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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADAM11
Full Name:
Disintegrin and metalloproteinase domain-containing protein 11
Alias:
Ada11; Adam metallopeptidase domain 11; Adam metallopeptidase domain 11 preproprotein; Adam11; Mdc
Type:
Plasma membrane, Integral membrane protein
Mass (Da):
83418
Number AA:
769
UniProt ID:
O75078
International Prot ID:
IPI00299652
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005178
GO:0004222
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007229
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T24
L
P
T
P
G
L
G
T
Q
G
P
A
G
A
L
Site 2
S57
P
S
R
L
V
R
E
S
S
G
G
E
V
R
K
Site 3
S58
S
R
L
V
R
E
S
S
G
G
E
V
R
K
Q
Site 4
T69
V
R
K
Q
Q
L
D
T
R
V
R
Q
E
P
P
Site 5
S110
L
N
H
H
L
L
S
S
Q
Y
V
E
R
H
F
Site 6
Y112
H
H
L
L
S
S
Q
Y
V
E
R
H
F
S
R
Site 7
S118
Q
Y
V
E
R
H
F
S
R
E
G
T
T
Q
H
Site 8
T122
R
H
F
S
R
E
G
T
T
Q
H
S
T
G
A
Site 9
S126
R
E
G
T
T
Q
H
S
T
G
A
G
D
H
C
Site 10
Y134
T
G
A
G
D
H
C
Y
Y
Q
G
K
L
R
G
Site 11
Y135
G
A
G
D
H
C
Y
Y
Q
G
K
L
R
G
N
Site 12
S145
K
L
R
G
N
P
H
S
F
A
A
L
S
T
C
Site 13
S150
P
H
S
F
A
A
L
S
T
C
Q
G
L
H
G
Site 14
T165
V
F
S
D
G
N
L
T
Y
I
V
E
P
Q
E
Site 15
Y189
G
P
L
P
H
L
I
Y
R
T
P
L
L
P
D
Site 16
S213
L
F
A
V
P
A
Q
S
A
P
P
N
R
P
R
Site 17
T308
V
Q
D
D
L
L
E
T
L
A
R
L
M
V
Y
Site 18
Y496
L
C
C
R
R
C
K
Y
E
P
R
G
V
S
C
Site 19
Y648
A
D
G
S
D
L
S
Y
V
E
D
G
T
A
C
Site 20
S739
G
T
N
I
I
I
G
S
I
A
G
A
V
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation