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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLA2G6
Full Name:
85 kDa calcium-independent phospholipase A2
Alias:
CaI-PLA2; Calcium-independent phospholipase A2; Cytosolic, calcium-independent phospholipase A2; Group VI phospholipase A2; GVI; GVI PLA2; IPLA2; PA2G6; PARK14; Phospholipase A2, group VI; Phospholipase A2, group VI (cytosolic, calcium-independent); PLA2; PNPLA9
Type:
EC 3.1.1.4; Phospholipase; Lipid Metabolism - ether lipid; Lipid Metabolism - linoleic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - glycerophospholipid
Mass (Da):
89903
Number AA:
806
UniProt ID:
O60733
International Prot ID:
IPI00031476
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0019898
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004623
PhosphoSite+
KinaseNET
Biological Process:
GO:0032049
GO:0008219
GO:0016042
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
S
G
V
T
N
L
F
S
N
P
F
R
V
K
E
Site 2
Y32
K
E
V
A
V
A
D
Y
T
S
S
D
R
V
R
Site 3
T33
E
V
A
V
A
D
Y
T
S
S
D
R
V
R
E
Site 4
S35
A
V
A
D
Y
T
S
S
D
R
V
R
E
E
G
Site 5
T50
Q
L
I
L
F
Q
N
T
P
N
R
T
W
D
C
Site 6
S65
V
L
V
N
P
R
N
S
Q
S
G
F
R
L
F
Site 7
S67
V
N
P
R
N
S
Q
S
G
F
R
L
F
Q
L
Site 8
Y95
S
S
Q
L
L
P
F
Y
E
S
S
P
Q
V
L
Site 9
S97
Q
L
L
P
F
Y
E
S
S
P
Q
V
L
H
T
Site 10
S98
L
L
P
F
Y
E
S
S
P
Q
V
L
H
T
E
Site 11
S121
I
R
N
H
P
S
W
S
V
A
H
L
A
V
E
Site 12
T154
A
E
N
E
E
G
C
T
P
L
H
L
A
C
R
Site 13
Y184
T
Q
M
D
V
T
D
Y
K
G
E
T
V
F
H
Site 14
Y192
K
G
E
T
V
F
H
Y
A
V
Q
G
D
N
S
Site 15
S199
Y
A
V
Q
G
D
N
S
Q
V
L
Q
L
L
G
Site 16
T222
Q
V
N
N
Q
G
L
T
P
L
H
L
A
C
Q
Site 17
Y254
N
I
M
G
P
N
G
Y
P
I
H
S
A
M
K
Site 18
S277
M
I
I
S
M
D
S
S
Q
I
H
S
K
D
P
Site 19
S281
M
D
S
S
Q
I
H
S
K
D
P
R
Y
G
A
Site 20
Y286
I
H
S
K
D
P
R
Y
G
A
S
P
L
H
W
Site 21
S289
K
D
P
R
Y
G
A
S
P
L
H
W
A
K
N
Site 22
S312
K
R
G
C
N
V
N
S
T
S
S
A
G
N
T
Site 23
S314
G
C
N
V
N
S
T
S
S
A
G
N
T
A
L
Site 24
T352
A
R
G
E
H
G
N
T
P
L
H
L
A
M
S
Site 25
T378
V
F
G
A
E
V
D
T
P
N
D
F
G
E
T
Site 26
T385
T
P
N
D
F
G
E
T
P
T
F
L
A
S
K
Site 27
T387
N
D
F
G
E
T
P
T
F
L
A
S
K
I
G
Site 28
S435
A
A
P
H
H
P
F
S
L
E
R
A
Q
P
P
Site 29
S445
R
A
Q
P
P
P
I
S
L
N
N
L
E
L
Q
Site 30
S458
L
Q
D
L
M
H
I
S
R
A
R
K
P
A
F
Site 31
S469
K
P
A
F
I
L
G
S
M
R
D
E
K
R
T
Site 32
T476
S
M
R
D
E
K
R
T
H
D
H
L
L
C
L
Site 33
T508
E
K
A
S
G
V
A
T
K
D
L
F
D
W
V
Site 34
Y536
L
H
S
K
S
M
A
Y
M
R
G
M
Y
F
R
Site 35
Y541
M
A
Y
M
R
G
M
Y
F
R
M
K
D
E
V
Site 36
S552
K
D
E
V
F
R
G
S
R
P
Y
E
S
G
P
Site 37
Y555
V
F
R
G
S
R
P
Y
E
S
G
P
L
E
E
Site 38
T585
R
K
P
K
V
M
L
T
G
T
L
S
D
R
Q
Site 39
T587
P
K
V
M
L
T
G
T
L
S
D
R
Q
P
A
Site 40
S589
V
M
L
T
G
T
L
S
D
R
Q
P
A
E
L
Site 41
Y602
E
L
H
L
F
R
N
Y
D
A
P
E
T
V
R
Site 42
T607
R
N
Y
D
A
P
E
T
V
R
E
P
R
F
N
Site 43
S637
V
W
R
A
A
R
S
S
G
A
A
P
T
Y
F
Site 44
Y643
S
S
G
A
A
P
T
Y
F
R
P
N
G
R
F
Site 45
Y671
A
M
T
E
I
H
E
Y
N
Q
D
L
I
R
K
Site 46
S692
K
K
L
S
I
V
V
S
L
G
T
G
R
S
P
Site 47
T704
R
S
P
Q
V
P
V
T
C
V
D
V
F
R
P
Site 48
S712
C
V
D
V
F
R
P
S
N
P
W
E
L
A
K
Site 49
T720
N
P
W
E
L
A
K
T
V
F
G
A
K
E
L
Site 50
Y788
A
L
W
E
T
E
V
Y
I
Y
E
H
R
E
E
Site 51
Y790
W
E
T
E
V
Y
I
Y
E
H
R
E
E
F
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation