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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
dyskerin
Full Name:
H/ACA ribonucleoprotein complex subunit 4
Alias:
CBF5 homolog; DKC; DKC1; Dyskeratosis congenita 1, dyskerin; Dyskerin; NAP57; NOLA4; Nopp140-associated protein of 57 kDa; Nucleolar protein family A member 4; Nucleolar protein NAP57; SnoRNP protein DKC1; XAP101
Type:
Isomerase; EC 5.4.99.-; RNA processing; RNA binding protein; Lyase
Mass (Da):
57674
Number AA:
514
UniProt ID:
O60832
International Prot ID:
IPI00221394
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015030
GO:0005730
GO:0005697
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005515
GO:0009982
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0001522
GO:0006364
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
K
K
K
K
E
R
K
S
L
P
E
E
D
V
A
Site 2
S42
E
F
L
I
K
P
E
S
K
V
A
K
L
D
T
Site 3
T49
S
K
V
A
K
L
D
T
S
Q
W
P
L
L
L
Site 4
S50
K
V
A
K
L
D
T
S
Q
W
P
L
L
L
K
Site 5
T67
D
K
L
N
V
R
T
T
H
Y
T
P
L
A
C
Site 6
T70
N
V
R
T
T
H
Y
T
P
L
A
C
G
S
N
Site 7
Y86
L
K
R
E
I
G
D
Y
I
R
T
G
F
I
N
Site 8
T89
E
I
G
D
Y
I
R
T
G
F
I
N
L
D
K
Site 9
S98
F
I
N
L
D
K
P
S
N
P
S
S
H
E
V
Site 10
S102
D
K
P
S
N
P
S
S
H
E
V
V
A
W
I
Site 11
T118
R
I
L
R
V
E
K
T
G
H
S
G
T
L
D
Site 12
T123
E
K
T
G
H
S
G
T
L
D
P
K
V
T
G
Site 13
T140
I
V
C
I
E
R
A
T
R
L
V
K
S
Q
Q
Site 14
S145
R
A
T
R
L
V
K
S
Q
Q
S
A
G
K
E
Site 15
Y153
Q
Q
S
A
G
K
E
Y
V
G
I
V
R
L
H
Site 16
S170
I
E
G
G
T
Q
L
S
R
A
L
E
T
L
T
Site 17
T198
K
R
Q
L
R
V
R
T
I
Y
E
S
K
M
I
Site 18
Y200
Q
L
R
V
R
T
I
Y
E
S
K
M
I
E
Y
Site 19
S251
Q
E
L
R
R
V
R
S
G
V
M
S
E
K
D
Site 20
S255
R
V
R
S
G
V
M
S
E
K
D
H
M
V
T
Site 21
Y273
V
L
D
A
Q
W
L
Y
D
N
H
K
D
E
S
Site 22
Y281
D
N
H
K
D
E
S
Y
L
R
R
V
V
Y
P
Site 23
T294
Y
P
L
E
K
L
L
T
S
H
K
R
L
V
M
Site 24
S295
P
L
E
K
L
L
T
S
H
K
R
L
V
M
K
Site 25
T375
R
V
I
M
E
R
D
T
Y
P
R
K
W
G
L
Site 26
Y376
V
I
M
E
R
D
T
Y
P
R
K
W
G
L
G
Site 27
S387
W
G
L
G
P
K
A
S
Q
K
K
L
M
I
K
Site 28
S407
K
H
G
K
P
T
D
S
T
P
A
T
W
K
Q
Site 29
T408
H
G
K
P
T
D
S
T
P
A
T
W
K
Q
E
Site 30
T411
P
T
D
S
T
P
A
T
W
K
Q
E
Y
V
D
Site 31
Y416
P
A
T
W
K
Q
E
Y
V
D
Y
S
E
S
A
Site 32
Y419
W
K
Q
E
Y
V
D
Y
S
E
S
A
K
K
E
Site 33
S420
K
Q
E
Y
V
D
Y
S
E
S
A
K
K
E
V
Site 34
S422
E
Y
V
D
Y
S
E
S
A
K
K
E
V
V
A
Site 35
T444
V
V
A
E
A
A
K
T
A
K
R
K
R
E
S
Site 36
S451
T
A
K
R
K
R
E
S
E
S
E
S
D
E
T
Site 37
S453
K
R
K
R
E
S
E
S
E
S
D
E
T
P
P
Site 38
S455
K
R
E
S
E
S
E
S
D
E
T
P
P
A
A
Site 39
T458
S
E
S
E
S
D
E
T
P
P
A
A
P
Q
L
Site 40
S473
I
K
K
E
K
K
K
S
K
K
D
K
K
A
K
Site 41
S485
K
A
K
A
G
L
E
S
G
A
E
P
G
D
G
Site 42
S494
A
E
P
G
D
G
D
S
D
T
T
K
K
K
K
Site 43
T496
P
G
D
G
D
S
D
T
T
K
K
K
K
K
K
Site 44
T497
G
D
G
D
S
D
T
T
K
K
K
K
K
K
K
Site 45
S513
A
K
E
V
E
L
V
S
E
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation