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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
diaphanous 1
Full Name:
Protein diaphanous homolog 1
Alias:
DFNA1; DIA1; DIAP1; DIAPH1; Diaphanous 1; Diaphanous-related formin 1; Diaphanous-related formin-1; DRF1; HDIA1; LFHL1
Type:
Actin binding protein; Adaptor/scaffold; Motility/polarity/chemotaxis
Mass (Da):
141347
Number AA:
1272
UniProt ID:
O60610
International Prot ID:
IPI00030876
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0032587
Uniprot
OncoNet
Molecular Function:
GO:0017048
GO:0003779
GO:0005102
PhosphoSite+
KinaseNET
Biological Process:
GO:0007605
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
E
P
P
G
G
S
L
G
P
G
R
G
T
Site 2
T14
S
L
G
P
G
R
G
T
R
D
K
K
K
G
R
Site 3
S22
R
D
K
K
K
G
R
S
P
D
E
L
P
S
A
Site 4
S28
R
S
P
D
E
L
P
S
A
G
G
D
G
G
K
Site 5
S36
A
G
G
D
G
G
K
S
K
K
F
T
L
K
R
Site 6
T40
G
G
K
S
K
K
F
T
L
K
R
L
M
A
D
Site 7
T53
A
D
E
L
E
R
F
T
S
M
R
I
K
K
E
Site 8
S54
D
E
L
E
R
F
T
S
M
R
I
K
K
E
K
Site 9
S66
K
E
K
E
K
P
N
S
A
H
R
N
S
S
A
Site 10
S71
P
N
S
A
H
R
N
S
S
A
S
Y
G
D
D
Site 11
S72
N
S
A
H
R
N
S
S
A
S
Y
G
D
D
P
Site 12
S74
A
H
R
N
S
S
A
S
Y
G
D
D
P
T
A
Site 13
Y75
H
R
N
S
S
A
S
Y
G
D
D
P
T
A
Q
Site 14
T80
A
S
Y
G
D
D
P
T
A
Q
S
L
Q
D
V
Site 15
S83
G
D
D
P
T
A
Q
S
L
Q
D
V
S
D
E
Site 16
S126
I
I
K
R
E
M
V
S
Q
Y
L
Y
T
S
K
Site 17
Y128
K
R
E
M
V
S
Q
Y
L
Y
T
S
K
A
G
Site 18
Y130
E
M
V
S
Q
Y
L
Y
T
S
K
A
G
M
S
Site 19
T131
M
V
S
Q
Y
L
Y
T
S
K
A
G
M
S
Q
Site 20
S132
V
S
Q
Y
L
Y
T
S
K
A
G
M
S
Q
K
Site 21
S137
Y
T
S
K
A
G
M
S
Q
K
E
S
S
K
S
Site 22
S141
A
G
M
S
Q
K
E
S
S
K
S
A
M
M
Y
Site 23
S144
S
Q
K
E
S
S
K
S
A
M
M
Y
I
Q
E
Site 24
Y148
S
S
K
S
A
M
M
Y
I
Q
E
L
R
S
G
Site 25
S171
C
L
E
S
L
R
V
S
L
N
N
N
P
V
S
Site 26
S178
S
L
N
N
N
P
V
S
W
V
Q
T
F
G
A
Site 27
T205
L
H
D
E
K
E
E
T
A
G
S
Y
D
S
R
Site 28
S208
E
K
E
E
T
A
G
S
Y
D
S
R
N
K
H
Site 29
Y209
K
E
E
T
A
G
S
Y
D
S
R
N
K
H
E
Site 30
S336
D
F
R
V
H
I
R
S
E
L
M
R
L
G
L
Site 31
S373
D
E
Q
G
E
E
D
S
Y
D
L
K
G
R
L
Site 32
Y374
E
Q
G
E
E
D
S
Y
D
L
K
G
R
L
D
Site 33
Y424
L
L
L
V
R
N
D
Y
E
A
R
P
Q
Y
Y
Site 34
Y430
D
Y
E
A
R
P
Q
Y
Y
K
L
I
E
E
C
Site 35
T472
I
D
Q
M
I
D
K
T
K
V
E
K
S
E
A
Site 36
S477
D
K
T
K
V
E
K
S
E
A
K
A
A
E
L
Site 37
S490
E
L
E
K
K
L
D
S
E
L
T
A
R
H
E
Site 38
T493
K
K
L
D
S
E
L
T
A
R
H
E
L
Q
V
Site 39
S542
Q
D
L
E
A
E
V
S
Q
L
T
G
E
V
A
Site 40
S578
T
V
P
P
S
V
P
S
R
A
P
V
P
P
A
Site 41
S592
A
P
P
L
P
G
D
S
G
T
I
I
P
P
P
Site 42
T594
P
L
P
G
D
S
G
T
I
I
P
P
P
P
A
Site 43
S605
P
P
P
A
P
G
D
S
T
T
P
P
P
P
P
Site 44
T606
P
P
A
P
G
D
S
T
T
P
P
P
P
P
P
Site 45
T607
P
A
P
G
D
S
T
T
P
P
P
P
P
P
P
Site 46
S646
I
S
P
P
P
P
L
S
G
D
A
T
I
P
P
Site 47
T650
P
P
L
S
G
D
A
T
I
P
P
P
P
P
L
Site 48
S665
P
E
G
V
G
I
P
S
P
S
S
L
P
G
G
Site 49
T673
P
S
S
L
P
G
G
T
A
I
P
P
P
P
P
Site 50
S684
P
P
P
P
L
P
G
S
A
R
I
P
P
P
P
Site 51
S697
P
P
P
P
L
P
G
S
A
G
I
P
P
P
P
Site 52
T768
P
V
L
P
F
G
L
T
P
K
K
L
Y
K
P
Site 53
Y773
G
L
T
P
K
K
L
Y
K
P
E
V
Q
L
R
Site 54
S785
Q
L
R
R
P
N
W
S
K
L
V
A
E
D
L
Site 55
S793
K
L
V
A
E
D
L
S
Q
D
C
F
W
T
K
Site 56
S820
A
K
L
T
L
T
F
S
A
Q
T
K
T
S
K
Site 57
S840
E
G
G
E
E
K
K
S
V
Q
K
K
K
V
K
Site 58
S854
K
E
L
K
V
L
D
S
K
T
A
Q
N
L
S
Site 59
S861
S
K
T
A
Q
N
L
S
I
F
L
G
S
F
R
Site 60
S866
N
L
S
I
F
L
G
S
F
R
M
P
Y
Q
E
Site 61
Y871
L
G
S
F
R
M
P
Y
Q
E
I
K
N
V
I
Site 62
Y914
L
S
E
L
K
D
E
Y
D
D
L
A
E
S
E
Site 63
T929
Q
F
G
V
V
M
G
T
V
P
R
L
R
P
R
Site 64
S959
N
I
K
P
E
I
V
S
V
T
A
A
C
E
E
Site 65
T961
K
P
E
I
V
S
V
T
A
A
C
E
E
L
R
Site 66
S970
A
C
E
E
L
R
K
S
E
S
F
S
N
L
L
Site 67
S972
E
E
L
R
K
S
E
S
F
S
N
L
L
E
I
Site 68
S974
L
R
K
S
E
S
F
S
N
L
L
E
I
T
L
Site 69
Y986
I
T
L
L
V
G
N
Y
M
N
A
G
S
R
N
Site 70
S991
G
N
Y
M
N
A
G
S
R
N
A
G
A
F
G
Site 71
T1010
F
L
C
K
L
R
D
T
K
S
T
D
Q
K
M
Site 72
S1012
C
K
L
R
D
T
K
S
T
D
Q
K
M
T
L
Site 73
T1013
K
L
R
D
T
K
S
T
D
Q
K
M
T
L
L
Site 74
Y1031
A
E
L
C
E
N
D
Y
P
D
V
L
K
F
P
Site 75
S1051
V
E
K
A
S
R
V
S
A
E
N
L
Q
K
N
Site 76
S1067
D
Q
M
K
K
Q
I
S
D
V
E
R
D
V
Q
Site 77
S1092
K
F
V
E
K
M
T
S
F
V
K
D
A
Q
E
Site 78
T1113
M
M
H
S
N
M
E
T
L
Y
K
E
L
G
E
Site 79
Y1115
H
S
N
M
E
T
L
Y
K
E
L
G
E
Y
F
Site 80
Y1121
L
Y
K
E
L
G
E
Y
F
L
F
D
P
K
K
Site 81
S1130
L
F
D
P
K
K
L
S
V
E
E
F
F
M
D
Site 82
T1158
E
N
Q
K
R
R
E
T
E
E
K
M
R
R
A
Site 83
T1196
M
N
A
E
G
D
E
T
G
V
M
D
S
L
L
Site 84
S1201
D
E
T
G
V
M
D
S
L
L
E
A
L
Q
S
Site 85
S1208
S
L
L
E
A
L
Q
S
G
A
A
F
R
R
K
Site 86
T1256
K
V
S
K
N
S
E
T
F
P
T
I
L
E
E
Site 87
S1272
K
E
L
V
G
R
A
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation