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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CDC40
Full Name:
Pre-mRNA-processing factor 17
Alias:
Cell division cycle 40; EHB3; EH-binding protein 3; FLJ10564; Pre-mRNA splicing factor 17; PRP17; PRPF17
Type:
RNA processing
Mass (Da):
65521
Number AA:
579
UniProt ID:
O60508
International Prot ID:
IPI00026307
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005681
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0000398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
A
A
I
A
A
L
A
Site 2
S11
A
I
A
A
L
A
A
S
Y
G
S
G
S
G
S
Site 3
Y12
I
A
A
L
A
A
S
Y
G
S
G
S
G
S
E
Site 4
S14
A
L
A
A
S
Y
G
S
G
S
G
S
E
S
D
Site 5
S16
A
A
S
Y
G
S
G
S
G
S
E
S
D
S
D
Site 6
S18
S
Y
G
S
G
S
G
S
E
S
D
S
D
S
E
Site 7
S20
G
S
G
S
G
S
E
S
D
S
D
S
E
S
S
Site 8
S22
G
S
G
S
E
S
D
S
D
S
E
S
S
R
C
Site 9
S24
G
S
E
S
D
S
D
S
E
S
S
R
C
P
L
Site 10
S26
E
S
D
S
D
S
E
S
S
R
C
P
L
P
A
Site 11
S27
S
D
S
D
S
E
S
S
R
C
P
L
P
A
A
Site 12
T41
A
D
S
L
M
H
L
T
K
S
P
S
S
K
P
Site 13
S43
S
L
M
H
L
T
K
S
P
S
S
K
P
S
L
Site 14
S45
M
H
L
T
K
S
P
S
S
K
P
S
L
A
V
Site 15
S46
H
L
T
K
S
P
S
S
K
P
S
L
A
V
A
Site 16
S49
K
S
P
S
S
K
P
S
L
A
V
A
V
D
S
Site 17
S56
S
L
A
V
A
V
D
S
A
P
E
V
A
V
K
Site 18
T68
A
V
K
E
D
L
E
T
G
V
H
L
D
P
A
Site 19
Y81
P
A
V
K
E
V
Q
Y
N
P
T
Y
E
T
M
Site 20
T84
K
E
V
Q
Y
N
P
T
Y
E
T
M
F
A
P
Site 21
Y85
E
V
Q
Y
N
P
T
Y
E
T
M
F
A
P
E
Site 22
S112
A
A
P
R
N
M
L
S
G
Y
A
E
P
A
H
Site 23
Y114
P
R
N
M
L
S
G
Y
A
E
P
A
H
I
N
Site 24
T134
Q
Q
R
R
T
F
A
T
Y
G
Y
A
L
D
P
Site 25
Y135
Q
R
R
T
F
A
T
Y
G
Y
A
L
D
P
S
Site 26
Y137
R
T
F
A
T
Y
G
Y
A
L
D
P
S
L
D
Site 27
S142
Y
G
Y
A
L
D
P
S
L
D
N
H
Q
V
S
Site 28
S149
S
L
D
N
H
Q
V
S
A
K
Y
I
G
S
V
Site 29
S155
V
S
A
K
Y
I
G
S
V
E
E
A
E
K
N
Site 30
T166
A
E
K
N
Q
G
L
T
V
F
E
T
G
Q
K
Site 31
T170
Q
G
L
T
V
F
E
T
G
Q
K
K
T
E
K
Site 32
S187
K
F
K
E
N
D
A
S
N
I
D
G
F
L
G
Site 33
Y199
F
L
G
P
W
A
K
Y
V
D
E
K
D
V
A
Site 34
S209
E
K
D
V
A
K
P
S
E
E
E
Q
K
E
L
Site 35
Y247
I
L
H
V
K
E
M
Y
D
Y
Q
G
R
S
Y
Site 36
Y249
H
V
K
E
M
Y
D
Y
Q
G
R
S
Y
L
H
Site 37
Y254
Y
D
Y
Q
G
R
S
Y
L
H
I
P
Q
D
V
Site 38
T268
V
G
V
N
L
R
S
T
M
P
P
E
K
C
Y
Site 39
Y275
T
M
P
P
E
K
C
Y
L
P
K
K
Q
I
H
Site 40
Y319
K
I
K
L
W
E
V
Y
G
E
R
R
C
L
R
Site 41
T327
G
E
R
R
C
L
R
T
F
I
G
H
S
K
A
Site 42
S349
T
A
G
T
Q
F
L
S
A
A
Y
D
R
Y
L
Site 43
Y355
L
S
A
A
Y
D
R
Y
L
K
L
W
D
T
E
Site 44
T361
R
Y
L
K
L
W
D
T
E
T
G
Q
C
I
S
Site 45
T363
L
K
L
W
D
T
E
T
G
Q
C
I
S
R
F
Site 46
T371
G
Q
C
I
S
R
F
T
N
R
K
V
P
Y
C
Site 47
Y377
F
T
N
R
K
V
P
Y
C
V
K
F
N
P
D
Site 48
Y414
S
G
E
I
V
Q
E
Y
D
R
H
L
G
A
V
Site 49
S435
D
E
N
R
R
F
V
S
T
S
D
D
K
S
L
Site 50
T436
E
N
R
R
F
V
S
T
S
D
D
K
S
L
R
Site 51
S437
N
R
R
F
V
S
T
S
D
D
K
S
L
R
V
Site 52
S441
V
S
T
S
D
D
K
S
L
R
V
W
E
W
D
Site 53
Y455
D
I
P
V
D
F
K
Y
I
A
E
P
S
M
H
Site 54
T468
M
H
S
M
P
A
V
T
L
S
P
N
G
K
W
Site 55
S521
V
D
F
S
P
D
M
S
Y
V
I
S
G
D
G
Site 56
Y522
D
F
S
P
D
M
S
Y
V
I
S
G
D
G
N
Site 57
S525
P
D
M
S
Y
V
I
S
G
D
G
N
G
K
L
Site 58
Y543
D
W
K
T
T
K
L
Y
S
R
F
K
A
H
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation