KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PFKFB2
Full Name:
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Alias:
6PF-2-K/Fru-2,6-P2ase heart-type isozyme; 6PF-2-K/Fru-2,6-P2ASE heart-type isozyme; 6-phosphofructo-2-kinase; F262; Fructose-2,6-bisphosphatase; PFK-2/FBPase-2; PFK-2/FBPase-2, heart type
Type:
Phosphatase (non-protein); EC 2.7.1.105; Carbohydrate Metabolism - fructose and mannose; Kinase (non-protein); EC 3.1.3.46
Mass (Da):
58477
Number AA:
505
UniProt ID:
O60825
International Prot ID:
IPI00305589
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0003873
GO:0005524
GO:0004331
PhosphoSite+
KinaseNET
Biological Process:
GO:0006003
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
G
A
S
S
S
E
Q
N
N
N
S
Site 2
S7
_
M
S
G
A
S
S
S
E
Q
N
N
N
S
Y
Site 3
S13
S
S
E
Q
N
N
N
S
Y
E
T
K
T
P
N
Site 4
Y14
S
E
Q
N
N
N
S
Y
E
T
K
T
P
N
L
Site 5
T18
N
N
S
Y
E
T
K
T
P
N
L
R
M
S
E
Site 6
S24
K
T
P
N
L
R
M
S
E
K
K
C
S
W
A
Site 7
S32
E
K
K
C
S
W
A
S
Y
M
T
N
S
P
T
Site 8
Y33
K
K
C
S
W
A
S
Y
M
T
N
S
P
T
L
Site 9
T52
G
L
P
A
R
G
K
T
Y
V
S
K
K
L
T
Site 10
Y53
L
P
A
R
G
K
T
Y
V
S
K
K
L
T
R
Site 11
S55
A
R
G
K
T
Y
V
S
K
K
L
T
R
Y
L
Site 12
T59
T
Y
V
S
K
K
L
T
R
Y
L
N
W
I
G
Site 13
Y61
V
S
K
K
L
T
R
Y
L
N
W
I
G
V
P
Site 14
S84
Y
R
R
E
A
V
K
S
Y
K
S
Y
D
F
F
Site 15
S87
E
A
V
K
S
Y
K
S
Y
D
F
F
R
H
D
Site 16
Y88
A
V
K
S
Y
K
S
Y
D
F
F
R
H
D
N
Site 17
S174
N
I
L
E
V
K
V
S
S
P
D
Y
P
E
R
Site 18
S175
I
L
E
V
K
V
S
S
P
D
Y
P
E
R
N
Site 19
Y178
V
K
V
S
S
P
D
Y
P
E
R
N
R
E
N
Site 20
Y197
F
L
K
R
I
E
C
Y
K
V
T
Y
R
P
L
Site 21
T200
R
I
E
C
Y
K
V
T
Y
R
P
L
D
P
D
Site 22
Y209
R
P
L
D
P
D
N
Y
D
K
D
L
S
F
I
Site 23
S214
D
N
Y
D
K
D
L
S
F
I
K
V
I
N
V
Site 24
Y233
L
V
N
R
V
Q
D
Y
I
Q
S
K
I
V
Y
Site 25
Y253
H
V
Q
P
R
T
I
Y
L
C
R
H
G
E
S
Site 26
S260
Y
L
C
R
H
G
E
S
E
F
N
L
L
G
K
Site 27
S272
L
G
K
I
G
G
D
S
G
L
S
V
R
G
K
Site 28
S275
I
G
G
D
S
G
L
S
V
R
G
K
Q
F
A
Site 29
T295
F
L
E
E
Q
E
I
T
D
L
K
V
W
T
S
Site 30
S302
T
D
L
K
V
W
T
S
Q
L
K
R
T
I
Q
Site 31
Y337
G
V
C
E
E
M
T
Y
A
E
I
E
K
R
Y
Site 32
Y344
Y
A
E
I
E
K
R
Y
P
E
E
F
A
L
R
Site 33
Y356
A
L
R
D
Q
E
K
Y
L
Y
R
Y
P
G
G
Site 34
Y358
R
D
Q
E
K
Y
L
Y
R
Y
P
G
G
E
S
Site 35
Y360
Q
E
K
Y
L
Y
R
Y
P
G
G
E
S
Y
Q
Site 36
Y366
R
Y
P
G
G
E
S
Y
Q
D
L
V
Q
R
L
Site 37
Y412
K
G
A
D
E
L
P
Y
L
R
C
P
L
H
T
Site 38
T444
L
N
V
E
A
V
N
T
H
R
D
K
P
T
N
Site 39
T450
N
T
H
R
D
K
P
T
N
N
F
P
K
N
Q
Site 40
T458
N
N
F
P
K
N
Q
T
P
V
R
M
R
R
N
Site 41
S466
P
V
R
M
R
R
N
S
F
T
P
L
S
S
S
Site 42
T468
R
M
R
R
N
S
F
T
P
L
S
S
S
N
T
Site 43
S471
R
N
S
F
T
P
L
S
S
S
N
T
I
R
R
Site 44
S473
S
F
T
P
L
S
S
S
N
T
I
R
R
P
R
Site 45
T475
T
P
L
S
S
S
N
T
I
R
R
P
R
N
Y
Site 46
Y482
T
I
R
R
P
R
N
Y
S
V
G
S
R
P
L
Site 47
S483
I
R
R
P
R
N
Y
S
V
G
S
R
P
L
K
Site 48
S486
P
R
N
Y
S
V
G
S
R
P
L
K
P
L
S
Site 49
S493
S
R
P
L
K
P
L
S
P
L
R
A
Q
D
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation