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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DNAJC6
Full Name:
Putative tyrosine-protein phosphatase auxilin
Alias:
AUXI; DJC6; DnaJ (Hsp40) homolog, subfamily B, member 6; DnaJ (Hsp40) homologue, subfamily B, member 6; EC 3.1.3.48
Type:
Uncharacterized protein
Mass (Da):
99997
Number AA:
913
UniProt ID:
O75061
International Prot ID:
IPI00639806
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0017124
GO:0031072
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0016044
GO:0006892
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
D
S
E
N
K
G
A
S
S
P
D
M
E
P
S
Site 2
S11
S
E
N
K
G
A
S
S
P
D
M
E
P
S
Y
Site 3
S17
S
S
P
D
M
E
P
S
Y
G
G
G
L
F
D
Site 4
Y18
S
P
D
M
E
P
S
Y
G
G
G
L
F
D
M
Site 5
S35
G
G
A
G
R
L
F
S
N
L
K
D
N
L
K
Site 6
T44
L
K
D
N
L
K
D
T
L
K
D
T
S
S
R
Site 7
T48
L
K
D
T
L
K
D
T
S
S
R
V
I
Q
S
Site 8
S49
K
D
T
L
K
D
T
S
S
R
V
I
Q
S
V
Site 9
S50
D
T
L
K
D
T
S
S
R
V
I
Q
S
V
T
Site 10
S55
T
S
S
R
V
I
Q
S
V
T
S
Y
T
K
G
Site 11
Y59
V
I
Q
S
V
T
S
Y
T
K
G
D
L
D
F
Site 12
T67
T
K
G
D
L
D
F
T
Y
V
T
S
R
I
I
Site 13
S96
N
Q
V
D
D
I
R
S
F
L
D
S
R
H
L
Site 14
S100
D
I
R
S
F
L
D
S
R
H
L
D
H
Y
T
Site 15
Y106
D
S
R
H
L
D
H
Y
T
V
Y
N
L
S
P
Site 16
T107
S
R
H
L
D
H
Y
T
V
Y
N
L
S
P
K
Site 17
Y109
H
L
D
H
Y
T
V
Y
N
L
S
P
K
S
Y
Site 18
S112
H
Y
T
V
Y
N
L
S
P
K
S
Y
R
T
A
Site 19
S115
V
Y
N
L
S
P
K
S
Y
R
T
A
K
F
H
Site 20
Y116
Y
N
L
S
P
K
S
Y
R
T
A
K
F
H
S
Site 21
S123
Y
R
T
A
K
F
H
S
R
V
S
E
C
S
W
Site 22
S126
A
K
F
H
S
R
V
S
E
C
S
W
P
I
R
Site 23
S129
H
S
R
V
S
E
C
S
W
P
I
R
Q
A
P
Site 24
Y185
M
F
I
F
C
N
L
Y
S
T
P
G
P
A
I
Site 25
Y196
G
P
A
I
R
L
L
Y
A
K
R
P
G
I
G
Site 26
S205
K
R
P
G
I
G
L
S
P
S
H
R
R
Y
L
Site 27
S207
P
G
I
G
L
S
P
S
H
R
R
Y
L
G
Y
Site 28
Y211
L
S
P
S
H
R
R
Y
L
G
Y
M
C
D
L
Site 29
Y214
S
H
R
R
Y
L
G
Y
M
C
D
L
L
A
D
Site 30
Y224
D
L
L
A
D
K
P
Y
R
P
H
F
K
P
L
Site 31
T232
R
P
H
F
K
P
L
T
I
K
S
I
T
V
S
Site 32
S239
T
I
K
S
I
T
V
S
P
I
P
F
F
N
K
Site 33
Y254
Q
R
N
G
C
R
P
Y
C
D
V
L
I
G
E
Site 34
Y265
L
I
G
E
T
K
I
Y
S
T
C
T
D
F
E
Site 35
S266
I
G
E
T
K
I
Y
S
T
C
T
D
F
E
R
Site 36
Y277
D
F
E
R
M
K
E
Y
R
V
Q
D
G
K
I
Site 37
S305
V
S
M
Y
H
L
R
S
T
I
G
S
R
L
Q
Site 38
T306
S
M
Y
H
L
R
S
T
I
G
S
R
L
Q
A
Site 39
S309
H
L
R
S
T
I
G
S
R
L
Q
A
K
V
T
Site 40
Y353
A
C
D
V
P
E
K
Y
P
Q
L
F
Q
V
T
Site 41
T375
H
D
K
V
I
D
L
T
P
P
W
E
H
Y
C
Site 42
S389
C
T
K
D
V
N
P
S
I
L
F
S
S
H
Q
Site 43
S393
V
N
P
S
I
L
F
S
S
H
Q
E
H
Q
D
Site 44
T401
S
H
Q
E
H
Q
D
T
L
A
L
G
G
Q
A
Site 45
Y420
P
P
D
N
P
R
H
Y
G
Q
S
G
F
F
A
Site 46
S439
Q
D
Q
K
S
E
K
S
F
C
E
E
D
H
A
Site 47
S456
V
N
Q
E
S
E
Q
S
D
D
E
L
L
T
L
Site 48
T462
Q
S
D
D
E
L
L
T
L
S
S
P
H
G
N
Site 49
S464
D
D
E
L
L
T
L
S
S
P
H
G
N
A
N
Site 50
S465
D
E
L
L
T
L
S
S
P
H
G
N
A
N
G
Site 51
S505
D
L
L
G
L
E
G
S
A
M
S
N
S
F
S
Site 52
S508
G
L
E
G
S
A
M
S
N
S
F
S
P
P
A
Site 53
S510
E
G
S
A
M
S
N
S
F
S
P
P
A
A
P
Site 54
S512
S
A
M
S
N
S
F
S
P
P
A
A
P
P
T
Site 55
T519
S
P
P
A
A
P
P
T
N
S
E
L
L
S
D
Site 56
S521
P
A
A
P
P
T
N
S
E
L
L
S
D
L
F
Site 57
S525
P
T
N
S
E
L
L
S
D
L
F
G
G
G
G
Site 58
T537
G
G
G
A
A
G
P
T
Q
A
G
Q
S
G
V
Site 59
S551
V
E
D
V
F
H
P
S
G
P
A
S
T
Q
S
Site 60
S555
F
H
P
S
G
P
A
S
T
Q
S
T
P
R
R
Site 61
S558
S
G
P
A
S
T
Q
S
T
P
R
R
S
A
T
Site 62
T559
G
P
A
S
T
Q
S
T
P
R
R
S
A
T
S
Site 63
S563
T
Q
S
T
P
R
R
S
A
T
S
T
S
A
S
Site 64
T565
S
T
P
R
R
S
A
T
S
T
S
A
S
P
T
Site 65
S566
T
P
R
R
S
A
T
S
T
S
A
S
P
T
L
Site 66
T567
P
R
R
S
A
T
S
T
S
A
S
P
T
L
R
Site 67
S568
R
R
S
A
T
S
T
S
A
S
P
T
L
R
V
Site 68
S570
S
A
T
S
T
S
A
S
P
T
L
R
V
G
E
Site 69
T572
T
S
T
S
A
S
P
T
L
R
V
G
E
G
A
Site 70
S588
F
D
P
F
G
A
P
S
K
P
S
G
Q
D
L
Site 71
S591
F
G
A
P
S
K
P
S
G
Q
D
L
L
G
S
Site 72
S598
S
G
Q
D
L
L
G
S
F
L
N
T
S
S
A
Site 73
T602
L
L
G
S
F
L
N
T
S
S
A
S
S
D
P
Site 74
S603
L
G
S
F
L
N
T
S
S
A
S
S
D
P
F
Site 75
S604
G
S
F
L
N
T
S
S
A
S
S
D
P
F
L
Site 76
S606
F
L
N
T
S
S
A
S
S
D
P
F
L
Q
P
Site 77
S607
L
N
T
S
S
A
S
S
D
P
F
L
Q
P
T
Site 78
T614
S
D
P
F
L
Q
P
T
R
S
P
S
P
T
V
Site 79
S616
P
F
L
Q
P
T
R
S
P
S
P
T
V
H
A
Site 80
S618
L
Q
P
T
R
S
P
S
P
T
V
H
A
S
S
Site 81
T620
P
T
R
S
P
S
P
T
V
H
A
S
S
T
P
Site 82
S624
P
S
P
T
V
H
A
S
S
T
P
A
V
N
I
Site 83
S625
S
P
T
V
H
A
S
S
T
P
A
V
N
I
Q
Site 84
T626
P
T
V
H
A
S
S
T
P
A
V
N
I
Q
P
Site 85
S652
P
G
G
F
G
M
G
S
K
S
A
A
T
S
P
Site 86
S654
G
F
G
M
G
S
K
S
A
A
T
S
P
T
G
Site 87
S658
G
S
K
S
A
A
T
S
P
T
G
S
S
H
G
Site 88
S662
A
A
T
S
P
T
G
S
S
H
G
T
P
T
H
Site 89
S663
A
T
S
P
T
G
S
S
H
G
T
P
T
H
Q
Site 90
T666
P
T
G
S
S
H
G
T
P
T
H
Q
S
K
P
Site 91
T668
G
S
S
H
G
T
P
T
H
Q
S
K
P
Q
T
Site 92
S671
H
G
T
P
T
H
Q
S
K
P
Q
T
L
D
P
Site 93
T675
T
H
Q
S
K
P
Q
T
L
D
P
F
A
D
L
Site 94
S687
A
D
L
G
T
L
G
S
S
S
F
A
S
K
P
Site 95
S689
L
G
T
L
G
S
S
S
F
A
S
K
P
T
T
Site 96
S692
L
G
S
S
S
F
A
S
K
P
T
T
P
T
G
Site 97
T696
S
F
A
S
K
P
T
T
P
T
G
L
G
G
G
Site 98
S708
G
G
G
F
P
P
L
S
S
P
Q
K
A
S
P
Site 99
S709
G
G
F
P
P
L
S
S
P
Q
K
A
S
P
Q
Site 100
S714
L
S
S
P
Q
K
A
S
P
Q
P
M
G
G
G
Site 101
S740
P
Q
P
K
P
Q
P
S
M
P
H
S
S
P
Q
Site 102
S744
P
Q
P
S
M
P
H
S
S
P
Q
N
R
P
N
Site 103
S745
Q
P
S
M
P
H
S
S
P
Q
N
R
P
N
Y
Site 104
Y752
S
P
Q
N
R
P
N
Y
N
V
S
F
S
A
M
Site 105
S755
N
R
P
N
Y
N
V
S
F
S
A
M
P
G
G
Site 106
S757
P
N
Y
N
V
S
F
S
A
M
P
G
G
Q
N
Site 107
S771
N
E
R
G
K
G
S
S
N
L
E
G
K
Q
K
Site 108
S787
A
D
F
E
D
L
L
S
G
Q
G
F
N
A
H
Site 109
T882
V
V
H
P
D
K
A
T
G
Q
P
Y
E
Q
Y
Site 110
Y889
T
G
Q
P
Y
E
Q
Y
A
K
M
I
F
M
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation