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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CCNT1
Full Name:
Cyclin-T1
Alias:
CCNT; Cyclin T1; Cyclin-T; CycT1; HIVE1
Type:
Transcription initiation complex
Mass (Da):
80685
Number AA:
726
UniProt ID:
O60563
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0051301
GO:0044419
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
K
N
N
N
K
R
W
Y
F
T
R
E
Q
L
E
Site 2
S22
T
R
E
Q
L
E
N
S
P
S
R
R
F
G
V
Site 3
S24
E
Q
L
E
N
S
P
S
R
R
F
G
V
D
P
Site 4
S36
V
D
P
D
K
E
L
S
Y
R
Q
Q
A
A
N
Site 5
S55
M
G
Q
R
L
N
V
S
Q
L
T
I
N
T
A
Site 6
S117
T
C
L
H
P
Q
E
S
L
P
D
T
R
S
E
Site 7
T121
P
Q
E
S
L
P
D
T
R
S
E
A
Y
L
Q
Site 8
S123
E
S
L
P
D
T
R
S
E
A
Y
L
Q
Q
V
Site 9
T149
Q
T
L
G
F
E
L
T
I
D
H
P
H
T
H
Site 10
T155
L
T
I
D
H
P
H
T
H
V
V
K
C
T
Q
Site 11
S167
C
T
Q
L
V
R
A
S
K
D
L
A
Q
T
S
Site 12
S174
S
K
D
L
A
Q
T
S
Y
F
M
A
T
N
S
Site 13
Y175
K
D
L
A
Q
T
S
Y
F
M
A
T
N
S
L
Site 14
T185
A
T
N
S
L
H
L
T
T
F
S
L
Q
Y
T
Site 15
T186
T
N
S
L
H
L
T
T
F
S
L
Q
Y
T
P
Site 16
Y224
D
G
K
H
W
W
E
Y
V
D
A
T
V
T
L
Site 17
T248
F
L
Q
I
L
E
K
T
P
N
R
L
K
R
I
Site 18
T274
T
K
A
D
D
R
G
T
D
E
K
T
S
E
Q
Site 19
T278
D
R
G
T
D
E
K
T
S
E
Q
T
I
L
N
Site 20
S288
Q
T
I
L
N
M
I
S
Q
S
S
S
D
T
T
Site 21
S290
I
L
N
M
I
S
Q
S
S
S
D
T
T
I
A
Site 22
S292
N
M
I
S
Q
S
S
S
D
T
T
I
A
G
L
Site 23
T294
I
S
Q
S
S
S
D
T
T
I
A
G
L
M
S
Site 24
T295
S
Q
S
S
S
D
T
T
I
A
G
L
M
S
M
Site 25
T307
M
S
M
S
T
S
T
T
S
A
V
P
S
L
P
Site 26
S312
S
T
T
S
A
V
P
S
L
P
V
S
E
E
S
Site 27
S316
A
V
P
S
L
P
V
S
E
E
S
S
S
N
L
Site 28
S319
S
L
P
V
S
E
E
S
S
S
N
L
T
S
V
Site 29
S320
L
P
V
S
E
E
S
S
S
N
L
T
S
V
E
Site 30
S321
P
V
S
E
E
S
S
S
N
L
T
S
V
E
M
Site 31
T324
E
E
S
S
S
N
L
T
S
V
E
M
L
P
G
Site 32
S325
E
S
S
S
N
L
T
S
V
E
M
L
P
G
K
Site 33
S336
L
P
G
K
R
W
L
S
S
Q
P
S
F
K
L
Site 34
S337
P
G
K
R
W
L
S
S
Q
P
S
F
K
L
E
Site 35
S340
R
W
L
S
S
Q
P
S
F
K
L
E
P
T
Q
Site 36
T351
E
P
T
Q
G
H
R
T
S
E
N
L
A
L
T
Site 37
S352
P
T
Q
G
H
R
T
S
E
N
L
A
L
T
G
Site 38
T358
T
S
E
N
L
A
L
T
G
V
D
H
S
L
P
Site 39
S363
A
L
T
G
V
D
H
S
L
P
Q
D
G
S
N
Site 40
S369
H
S
L
P
Q
D
G
S
N
A
F
I
S
Q
K
Site 41
S374
D
G
S
N
A
F
I
S
Q
K
Q
N
S
K
S
Site 42
S379
F
I
S
Q
K
Q
N
S
K
S
V
P
S
A
K
Site 43
S381
S
Q
K
Q
N
S
K
S
V
P
S
A
K
V
S
Site 44
S384
Q
N
S
K
S
V
P
S
A
K
V
S
L
K
E
Site 45
S388
S
V
P
S
A
K
V
S
L
K
E
Y
R
A
K
Site 46
Y392
A
K
V
S
L
K
E
Y
R
A
K
H
A
E
E
Site 47
Y418
E
A
N
V
K
S
Q
Y
A
Y
A
A
Q
N
L
Site 48
Y420
N
V
K
S
Q
Y
A
Y
A
A
Q
N
L
L
S
Site 49
S427
Y
A
A
Q
N
L
L
S
H
H
D
S
H
S
S
Site 50
S431
N
L
L
S
H
H
D
S
H
S
S
V
I
L
K
Site 51
S433
L
S
H
H
D
S
H
S
S
V
I
L
K
M
P
Site 52
S444
L
K
M
P
I
E
G
S
E
N
P
E
R
P
F
Site 53
T458
F
L
E
K
A
D
K
T
A
L
K
M
R
I
P
Site 54
S474
A
G
G
D
K
A
A
S
S
K
P
E
E
I
K
Site 55
S475
G
G
D
K
A
A
S
S
K
P
E
E
I
K
M
Site 56
S495
A
A
A
D
K
H
N
S
V
E
D
S
V
T
K
Site 57
S499
K
H
N
S
V
E
D
S
V
T
K
S
R
E
H
Site 58
T501
N
S
V
E
D
S
V
T
K
S
R
E
H
K
E
Site 59
S503
V
E
D
S
V
T
K
S
R
E
H
K
E
K
H
Site 60
S515
E
K
H
K
T
H
P
S
N
H
H
H
H
H
N
Site 61
S529
N
H
H
S
H
K
H
S
H
S
Q
L
P
V
G
Site 62
S531
H
S
H
K
H
S
H
S
Q
L
P
V
G
T
G
Site 63
S549
P
G
D
P
K
H
S
S
Q
T
S
N
L
A
H
Site 64
S552
P
K
H
S
S
Q
T
S
N
L
A
H
K
T
Y
Site 65
T558
T
S
N
L
A
H
K
T
Y
S
L
S
S
S
F
Site 66
Y559
S
N
L
A
H
K
T
Y
S
L
S
S
S
F
S
Site 67
S560
N
L
A
H
K
T
Y
S
L
S
S
S
F
S
S
Site 68
S562
A
H
K
T
Y
S
L
S
S
S
F
S
S
S
S
Site 69
S563
H
K
T
Y
S
L
S
S
S
F
S
S
S
S
S
Site 70
S564
K
T
Y
S
L
S
S
S
F
S
S
S
S
S
T
Site 71
S566
Y
S
L
S
S
S
F
S
S
S
S
S
T
R
K
Site 72
S567
S
L
S
S
S
F
S
S
S
S
S
T
R
K
R
Site 73
S568
L
S
S
S
F
S
S
S
S
S
T
R
K
R
G
Site 74
S569
S
S
S
F
S
S
S
S
S
T
R
K
R
G
P
Site 75
S570
S
S
F
S
S
S
S
S
T
R
K
R
G
P
S
Site 76
T571
S
F
S
S
S
S
S
T
R
K
R
G
P
S
E
Site 77
S577
S
T
R
K
R
G
P
S
E
E
T
G
G
A
V
Site 78
S594
H
P
A
K
I
A
K
S
T
K
S
S
S
L
N
Site 79
T595
P
A
K
I
A
K
S
T
K
S
S
S
L
N
F
Site 80
S597
K
I
A
K
S
T
K
S
S
S
L
N
F
S
F
Site 81
S598
I
A
K
S
T
K
S
S
S
L
N
F
S
F
P
Site 82
S599
A
K
S
T
K
S
S
S
L
N
F
S
F
P
S
Site 83
S603
K
S
S
S
L
N
F
S
F
P
S
L
P
T
M
Site 84
S617
M
G
Q
M
P
G
H
S
S
D
T
S
G
L
S
Site 85
S618
G
Q
M
P
G
H
S
S
D
T
S
G
L
S
F
Site 86
T620
M
P
G
H
S
S
D
T
S
G
L
S
F
S
Q
Site 87
S621
P
G
H
S
S
D
T
S
G
L
S
F
S
Q
P
Site 88
S624
S
S
D
T
S
G
L
S
F
S
Q
P
S
C
K
Site 89
S626
D
T
S
G
L
S
F
S
Q
P
S
C
K
T
R
Site 90
T632
F
S
Q
P
S
C
K
T
R
V
P
H
S
K
L
Site 91
S637
C
K
T
R
V
P
H
S
K
L
D
K
G
P
T
Site 92
Y657
N
T
T
Q
T
I
D
Y
Q
D
T
V
N
M
L
Site 93
T660
Q
T
I
D
Y
Q
D
T
V
N
M
L
H
S
L
Site 94
S669
N
M
L
H
S
L
L
S
A
Q
G
V
Q
P
T
Site 95
Y687
A
F
E
F
V
R
P
Y
S
D
Y
L
N
P
R
Site 96
S688
F
E
F
V
R
P
Y
S
D
Y
L
N
P
R
S
Site 97
Y690
F
V
R
P
Y
S
D
Y
L
N
P
R
S
G
G
Site 98
S695
S
D
Y
L
N
P
R
S
G
G
I
S
S
R
S
Site 99
S699
N
P
R
S
G
G
I
S
S
R
S
G
N
T
D
Site 100
S700
P
R
S
G
G
I
S
S
R
S
G
N
T
D
K
Site 101
S702
S
G
G
I
S
S
R
S
G
N
T
D
K
P
R
Site 102
S715
P
R
P
P
P
L
P
S
E
P
P
P
P
L
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation