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Updated November 2019
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Protein Info
Short Name:
TDRD6
Full Name:
Tudor domain-containing protein 6
Alias:
Antigen NY-CO-45;Cancer/testis antigen 41.2
Type:
Mass (Da):
236517
Number AA:
2096
UniProt ID:
O60522
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y43
V
G
E
R
R
G
E
Y
L
R
L
S
R
E
I
Site 2
S47
R
G
E
Y
L
R
L
S
R
E
I
Q
E
A
A
Site 3
S64
R
G
Q
W
A
L
G
S
A
S
A
S
P
G
E
Site 4
S66
Q
W
A
L
G
S
A
S
A
S
P
G
E
L
C
Site 5
S88
W
H
R
C
R
V
V
S
R
Q
A
Q
E
S
R
Site 6
S94
V
S
R
Q
A
Q
E
S
R
V
F
L
L
D
E
Site 7
S111
T
I
T
A
G
A
G
S
L
A
P
G
R
R
E
Site 8
S143
P
A
G
C
G
A
G
S
G
E
P
P
Q
H
W
Site 9
S159
A
D
A
V
D
F
L
S
N
L
Q
G
K
E
V
Site 10
S203
L
A
R
R
V
P
D
S
L
F
R
S
L
L
E
Site 11
S207
V
P
D
S
L
F
R
S
L
L
E
R
Y
L
T
Site 12
S228
G
S
G
V
P
V
L
S
R
V
P
L
K
Q
K
Site 13
Y241
Q
K
Q
P
G
L
D
Y
F
Y
P
Q
L
Q
L
Site 14
Y243
Q
P
G
L
D
Y
F
Y
P
Q
L
Q
L
G
V
Site 15
S271
R
I
H
C
Q
L
R
S
V
S
Q
E
I
H
R
Site 16
S273
H
C
Q
L
R
S
V
S
Q
E
I
H
R
L
S
Site 17
S280
S
Q
E
I
H
R
L
S
E
S
M
A
Q
V
Y
Site 18
S282
E
I
H
R
L
S
E
S
M
A
Q
V
Y
R
G
Site 19
Y287
S
E
S
M
A
Q
V
Y
R
G
S
T
G
T
G
Site 20
S290
M
A
Q
V
Y
R
G
S
T
G
T
G
D
E
N
Site 21
T291
A
Q
V
Y
R
G
S
T
G
T
G
D
E
N
S
Site 22
T293
V
Y
R
G
S
T
G
T
G
D
E
N
S
T
S
Site 23
S298
T
G
T
G
D
E
N
S
T
S
A
T
W
E
E
Site 24
S300
T
G
D
E
N
S
T
S
A
T
W
E
E
R
E
Site 25
T302
D
E
N
S
T
S
A
T
W
E
E
R
E
E
S
Site 26
S309
T
W
E
E
R
E
E
S
P
D
K
P
G
S
P
Site 27
S315
E
S
P
D
K
P
G
S
P
C
A
S
C
G
L
Site 28
S319
K
P
G
S
P
C
A
S
C
G
L
D
G
H
W
Site 29
T334
Y
R
A
L
L
L
E
T
F
R
P
Q
R
C
A
Site 30
Y348
A
Q
V
L
H
V
D
Y
G
R
K
E
L
V
S
Site 31
S355
Y
G
R
K
E
L
V
S
C
S
S
L
R
Y
L
Site 32
S357
R
K
E
L
V
S
C
S
S
L
R
Y
L
L
P
Site 33
S358
K
E
L
V
S
C
S
S
L
R
Y
L
L
P
E
Site 34
Y361
V
S
C
S
S
L
R
Y
L
L
P
E
Y
F
R
Site 35
Y366
L
R
Y
L
L
P
E
Y
F
R
M
P
V
V
T
Site 36
T373
Y
F
R
M
P
V
V
T
Y
P
C
A
L
Y
G
Site 37
Y374
F
R
M
P
V
V
T
Y
P
C
A
L
Y
G
L
Site 38
S389
W
D
G
G
R
G
W
S
R
S
Q
V
G
D
L
Site 39
S391
G
G
R
G
W
S
R
S
Q
V
G
D
L
K
T
Site 40
Y419
Y
C
S
F
E
H
V
Y
Y
V
S
L
Y
G
E
Site 41
Y420
C
S
F
E
H
V
Y
Y
V
S
L
Y
G
E
D
Site 42
Y424
H
V
Y
Y
V
S
L
Y
G
E
D
G
I
N
L
Site 43
T459
T
E
E
E
E
P
E
T
S
Q
S
Q
S
P
A
Site 44
S460
E
E
E
E
P
E
T
S
Q
S
Q
S
P
A
E
Site 45
S462
E
E
P
E
T
S
Q
S
Q
S
P
A
E
E
V
Site 46
S464
P
E
T
S
Q
S
Q
S
P
A
E
E
V
D
E
Site 47
S474
E
E
V
D
E
E
I
S
L
P
A
L
R
S
I
Site 48
Y489
R
L
K
M
N
A
F
Y
D
A
Q
V
E
F
V
Site 49
T512
R
L
R
K
H
N
V
T
F
S
K
L
M
R
R
Site 50
Y524
M
R
R
M
C
G
F
Y
S
S
A
S
K
L
D
Site 51
S525
R
R
M
C
G
F
Y
S
S
A
S
K
L
D
G
Site 52
S526
R
M
C
G
F
Y
S
S
A
S
K
L
D
G
V
Site 53
Y552
V
K
W
K
E
N
G
Y
Y
R
A
I
V
T
K
Site 54
Y553
K
W
K
E
N
G
Y
Y
R
A
I
V
T
K
L
Site 55
S564
V
T
K
L
D
D
K
S
V
D
V
F
L
V
D
Site 56
Y581
N
S
E
N
V
D
W
Y
D
V
R
M
L
L
P
Site 57
T611
D
I
W
P
L
G
K
T
W
S
Q
E
A
V
S
Site 58
S613
W
P
L
G
K
T
W
S
Q
E
A
V
S
F
F
Site 59
S618
T
W
S
Q
E
A
V
S
F
F
K
K
T
V
L
Site 60
Y641
L
D
K
Q
D
H
Q
Y
V
I
E
I
L
D
E
Site 61
S649
V
I
E
I
L
D
E
S
R
T
G
E
E
N
I
Site 62
S657
R
T
G
E
E
N
I
S
K
V
I
A
Q
A
G
Site 63
Y668
A
Q
A
G
Y
A
K
Y
Q
E
F
E
T
K
E
Site 64
S683
N
I
L
V
N
A
H
S
P
G
H
V
S
N
H
Site 65
S688
A
H
S
P
G
H
V
S
N
H
F
T
T
E
S
Site 66
T692
G
H
V
S
N
H
F
T
T
E
S
N
K
I
P
Site 67
S695
S
N
H
F
T
T
E
S
N
K
I
P
F
A
K
Site 68
T716
K
A
K
R
E
N
K
T
T
S
V
S
K
A
L
Site 69
T717
A
K
R
E
N
K
T
T
S
V
S
K
A
L
S
Site 70
S718
K
R
E
N
K
T
T
S
V
S
K
A
L
S
D
Site 71
S724
T
S
V
S
K
A
L
S
D
T
T
V
V
T
N
Site 72
T726
V
S
K
A
L
S
D
T
T
V
V
T
N
G
S
Site 73
T727
S
K
A
L
S
D
T
T
V
V
T
N
G
S
T
Site 74
S746
Q
E
K
V
K
R
A
S
V
Y
F
P
L
M
Q
Site 75
Y748
K
V
K
R
A
S
V
Y
F
P
L
M
Q
N
C
Site 76
S762
C
L
E
I
K
P
G
S
S
S
K
G
E
L
E
Site 77
S764
E
I
K
P
G
S
S
S
K
G
E
L
E
V
G
Site 78
S772
K
G
E
L
E
V
G
S
T
V
E
V
R
V
S
Site 79
T773
G
E
L
E
V
G
S
T
V
E
V
R
V
S
Y
Site 80
S779
S
T
V
E
V
R
V
S
Y
V
E
N
P
G
Y
Site 81
Y780
T
V
E
V
R
V
S
Y
V
E
N
P
G
Y
F
Site 82
Y786
S
Y
V
E
N
P
G
Y
F
W
C
Q
L
T
R
Site 83
T800
R
N
I
Q
G
L
K
T
L
M
S
D
I
Q
Y
Site 84
Y807
T
L
M
S
D
I
Q
Y
Y
C
K
N
T
A
A
Site 85
T820
A
A
P
H
Q
R
N
T
L
A
C
L
A
K
R
Site 86
T828
L
A
C
L
A
K
R
T
V
N
R
Q
W
S
R
Site 87
S834
R
T
V
N
R
Q
W
S
R
A
L
I
S
G
I
Site 88
S839
Q
W
S
R
A
L
I
S
G
I
Q
S
V
E
H
Site 89
T850
S
V
E
H
V
N
V
T
F
V
D
Y
G
D
R
Site 90
Y854
V
N
V
T
F
V
D
Y
G
D
R
E
M
V
S
Site 91
S867
V
S
V
K
N
I
Y
S
I
S
E
E
F
L
K
Site 92
S869
V
K
N
I
Y
S
I
S
E
E
F
L
K
V
K
Site 93
S883
K
A
Q
A
F
R
C
S
L
Y
N
L
I
Q
P
Site 94
S968
K
L
Q
K
P
L
E
S
S
V
Q
L
H
S
Y
Site 95
S969
L
Q
K
P
L
E
S
S
V
Q
L
H
S
Y
F
Site 96
S974
E
S
S
V
Q
L
H
S
Y
F
Y
S
T
H
D
Site 97
Y975
S
S
V
Q
L
H
S
Y
F
Y
S
T
H
D
M
Site 98
Y991
I
G
S
E
E
L
V
Y
I
T
H
I
D
D
P
Site 99
T1031
K
V
L
L
N
L
K
T
S
P
L
N
P
G
T
Site 100
T1038
T
S
P
L
N
P
G
T
L
C
L
A
K
Y
T
Site 101
Y1044
G
T
L
C
L
A
K
Y
T
D
G
N
W
Y
R
Site 102
S1099
P
M
Q
A
V
R
C
S
L
S
D
I
P
D
H
Site 103
S1101
Q
A
V
R
C
S
L
S
D
I
P
D
H
I
P
Site 104
T1136
V
A
K
D
P
D
G
T
L
I
I
E
L
Y
G
Site 105
Y1142
G
T
L
I
I
E
L
Y
G
D
N
I
Q
I
S
Site 106
S1160
N
K
K
L
G
L
L
S
Y
K
D
R
I
R
K
Site 107
Y1161
K
K
L
G
L
L
S
Y
K
D
R
I
R
K
K
Site 108
S1170
D
R
I
R
K
K
E
S
E
V
L
C
S
T
T
Site 109
S1175
K
E
S
E
V
L
C
S
T
T
E
T
L
E
E
Site 110
T1179
V
L
C
S
T
T
E
T
L
E
E
K
N
E
N
Site 111
T1192
E
N
M
K
L
P
C
T
E
Y
L
S
K
S
V
Site 112
Y1194
M
K
L
P
C
T
E
Y
L
S
K
S
V
G
Y
Site 113
S1196
L
P
C
T
E
Y
L
S
K
S
V
G
Y
K
L
Site 114
S1198
C
T
E
Y
L
S
K
S
V
G
Y
K
L
P
N
Site 115
S1229
K
E
L
K
L
L
Q
S
L
T
K
T
N
L
V
Site 116
T1233
L
L
Q
S
L
T
K
T
N
L
V
T
Q
Y
Q
Site 117
Y1239
K
T
N
L
V
T
Q
Y
Q
D
S
V
G
N
K
Site 118
S1242
L
V
T
Q
Y
Q
D
S
V
G
N
K
N
S
Q
Site 119
S1248
D
S
V
G
N
K
N
S
Q
V
F
P
L
T
T
Site 120
T1254
N
S
Q
V
F
P
L
T
T
E
K
K
E
E
I
Site 121
T1265
K
E
E
I
S
A
E
T
P
L
K
T
A
R
V
Site 122
T1269
S
A
E
T
P
L
K
T
A
R
V
E
A
T
L
Site 123
S1277
A
R
V
E
A
T
L
S
E
R
K
I
G
D
S
Site 124
S1284
S
E
R
K
I
G
D
S
C
D
K
D
L
P
L
Site 125
Y1310
P
G
F
K
T
T
V
Y
V
S
H
I
N
D
L
Site 126
Y1321
I
N
D
L
S
D
F
Y
V
Q
L
I
E
D
E
Site 127
S1332
I
E
D
E
A
E
I
S
H
L
S
E
R
L
N
Site 128
S1335
E
A
E
I
S
H
L
S
E
R
L
N
S
V
K
Site 129
S1340
H
L
S
E
R
L
N
S
V
K
T
R
P
E
Y
Site 130
Y1347
S
V
K
T
R
P
E
Y
Y
V
G
P
P
L
Q
Site 131
Y1348
V
K
T
R
P
E
Y
Y
V
G
P
P
L
Q
R
Site 132
S1384
Q
Q
P
N
D
L
L
S
V
Q
F
I
D
Y
G
Site 133
T1398
G
N
V
S
V
V
H
T
N
K
I
G
R
L
D
Site 134
Y1437
N
S
K
K
M
M
H
Y
F
S
Q
R
T
S
E
Site 135
S1439
K
K
M
M
H
Y
F
S
Q
R
T
S
E
A
A
Site 136
S1443
H
Y
F
S
Q
R
T
S
E
A
A
I
R
C
E
Site 137
S1475
I
I
A
D
D
M
I
S
R
Y
A
L
S
E
K
Site 138
Y1477
A
D
D
M
I
S
R
Y
A
L
S
E
K
S
Q
Site 139
S1480
M
I
S
R
Y
A
L
S
E
K
S
Q
V
E
L
Site 140
S1483
R
Y
A
L
S
E
K
S
Q
V
E
L
S
T
Q
Site 141
S1488
E
K
S
Q
V
E
L
S
T
Q
V
I
K
S
A
Site 142
T1489
K
S
Q
V
E
L
S
T
Q
V
I
K
S
A
S
Site 143
S1494
L
S
T
Q
V
I
K
S
A
S
S
K
S
V
N
Site 144
S1497
Q
V
I
K
S
A
S
S
K
S
V
N
K
S
D
Site 145
S1499
I
K
S
A
S
S
K
S
V
N
K
S
D
I
D
Site 146
S1503
S
S
K
S
V
N
K
S
D
I
D
T
S
V
F
Site 147
T1507
V
N
K
S
D
I
D
T
S
V
F
L
N
W
Y
Site 148
Y1514
T
S
V
F
L
N
W
Y
N
P
E
K
K
M
I
Site 149
Y1524
E
K
K
M
I
R
A
Y
A
T
V
I
D
G
P
Site 150
T1526
K
M
I
R
A
Y
A
T
V
I
D
G
P
E
Y
Site 151
Y1578
G
D
P
C
I
V
R
Y
R
E
D
G
H
Y
Y
Site 152
Y1584
R
Y
R
E
D
G
H
Y
Y
R
A
L
I
T
N
Site 153
S1622
K
A
L
W
A
I
P
S
E
L
L
S
V
P
M
Site 154
S1647
N
I
S
E
G
L
C
S
Q
E
G
N
D
Y
F
Site 155
Y1653
C
S
Q
E
G
N
D
Y
F
Y
E
I
I
T
E
Site 156
Y1655
Q
E
G
N
D
Y
F
Y
E
I
I
T
E
D
V
Site 157
S1686
L
A
I
V
D
L
K
S
K
G
K
S
I
N
E
Site 158
S1690
D
L
K
S
K
G
K
S
I
N
E
K
M
E
K
Site 159
T1701
K
M
E
K
Y
S
K
T
G
I
K
S
A
L
P
Site 160
Y1709
G
I
K
S
A
L
P
Y
E
N
I
D
S
E
I
Site 161
S1714
L
P
Y
E
N
I
D
S
E
I
K
Q
T
L
G
Site 162
T1719
I
D
S
E
I
K
Q
T
L
G
S
Y
N
L
D
Site 163
Y1723
I
K
Q
T
L
G
S
Y
N
L
D
V
G
L
K
Site 164
S1766
N
I
I
G
T
K
P
S
N
F
R
D
P
K
T
Site 165
T1773
S
N
F
R
D
P
K
T
D
N
I
C
E
G
F
Site 166
T1790
P
C
K
D
K
I
D
T
E
E
L
E
G
E
L
Site 167
Y1811
K
A
E
F
D
D
K
Y
L
I
T
G
F
N
T
Site 168
S1834
K
E
I
L
E
L
N
S
L
E
V
P
L
S
P
Site 169
S1840
N
S
L
E
V
P
L
S
P
D
D
E
S
K
E
Site 170
S1845
P
L
S
P
D
D
E
S
K
E
F
L
E
L
E
Site 171
S1859
E
S
I
E
L
Q
N
S
L
V
V
D
E
E
K
Site 172
S1870
D
E
E
K
G
E
L
S
P
V
P
P
N
V
P
Site 173
S1879
V
P
P
N
V
P
L
S
Q
E
C
V
T
K
G
Site 174
S1898
F
T
L
Q
L
P
L
S
C
E
A
E
K
Q
P
Site 175
S1924
D
D
K
M
D
P
L
S
L
G
V
S
Q
K
A
Site 176
S1928
D
P
L
S
L
G
V
S
Q
K
A
Q
E
S
M
Site 177
T1937
K
A
Q
E
S
M
C
T
E
D
M
R
K
S
S
Site 178
S1943
C
T
E
D
M
R
K
S
S
C
V
E
S
F
D
Site 179
S1944
T
E
D
M
R
K
S
S
C
V
E
S
F
D
D
Site 180
S1948
R
K
S
S
C
V
E
S
F
D
D
Q
R
R
M
Site 181
S1956
F
D
D
Q
R
R
M
S
L
H
L
H
G
A
D
Site 182
T1968
G
A
D
C
D
P
K
T
Q
N
E
M
N
I
C
Site 183
Y1982
C
E
E
E
F
V
E
Y
K
N
R
D
A
I
S
Site 184
S1996
S
A
L
M
P
L
F
S
E
E
E
S
S
D
G
Site 185
S2000
P
L
F
S
E
E
E
S
S
D
G
S
K
H
N
Site 186
S2001
L
F
S
E
E
E
S
S
D
G
S
K
H
N
N
Site 187
S2004
E
E
E
S
S
D
G
S
K
H
N
N
G
L
P
Site 188
S2015
N
G
L
P
D
H
I
S
A
Q
L
Q
N
T
Y
Site 189
T2023
A
Q
L
Q
N
T
Y
T
L
K
A
F
T
V
G
Site 190
S2038
S
K
C
V
V
W
S
S
L
R
N
T
W
S
K
Site 191
T2042
V
W
S
S
L
R
N
T
W
S
K
C
E
I
L
Site 192
S2044
S
S
L
R
N
T
W
S
K
C
E
I
L
E
T
Site 193
T2051
S
K
C
E
I
L
E
T
A
E
E
G
T
R
V
Site 194
S2084
G
I
P
K
L
D
K
S
P
P
E
K
R
G
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation