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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CACNA1F
Full Name:
Voltage-dependent L-type calcium channel subunit alpha-1F
Alias:
Voltage-gated calcium channel subunit alpha Cav1.4
Type:
Mass (Da):
220678
Number AA:
1977
UniProt ID:
O60840
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
E
S
E
G
G
K
D
T
T
P
E
P
S
P
A
Site 2
T11
S
E
G
G
K
D
T
T
P
E
P
S
P
A
N
Site 3
S15
K
D
T
T
P
E
P
S
P
A
N
G
A
G
P
Site 4
S39
P
P
A
V
E
G
E
S
S
G
A
S
G
L
G
Site 5
S40
P
A
V
E
G
E
S
S
G
A
S
G
L
G
T
Site 6
S43
E
G
E
S
S
G
A
S
G
L
G
T
P
K
R
Site 7
T47
S
G
A
S
G
L
G
T
P
K
R
R
N
Q
H
Site 8
S55
P
K
R
R
N
Q
H
S
K
H
K
T
V
A
V
Site 9
T59
N
Q
H
S
K
H
K
T
V
A
V
A
S
A
Q
Site 10
S64
H
K
T
V
A
V
A
S
A
Q
R
S
P
R
A
Site 11
S87
P
L
R
R
S
C
I
S
I
V
E
W
K
P
F
Site 12
S120
I
P
F
P
E
D
D
S
N
T
A
N
H
N
L
Site 13
T122
F
P
E
D
D
S
N
T
A
N
H
N
L
E
Q
Site 14
Y158
L
V
L
H
P
S
A
Y
I
R
N
G
W
N
L
Site 15
T193
R
P
G
D
A
P
H
T
G
G
K
P
G
G
F
Site 16
Y268
G
R
M
H
K
T
C
Y
F
L
G
S
D
M
E
Site 17
S272
K
T
C
Y
F
L
G
S
D
M
E
A
E
E
D
Site 18
S281
M
E
A
E
E
D
P
S
P
C
A
S
S
G
S
Site 19
S285
E
D
P
S
P
C
A
S
S
G
S
G
R
A
C
Site 20
S286
D
P
S
P
C
A
S
S
G
S
G
R
A
C
T
Site 21
S288
S
P
C
A
S
S
G
S
G
R
A
C
T
L
N
Site 22
T293
S
G
S
G
R
A
C
T
L
N
Q
T
E
C
R
Site 23
Y337
E
G
W
T
D
V
L
Y
W
M
Q
D
A
M
G
Site 24
S372
N
L
V
L
G
V
L
S
G
E
F
S
K
E
R
Site 25
S376
G
V
L
S
G
E
F
S
K
E
R
E
K
A
K
Site 26
Y404
M
E
E
D
L
R
G
Y
L
D
W
I
T
Q
A
Site 27
S420
E
L
D
M
E
D
P
S
A
D
D
N
L
G
S
Site 28
S427
S
A
D
D
N
L
G
S
M
A
E
E
G
R
A
Site 29
T444
R
P
Q
L
A
E
L
T
N
R
R
R
G
R
L
Site 30
S455
R
G
R
L
R
W
F
S
H
S
T
R
S
T
H
Site 31
S457
R
L
R
W
F
S
H
S
T
R
S
T
H
S
T
Site 32
S460
W
F
S
H
S
T
R
S
T
H
S
T
S
S
H
Site 33
T461
F
S
H
S
T
R
S
T
H
S
T
S
S
H
A
Site 34
S463
H
S
T
R
S
T
H
S
T
S
S
H
A
S
L
Site 35
T464
S
T
R
S
T
H
S
T
S
S
H
A
S
L
P
Site 36
S465
T
R
S
T
H
S
T
S
S
H
A
S
L
P
A
Site 37
S466
R
S
T
H
S
T
S
S
H
A
S
L
P
A
S
Site 38
S469
H
S
T
S
S
H
A
S
L
P
A
S
D
T
G
Site 39
S473
S
H
A
S
L
P
A
S
D
T
G
S
M
T
E
Site 40
T475
A
S
L
P
A
S
D
T
G
S
M
T
E
T
Q
Site 41
S477
L
P
A
S
D
T
G
S
M
T
E
T
Q
G
D
Site 42
T481
D
T
G
S
M
T
E
T
Q
G
D
E
D
E
E
Site 43
S494
E
E
E
G
A
L
A
S
C
T
R
C
L
N
K
Site 44
Y588
Y
G
L
G
P
S
A
Y
V
S
S
F
F
N
R
Site 45
S590
L
G
P
S
A
Y
V
S
S
F
F
N
R
F
D
Site 46
S591
G
P
S
A
Y
V
S
S
F
F
N
R
F
D
C
Site 47
S641
K
V
T
R
H
W
A
S
L
S
N
L
V
A
S
Site 48
T687
G
K
F
N
F
D
Q
T
H
T
K
R
S
T
F
Site 49
T693
Q
T
H
T
K
R
S
T
F
D
T
F
P
Q
A
Site 50
T696
T
K
R
S
T
F
D
T
F
P
Q
A
L
L
T
Site 51
Y718
E
D
W
N
V
V
M
Y
D
G
I
M
A
Y
G
Site 52
S777
K
D
K
G
G
E
K
S
N
E
K
D
L
P
Q
Site 53
S855
G
S
A
F
F
C
L
S
Q
T
N
P
L
R
K
Site 54
S898
E
D
P
I
R
A
H
S
F
R
N
H
I
L
G
Site 55
Y906
F
R
N
H
I
L
G
Y
F
D
Y
A
F
T
S
Site 56
S938
H
R
G
S
F
C
R
S
W
F
N
M
L
D
L
Site 57
S960
I
S
F
G
I
H
S
S
A
I
S
V
V
K
I
Site 58
T1030
K
G
K
F
Y
T
C
T
D
E
A
K
H
T
P
Site 59
T1036
C
T
D
E
A
K
H
T
P
Q
E
C
K
G
S
Site 60
S1043
T
P
Q
E
C
K
G
S
F
L
V
Y
P
D
G
Site 61
Y1047
C
K
G
S
F
L
V
Y
P
D
G
D
V
S
R
Site 62
S1053
V
Y
P
D
G
D
V
S
R
P
L
V
R
E
R
Site 63
Y1099
L
Y
K
A
I
D
A
Y
A
E
D
H
G
P
I
Site 64
Y1107
A
E
D
H
G
P
I
Y
N
Y
R
V
E
I
S
Site 65
Y1109
D
H
G
P
I
Y
N
Y
R
V
E
I
S
V
F
Site 66
Y1148
R
A
Q
G
E
Q
E
Y
Q
N
C
E
L
D
K
Site 67
Y1163
N
Q
R
Q
C
V
E
Y
A
L
K
A
Q
P
L
Site 68
Y1173
K
A
Q
P
L
R
R
Y
I
P
K
N
P
H
Q
Site 69
Y1212
V
A
L
A
M
Q
H
Y
E
Q
T
A
P
F
N
Site 70
S1283
N
G
G
H
L
G
E
S
S
E
D
S
S
R
I
Site 71
S1284
G
G
H
L
G
E
S
S
E
D
S
S
R
I
S
Site 72
S1287
L
G
E
S
S
E
D
S
S
R
I
S
I
T
F
Site 73
S1288
G
E
S
S
E
D
S
S
R
I
S
I
T
F
F
Site 74
S1291
S
E
D
S
S
R
I
S
I
T
F
F
R
L
F
Site 75
S1308
M
R
L
V
K
L
L
S
K
G
E
G
I
R
T
Site 76
T1315
S
K
G
E
G
I
R
T
L
L
W
T
F
I
K
Site 77
S1402
G
N
R
C
D
P
E
S
D
F
G
P
G
E
E
Site 78
Y1446
V
I
M
D
N
F
D
Y
L
T
R
D
W
S
I
Site 79
S1452
D
Y
L
T
R
D
W
S
I
L
G
P
H
H
L
Site 80
S1467
D
E
F
K
R
I
W
S
E
Y
D
P
G
A
K
Site 81
Y1469
F
K
R
I
W
S
E
Y
D
P
G
A
K
G
R
Site 82
T1579
P
P
D
E
E
E
V
T
V
G
K
F
Y
A
T
Site 83
Y1592
A
T
F
L
I
Q
D
Y
F
R
K
F
R
R
R
Site 84
S1612
L
G
N
D
A
A
P
S
T
S
S
A
L
Q
A
Site 85
S1623
A
L
Q
A
G
L
R
S
L
Q
D
L
G
P
E
Site 86
T1636
P
E
M
R
Q
A
L
T
C
D
T
E
E
E
E
Site 87
T1639
R
Q
A
L
T
C
D
T
E
E
E
E
E
E
G
Site 88
S1667
T
N
K
A
T
M
V
S
Q
P
S
A
R
R
G
Site 89
S1670
A
T
M
V
S
Q
P
S
A
R
R
G
S
G
I
Site 90
S1675
Q
P
S
A
R
R
G
S
G
I
S
V
S
L
P
Site 91
S1678
A
R
R
G
S
G
I
S
V
S
L
P
V
G
D
Site 92
S1680
R
G
S
G
I
S
V
S
L
P
V
G
D
R
L
Site 93
S1690
V
G
D
R
L
P
D
S
L
S
F
G
P
S
D
Site 94
S1692
D
R
L
P
D
S
L
S
F
G
P
S
D
D
D
Site 95
S1696
D
S
L
S
F
G
P
S
D
D
D
R
G
T
P
Site 96
T1702
P
S
D
D
D
R
G
T
P
T
S
S
Q
P
S
Site 97
S1705
D
D
R
G
T
P
T
S
S
Q
P
S
V
P
Q
Site 98
S1706
D
R
G
T
P
T
S
S
Q
P
S
V
P
Q
A
Site 99
S1709
T
P
T
S
S
Q
P
S
V
P
Q
A
G
S
N
Site 100
S1715
P
S
V
P
Q
A
G
S
N
T
H
R
R
G
S
Site 101
T1717
V
P
Q
A
G
S
N
T
H
R
R
G
S
G
A
Site 102
S1722
S
N
T
H
R
R
G
S
G
A
L
I
F
T
I
Site 103
S1735
T
I
P
E
E
G
N
S
Q
P
K
G
T
K
G
Site 104
S1757
E
E
V
P
D
R
L
S
Y
L
D
E
Q
A
G
Site 105
Y1758
E
V
P
D
R
L
S
Y
L
D
E
Q
A
G
T
Site 106
S1769
Q
A
G
T
P
P
C
S
V
L
L
P
P
H
R
Site 107
T1795
R
R
R
L
L
P
P
T
P
A
G
R
K
P
S
Site 108
S1802
T
P
A
G
R
K
P
S
F
T
I
Q
C
L
Q
Site 109
T1804
A
G
R
K
P
S
F
T
I
Q
C
L
Q
R
Q
Site 110
S1813
Q
C
L
Q
R
Q
G
S
C
E
D
L
P
I
P
Site 111
T1822
E
D
L
P
I
P
G
T
Y
H
R
G
R
N
S
Site 112
Y1823
D
L
P
I
P
G
T
Y
H
R
G
R
N
S
G
Site 113
S1829
T
Y
H
R
G
R
N
S
G
P
N
R
A
Q
G
Site 114
T1840
R
A
Q
G
S
W
A
T
P
P
Q
R
G
R
L
Site 115
Y1849
P
Q
R
G
R
L
L
Y
A
P
L
L
L
V
E
Site 116
Y1864
E
G
A
A
G
E
G
Y
L
G
R
S
S
G
P
Site 117
S1869
E
G
Y
L
G
R
S
S
G
P
L
R
T
F
T
Site 118
T1874
R
S
S
G
P
L
R
T
F
T
C
L
H
V
P
Site 119
T1883
T
C
L
H
V
P
G
T
H
S
D
P
S
H
G
Site 120
S1888
P
G
T
H
S
D
P
S
H
G
K
R
G
S
A
Site 121
S1894
P
S
H
G
K
R
G
S
A
D
S
L
V
E
A
Site 122
T1932
I
A
D
A
C
R
L
T
L
D
E
M
D
N
A
Site 123
S1949
D
L
L
A
Q
G
T
S
S
L
Y
S
D
E
E
Site 124
S1950
L
L
A
Q
G
T
S
S
L
Y
S
D
E
E
S
Site 125
Y1952
A
Q
G
T
S
S
L
Y
S
D
E
E
S
I
L
Site 126
S1953
Q
G
T
S
S
L
Y
S
D
E
E
S
I
L
S
Site 127
S1957
S
L
Y
S
D
E
E
S
I
L
S
R
F
D
E
Site 128
S1960
S
D
E
E
S
I
L
S
R
F
D
E
E
D
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation