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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MEGF6
Full Name:
Multiple epidermal growth factor-like domains protein 6
Alias:
Epidermal growth factor-like protein 3
Type:
Mass (Da):
161185
Number AA:
1541
UniProt ID:
O75095
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T54
V
C
A
E
Q
E
L
T
L
V
G
R
R
Q
P
Site 2
Y92
G
H
E
R
R
T
V
Y
Y
M
G
Y
R
Q
V
Site 3
Y93
H
E
R
R
T
V
Y
Y
M
G
Y
R
Q
V
Y
Site 4
Y96
R
T
V
Y
Y
M
G
Y
R
Q
V
Y
T
T
E
Site 5
Y100
Y
M
G
Y
R
Q
V
Y
T
T
E
A
R
T
V
Site 6
T101
M
G
Y
R
Q
V
Y
T
T
E
A
R
T
V
L
Site 7
T102
G
Y
R
Q
V
Y
T
T
E
A
R
T
V
L
R
Site 8
S125
P
D
E
E
G
C
L
S
A
E
C
S
A
S
L
Site 9
Y160
F
Q
G
P
R
C
Q
Y
D
V
D
E
C
R
T
Site 10
T179
C
Q
H
R
C
V
N
T
P
G
S
Y
L
C
E
Site 11
T195
K
P
G
F
R
L
H
T
D
S
R
T
C
L
A
Site 12
S197
G
F
R
L
H
T
D
S
R
T
C
L
A
I
N
Site 13
T199
R
L
H
T
D
S
R
T
C
L
A
I
N
S
C
Site 14
S246
G
R
H
C
V
R
R
S
P
C
A
N
R
N
G
Site 15
Y274
R
C
E
C
H
V
G
Y
Q
L
A
A
D
G
K
Site 16
Y325
G
A
D
G
R
Q
C
Y
R
I
E
M
E
I
V
Site 17
S343
E
A
N
N
G
G
C
S
H
G
C
S
H
T
S
Site 18
S347
G
G
C
S
H
G
C
S
H
T
S
A
G
P
L
Site 19
Y361
L
C
T
C
P
R
G
Y
E
L
D
T
D
Q
R
Site 20
T365
P
R
G
Y
E
L
D
T
D
Q
R
T
C
I
D
Site 21
Y398
G
G
Y
E
C
G
C
Y
A
G
Y
R
L
S
A
Site 22
S418
E
D
V
D
E
C
A
S
S
R
G
G
C
E
H
Site 23
S419
D
V
D
E
C
A
S
S
R
G
G
C
E
H
H
Site 24
S452
H
E
D
R
R
G
C
S
P
L
E
E
P
M
V
Site 25
T504
A
E
L
R
G
E
H
T
L
T
E
K
F
V
C
Site 26
T506
L
R
G
E
H
T
L
T
E
K
F
V
C
L
D
Site 27
T554
T
G
L
I
C
N
E
T
C
P
P
D
T
F
G
Site 28
T559
N
E
T
C
P
P
D
T
F
G
K
N
C
S
F
Site 29
T580
G
G
T
C
D
S
V
T
G
A
C
R
C
P
P
Site 30
Y602
E
D
G
C
P
K
G
Y
Y
G
K
H
C
R
K
Site 31
Y603
D
G
C
P
K
G
Y
Y
G
K
H
C
R
K
K
Site 32
Y623
R
G
R
C
H
R
L
Y
G
A
C
L
C
D
P
Site 33
S670
S
C
D
K
R
D
G
S
C
S
C
K
A
G
F
Site 34
S672
D
K
R
D
G
S
C
S
C
K
A
G
F
R
G
Site 35
Y690
Q
A
E
C
E
L
G
Y
F
G
P
G
C
W
Q
Site 36
S711
G
V
A
C
D
S
V
S
G
E
C
G
K
R
C
Site 37
T735
G
Q
E
C
P
V
G
T
F
G
V
N
C
S
S
Site 38
T989
R
G
P
R
C
A
E
T
C
P
A
H
T
Y
G
Site 39
Y1038
Q
A
C
P
A
G
L
Y
G
D
N
C
R
H
S
Site 40
S1088
V
R
A
G
C
R
H
S
G
G
C
L
N
G
G
Site 41
S1156
C
P
P
G
F
T
G
S
G
C
E
Q
A
C
P
Site 42
S1166
E
Q
A
C
P
P
G
S
F
G
E
D
C
A
Q
Site 43
Y1197
T
C
S
C
A
A
G
Y
H
G
P
S
C
Q
Q
Site 44
T1231
G
G
S
C
D
A
A
T
G
A
C
R
C
P
T
Site 45
T1248
L
G
T
D
C
N
L
T
C
P
Q
G
R
F
G
Site 46
T1362
T
C
E
P
A
T
G
T
C
R
C
G
P
G
F
Site 47
S1425
E
R
G
C
E
P
G
S
F
G
E
G
C
H
Q
Site 48
T1502
V
D
G
Y
M
G
P
T
C
R
E
G
G
P
L
Site 49
S1516
L
R
L
P
E
N
P
S
L
A
Q
G
S
A
G
Site 50
T1524
L
A
Q
G
S
A
G
T
L
P
A
S
S
R
P
Site 51
S1528
S
A
G
T
L
P
A
S
S
R
P
T
S
R
S
Site 52
S1529
A
G
T
L
P
A
S
S
R
P
T
S
R
S
G
Site 53
T1532
L
P
A
S
S
R
P
T
S
R
S
G
G
P
A
Site 54
S1533
P
A
S
S
R
P
T
S
R
S
G
G
P
A
R
Site 55
S1535
S
S
R
P
T
S
R
S
G
G
P
A
R
H
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation