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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TPST2
Full Name:
Protein-tyrosine sulfotransferase 2
Alias:
EC 2.8.2.20; Protein-tyrosine sulfotransferase 2; TPST-2
Type:
Enzyme, protein-tyrosine sulfotransferase
Mass (Da):
41912
Number AA:
377
UniProt ID:
O60704
International Prot ID:
IPI00031421
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005783
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0008476
PhosphoSite+
KinaseNET
Biological Process:
GO:0006478
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S40
A
V
L
A
G
L
R
S
P
R
G
A
M
R
P
Site 2
Y62
V
G
T
N
H
V
E
Y
R
Y
G
K
A
M
P
Site 3
S116
M
R
Q
A
W
S
K
S
G
R
E
K
L
R
L
Site 4
T129
R
L
D
E
A
G
V
T
D
E
V
L
D
A
A
Site 5
T162
L
C
N
K
D
P
F
T
L
K
S
S
V
Y
L
Site 6
S165
K
D
P
F
T
L
K
S
S
V
Y
L
S
R
L
Site 7
Y168
F
T
L
K
S
S
V
Y
L
S
R
L
F
P
N
Site 8
S170
L
K
S
S
V
Y
L
S
R
L
F
P
N
S
K
Site 9
S188
M
V
R
D
G
R
A
S
V
H
S
M
I
T
R
Site 10
S191
D
G
R
A
S
V
H
S
M
I
T
R
K
V
T
Site 11
T198
S
M
I
T
R
K
V
T
I
A
G
F
D
L
S
Site 12
S206
I
A
G
F
D
L
S
S
Y
R
D
C
L
T
K
Site 13
Y207
A
G
F
D
L
S
S
Y
R
D
C
L
T
K
W
Site 14
T212
S
S
Y
R
D
C
L
T
K
W
N
K
A
I
E
Site 15
Y237
K
E
K
C
L
P
V
Y
Y
E
Q
L
V
L
H
Site 16
Y238
E
K
C
L
P
V
Y
Y
E
Q
L
V
L
H
P
Site 17
S278
I
G
K
P
G
G
V
S
L
S
K
I
E
R
S
Site 18
S280
K
P
G
G
V
S
L
S
K
I
E
R
S
T
D
Site 19
T286
L
S
K
I
E
R
S
T
D
Q
V
I
K
P
V
Site 20
Y328
A
Q
L
G
Y
D
P
Y
A
N
P
P
N
Y
G
Site 21
Y334
P
Y
A
N
P
P
N
Y
G
N
P
D
P
F
V
Site 22
T345
D
P
F
V
I
N
N
T
Q
R
V
L
K
G
D
Site 23
Y353
Q
R
V
L
K
G
D
Y
K
T
P
A
N
L
K
Site 24
T355
V
L
K
G
D
Y
K
T
P
A
N
L
K
G
Y
Site 25
Y362
T
P
A
N
L
K
G
Y
F
Q
V
N
Q
N
S
Site 26
S369
Y
F
Q
V
N
Q
N
S
T
S
S
H
L
G
S
Site 27
S371
Q
V
N
Q
N
S
T
S
S
H
L
G
S
S
_
Site 28
S372
V
N
Q
N
S
T
S
S
H
L
G
S
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation