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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BUB1B
Full Name:
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Alias:
BUB1 budding uninhibited by benzimidazoles 1 homologue beta (yeast); EC 2.7.11.1; HBUBR1; Kinase BubR1; MAD3/BUB1-related protein kinase
Type:
Spindle midzone, Anaphase-promoting complex, Cytoplasm, Nucleus, Outer kinetochore of condensed chromosome protein
Mass (Da):
119545
Number AA:
1050
UniProt ID:
O60566
International Prot ID:
IPI00141933
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005680
GO:0005813
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0031145
GO:0006915
GO:0051301
Phosida
TranscriptoNet
STRING
Kinexus Products
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta S670 phosphosite-specific antibody AB-PK552#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK552
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
K
K
E
G
G
A
L
S
E
A
M
S
L
E
G
Site 2
S16
G
A
L
S
E
A
M
S
L
E
G
D
E
W
E
Site 3
S25
E
G
D
E
W
E
L
S
K
E
N
V
Q
P
L
Site 4
S39
L
R
Q
G
R
I
M
S
T
L
Q
G
A
L
A
Site 5
T40
R
Q
G
R
I
M
S
T
L
Q
G
A
L
A
Q
Site 6
T54
Q
E
S
A
C
N
N
T
L
Q
Q
Q
K
R
A
Site 7
Y64
Q
Q
K
R
A
F
E
Y
E
I
R
F
Y
T
G
Site 8
Y69
F
E
Y
E
I
R
F
Y
T
G
N
D
P
L
D
Site 9
T70
E
Y
E
I
R
F
Y
T
G
N
D
P
L
D
V
Site 10
Y81
P
L
D
V
W
D
R
Y
I
S
W
T
E
Q
N
Site 11
S83
D
V
W
D
R
Y
I
S
W
T
E
Q
N
Y
P
Site 12
Y89
I
S
W
T
E
Q
N
Y
P
Q
G
G
K
E
S
Site 13
S99
G
G
K
E
S
N
M
S
T
L
L
E
R
A
V
Site 14
T100
G
K
E
S
N
M
S
T
L
L
E
R
A
V
E
Site 15
Y116
L
Q
G
E
K
R
Y
Y
S
D
P
R
F
L
N
Site 16
S117
Q
G
E
K
R
Y
Y
S
D
P
R
F
L
N
L
Site 17
Y139
C
N
E
P
L
D
M
Y
S
Y
L
H
N
Q
G
Site 18
Y141
E
P
L
D
M
Y
S
Y
L
H
N
Q
G
I
G
Site 19
S157
S
L
A
Q
F
Y
I
S
W
A
E
E
Y
E
A
Site 20
Y162
Y
I
S
W
A
E
E
Y
E
A
R
E
N
F
R
Site 21
S191
E
P
L
E
R
L
Q
S
Q
H
R
Q
F
Q
A
Site 22
S201
R
Q
F
Q
A
R
V
S
R
Q
T
L
L
A
L
Site 23
T204
Q
A
R
V
S
R
Q
T
L
L
A
L
E
K
E
Site 24
S219
E
E
E
E
V
F
E
S
S
V
P
Q
R
S
T
Site 25
S220
E
E
E
V
F
E
S
S
V
P
Q
R
S
T
L
Site 26
S225
E
S
S
V
P
Q
R
S
T
L
A
E
L
K
S
Site 27
T226
S
S
V
P
Q
R
S
T
L
A
E
L
K
S
K
Site 28
S232
S
T
L
A
E
L
K
S
K
G
K
K
T
A
R
Site 29
T237
L
K
S
K
G
K
K
T
A
R
A
P
I
I
R
Site 30
S253
G
G
A
L
K
A
P
S
Q
N
R
G
L
Q
N
Site 31
T273
M
Q
N
N
S
R
I
T
V
F
D
E
N
A
D
Site 32
S283
D
E
N
A
D
E
A
S
T
A
E
L
S
K
P
Site 33
S288
E
A
S
T
A
E
L
S
K
P
T
V
Q
P
W
Site 34
T291
T
A
E
L
S
K
P
T
V
Q
P
W
I
A
P
Site 35
T315
L
Q
A
G
P
W
N
T
G
R
S
L
E
H
R
Site 36
S318
G
P
W
N
T
G
R
S
L
E
H
R
P
R
G
Site 37
T327
E
H
R
P
R
G
N
T
A
S
L
I
A
V
P
Site 38
Y343
V
L
P
S
F
T
P
Y
V
E
E
T
A
R
Q
Site 39
T354
T
A
R
Q
P
V
M
T
P
C
K
I
E
P
S
Site 40
S361
T
P
C
K
I
E
P
S
I
N
H
I
L
S
T
Site 41
S367
P
S
I
N
H
I
L
S
T
R
K
P
G
K
E
Site 42
T368
S
I
N
H
I
L
S
T
R
K
P
G
K
E
E
Site 43
S384
D
P
L
Q
R
V
Q
S
H
Q
Q
A
S
E
E
Site 44
Y398
E
K
K
E
K
M
M
Y
C
K
E
K
I
Y
A
Site 45
Y404
M
Y
C
K
E
K
I
Y
A
G
V
G
E
F
S
Site 46
S411
Y
A
G
V
G
E
F
S
F
E
E
I
R
A
E
Site 47
T434
Q
R
E
A
E
L
L
T
S
A
E
K
R
A
E
Site 48
S435
R
E
A
E
L
L
T
S
A
E
K
R
A
E
M
Site 49
T459
K
L
K
E
I
Q
T
T
Q
Q
E
R
T
G
D
Site 50
T471
T
G
D
Q
Q
E
E
T
M
P
T
K
E
T
T
Site 51
T474
Q
Q
E
E
T
M
P
T
K
E
T
T
K
L
Q
Site 52
S486
K
L
Q
I
A
S
E
S
Q
K
I
P
G
M
T
Site 53
T493
S
Q
K
I
P
G
M
T
L
S
S
S
V
C
Q
Site 54
S521
I
W
Q
E
Q
P
H
S
K
G
P
S
V
P
F
Site 55
S525
Q
P
H
S
K
G
P
S
V
P
F
S
I
F
D
Site 56
S537
I
F
D
E
F
L
L
S
E
K
K
N
K
S
P
Site 57
S543
L
S
E
K
K
N
K
S
P
P
A
D
P
P
R
Site 58
T563
R
P
L
A
V
L
K
T
S
E
S
I
T
S
N
Site 59
S566
A
V
L
K
T
S
E
S
I
T
S
N
E
D
V
Site 60
T568
L
K
T
S
E
S
I
T
S
N
E
D
V
S
P
Site 61
S569
K
T
S
E
S
I
T
S
N
E
D
V
S
P
D
Site 62
S574
I
T
S
N
E
D
V
S
P
D
V
C
D
E
F
Site 63
T600
I
T
G
F
R
N
V
T
I
C
P
N
P
E
D
Site 64
T620
R
A
A
R
F
V
S
T
P
F
H
E
I
M
S
Site 65
S627
T
P
F
H
E
I
M
S
L
K
D
L
P
S
D
Site 66
S633
M
S
L
K
D
L
P
S
D
P
E
R
L
L
P
Site 67
T648
E
E
D
L
D
V
K
T
S
E
D
Q
Q
T
A
Site 68
T654
K
T
S
E
D
Q
Q
T
A
C
G
T
I
Y
S
Site 69
Y660
Q
T
A
C
G
T
I
Y
S
Q
T
L
S
I
K
Site 70
S661
T
A
C
G
T
I
Y
S
Q
T
L
S
I
K
K
Site 71
T663
C
G
T
I
Y
S
Q
T
L
S
I
K
K
L
S
Site 72
S670
T
L
S
I
K
K
L
S
P
I
I
E
D
S
R
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta S670 phosphosite-specific antibody
Site 73
S676
L
S
P
I
I
E
D
S
R
E
A
T
H
S
S
Site 74
T680
I
E
D
S
R
E
A
T
H
S
S
G
F
S
G
Site 75
S682
D
S
R
E
A
T
H
S
S
G
F
S
G
S
S
Site 76
S683
S
R
E
A
T
H
S
S
G
F
S
G
S
S
A
Site 77
S686
A
T
H
S
S
G
F
S
G
S
S
A
S
V
A
Site 78
S688
H
S
S
G
F
S
G
S
S
A
S
V
A
S
T
Site 79
S689
S
S
G
F
S
G
S
S
A
S
V
A
S
T
S
Site 80
T710
I
P
E
K
L
E
L
T
N
E
T
S
E
N
P
Site 81
S714
L
E
L
T
N
E
T
S
E
N
P
T
Q
S
P
Site 82
T718
N
E
T
S
E
N
P
T
Q
S
P
W
C
S
Q
Site 83
S720
T
S
E
N
P
T
Q
S
P
W
C
S
Q
Y
R
Site 84
S724
P
T
Q
S
P
W
C
S
Q
Y
R
R
Q
L
L
Site 85
Y726
Q
S
P
W
C
S
Q
Y
R
R
Q
L
L
K
S
Site 86
S733
Y
R
R
Q
L
L
K
S
L
P
E
L
S
A
S
Site 87
Y766
I
E
L
G
N
E
D
Y
C
I
K
R
E
Y
L
Site 88
Y772
D
Y
C
I
K
R
E
Y
L
I
C
E
D
Y
K
Site 89
T792
P
R
N
S
A
E
L
T
V
I
K
V
S
S
Q
Site 90
S797
E
L
T
V
I
K
V
S
S
Q
P
V
P
W
D
Site 91
Y806
Q
P
V
P
W
D
F
Y
I
N
L
K
L
K
E
Site 92
Y853
D
L
L
Q
H
S
E
Y
I
T
H
E
I
T
V
Site 93
S884
E
I
V
H
G
D
L
S
P
R
C
L
I
L
R
Site 94
Y898
R
N
R
I
H
D
P
Y
D
C
N
K
N
N
Q
Site 95
S947
K
I
L
A
N
C
S
S
P
Y
Q
V
D
L
F
Site 96
S981
D
G
S
F
W
K
L
S
Q
N
I
S
E
L
K
Site 97
S985
W
K
L
S
Q
N
I
S
E
L
K
D
G
E
L
Site 98
T1008
L
N
A
N
D
E
A
T
V
S
V
L
G
E
L
Site 99
S1029
V
F
D
T
T
F
Q
S
H
L
N
K
A
L
W
Site 100
T1042
L
W
K
V
G
K
L
T
S
P
G
A
L
L
F
Site 101
S1043
W
K
V
G
K
L
T
S
P
G
A
L
L
F
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation