KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PDE8A
Full Name:
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Alias:
cAMP-specific cyclic nucleotide phosphodiesterase 8A; high-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; HsT19550; phosphodiesterase 8A
Type:
Phosphodiesterase; EC 3.1.4.17; Nucleotide Metabolism - purine
Mass (Da):
93304
Number AA:
829
UniProt ID:
O60658
International Prot ID:
IPI00030976
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005794
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0000287
GO:0030145
GO:0000156
PhosphoSite+
KinaseNET
Biological Process:
GO:0006198
GO:0006355
GO:0000160
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
C
A
P
S
I
H
I
S
E
R
L
V
A
E
D
Site 2
S20
L
V
A
E
D
A
P
S
P
A
A
P
P
L
S
Site 3
S27
S
P
A
A
P
P
L
S
S
G
G
P
R
L
P
Site 4
S28
P
A
A
P
P
L
S
S
G
G
P
R
L
P
Q
Site 5
T39
R
L
P
Q
G
Q
K
T
A
A
L
P
R
T
R
Site 6
T45
K
T
A
A
L
P
R
T
R
G
A
G
L
L
E
Site 7
S53
R
G
A
G
L
L
E
S
E
L
R
D
G
S
G
Site 8
S59
E
S
E
L
R
D
G
S
G
K
K
V
A
V
A
Site 9
T108
E
K
A
G
F
K
C
T
V
T
K
E
A
Q
A
Site 10
S146
D
A
E
A
L
C
R
S
I
R
S
S
K
L
S
Site 11
S150
L
C
R
S
I
R
S
S
K
L
S
E
N
T
V
Site 12
S153
S
I
R
S
S
K
L
S
E
N
T
V
I
V
G
Site 13
S171
R
V
D
R
E
E
L
S
V
M
P
F
I
S
A
Site 14
T181
P
F
I
S
A
G
F
T
R
R
Y
V
E
N
P
Site 15
Y184
S
A
G
F
T
R
R
Y
V
E
N
P
N
I
M
Site 16
Y194
N
P
N
I
M
A
C
Y
N
E
L
L
Q
L
E
Site 17
T219
R
A
C
N
S
V
F
T
A
L
E
N
S
E
D
Site 18
S232
E
D
A
I
E
I
T
S
E
D
R
F
I
Q
Y
Site 19
Y239
S
E
D
R
F
I
Q
Y
A
N
P
A
F
E
T
Site 20
Y250
A
F
E
T
T
M
G
Y
Q
S
G
E
L
I
G
Site 21
T275
K
K
A
D
L
L
D
T
I
N
S
C
I
R
I
Site 22
S278
D
L
L
D
T
I
N
S
C
I
R
I
G
K
E
Site 23
Y290
G
K
E
W
Q
G
I
Y
Y
A
K
K
K
N
G
Site 24
Y291
K
E
W
Q
G
I
Y
Y
A
K
K
K
N
G
D
Site 25
Y319
Q
G
G
K
I
R
H
Y
V
S
I
I
R
V
C
Site 26
S341
K
I
S
E
C
V
Q
S
D
T
H
T
D
N
Q
Site 27
T345
C
V
Q
S
D
T
H
T
D
N
Q
T
G
K
H
Site 28
S359
H
K
D
R
R
K
G
S
L
D
V
K
A
V
A
Site 29
S367
L
D
V
K
A
V
A
S
R
A
T
E
V
S
S
Site 30
T370
K
A
V
A
S
R
A
T
E
V
S
S
Q
R
R
Site 31
S373
A
S
R
A
T
E
V
S
S
Q
R
R
H
S
S
Site 32
S374
S
R
A
T
E
V
S
S
Q
R
R
H
S
S
M
Site 33
S379
V
S
S
Q
R
R
H
S
S
M
A
R
I
H
S
Site 34
S380
S
S
Q
R
R
H
S
S
M
A
R
I
H
S
M
Site 35
S386
S
S
M
A
R
I
H
S
M
T
I
E
A
P
I
Site 36
S407
I
N
A
A
Q
E
S
S
P
M
P
V
T
E
A
Site 37
T412
E
S
S
P
M
P
V
T
E
A
L
D
R
V
L
Site 38
T424
R
V
L
E
I
L
R
T
T
E
L
Y
S
P
Q
Site 39
Y428
I
L
R
T
T
E
L
Y
S
P
Q
F
G
A
K
Site 40
S429
L
R
T
T
E
L
Y
S
P
Q
F
G
A
K
D
Site 41
S457
S
D
G
L
R
R
L
S
G
N
E
Y
V
L
S
Site 42
Y461
R
R
L
S
G
N
E
Y
V
L
S
T
K
N
T
Site 43
S464
S
G
N
E
Y
V
L
S
T
K
N
T
Q
M
V
Site 44
T465
G
N
E
Y
V
L
S
T
K
N
T
Q
M
V
S
Site 45
T468
Y
V
L
S
T
K
N
T
Q
M
V
S
S
N
I
Site 46
S480
S
N
I
I
T
P
I
S
L
D
D
V
P
P
R
Site 47
Y497
R
A
M
E
N
E
E
Y
W
D
F
D
I
F
E
Site 48
S536
E
F
L
H
C
S
E
S
T
L
R
S
W
L
Q
Site 49
T537
F
L
H
C
S
E
S
T
L
R
S
W
L
Q
I
Site 50
S540
C
S
E
S
T
L
R
S
W
L
Q
I
I
E
A
Site 51
Y549
L
Q
I
I
E
A
N
Y
H
S
S
N
P
Y
H
Site 52
Y555
N
Y
H
S
S
N
P
Y
H
N
S
T
H
S
A
Site 53
S558
S
S
N
P
Y
H
N
S
T
H
S
A
D
V
L
Site 54
S561
P
Y
H
N
S
T
H
S
A
D
V
L
H
A
T
Site 55
Y570
D
V
L
H
A
T
A
Y
F
L
S
K
E
R
I
Site 56
S606
D
H
P
G
R
T
N
S
F
L
C
N
A
G
S
Site 57
Y654
K
N
M
E
R
N
D
Y
R
T
L
R
Q
G
I
Site 58
T656
M
E
R
N
D
Y
R
T
L
R
Q
G
I
I
D
Site 59
T697
T
L
E
E
N
G
E
T
D
K
N
Q
E
V
I
Site 60
T706
K
N
Q
E
V
I
N
T
M
L
R
T
P
E
N
Site 61
T710
V
I
N
T
M
L
R
T
P
E
N
R
T
L
I
Site 62
S728
L
I
K
C
A
D
V
S
N
P
C
R
P
L
Q
Site 63
S745
I
E
W
A
A
R
I
S
E
E
Y
F
S
Q
T
Site 64
Y748
A
A
R
I
S
E
E
Y
F
S
Q
T
D
E
E
Site 65
S750
R
I
S
E
E
Y
F
S
Q
T
D
E
E
K
Q
Site 66
T771
M
P
V
F
D
R
N
T
C
S
I
P
K
S
Q
Site 67
S773
V
F
D
R
N
T
C
S
I
P
K
S
Q
I
S
Site 68
Y812
H
L
D
N
N
F
K
Y
W
K
G
L
D
E
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation