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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TPST1
Full Name:
Protein-tyrosine sulfotransferase 1
Alias:
EC 2.8.2.20; Protein-tyrosine sulfotransferase 1; TPS1; TPST-1; Tyrosylprotein sulfotransferase 1
Type:
Transferase; EC 2.8.2.20
Mass (Da):
42188
Number AA:
370
UniProt ID:
O60507
International Prot ID:
IPI00030106
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0016021
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0008476
PhosphoSite+
KinaseNET
Biological Process:
GO:0006954
GO:0006478
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S39
H
H
R
I
E
E
R
S
Q
P
V
K
L
E
S
Site 2
S46
S
Q
P
V
K
L
E
S
T
R
T
T
V
R
T
Site 3
T49
V
K
L
E
S
T
R
T
T
V
R
T
G
L
D
Site 4
T50
K
L
E
S
T
R
T
T
V
R
T
G
L
D
L
Site 5
T53
S
T
R
T
T
V
R
T
G
L
D
L
K
A
N
Site 6
T62
L
D
L
K
A
N
K
T
F
A
Y
H
K
D
M
Site 7
Y65
K
A
N
K
T
F
A
Y
H
K
D
M
P
L
I
Site 8
T101
D
I
R
C
G
E
E
T
R
V
I
P
R
I
L
Site 9
S115
L
A
L
K
Q
M
W
S
R
S
S
K
E
K
I
Site 10
S117
L
K
Q
M
W
S
R
S
S
K
E
K
I
R
L
Site 11
S118
K
Q
M
W
S
R
S
S
K
E
K
I
R
L
D
Site 12
T130
R
L
D
E
A
G
V
T
D
E
V
L
D
S
A
Site 13
Y155
K
H
G
E
P
A
P
Y
L
C
N
K
D
P
F
Site 14
S166
K
D
P
F
A
L
K
S
L
T
Y
L
S
R
L
Site 15
S171
L
K
S
L
T
Y
L
S
R
L
F
P
N
A
K
Site 16
S189
M
V
R
D
G
R
A
S
V
H
S
M
I
S
R
Site 17
S192
D
G
R
A
S
V
H
S
M
I
S
R
K
V
T
Site 18
S207
I
A
G
F
D
L
N
S
Y
R
D
C
L
T
K
Site 19
Y208
A
G
F
D
L
N
S
Y
R
D
C
L
T
K
W
Site 20
Y239
K
K
C
M
L
V
H
Y
E
Q
L
V
L
H
P
Site 21
S279
I
G
K
A
G
G
V
S
L
S
K
V
E
R
S
Site 22
S281
K
A
G
G
V
S
L
S
K
V
E
R
S
T
D
Site 23
T287
L
S
K
V
E
R
S
T
D
Q
V
I
K
P
V
Site 24
Y326
P
M
L
A
K
L
G
Y
D
P
Y
A
N
P
P
Site 25
Y329
A
K
L
G
Y
D
P
Y
A
N
P
P
N
Y
G
Site 26
Y335
P
Y
A
N
P
P
N
Y
G
K
P
D
P
K
I
Site 27
Y350
I
E
N
T
R
R
V
Y
K
G
E
F
Q
L
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation