KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
KIAA0476
Full Name:
DENN domain-containing protein 4B
Alias:
DEN4B; DENN/MADD domain containing 4B; DENND4B
Type:
Mass (Da):
163847
Number AA:
1496
UniProt ID:
O75064
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T29
G
A
P
I
P
E
E
T
W
V
P
E
P
S
G
Site 2
S35
E
T
W
V
P
E
P
S
G
P
L
R
P
P
R
Site 3
Y93
G
T
Q
P
V
I
C
Y
R
R
G
R
D
K
P
Site 4
Y109
L
V
E
L
G
V
L
Y
E
G
K
E
R
P
K
Site 5
T124
P
G
F
Q
V
L
D
T
T
P
Y
S
H
S
A
Site 6
T125
G
F
Q
V
L
D
T
T
P
Y
S
H
S
A
N
Site 7
Y127
Q
V
L
D
T
T
P
Y
S
H
S
A
N
L
A
Site 8
S128
V
L
D
T
T
P
Y
S
H
S
A
N
L
A
P
Site 9
T143
P
G
P
G
H
P
R
T
Y
L
T
Y
R
R
A
Site 10
Y144
G
P
G
H
P
R
T
Y
L
T
Y
R
R
A
A
Site 11
T146
G
H
P
R
T
Y
L
T
Y
R
R
A
A
E
G
Site 12
Y147
H
P
R
T
Y
L
T
Y
R
R
A
A
E
G
A
Site 13
T175
L
P
S
K
G
E
G
T
P
H
T
Y
C
R
L
Site 14
T178
K
G
E
G
T
P
H
T
Y
C
R
L
P
R
N
Site 15
Y179
G
E
G
T
P
H
T
Y
C
R
L
P
R
N
L
Site 16
Y211
A
K
A
N
T
L
V
Y
E
A
E
L
L
G
R
Site 17
Y219
E
A
E
L
L
G
R
Y
P
E
E
D
N
E
A
Site 18
Y253
C
W
P
A
Q
T
K
Y
P
V
P
V
F
S
T
Site 19
Y279
Y
G
A
A
L
Q
F
Y
E
A
F
P
R
A
R
Site 20
S288
A
F
P
R
A
R
L
S
E
R
Q
A
R
A
L
Site 21
Y340
F
L
T
F
L
Y
R
Y
S
V
S
G
P
H
R
Site 22
S341
L
T
F
L
Y
R
Y
S
V
S
G
P
H
R
L
Site 23
S365
I
H
N
V
P
F
P
S
P
Q
R
P
R
I
L
Site 24
S427
E
H
K
L
L
V
H
S
L
R
P
D
L
L
T
Site 25
Y479
I
V
G
I
H
S
S
Y
F
D
L
H
D
P
P
Site 26
T498
C
V
D
L
D
T
N
T
L
F
Q
T
E
E
K
Site 27
S509
T
E
E
K
K
L
L
S
P
R
T
L
P
R
R
Site 28
T512
K
K
L
L
S
P
R
T
L
P
R
R
P
Y
K
Site 29
Y518
R
T
L
P
R
R
P
Y
K
V
L
L
A
T
L
Site 30
T535
L
Y
Q
Q
L
D
Q
T
Y
T
G
P
E
E
E
Site 31
Y536
Y
Q
Q
L
D
Q
T
Y
T
G
P
E
E
E
A
Site 32
S544
T
G
P
E
E
E
A
S
L
E
F
L
L
T
D
Site 33
T589
R
V
F
L
R
P
L
T
Q
A
P
S
E
G
A
Site 34
S593
R
P
L
T
Q
A
P
S
E
G
A
R
D
V
D
Site 35
S611
F
L
Q
G
F
L
K
S
R
E
R
S
S
H
K
Site 36
S615
F
L
K
S
R
E
R
S
S
H
K
L
Y
S
Q
Site 37
S616
L
K
S
R
E
R
S
S
H
K
L
Y
S
Q
L
Site 38
Y620
E
R
S
S
H
K
L
Y
S
Q
L
L
H
T
Q
Site 39
S621
R
S
S
H
K
L
Y
S
Q
L
L
H
T
Q
M
Site 40
S637
S
Q
F
I
E
E
C
S
F
G
S
A
R
H
A
Site 41
T666
E
Q
E
K
P
E
P
T
P
L
V
E
L
E
E
Site 42
S677
E
L
E
E
L
S
G
S
E
L
T
V
F
I
T
Site 43
T680
E
L
S
G
S
E
L
T
V
F
I
T
P
P
E
Site 44
T684
S
E
L
T
V
F
I
T
P
P
E
E
P
A
L
Site 45
S695
E
P
A
L
P
E
G
S
E
S
T
P
Q
Y
C
Site 46
S697
A
L
P
E
G
S
E
S
T
P
Q
Y
C
Y
D
Site 47
T698
L
P
E
G
S
E
S
T
P
Q
Y
C
Y
D
G
Site 48
Y701
G
S
E
S
T
P
Q
Y
C
Y
D
G
F
P
E
Site 49
S716
L
R
A
E
L
F
E
S
L
Q
E
Q
P
G
A
Site 50
S730
A
L
P
V
P
G
P
S
R
S
A
P
S
S
P
Site 51
S732
P
V
P
G
P
S
R
S
A
P
S
S
P
A
P
Site 52
S736
P
S
R
S
A
P
S
S
P
A
P
R
R
T
K
Site 53
T742
S
S
P
A
P
R
R
T
K
Q
E
M
K
V
A
Site 54
S756
A
Q
R
M
A
Q
K
S
A
A
V
P
E
L
W
Site 55
S805
H
V
L
R
Q
M
E
S
G
K
V
V
L
P
D
Site 56
T848
Q
A
G
I
V
P
N
T
I
T
Y
G
Y
Y
N
Site 57
S865
V
L
E
S
K
W
P
S
G
T
P
G
G
R
L
Site 58
T867
E
S
K
W
P
S
G
T
P
G
G
R
L
R
W
Site 59
S922
A
H
Q
E
A
G
S
S
Q
A
E
P
Y
L
E
Site 60
Y927
G
S
S
Q
A
E
P
Y
L
E
R
P
S
P
T
Site 61
S932
E
P
Y
L
E
R
P
S
P
T
R
P
L
Q
R
Site 62
T941
T
R
P
L
Q
R
Q
T
T
W
A
G
R
S
L
Site 63
T942
R
P
L
Q
R
Q
T
T
W
A
G
R
S
L
R
Site 64
S947
Q
T
T
W
A
G
R
S
L
R
D
P
A
S
P
Site 65
S953
R
S
L
R
D
P
A
S
P
P
G
R
L
V
K
Site 66
S961
P
P
G
R
L
V
K
S
G
S
L
G
S
A
R
Site 67
S963
G
R
L
V
K
S
G
S
L
G
S
A
R
G
A
Site 68
S966
V
K
S
G
S
L
G
S
A
R
G
A
Q
P
T
Site 69
T973
S
A
R
G
A
Q
P
T
V
E
A
G
V
A
H
Site 70
S993
G
V
L
E
P
R
G
S
P
V
P
W
H
D
G
Site 71
S1001
P
V
P
W
H
D
G
S
L
S
D
L
S
L
T
Site 72
S1003
P
W
H
D
G
S
L
S
D
L
S
L
T
G
E
Site 73
S1006
D
G
S
L
S
D
L
S
L
T
G
E
E
P
L
Site 74
T1008
S
L
S
D
L
S
L
T
G
E
E
P
L
P
G
Site 75
S1017
E
E
P
L
P
G
G
S
P
G
G
S
G
S
A
Site 76
S1021
P
G
G
S
P
G
G
S
G
S
A
L
S
A
Q
Site 77
S1023
G
S
P
G
G
S
G
S
A
L
S
A
Q
S
T
Site 78
S1026
G
G
S
G
S
A
L
S
A
Q
S
T
E
A
L
Site 79
T1030
S
A
L
S
A
Q
S
T
E
A
L
E
G
L
S
Site 80
S1037
T
E
A
L
E
G
L
S
G
R
G
P
K
A
G
Site 81
T1052
G
R
Q
D
E
A
G
T
P
R
R
G
L
G
A
Site 82
T1066
A
R
L
Q
Q
L
L
T
P
S
R
H
S
P
A
Site 83
S1068
L
Q
Q
L
L
T
P
S
R
H
S
P
A
S
R
Site 84
S1071
L
L
T
P
S
R
H
S
P
A
S
R
I
P
P
Site 85
S1074
P
S
R
H
S
P
A
S
R
I
P
P
P
E
L
Site 86
S1092
L
P
P
P
A
R
R
S
P
M
D
S
L
L
H
Site 87
S1096
A
R
R
S
P
M
D
S
L
L
H
P
R
E
R
Site 88
S1106
H
P
R
E
R
P
G
S
T
A
S
E
S
S
A
Site 89
T1107
P
R
E
R
P
G
S
T
A
S
E
S
S
A
S
Site 90
S1109
E
R
P
G
S
T
A
S
E
S
S
A
S
L
G
Site 91
S1111
P
G
S
T
A
S
E
S
S
A
S
L
G
S
E
Site 92
S1112
G
S
T
A
S
E
S
S
A
S
L
G
S
E
W
Site 93
S1114
T
A
S
E
S
S
A
S
L
G
S
E
W
D
L
Site 94
S1117
E
S
S
A
S
L
G
S
E
W
D
L
S
E
S
Site 95
S1122
L
G
S
E
W
D
L
S
E
S
S
L
S
N
L
Site 96
S1124
S
E
W
D
L
S
E
S
S
L
S
N
L
S
L
Site 97
S1125
E
W
D
L
S
E
S
S
L
S
N
L
S
L
R
Site 98
S1127
D
L
S
E
S
S
L
S
N
L
S
L
R
R
S
Site 99
S1130
E
S
S
L
S
N
L
S
L
R
R
S
S
E
R
Site 100
S1134
S
N
L
S
L
R
R
S
S
E
R
L
S
D
T
Site 101
S1135
N
L
S
L
R
R
S
S
E
R
L
S
D
T
P
Site 102
S1139
R
R
S
S
E
R
L
S
D
T
P
G
S
F
Q
Site 103
T1141
S
S
E
R
L
S
D
T
P
G
S
F
Q
S
P
Site 104
S1144
R
L
S
D
T
P
G
S
F
Q
S
P
S
L
E
Site 105
S1147
D
T
P
G
S
F
Q
S
P
S
L
E
I
L
L
Site 106
S1149
P
G
S
F
Q
S
P
S
L
E
I
L
L
S
S
Site 107
S1165
S
L
C
R
A
C
D
S
L
V
Y
D
E
E
I
Site 108
S1181
A
G
W
A
P
D
D
S
N
L
N
T
T
C
P
Site 109
S1205
L
S
V
Q
T
L
D
S
R
P
S
V
P
S
P
Site 110
S1208
Q
T
L
D
S
R
P
S
V
P
S
P
K
S
A
Site 111
S1211
D
S
R
P
S
V
P
S
P
K
S
A
G
A
S
Site 112
S1214
P
S
V
P
S
P
K
S
A
G
A
S
G
S
K
Site 113
S1218
S
P
K
S
A
G
A
S
G
S
K
D
A
P
V
Site 114
S1220
K
S
A
G
A
S
G
S
K
D
A
P
V
P
G
Site 115
S1256
N
G
H
M
G
G
A
S
R
R
V
E
S
G
A
Site 116
S1261
G
A
S
R
R
V
E
S
G
A
W
A
Y
L
S
Site 117
S1268
S
G
A
W
A
Y
L
S
P
L
V
L
R
K
E
Site 118
S1278
V
L
R
K
E
L
E
S
L
V
E
N
E
G
S
Site 119
S1285
S
L
V
E
N
E
G
S
E
V
L
A
L
P
E
Site 120
S1329
L
A
S
C
D
G
P
S
H
S
Q
A
P
S
P
Site 121
S1331
S
C
D
G
P
S
H
S
Q
A
P
S
P
W
L
Site 122
S1335
P
S
H
S
Q
A
P
S
P
W
L
T
P
D
P
Site 123
T1339
Q
A
P
S
P
W
L
T
P
D
P
A
S
V
Q
Site 124
T1355
R
L
L
W
D
V
L
T
P
D
P
N
S
C
P
Site 125
Y1365
P
N
S
C
P
P
L
Y
V
L
W
R
V
H
S
Site 126
S1372
Y
V
L
W
R
V
H
S
Q
I
P
Q
R
V
V
Site 127
T1421
E
T
L
G
P
P
P
T
G
L
H
L
Q
R
G
Site 128
Y1455
I
V
A
F
D
K
K
Y
K
S
A
F
N
K
L
Site 129
S1457
A
F
D
K
K
Y
K
S
A
F
N
K
L
A
S
Site 130
S1464
S
A
F
N
K
L
A
S
S
M
G
K
E
E
L
Site 131
T1480
H
R
R
A
Q
M
P
T
P
K
A
I
D
C
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation