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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMPD2
Full Name:
Sphingomyelin phosphodiesterase 2
Alias:
Lyso-platelet-activating factor-phospholipase C;Neutral sphingomyelinase
Type:
Mass (Da):
Number AA:
UniProt ID:
O60906
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0000287
GO:0004767
PhosphoSite+
KinaseNET
Biological Process:
GO:0008624
GO:0006684
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y21
L
N
C
W
G
I
P
Y
L
S
K
H
R
A
D
Site 2
S41
G
D
F
L
N
Q
E
S
F
D
L
A
L
L
E
Site 3
S52
A
L
L
E
E
V
W
S
E
Q
D
F
Q
Y
L
Site 4
Y58
W
S
E
Q
D
F
Q
Y
L
R
Q
K
L
S
P
Site 5
S64
Q
Y
L
R
Q
K
L
S
P
T
Y
P
A
A
H
Site 6
T66
L
R
Q
K
L
S
P
T
Y
P
A
A
H
H
F
Site 7
Y67
R
Q
K
L
S
P
T
Y
P
A
A
H
H
F
R
Site 8
Y98
Q
E
L
T
Q
H
I
Y
T
L
N
G
Y
P
Y
Site 9
T99
E
L
T
Q
H
I
Y
T
L
N
G
Y
P
Y
M
Site 10
Y141
V
T
H
L
H
A
E
Y
N
R
Q
K
D
I
Y
Site 11
Y148
Y
N
R
Q
K
D
I
Y
L
A
H
R
V
A
Q
Site 12
Y201
W
T
G
L
H
D
A
Y
L
E
T
R
D
F
K
Site 13
S210
E
T
R
D
F
K
G
S
E
E
G
N
T
M
V
Site 14
T215
K
G
S
E
E
G
N
T
M
V
P
K
N
C
Y
Site 15
Y222
T
M
V
P
K
N
C
Y
V
S
Q
Q
E
L
K
Site 16
S224
V
P
K
N
C
Y
V
S
Q
Q
E
L
K
P
F
Site 17
T257
I
S
C
K
S
F
E
T
T
T
G
F
D
P
H
Site 18
T258
S
C
K
S
F
E
T
T
T
G
F
D
P
H
R
Site 19
T267
G
F
D
P
H
R
G
T
P
L
S
D
H
E
A
Site 20
S270
P
H
R
G
T
P
L
S
D
H
E
A
L
M
A
Site 21
S284
A
T
L
F
V
R
H
S
P
P
Q
Q
N
P
S
Site 22
S291
S
P
P
Q
Q
N
P
S
S
T
H
G
P
A
E
Site 23
S292
P
P
Q
Q
N
P
S
S
T
H
G
P
A
E
R
Site 24
S300
T
H
G
P
A
E
R
S
P
L
M
C
V
L
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation