KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CCNT2
Full Name:
Cyclin-T2
Alias:
CCT2; Cyclin T2; CycT2
Type:
Protein-serine kinase regulatory subunit, activator, cyclin
Mass (Da):
81029
Number AA:
730
UniProt ID:
O60583
International Prot ID:
IPI00217564
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0051301
GO:0044419
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
S
G
R
G
A
S
S
R
W
F
F
T
R
Site 2
T21
T
R
E
Q
L
E
N
T
P
S
R
R
C
G
V
Site 3
S23
E
Q
L
E
N
T
P
S
R
R
C
G
V
E
A
Site 4
S35
V
E
A
D
K
E
L
S
C
R
Q
Q
A
A
N
Site 5
S54
M
G
Q
R
L
N
V
S
Q
L
T
I
N
T
A
Site 6
T120
P
L
E
P
L
L
D
T
K
C
D
A
Y
L
Q
Site 7
Y125
L
D
T
K
C
D
A
Y
L
Q
Q
T
Q
E
L
Site 8
T154
I
T
I
E
H
P
H
T
D
V
V
K
C
T
Q
Site 9
S166
C
T
Q
L
V
R
A
S
K
D
L
A
Q
T
S
Site 10
S173
S
K
D
L
A
Q
T
S
Y
F
M
A
T
N
S
Site 11
Y174
K
D
L
A
Q
T
S
Y
F
M
A
T
N
S
L
Site 12
T184
A
T
N
S
L
H
L
T
T
F
C
L
Q
Y
K
Site 13
T185
T
N
S
L
H
L
T
T
F
C
L
Q
Y
K
P
Site 14
Y223
D
G
K
H
W
W
E
Y
V
D
P
T
V
T
L
Site 15
T227
W
W
E
Y
V
D
P
T
V
T
L
E
L
L
D
Site 16
T247
F
L
Q
I
L
E
K
T
P
N
R
L
K
K
I
Site 17
S273
P
K
V
D
G
Q
V
S
E
T
P
L
L
G
S
Site 18
S291
Q
N
S
I
L
V
D
S
V
T
G
V
P
T
N
Site 19
S300
T
G
V
P
T
N
P
S
F
Q
K
P
S
T
S
Site 20
S305
N
P
S
F
Q
K
P
S
T
S
A
F
P
A
P
Site 21
T306
P
S
F
Q
K
P
S
T
S
A
F
P
A
P
V
Site 22
S307
S
F
Q
K
P
S
T
S
A
F
P
A
P
V
P
Site 23
S317
P
A
P
V
P
L
N
S
G
N
I
S
V
Q
D
Site 24
S321
P
L
N
S
G
N
I
S
V
Q
D
S
H
T
S
Site 25
S325
G
N
I
S
V
Q
D
S
H
T
S
D
N
L
S
Site 26
T327
I
S
V
Q
D
S
H
T
S
D
N
L
S
M
L
Site 27
S332
S
H
T
S
D
N
L
S
M
L
A
T
G
M
P
Site 28
T336
D
N
L
S
M
L
A
T
G
M
P
S
T
S
Y
Site 29
T341
L
A
T
G
M
P
S
T
S
Y
G
L
S
S
H
Site 30
S342
A
T
G
M
P
S
T
S
Y
G
L
S
S
H
Q
Site 31
Y343
T
G
M
P
S
T
S
Y
G
L
S
S
H
Q
E
Site 32
S346
P
S
T
S
Y
G
L
S
S
H
Q
E
W
P
Q
Site 33
S347
S
T
S
Y
G
L
S
S
H
Q
E
W
P
Q
H
Site 34
S357
E
W
P
Q
H
Q
D
S
A
R
T
E
Q
L
Y
Site 35
Y364
S
A
R
T
E
Q
L
Y
S
Q
K
Q
E
T
S
Site 36
S365
A
R
T
E
Q
L
Y
S
Q
K
Q
E
T
S
L
Site 37
S371
Y
S
Q
K
Q
E
T
S
L
S
G
S
Q
Y
N
Site 38
S373
Q
K
Q
E
T
S
L
S
G
S
Q
Y
N
I
N
Site 39
S375
Q
E
T
S
L
S
G
S
Q
Y
N
I
N
F
Q
Site 40
Y377
T
S
L
S
G
S
Q
Y
N
I
N
F
Q
Q
G
Site 41
S388
F
Q
Q
G
P
S
I
S
L
H
S
G
L
H
H
Site 42
S401
H
H
R
P
D
K
I
S
D
H
S
S
V
K
Q
Site 43
S405
D
K
I
S
D
H
S
S
V
K
Q
E
Y
T
H
Site 44
Y410
H
S
S
V
K
Q
E
Y
T
H
K
A
G
S
S
Site 45
T411
S
S
V
K
Q
E
Y
T
H
K
A
G
S
S
K
Site 46
S424
S
K
H
H
G
P
I
S
T
T
P
G
I
I
P
Site 47
T426
H
H
G
P
I
S
T
T
P
G
I
I
P
Q
K
Site 48
S435
G
I
I
P
Q
K
M
S
L
D
K
Y
R
E
K
Site 49
Y439
Q
K
M
S
L
D
K
Y
R
E
K
R
K
L
E
Site 50
Y456
D
L
D
V
R
D
H
Y
I
A
A
Q
V
E
Q
Site 51
S470
Q
Q
H
K
Q
G
Q
S
Q
A
A
S
S
S
S
Site 52
S474
Q
G
Q
S
Q
A
A
S
S
S
S
V
T
S
P
Site 53
S475
G
Q
S
Q
A
A
S
S
S
S
V
T
S
P
I
Site 54
S476
Q
S
Q
A
A
S
S
S
S
V
T
S
P
I
K
Site 55
S477
S
Q
A
A
S
S
S
S
V
T
S
P
I
K
M
Site 56
T479
A
A
S
S
S
S
V
T
S
P
I
K
M
K
I
Site 57
S480
A
S
S
S
S
V
T
S
P
I
K
M
K
I
P
Site 58
Y494
P
I
A
N
T
E
K
Y
M
A
D
K
K
E
K
Site 59
S502
M
A
D
K
K
E
K
S
G
S
L
K
L
R
I
Site 60
S504
D
K
K
E
K
S
G
S
L
K
L
R
I
P
I
Site 61
T514
L
R
I
P
I
P
P
T
D
K
S
A
S
K
E
Site 62
S517
P
I
P
P
T
D
K
S
A
S
K
E
E
L
K
Site 63
S530
L
K
M
K
I
K
V
S
S
S
E
R
H
S
S
Site 64
S531
K
M
K
I
K
V
S
S
S
E
R
H
S
S
S
Site 65
S532
M
K
I
K
V
S
S
S
E
R
H
S
S
S
D
Site 66
S536
V
S
S
S
E
R
H
S
S
S
D
E
G
S
G
Site 67
S537
S
S
S
E
R
H
S
S
S
D
E
G
S
G
K
Site 68
S538
S
S
E
R
H
S
S
S
D
E
G
S
G
K
S
Site 69
S542
H
S
S
S
D
E
G
S
G
K
S
K
H
S
S
Site 70
S545
S
D
E
G
S
G
K
S
K
H
S
S
P
H
I
Site 71
S548
G
S
G
K
S
K
H
S
S
P
H
I
S
R
D
Site 72
S549
S
G
K
S
K
H
S
S
P
H
I
S
R
D
H
Site 73
S553
K
H
S
S
P
H
I
S
R
D
H
K
E
K
H
Site 74
S565
E
K
H
K
E
H
P
S
S
R
H
H
T
S
S
Site 75
S566
K
H
K
E
H
P
S
S
R
H
H
T
S
S
H
Site 76
T570
H
P
S
S
R
H
H
T
S
S
H
K
H
S
H
Site 77
S571
P
S
S
R
H
H
T
S
S
H
K
H
S
H
S
Site 78
S572
S
S
R
H
H
T
S
S
H
K
H
S
H
S
H
Site 79
S576
H
T
S
S
H
K
H
S
H
S
H
S
G
S
S
Site 80
S578
S
S
H
K
H
S
H
S
H
S
G
S
S
S
G
Site 81
S580
H
K
H
S
H
S
H
S
G
S
S
S
G
G
S
Site 82
S582
H
S
H
S
H
S
G
S
S
S
G
G
S
K
H
Site 83
S583
S
H
S
H
S
G
S
S
S
G
G
S
K
H
S
Site 84
S584
H
S
H
S
G
S
S
S
G
G
S
K
H
S
A
Site 85
S587
S
G
S
S
S
G
G
S
K
H
S
A
D
G
I
Site 86
S590
S
S
G
G
S
K
H
S
A
D
G
I
P
P
T
Site 87
T597
S
A
D
G
I
P
P
T
V
L
R
S
P
V
G
Site 88
S601
I
P
P
T
V
L
R
S
P
V
G
L
S
S
D
Site 89
S606
L
R
S
P
V
G
L
S
S
D
G
I
S
S
S
Site 90
S607
R
S
P
V
G
L
S
S
D
G
I
S
S
S
S
Site 91
S611
G
L
S
S
D
G
I
S
S
S
S
S
S
S
R
Site 92
S612
L
S
S
D
G
I
S
S
S
S
S
S
S
R
K
Site 93
S613
S
S
D
G
I
S
S
S
S
S
S
S
R
K
R
Site 94
S614
S
D
G
I
S
S
S
S
S
S
S
R
K
R
L
Site 95
S615
D
G
I
S
S
S
S
S
S
S
R
K
R
L
H
Site 96
S616
G
I
S
S
S
S
S
S
S
R
K
R
L
H
V
Site 97
S617
I
S
S
S
S
S
S
S
R
K
R
L
H
V
N
Site 98
S632
D
A
S
H
N
H
H
S
K
M
S
K
S
S
K
Site 99
S635
H
N
H
H
S
K
M
S
K
S
S
K
S
S
G
Site 100
S637
H
H
S
K
M
S
K
S
S
K
S
S
G
S
S
Site 101
S638
H
S
K
M
S
K
S
S
K
S
S
G
S
S
S
Site 102
S640
K
M
S
K
S
S
K
S
S
G
S
S
S
S
S
Site 103
S641
M
S
K
S
S
K
S
S
G
S
S
S
S
S
S
Site 104
S643
K
S
S
K
S
S
G
S
S
S
S
S
S
S
S
Site 105
S644
S
S
K
S
S
G
S
S
S
S
S
S
S
S
V
Site 106
S645
S
K
S
S
G
S
S
S
S
S
S
S
S
V
K
Site 107
S646
K
S
S
G
S
S
S
S
S
S
S
S
V
K
Q
Site 108
S647
S
S
G
S
S
S
S
S
S
S
S
V
K
Q
Y
Site 109
S648
S
G
S
S
S
S
S
S
S
S
V
K
Q
Y
I
Site 110
S649
G
S
S
S
S
S
S
S
S
V
K
Q
Y
I
S
Site 111
S650
S
S
S
S
S
S
S
S
V
K
Q
Y
I
S
S
Site 112
Y654
S
S
S
S
V
K
Q
Y
I
S
S
H
N
S
V
Site 113
S656
S
S
V
K
Q
Y
I
S
S
H
N
S
V
F
N
Site 114
S660
Q
Y
I
S
S
H
N
S
V
F
N
H
P
L
P
Site 115
T673
L
P
P
P
P
P
V
T
Y
Q
V
G
Y
G
H
Site 116
Y674
P
P
P
P
P
V
T
Y
Q
V
G
Y
G
H
L
Site 117
S682
Q
V
G
Y
G
H
L
S
T
L
V
K
L
D
K
Site 118
Y703
G
P
D
A
N
H
E
Y
S
T
S
S
Q
H
M
Site 119
S704
P
D
A
N
H
E
Y
S
T
S
S
Q
H
M
D
Site 120
Y712
T
S
S
Q
H
M
D
Y
K
D
T
F
D
M
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation