
V
K
R
H
A
T
S
S
P
K
N
R
K
K
Site 46
S365
V
K
R
H
A
T
S
S
P
K
N
R
K
K
K
Site 47
S373
P
K
N
R
K
K
K
S
S
I
Q
K
A
P
I
Site 48
S374
K
N
R
K
K
K
S
S
I
Q
K
A
P
I
A
Site 49
S407
I
V
G
F
T
K
M
S
A
N
K
S
A
H
A
Site 50
S411
T
K
M
S
A
N
K
S
A
H
A
L
V
G
L
Site 51
T433
F
D
R
L
C
E
E
T
K
C
E
K
I
S
T
Site 52
T440
T
K
C
E
K
I
S
T
L
G
D
C
Y
Y
C
Site 53
Y460
E
P
R
A
D
H
A
Y
C
C
I
E
M
G
L
Site 54
Y538
I
S
E
A
T
A
K
Y
L
D
D
R
Y
E
M
Site 55
Y543
A
K
Y
L
D
D
R
Y
E
M
E
D
G
K
V
Site 56
T568
D
Q
L
K
G
L
K
T
Y
L
I
S
G
Q
R
Site 57
Y569
Q
L
K
G
L
K
T
Y
L
I
S
G
Q
R
A
Site 58
S572
G
L
K
T
Y
L
I
S
G
Q
R
A
K
E
S
Site 59
S579
S
G
Q
R
A
K
E
S
R
C
S
C
A
E
A
Site 60
S582
R
A
K
E
S
R
C
S
C
A
E
A
L
L
S
Site 61
S597
G
F
E
V
I
D
G
S
Q
V
S
S
G
P
R
Site 62
S600
V
I
D
G
S
Q
V
S
S
G
P
R
G
Q
G
Site 63
S601
I
D
G
S
Q
V
S
S
G
P
R
G
Q
G
T
Site 64
T608
S
G
P
R
G
Q
G
T
A
S
S
G
N
V
S
Site 65
S610
P
R
G
Q
G
T
A
S
S
G
N
V
S
D
L
Site 66
S611
R
G
Q
G
T
A
S
S
G
N
V
S
D
L
A
Site 67
S615
T
A
S
S
G
N
V
S
D
L
A
Q
T
V
K
Site 68
T620
N
V
S
D
L
A
Q
T
V
K
T
F
D
N
L
Site 69
T623
D
L
A
Q
T
V
K
T
F
D
N
L
K
T
C
Site 70
T629
K
T
F
D
N
L
K
T
C
P
S
C
G
I
T
Site 71
S632
D
N
L
K
T
C
P
S
C
G
I
T
F
A
P
Site 72
T636
T
C
P
S
C
G
I
T
F
A
P
K
S
E
A
Site 73
S641
G
I
T
F
A
P
K
S
E
A
G
A
E
G
G
Site 74
S661
C
Q
D
E
H
K
N
S
T
K
A
S
G
G
P
Site 75
S665
H
K
N
S
T
K
A
S
G
G
P
N
P
K
T
Site 76
T672
S
G
G
P
N
P
K
T
Q
N
G
L
L
S
P
Site 77
S678
K
T
Q
N
G
L
L
S
P
P
Q
E
E
K
L
Site 78
T686
P
P
Q
E
E
K
L
T
N
S
Q
T
S
L
C
Site 79
S688
Q
E
E
K
L
T
N
S
Q
T
S
L
C
E
I
Site 80
T690
E
K
L
T
N
S
Q
T
S
L
C
E
I
L
Q
Site 81
S691
K
L
T
N
S
Q
T
S
L
C
E
I
L
Q
E
Site 82
S706
K
G
R
W
A
G
V
S
L
D
Q
S
A
L
L
Site 83
S710
A
G
V
S
L
D
Q
S
A
L
L
P
L
R
F
Site 84
T724
F
K
N
I
R
E
K
T
D
A
H
F
V
D
V
Site 85
Y741
E
D
S
L
M
K
D
Y
F
F
K
P
P
I
N
Site 86
S751
K
P
P
I
N
Q
F
S
L
N
F
L
D
Q
E
Site 87
S762
L
D
Q
E
L
E
R
S
Y
R
T
S
Y
Q
E
Site 88
Y763
D
Q
E
L
E
R
S
Y
R
T
S
Y
Q
E
E
Site 89
S766
L
E
R
S
Y
R
T
S
Y
Q
E
E
V
I
K
Site 90
Y767
E
R
S
Y
R
T
S
Y
Q
E
E
V
I
K
N
Site 91
S775
Q
E
E
V
I
K
N
S
P
V
K
T
F
A
S
Site 92
T779
I
K
N
S
P
V
K
T
F
A
S
P
T
F
S
Site 93
S886
A
V
Y
S
H
V
T
S
E
Y
E
T
N
I
H
Site 94
S948
P
D
S
S
V
L
T
S
P
L
D
A
V
Q
N
Site 95
S958
D
A
V
Q
N
F
S
S
E
R
N
P
C
N
S
Site 96
S965
S
E
R
N
P
C
N
S
S
V
P
R
D
L
R
Site 97
S966
E
R
N
P
C
N
S
S
V
P
R
D
L
R
R
Site 98
S976
R
D
L
R
R
P
A
S
L
I
G
Q
E
V
V
Site 99
Y1008
E
V
S
Y
R
L
H
Y
H
G
D
V
E
A
D
Site 100
S1047
V
A
E
Q
L
K
V
S
Q
T
Y
S
K
N
H
Site 101
T1049
E
Q
L
K
V
S
Q
T
Y
S
K
N
H
D
S
Site 102
S1051
L
K
V
S
Q
T
Y
S
K
N
H
D
S
G
G
Site 103
Y1071
I
V
N
F
S
E
F
Y
E
E
N
Y
E
G
G
Site 104
Y1075
S
E
F
Y
E
E
N
Y
E
G
G
K
E
C
Y
Site 105
S1097
G
D
F
D
E
L
L
S
K
P
D
Y
S
S
I
Site 106
Y1101
E
L
L
S
K
P
D
Y
S
S
I
E
K
I
K
Site 107
S1103
L
S
K
P
D
Y
S
S
I
E
K
I
K
T
I
Site 108
T1109
S
S
I
E
K
I
K
T
I
G
A
T
Y
M
A
Site 109
T1199
N
I
A
S
R
M
D
T
T
G
V
E
C
R
I
Site 110
S1212
R
I
Q
V
S
E
E
S
Y
R
V
L
S
K
M
Site 111
Y1213
I
Q
V
S
E
E
S
Y
R
V
L
S
K
M
G
Site 112
S1217
E
E
S
Y
R
V
L
S
K
M
G
Y
D
F
D
Site 113
Y1221
R
V
L
S
K
M
G
Y
D
F
D
Y
R
G
T
Site 114
Y1225
K
M
G
Y
D
F
D
Y
R
G
T
V
N
V
K
Site 115
T1228
Y
D
F
D
Y
R
G
T
V
N
V
K
G
K
G
Site 116
T1239
K
G
K
G
Q
M
K
T
Y
L
Y
P
K
C
T
Site 117
Y1240
G
K
G
Q
M
K
T
Y
L
Y
P
K
C
T
D
Site 118
Y1242
G
Q
M
K
T
Y
L
Y
P
K
C
T
D
H
R
Site 119
S1257
V
I
P
Q
H
Q
L
S
I
S
P
D
I
R
V
Site 120
S1259
P
Q
H
Q
L
S
I
S
P
D
I
R
V
Q
V
Site 121
S1269
I
R
V
Q
V
D
G
S
I
G
R
S
P
T
D
Site 122
S1273
V
D
G
S
I
G
R
S
P
T
D
E
I
A
N
Site 123
T1275
G
S
I
G
R
S
P
T
D
E
I
A
N
L
V
Site 124
Y1287
N
L
V
P
S
V
Q
Y
V
D
K
T
S
L
G
Site 125
T1291
S
V
Q
Y
V
D
K
T
S
L
G
S
D
S
S
Site 126
S1292
V
Q
Y
V
D
K
T
S
L
G
S
D
S
S
T
Site 127
S1295
V
D
K
T
S
L
G
S
D
S
S
T
Q
A
K
Site 128
S1298
T
S
L
G
S
D
S
S
T
Q
A
K
D
A
H
Site 129
T1299
S
L
G
S
D
S
S
T
Q
A
K
D
A
H
L
Site 130
S1307
Q
A
K
D
A
H
L
S
P
K
R
P
W
K
E
Site 131
T1336
E
K
D
D
C
D
E
T
G
I
E
E
A
N
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation