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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRMT3
Full Name:
Protein arginine N-methyltransferase 3
Alias:
ANM3; EC 2.1.1.-; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3; HMT1 hnRNP methyltransferase-like 3; HRMT1L3; Protein arginine methyltransferase 3
Type:
Methyltransferase; EC 2.1.1.-
Mass (Da):
59903
Number AA:
531
UniProt ID:
O60678
International Prot ID:
IPI00401321
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0016274
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
E
E
D
L
P
E
L
S
D
S
G
D
E
A
A
Site 2
S27
D
L
P
E
L
S
D
S
G
D
E
A
A
W
E
Site 3
T48
L
P
H
G
K
Q
Q
T
P
C
L
F
C
N
R
Site 4
S59
F
C
N
R
L
F
T
S
A
E
E
T
F
S
H
Site 5
T63
L
F
T
S
A
E
E
T
F
S
H
C
K
S
E
Site 6
S65
T
S
A
E
E
T
F
S
H
C
K
S
E
H
Q
Site 7
Y87
H
K
H
G
L
E
F
Y
G
Y
I
K
L
I
N
Site 8
T102
F
I
R
L
K
N
P
T
V
E
Y
M
N
S
I
Site 9
Y105
L
K
N
P
T
V
E
Y
M
N
S
I
Y
N
P
Site 10
Y110
V
E
Y
M
N
S
I
Y
N
P
V
P
W
E
K
Site 11
Y120
V
P
W
E
K
E
E
Y
L
K
P
V
L
E
D
Site 12
Y139
Q
F
D
V
E
D
L
Y
E
P
V
S
V
P
F
Site 13
S143
E
D
L
Y
E
P
V
S
V
P
F
S
Y
P
N
Site 14
S147
E
P
V
S
V
P
F
S
Y
P
N
G
L
S
E
Site 15
Y148
P
V
S
V
P
F
S
Y
P
N
G
L
S
E
N
Site 16
S153
F
S
Y
P
N
G
L
S
E
N
T
S
V
V
E
Site 17
S157
N
G
L
S
E
N
T
S
V
V
E
K
L
K
H
Site 18
S171
H
M
E
A
R
A
L
S
A
E
A
A
L
A
R
Site 19
T197
A
Q
D
F
V
M
H
T
D
V
R
T
C
S
S
Site 20
T201
V
M
H
T
D
V
R
T
C
S
S
S
T
S
V
Site 21
S203
H
T
D
V
R
T
C
S
S
S
T
S
V
I
A
Site 22
S204
T
D
V
R
T
C
S
S
S
T
S
V
I
A
D
Site 23
S207
R
T
C
S
S
S
T
S
V
I
A
D
L
Q
E
Site 24
Y220
Q
E
D
E
D
G
V
Y
F
S
S
Y
G
H
Y
Site 25
Y224
D
G
V
Y
F
S
S
Y
G
H
Y
G
I
H
E
Site 26
Y227
Y
F
S
S
Y
G
H
Y
G
I
H
E
E
M
L
Site 27
S242
K
D
K
I
R
T
E
S
Y
R
D
F
I
Y
Q
Site 28
Y248
E
S
Y
R
D
F
I
Y
Q
N
P
H
I
F
K
Site 29
Y291
V
D
Q
S
E
I
L
Y
Q
A
M
D
I
I
R
Site 30
T307
N
K
L
E
D
T
I
T
L
I
K
G
K
I
E
Site 31
S343
L
F
E
S
M
L
D
S
V
L
Y
A
K
N
K
Site 32
Y346
S
M
L
D
S
V
L
Y
A
K
N
K
Y
L
A
Site 33
Y351
V
L
Y
A
K
N
K
Y
L
A
K
G
G
S
V
Site 34
S357
K
Y
L
A
K
G
G
S
V
Y
P
D
I
C
T
Site 35
Y387
I
A
F
W
D
D
V
Y
G
F
K
M
S
C
M
Site 36
S414
L
D
P
K
T
L
I
S
E
P
C
G
I
K
H
Site 37
T426
I
K
H
I
D
C
H
T
T
S
I
S
D
L
E
Site 38
S428
H
I
D
C
H
T
T
S
I
S
D
L
E
F
S
Site 39
S430
D
C
H
T
T
S
I
S
D
L
E
F
S
S
D
Site 40
T439
L
E
F
S
S
D
F
T
L
K
I
T
R
T
S
Site 41
Y458
I
A
G
Y
F
D
I
Y
F
E
K
N
C
H
N
Site 42
T471
H
N
R
V
V
F
S
T
G
P
Q
S
T
K
T
Site 43
T478
T
G
P
Q
S
T
K
T
H
W
K
Q
T
V
F
Site 44
T504
E
A
L
K
G
K
V
T
V
H
K
N
K
K
D
Site 45
S514
K
N
K
K
D
P
R
S
L
T
V
T
L
T
L
Site 46
T516
K
K
D
P
R
S
L
T
V
T
L
T
L
N
N
Site 47
T518
D
P
R
S
L
T
V
T
L
T
L
N
N
S
T
Site 48
T520
R
S
L
T
V
T
L
T
L
N
N
S
T
Q
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation