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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GMD
Full Name:
GDP-mannose 4,6 dehydratase
Alias:
GDP-D-mannose dehydratase; GDP-mannose 4,6-dehydratase; GMDS; SDR3E1; short chain dehydrogenase/reductase family 3E, member 1
Type:
EC 4.2.1.47; Lyase; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose
Mass (Da):
41950
Number AA:
372
UniProt ID:
O60547
International Prot ID:
IPI00030207
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0008446
GO:0050662
PhosphoSite+
KinaseNET
Biological Process:
GO:0042351
GO:0019673
GO:0007159
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
H
A
P
A
R
C
P
S
A
R
G
S
G
D
G
Site 2
S14
R
C
P
S
A
R
G
S
G
D
G
E
M
G
K
Site 3
Y48
E
F
L
L
E
K
G
Y
E
V
H
G
I
V
R
Site 4
S57
V
H
G
I
V
R
R
S
S
S
F
N
T
G
R
Site 5
S58
H
G
I
V
R
R
S
S
S
F
N
T
G
R
I
Site 6
S59
G
I
V
R
R
S
S
S
F
N
T
G
R
I
E
Site 7
T62
R
R
S
S
S
F
N
T
G
R
I
E
H
L
Y
Site 8
Y69
T
G
R
I
E
H
L
Y
K
N
P
Q
A
H
I
Site 9
Y84
E
G
N
M
K
L
H
Y
G
D
L
T
D
S
T
Site 10
T88
K
L
H
Y
G
D
L
T
D
S
T
C
L
V
K
Site 11
S117
A
Q
S
H
V
K
I
S
F
D
L
A
E
Y
T
Site 12
S147
K
T
C
G
L
I
N
S
V
K
F
Y
Q
A
S
Site 13
Y151
L
I
N
S
V
K
F
Y
Q
A
S
T
S
E
L
Site 14
S154
S
V
K
F
Y
Q
A
S
T
S
E
L
Y
G
K
Site 15
S156
K
F
Y
Q
A
S
T
S
E
L
Y
G
K
V
Q
Site 16
T171
E
I
P
Q
K
E
T
T
P
F
Y
P
R
S
P
Site 17
Y174
Q
K
E
T
T
P
F
Y
P
R
S
P
Y
G
A
Site 18
S177
T
T
P
F
Y
P
R
S
P
Y
G
A
A
K
L
Site 19
Y179
P
F
Y
P
R
S
P
Y
G
A
A
K
L
Y
A
Site 20
S211
G
I
L
F
N
H
E
S
P
R
R
G
A
N
F
Site 21
T220
R
R
G
A
N
F
V
T
R
K
I
S
R
S
V
Site 22
S224
N
F
V
T
R
K
I
S
R
S
V
A
K
I
Y
Site 23
Y231
S
R
S
V
A
K
I
Y
L
G
Q
L
E
C
F
Site 24
S280
I
A
T
G
E
V
H
S
V
R
E
F
V
E
K
Site 25
S288
V
R
E
F
V
E
K
S
F
L
H
I
G
K
T
Site 26
T295
S
F
L
H
I
G
K
T
I
V
W
E
G
K
N
Site 27
T318
E
T
G
K
V
H
V
T
V
D
L
K
Y
Y
R
Site 28
Y323
H
V
T
V
D
L
K
Y
Y
R
P
T
E
V
D
Site 29
Y324
V
T
V
D
L
K
Y
Y
R
P
T
E
V
D
F
Site 30
T327
D
L
K
Y
Y
R
P
T
E
V
D
F
L
Q
G
Site 31
T337
D
F
L
Q
G
D
C
T
K
A
K
Q
K
L
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation