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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EIF5B
Full Name:
Eukaryotic translation initiation factor 5B
Alias:
Translation initiation factor IF-2
Type:
Translation protein, initiation complex
Mass (Da):
138827
Number AA:
1220
UniProt ID:
O60841
International Prot ID:
IPI00299254
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006446
GO:0006412
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
G
K
K
Q
K
N
K
S
E
D
S
T
K
D
D
Site 2
S12
Q
K
N
K
S
E
D
S
T
K
D
D
I
D
L
Site 3
T13
K
N
K
S
E
D
S
T
K
D
D
I
D
L
D
Site 4
S40
K
E
Q
E
P
Q
K
S
K
G
K
K
K
K
E
Site 5
S66
L
K
E
L
E
E
L
S
L
E
A
Q
G
I
K
Site 6
T78
G
I
K
A
D
R
E
T
V
A
V
K
P
T
E
Site 7
T92
E
N
N
E
E
E
F
T
S
K
D
K
K
K
K
Site 8
S107
G
Q
K
G
K
K
Q
S
F
D
D
N
D
S
E
Site 9
S113
Q
S
F
D
D
N
D
S
E
E
L
E
D
K
D
Site 10
S121
E
E
L
E
D
K
D
S
K
S
K
K
T
A
K
Site 11
S123
L
E
D
K
D
S
K
S
K
K
T
A
K
P
K
Site 12
Y134
A
K
P
K
V
E
M
Y
S
G
S
D
D
D
D
Site 13
S135
K
P
K
V
E
M
Y
S
G
S
D
D
D
D
D
Site 14
S137
K
V
E
M
Y
S
G
S
D
D
D
D
D
F
N
Site 15
S157
A
K
G
K
A
Q
K
S
N
K
K
W
D
G
S
Site 16
S164
S
N
K
K
W
D
G
S
E
E
D
E
D
N
S
Site 17
S171
S
E
E
D
E
D
N
S
K
K
I
K
E
R
S
Site 18
S178
S
K
K
I
K
E
R
S
R
I
N
S
S
G
E
Site 19
S182
K
E
R
S
R
I
N
S
S
G
E
S
G
D
E
Site 20
S183
E
R
S
R
I
N
S
S
G
E
S
G
D
E
S
Site 21
S186
R
I
N
S
S
G
E
S
G
D
E
S
D
E
F
Site 22
S190
S
G
E
S
G
D
E
S
D
E
F
L
Q
S
R
Site 23
S196
E
S
D
E
F
L
Q
S
R
K
G
Q
K
K
N
Site 24
S214
K
P
G
P
N
I
E
S
G
N
E
D
D
D
A
Site 25
S222
G
N
E
D
D
D
A
S
F
K
I
K
T
V
A
Site 26
T227
D
A
S
F
K
I
K
T
V
A
Q
K
K
A
E
Site 27
T261
K
E
K
E
E
L
E
T
G
K
K
D
Q
S
K
Site 28
S267
E
T
G
K
K
D
Q
S
K
Q
K
E
S
Q
R
Site 29
S272
D
Q
S
K
Q
K
E
S
Q
R
K
F
E
E
E
Site 30
S283
F
E
E
E
T
V
K
S
K
V
T
V
D
T
G
Site 31
S295
D
T
G
V
I
P
A
S
E
E
K
A
E
T
P
Site 32
T301
A
S
E
E
K
A
E
T
P
T
A
A
E
D
D
Site 33
T303
E
E
K
A
E
T
P
T
A
A
E
D
D
N
E
Site 34
S411
E
G
K
L
L
T
K
S
Q
R
E
A
R
A
R
Site 35
S435
A
Q
G
V
E
V
P
S
K
D
S
L
P
K
K
Site 36
S438
V
E
V
P
S
K
D
S
L
P
K
K
R
P
I
Site 37
Y446
L
P
K
K
R
P
I
Y
E
D
K
K
R
K
K
Site 38
S460
K
I
P
Q
Q
L
E
S
K
E
V
S
E
S
M
Site 39
S464
Q
L
E
S
K
E
V
S
E
S
M
E
L
C
A
Site 40
T486
G
V
P
E
K
E
E
T
P
P
P
V
E
P
E
Site 41
T498
E
P
E
E
E
E
D
T
E
D
A
G
L
D
D
Site 42
S511
D
D
W
E
A
M
A
S
D
E
E
T
E
K
V
Site 43
T515
A
M
A
S
D
E
E
T
E
K
V
E
G
N
T
Site 44
S547
E
E
E
E
D
E
E
S
E
E
E
E
E
E
E
Site 45
S557
E
E
E
E
E
G
E
S
E
G
S
E
G
D
E
Site 46
S560
E
E
G
E
S
E
G
S
E
G
D
E
E
D
E
Site 47
S570
D
E
E
D
E
K
V
S
D
E
K
D
S
G
K
Site 48
T578
D
E
K
D
S
G
K
T
L
D
K
K
P
S
K
Site 49
S584
K
T
L
D
K
K
P
S
K
E
M
S
S
D
S
Site 50
S588
K
K
P
S
K
E
M
S
S
D
S
E
Y
D
S
Site 51
S589
K
P
S
K
E
M
S
S
D
S
E
Y
D
S
D
Site 52
S591
S
K
E
M
S
S
D
S
E
Y
D
S
D
D
D
Site 53
Y593
E
M
S
S
D
S
E
Y
D
S
D
D
D
R
T
Site 54
S595
S
S
D
S
E
Y
D
S
D
D
D
R
T
K
E
Site 55
T600
Y
D
S
D
D
D
R
T
K
E
E
R
A
Y
D
Site 56
Y606
R
T
K
E
E
R
A
Y
D
K
A
K
R
R
I
Site 57
S621
E
K
R
R
L
E
H
S
K
N
V
N
T
E
K
Site 58
T654
I
L
D
K
L
R
H
T
H
V
Q
D
G
E
A
Site 59
T703
P
G
M
L
I
I
D
T
P
G
H
E
S
F
S
Site 60
S708
I
D
T
P
G
H
E
S
F
S
N
L
R
N
R
Site 61
S717
S
N
L
R
N
R
G
S
S
L
C
D
I
A
I
Site 62
Y762
L
N
K
I
D
R
L
Y
D
W
K
K
S
P
D
Site 63
S767
R
L
Y
D
W
K
K
S
P
D
S
D
V
A
A
Site 64
S770
D
W
K
K
S
P
D
S
D
V
A
A
T
L
K
Site 65
T816
Y
E
N
K
D
P
R
T
F
V
S
L
V
P
T
Site 66
S819
K
D
P
R
T
F
V
S
L
V
P
T
S
A
H
Site 67
S847
E
L
T
Q
T
M
L
S
K
R
L
A
H
C
E
Site 68
T887
G
R
L
K
E
G
D
T
I
I
V
P
G
V
E
Site 69
Y919
E
L
R
V
K
N
Q
Y
E
K
H
K
E
V
E
Site 70
T970
L
I
H
E
L
K
Q
T
L
N
A
I
K
L
E
Site 71
Y982
K
L
E
E
K
G
V
Y
V
Q
A
S
T
L
G
Site 72
T1000
A
L
L
E
F
L
K
T
S
E
V
P
Y
A
G
Site 73
S1001
L
L
E
F
L
K
T
S
E
V
P
Y
A
G
I
Site 74
Y1005
L
K
T
S
E
V
P
Y
A
G
I
N
I
G
P
Site 75
S1022
K
K
D
V
M
K
A
S
V
M
L
E
H
D
P
Site 76
S1051
D
A
Q
E
M
A
D
S
L
G
V
R
I
F
S
Site 77
Y1072
L
F
D
A
F
T
K
Y
R
Q
D
Y
K
K
Q
Site 78
Y1076
F
T
K
Y
R
Q
D
Y
K
K
Q
K
Q
E
E
Site 79
Y1100
K
I
K
I
L
P
Q
Y
I
F
N
S
R
D
P
Site 80
S1104
L
P
Q
Y
I
F
N
S
R
D
P
I
V
M
G
Site 81
T1123
A
G
Q
V
K
Q
G
T
P
M
C
V
P
S
K
Site 82
S1168
I
E
P
I
P
G
E
S
P
K
M
F
G
R
H
Site 83
S1184
E
A
T
D
I
L
V
S
K
I
S
R
Q
S
I
Site 84
S1190
V
S
K
I
S
R
Q
S
I
D
A
L
K
D
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation