KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SRGAP2
Full Name:
SLIT-ROBO Rho GTPase-activating protein 2
Alias:
FNBP; FNBP2; Formin-binding protein 2; KIAA0456; SLIT-ROBO Rho GTPase activating protein 2; SrGAP2
Type:
GTPase activating protein, Rac/Rho
Mass (Da):
120881
Number AA:
1071
UniProt ID:
O75044
International Prot ID:
IPI00479125
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005096
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T19
E
I
I
A
E
Y
D
T
Q
V
K
E
I
R
A
Site 2
Y63
K
A
E
I
E
M
D
Y
S
R
N
L
E
K
L
Site 3
S64
A
E
I
E
M
D
Y
S
R
N
L
E
K
L
A
Site 4
T78
A
E
R
F
L
A
K
T
R
S
T
K
D
Q
Q
Site 5
S80
R
F
L
A
K
T
R
S
T
K
D
Q
Q
F
K
Site 6
T81
F
L
A
K
T
R
S
T
K
D
Q
Q
F
K
K
Site 7
S94
K
K
D
Q
N
V
L
S
P
V
N
C
W
N
L
Site 8
S110
L
N
Q
V
K
R
E
S
R
D
H
T
T
L
S
Site 9
T114
K
R
E
S
R
D
H
T
T
L
S
D
I
Y
L
Site 10
T115
R
E
S
R
D
H
T
T
L
S
D
I
Y
L
N
Site 11
S117
S
R
D
H
T
T
L
S
D
I
Y
L
N
N
I
Site 12
Y120
H
T
T
L
S
D
I
Y
L
N
N
I
I
P
R
Site 13
S132
I
P
R
F
V
Q
V
S
E
D
S
G
R
L
F
Site 14
S135
F
V
Q
V
S
E
D
S
G
R
L
F
K
K
S
Site 15
S142
S
G
R
L
F
K
K
S
K
E
V
G
Q
Q
L
Site 16
Y161
M
K
V
L
N
E
L
Y
S
V
M
K
T
Y
H
Site 17
Y170
V
M
K
T
Y
H
M
Y
N
A
D
S
I
S
A
Site 18
S174
Y
H
M
Y
N
A
D
S
I
S
A
Q
S
K
L
Site 19
S176
M
Y
N
A
D
S
I
S
A
Q
S
K
L
K
E
Site 20
S195
E
E
K
Q
I
G
K
S
V
K
Q
E
D
R
Q
Site 21
T203
V
K
Q
E
D
R
Q
T
P
R
S
P
D
S
T
Site 22
S206
E
D
R
Q
T
P
R
S
P
D
S
T
A
N
V
Site 23
S209
Q
T
P
R
S
P
D
S
T
A
N
V
R
I
E
Site 24
T210
T
P
R
S
P
D
S
T
A
N
V
R
I
E
E
Site 25
S223
E
E
K
H
V
R
R
S
S
V
K
K
I
E
K
Site 26
S224
E
K
H
V
R
R
S
S
V
K
K
I
E
K
M
Site 27
Y239
K
E
K
R
Q
A
K
Y
T
E
N
K
L
K
A
Site 28
T240
E
K
R
Q
A
K
Y
T
E
N
K
L
K
A
I
Site 29
Y267
T
N
A
S
V
F
K
Y
Y
I
H
D
L
S
D
Site 30
Y284
D
Q
C
C
D
L
G
Y
H
A
S
L
N
R
A
Site 31
S287
C
D
L
G
Y
H
A
S
L
N
R
A
L
R
T
Site 32
T294
S
L
N
R
A
L
R
T
F
L
S
A
E
L
N
Site 33
S297
R
A
L
R
T
F
L
S
A
E
L
N
L
E
Q
Site 34
S305
A
E
L
N
L
E
Q
S
K
H
E
G
L
D
A
Site 35
S324
V
E
N
L
D
A
T
S
D
K
Q
R
L
M
E
Site 36
Y333
K
Q
R
L
M
E
M
Y
N
N
V
F
C
P
P
Site 37
S378
Q
Q
L
Q
S
R
L
S
T
L
K
I
E
N
E
Site 38
T379
Q
L
Q
S
R
L
S
T
L
K
I
E
N
E
E
Site 39
T390
E
N
E
E
V
K
K
T
M
E
A
T
L
Q
T
Site 40
T403
Q
T
I
Q
D
I
V
T
V
E
D
F
D
V
S
Site 41
S416
V
S
D
C
F
Q
Y
S
N
S
M
E
S
V
K
Site 42
S418
D
C
F
Q
Y
S
N
S
M
E
S
V
K
S
T
Site 43
S421
Q
Y
S
N
S
M
E
S
V
K
S
T
V
S
E
Site 44
S424
N
S
M
E
S
V
K
S
T
V
S
E
T
F
M
Site 45
T425
S
M
E
S
V
K
S
T
V
S
E
T
F
M
S
Site 46
S427
E
S
V
K
S
T
V
S
E
T
F
M
S
K
P
Site 47
T429
V
K
S
T
V
S
E
T
F
M
S
K
P
S
I
Site 48
S432
T
V
S
E
T
F
M
S
K
P
S
I
A
K
R
Site 49
Y450
Q
Q
E
T
E
Q
F
Y
F
T
K
M
K
E
Y
Site 50
T477
K
H
D
L
L
Q
K
T
L
G
E
S
Q
R
T
Site 51
S481
L
Q
K
T
L
G
E
S
Q
R
T
D
C
S
L
Site 52
T484
T
L
G
E
S
Q
R
T
D
C
S
L
A
R
R
Site 53
S487
E
S
Q
R
T
D
C
S
L
A
R
R
S
S
T
Site 54
S492
D
C
S
L
A
R
R
S
S
T
V
R
K
Q
D
Site 55
S493
C
S
L
A
R
R
S
S
T
V
R
K
Q
D
S
Site 56
T494
S
L
A
R
R
S
S
T
V
R
K
Q
D
S
S
Site 57
S500
S
T
V
R
K
Q
D
S
S
Q
A
I
P
L
V
Site 58
S501
T
V
R
K
Q
D
S
S
Q
A
I
P
L
V
V
Site 59
S516
E
S
C
I
R
F
I
S
R
H
G
L
Q
H
E
Site 60
S529
H
E
G
I
F
R
V
S
G
S
Q
V
E
V
N
Site 61
S560
Q
N
D
H
D
M
D
S
I
A
G
V
L
K
L
Site 62
S627
F
A
F
L
N
H
L
S
Q
F
S
E
E
N
M
Site 63
Y638
E
E
N
M
M
D
P
Y
N
L
A
I
C
F
G
Site 64
S650
C
F
G
P
S
L
M
S
V
P
E
G
H
D
Q
Site 65
T670
H
V
N
E
L
I
K
T
I
I
I
Q
H
E
N
Site 66
S681
Q
H
E
N
I
F
P
S
P
R
E
L
E
G
P
Site 67
Y690
R
E
L
E
G
P
V
Y
S
R
G
G
S
M
E
Site 68
S691
E
L
E
G
P
V
Y
S
R
G
G
S
M
E
D
Site 69
S695
P
V
Y
S
R
G
G
S
M
E
D
Y
C
D
S
Site 70
Y699
R
G
G
S
M
E
D
Y
C
D
S
P
H
G
E
Site 71
S702
S
M
E
D
Y
C
D
S
P
H
G
E
T
T
P
Site 72
T708
D
S
P
H
G
E
T
T
P
V
E
D
S
T
Q
Site 73
T714
T
T
P
V
E
D
S
T
Q
D
V
T
A
E
H
Site 74
T718
E
D
S
T
Q
D
V
T
A
E
H
H
T
S
D
Site 75
T723
D
V
T
A
E
H
H
T
S
D
D
E
C
E
P
Site 76
S724
V
T
A
E
H
H
T
S
D
D
E
C
E
P
I
Site 77
Y739
E
A
I
A
K
F
D
Y
V
G
R
T
A
R
E
Site 78
T743
K
F
D
Y
V
G
R
T
A
R
E
L
S
F
K
Site 79
S748
G
R
T
A
R
E
L
S
F
K
K
G
A
S
L
Site 80
Y758
K
G
A
S
L
L
L
Y
Q
R
A
S
D
D
W
Site 81
S762
L
L
L
Y
Q
R
A
S
D
D
W
W
E
G
R
Site 82
Y781
D
G
L
I
P
H
Q
Y
I
V
V
Q
D
T
E
Site 83
T787
Q
Y
I
V
V
Q
D
T
E
D
G
V
V
E
R
Site 84
S795
E
D
G
V
V
E
R
S
S
P
K
S
E
I
E
Site 85
S796
D
G
V
V
E
R
S
S
P
K
S
E
I
E
V
Site 86
S799
V
E
R
S
S
P
K
S
E
I
E
V
I
S
E
Site 87
S805
K
S
E
I
E
V
I
S
E
P
P
E
E
K
V
Site 88
T813
E
P
P
E
E
K
V
T
A
R
A
G
A
S
C
Site 89
Y830
G
G
H
V
A
D
I
Y
L
A
N
I
N
K
Q
Site 90
S843
K
Q
R
K
R
P
E
S
G
S
I
R
K
T
F
Site 91
S845
R
K
R
P
E
S
G
S
I
R
K
T
F
R
S
Site 92
T849
E
S
G
S
I
R
K
T
F
R
S
D
S
H
G
Site 93
S852
S
I
R
K
T
F
R
S
D
S
H
G
L
S
S
Site 94
S854
R
K
T
F
R
S
D
S
H
G
L
S
S
S
L
Site 95
S858
R
S
D
S
H
G
L
S
S
S
L
T
D
S
S
Site 96
S859
S
D
S
H
G
L
S
S
S
L
T
D
S
S
S
Site 97
S860
D
S
H
G
L
S
S
S
L
T
D
S
S
S
P
Site 98
T862
H
G
L
S
S
S
L
T
D
S
S
S
P
G
V
Site 99
S864
L
S
S
S
L
T
D
S
S
S
P
G
V
G
A
Site 100
S865
S
S
S
L
T
D
S
S
S
P
G
V
G
A
S
Site 101
S866
S
S
L
T
D
S
S
S
P
G
V
G
A
S
C
Site 102
S872
S
S
P
G
V
G
A
S
C
R
P
S
S
Q
P
Site 103
S876
V
G
A
S
C
R
P
S
S
Q
P
I
M
S
Q
Site 104
S877
G
A
S
C
R
P
S
S
Q
P
I
M
S
Q
S
Site 105
S882
P
S
S
Q
P
I
M
S
Q
S
L
P
K
E
G
Site 106
S884
S
Q
P
I
M
S
Q
S
L
P
K
E
G
P
D
Site 107
S894
K
E
G
P
D
K
C
S
I
S
G
H
G
S
L
Site 108
S896
G
P
D
K
C
S
I
S
G
H
G
S
L
N
S
Site 109
S900
C
S
I
S
G
H
G
S
L
N
S
I
S
R
H
Site 110
S903
S
G
H
G
S
L
N
S
I
S
R
H
S
S
L
Site 111
S905
H
G
S
L
N
S
I
S
R
H
S
S
L
K
N
Site 112
S908
L
N
S
I
S
R
H
S
S
L
K
N
R
L
D
Site 113
S909
N
S
I
S
R
H
S
S
L
K
N
R
L
D
S
Site 114
S916
S
L
K
N
R
L
D
S
P
Q
I
R
K
T
A
Site 115
T922
D
S
P
Q
I
R
K
T
A
T
A
G
R
S
K
Site 116
T924
P
Q
I
R
K
T
A
T
A
G
R
S
K
S
F
Site 117
S930
A
T
A
G
R
S
K
S
F
N
N
H
R
P
M
Site 118
T949
I
A
Q
D
I
E
A
T
M
N
S
A
L
N
E
Site 119
S952
D
I
E
A
T
M
N
S
A
L
N
E
L
R
E
Site 120
S964
L
R
E
L
E
R
Q
S
S
V
K
H
T
P
D
Site 121
S965
R
E
L
E
R
Q
S
S
V
K
H
T
P
D
V
Site 122
T969
R
Q
S
S
V
K
H
T
P
D
V
V
L
D
T
Site 123
T976
T
P
D
V
V
L
D
T
L
E
P
L
K
T
S
Site 124
T982
D
T
L
E
P
L
K
T
S
P
V
V
A
P
T
Site 125
S983
T
L
E
P
L
K
T
S
P
V
V
A
P
T
S
Site 126
T989
T
S
P
V
V
A
P
T
S
E
P
S
S
P
L
Site 127
S990
S
P
V
V
A
P
T
S
E
P
S
S
P
L
H
Site 128
S993
V
A
P
T
S
E
P
S
S
P
L
H
T
Q
L
Site 129
S994
A
P
T
S
E
P
S
S
P
L
H
T
Q
L
L
Site 130
T998
E
P
S
S
P
L
H
T
Q
L
L
K
D
P
E
Site 131
S1011
P
E
P
A
F
Q
R
S
A
S
T
A
G
D
I
Site 132
S1013
P
A
F
Q
R
S
A
S
T
A
G
D
I
A
C
Site 133
T1014
A
F
Q
R
S
A
S
T
A
G
D
I
A
C
A
Site 134
T1044
P
A
T
R
P
K
P
T
V
F
P
K
T
N
A
Site 135
T1049
K
P
T
V
F
P
K
T
N
A
T
S
P
G
V
Site 136
T1052
V
F
P
K
T
N
A
T
S
P
G
V
N
S
S
Site 137
S1053
F
P
K
T
N
A
T
S
P
G
V
N
S
S
T
Site 138
S1058
A
T
S
P
G
V
N
S
S
T
S
P
Q
S
T
Site 139
S1059
T
S
P
G
V
N
S
S
T
S
P
Q
S
T
D
Site 140
T1060
S
P
G
V
N
S
S
T
S
P
Q
S
T
D
K
Site 141
S1061
P
G
V
N
S
S
T
S
P
Q
S
T
D
K
S
Site 142
S1064
N
S
S
T
S
P
Q
S
T
D
K
S
C
T
V
Site 143
T1065
S
S
T
S
P
Q
S
T
D
K
S
C
T
V
_
Site 144
T1070
Q
S
T
D
K
S
C
T
V
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation