KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
RNGTT
Full Name:
mRNA-capping enzyme
Alias:
CAP1A; GTase; GTP-RNA guanylyltransferase; HCAP1; HCE; HCE1; MCE1; RNA guanylyltransferase and 5' phosphatase; RNA guanylyltransferase and 5'-phosphatase; TPase
Type:
EC 3.1.3.33; EC 2.7.7.50; Transferase; Phosphatase (non-protein)
Mass (Da):
68557
Number AA:
597
UniProt ID:
O60942
International Prot ID:
IPI00000104
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
GO:0005654
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0004484
GO:0004651
PhosphoSite+
KinaseNET
Biological Process:
GO:0044419
GO:0006370
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T29
G
R
F
L
P
L
K
T
M
L
G
P
R
Y
D
Site 2
Y35
K
T
M
L
G
P
R
Y
D
S
Q
V
A
E
E
Site 3
S37
M
L
G
P
R
Y
D
S
Q
V
A
E
E
N
R
Site 4
S51
R
F
H
P
S
M
L
S
N
Y
L
K
S
L
K
Site 5
Y53
H
P
S
M
L
S
N
Y
L
K
S
L
K
V
K
Site 6
Y74
L
T
N
T
S
R
F
Y
D
R
N
D
I
E
K
Site 7
Y86
I
E
K
E
G
I
K
Y
I
K
L
Q
C
K
G
Site 8
T100
G
H
G
E
C
P
T
T
E
N
T
E
T
F
I
Site 9
T105
P
T
T
E
N
T
E
T
F
I
R
L
C
E
R
Site 10
Y165
Q
A
R
P
P
G
I
Y
K
G
D
Y
L
K
E
Site 11
Y169
P
G
I
Y
K
G
D
Y
L
K
E
L
F
R
R
Site 12
Y177
L
K
E
L
F
R
R
Y
G
D
I
E
E
A
P
Site 13
S210
D
E
D
G
K
K
E
S
E
P
G
S
S
A
S
Site 14
S214
K
K
E
S
E
P
G
S
S
A
S
F
G
K
R
Site 15
S215
K
E
S
E
P
G
S
S
A
S
F
G
K
R
R
Site 16
S217
S
E
P
G
S
S
A
S
F
G
K
R
R
K
E
Site 17
T246
K
G
V
T
Q
V
T
T
Q
P
K
L
G
E
V
Site 18
S275
F
P
G
A
Q
P
V
S
M
D
K
Q
N
I
K
Site 19
Y289
K
L
L
D
L
K
P
Y
K
V
S
W
K
A
D
Site 20
Y300
W
K
A
D
G
T
R
Y
M
M
L
I
D
G
T
Site 21
S323
D
N
S
V
F
H
V
S
N
L
E
F
P
F
R
Site 22
S338
K
D
L
R
M
H
L
S
N
T
L
L
D
G
E
Site 23
Y359
N
G
Q
A
V
P
R
Y
L
I
Y
D
I
I
K
Site 24
Y362
A
V
P
R
Y
L
I
Y
D
I
I
K
F
N
S
Site 25
S390
C
I
E
R
E
I
I
S
P
R
H
E
K
M
K
Site 26
T398
P
R
H
E
K
M
K
T
G
L
I
D
K
T
Q
Site 27
T404
K
T
G
L
I
D
K
T
Q
E
P
F
S
V
R
Site 28
S409
D
K
T
Q
E
P
F
S
V
R
N
K
P
F
F
Site 29
T420
K
P
F
F
D
I
C
T
S
R
K
L
L
E
G
Site 30
S421
P
F
F
D
I
C
T
S
R
K
L
L
E
G
N
Site 31
T445
D
G
L
I
F
Q
P
T
G
K
Y
K
P
G
R
Site 32
S463
I
L
K
W
K
P
P
S
L
N
S
V
D
F
R
Site 33
S466
W
K
P
P
S
L
N
S
V
D
F
R
L
K
I
Site 34
Y490
P
Q
N
V
G
L
L
Y
V
G
G
Y
E
R
P
Site 35
Y510
V
T
K
E
L
K
Q
Y
D
N
K
I
I
E
C
Site 36
T531
W
V
F
M
R
Q
R
T
D
K
S
F
P
N
A
Site 37
S534
M
R
Q
R
T
D
K
S
F
P
N
A
Y
N
T
Site 38
T554
N
S
I
S
N
P
V
T
K
E
M
L
F
E
F
Site 39
T566
F
E
F
I
D
R
C
T
A
A
S
Q
G
Q
K
Site 40
S569
I
D
R
C
T
A
A
S
Q
G
Q
K
R
K
H
Site 41
T582
K
H
H
L
D
P
D
T
E
L
M
P
P
P
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation