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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
OPHN1
Full Name:
Oligophrenin-1
Alias:
MRX60; oligophrenin 1; oligophrenin-1, Rho-GTPase activating protein; OPN1
Type:
GTPase activating protein, Rac/Rho
Mass (Da):
91641
Number AA:
802
UniProt ID:
O60890
International Prot ID:
IPI00001762
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030424
GO:0030054
GO:0043197
Uniprot
OncoNet
Molecular Function:
GO:0005100
PhosphoSite+
KinaseNET
Biological Process:
GO:0007411
GO:0006897
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
G
H
P
P
L
E
F
S
D
C
Y
L
D
S
P
Site 2
Y12
P
L
E
F
S
D
C
Y
L
D
S
P
D
F
R
Site 3
S15
F
S
D
C
Y
L
D
S
P
D
F
R
E
R
L
Site 4
S48
K
D
G
N
A
L
I
S
A
M
R
N
Y
S
S
Site 5
Y53
L
I
S
A
M
R
N
Y
S
S
A
V
Q
K
F
Site 6
S54
I
S
A
M
R
N
Y
S
S
A
V
Q
K
F
S
Site 7
S55
S
A
M
R
N
Y
S
S
A
V
Q
K
F
S
Q
Site 8
S61
S
S
A
V
Q
K
F
S
Q
T
L
Q
S
F
Q
Site 9
S66
K
F
S
Q
T
L
Q
S
F
Q
F
D
F
I
G
Site 10
T75
Q
F
D
F
I
G
D
T
L
T
D
D
E
I
N
Site 11
T77
D
F
I
G
D
T
L
T
D
D
E
I
N
I
A
Site 12
S86
D
E
I
N
I
A
E
S
F
K
E
F
A
E
L
Site 13
Y142
E
K
D
G
E
R
F
Y
S
L
L
D
R
H
L
Site 14
S143
K
D
G
E
R
F
Y
S
L
L
D
R
H
L
H
Site 15
S152
L
D
R
H
L
H
L
S
S
K
K
K
E
S
Q
Site 16
S153
D
R
H
L
H
L
S
S
K
K
K
E
S
Q
L
Site 17
Y181
F
F
E
S
S
L
D
Y
V
Y
Q
I
Q
E
V
Site 18
Y183
E
S
S
L
D
Y
V
Y
Q
I
Q
E
V
Q
E
Site 19
S191
Q
I
Q
E
V
Q
E
S
K
K
F
N
I
V
E
Site 20
T218
N
S
L
T
V
E
L
T
Q
D
F
L
P
Y
K
Site 21
S231
Y
K
Q
Q
L
Q
L
S
L
Q
N
T
R
N
H
Site 22
T235
L
Q
L
S
L
Q
N
T
R
N
H
F
S
S
T
Site 23
S240
Q
N
T
R
N
H
F
S
S
T
R
E
E
M
E
Site 24
S241
N
T
R
N
H
F
S
S
T
R
E
E
M
E
E
Site 25
T259
R
M
K
E
A
P
Q
T
C
K
L
P
G
Q
P
Site 26
T267
C
K
L
P
G
Q
P
T
I
E
G
Y
L
Y
T
Site 27
Y271
G
Q
P
T
I
E
G
Y
L
Y
T
Q
E
K
W
Site 28
Y273
P
T
I
E
G
Y
L
Y
T
Q
E
K
W
A
L
Site 29
Y287
L
G
I
S
W
V
K
Y
Y
C
Q
Y
E
K
E
Site 30
T297
Q
Y
E
K
E
T
K
T
L
T
M
T
P
M
E
Site 31
T299
E
K
E
T
K
T
L
T
M
T
P
M
E
Q
K
Site 32
T301
E
T
K
T
L
T
M
T
P
M
E
Q
K
P
G
Site 33
T317
K
Q
G
P
L
D
L
T
L
K
Y
C
V
R
R
Site 34
Y320
P
L
D
L
T
L
K
Y
C
V
R
R
K
T
E
Site 35
T326
K
Y
C
V
R
R
K
T
E
S
I
D
K
R
F
Site 36
T339
R
F
C
F
D
I
E
T
N
E
R
P
G
T
I
Site 37
T345
E
T
N
E
R
P
G
T
I
T
L
Q
A
L
S
Site 38
T347
N
E
R
P
G
T
I
T
L
Q
A
L
S
E
A
Site 39
S352
T
I
T
L
Q
A
L
S
E
A
N
R
R
L
W
Site 40
Y370
M
D
G
K
E
P
I
Y
H
S
P
I
T
K
Q
Site 41
S372
G
K
E
P
I
Y
H
S
P
I
T
K
Q
Q
E
Site 42
Y408
G
I
K
T
E
G
L
Y
R
T
V
G
S
N
I
Site 43
T410
K
T
E
G
L
Y
R
T
V
G
S
N
I
Q
V
Site 44
T444
N
S
D
W
D
I
K
T
I
T
S
S
L
K
F
Site 45
S448
D
I
K
T
I
T
S
S
L
K
F
Y
L
R
N
Site 46
Y452
I
T
S
S
L
K
F
Y
L
R
N
L
S
E
P
Site 47
S457
K
F
Y
L
R
N
L
S
E
P
V
M
T
Y
R
Site 48
T462
N
L
S
E
P
V
M
T
Y
R
L
H
K
E
L
Site 49
S471
R
L
H
K
E
L
V
S
A
A
K
S
D
N
L
Site 50
S475
E
L
V
S
A
A
K
S
D
N
L
D
Y
R
L
Site 51
Y480
A
K
S
D
N
L
D
Y
R
L
G
A
I
H
S
Site 52
Y490
G
A
I
H
S
L
V
Y
K
L
P
E
K
N
R
Site 53
T520
H
S
K
E
N
L
M
T
P
S
N
M
G
V
I
Site 54
Y564
I
E
H
F
G
K
I
Y
L
G
P
P
E
E
S
Site 55
S571
Y
L
G
P
P
E
E
S
A
A
P
P
V
P
P
Site 56
T582
P
V
P
P
P
R
V
T
A
R
R
H
K
P
I
Site 57
T590
A
R
R
H
K
P
I
T
I
S
K
R
L
L
R
Site 58
S592
R
H
K
P
I
T
I
S
K
R
L
L
R
E
R
Site 59
T600
K
R
L
L
R
E
R
T
V
F
Y
T
S
S
L
Site 60
T604
R
E
R
T
V
F
Y
T
S
S
L
D
E
S
E
Site 61
S605
E
R
T
V
F
Y
T
S
S
L
D
E
S
E
D
Site 62
S606
R
T
V
F
Y
T
S
S
L
D
E
S
E
D
E
Site 63
S610
Y
T
S
S
L
D
E
S
E
D
E
I
Q
H
Q
Site 64
T618
E
D
E
I
Q
H
Q
T
P
N
G
T
I
T
S
Site 65
T624
Q
T
P
N
G
T
I
T
S
S
I
E
P
P
K
Site 66
S626
P
N
G
T
I
T
S
S
I
E
P
P
K
P
P
Site 67
S643
P
K
L
P
I
Q
R
S
G
E
T
D
P
G
R
Site 68
S652
E
T
D
P
G
R
K
S
P
S
R
P
I
L
D
Site 69
S654
D
P
G
R
K
S
P
S
R
P
I
L
D
G
K
Site 70
T685
Q
D
G
G
T
K
I
T
P
K
A
T
N
G
P
Site 71
T689
T
K
I
T
P
K
A
T
N
G
P
M
P
G
S
Site 72
S696
T
N
G
P
M
P
G
S
G
P
T
K
T
P
S
Site 73
T699
P
M
P
G
S
G
P
T
K
T
P
S
F
H
I
Site 74
T701
P
G
S
G
P
T
K
T
P
S
F
H
I
K
R
Site 75
S703
S
G
P
T
K
T
P
S
F
H
I
K
R
P
A
Site 76
S724
H
K
E
G
D
A
D
S
F
S
K
V
R
P
P
Site 77
S726
E
G
D
A
D
S
F
S
K
V
R
P
P
G
E
Site 78
T736
R
P
P
G
E
K
P
T
I
I
R
P
P
V
R
Site 79
T753
D
P
P
C
R
A
A
T
P
Q
K
P
E
P
K
Site 80
S773
G
N
A
G
E
I
T
S
S
V
V
A
S
R
T
Site 81
S774
N
A
G
E
I
T
S
S
V
V
A
S
R
T
R
Site 82
T785
S
R
T
R
F
F
E
T
A
S
R
K
T
G
S
Site 83
T790
F
E
T
A
S
R
K
T
G
S
S
Q
G
R
L
Site 84
S792
T
A
S
R
K
T
G
S
S
Q
G
R
L
P
G
Site 85
S793
A
S
R
K
T
G
S
S
Q
G
R
L
P
G
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation