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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LDB3
Full Name:
LIM domain-binding protein 3
Alias:
CYPHER; Cypher; KIAA0613; Ldb3z1; Ldb3z4; LIM domain binding 3; ORACLE; PDLIM6; PDZ and LIM domain 6; Protein cypher; ZASP; Z-band alternatively spliced PDZ-motif; Z-band alternatively spliced PDZ-motif protein
Type:
Cytoskeletal protein
Mass (Da):
77116
Number AA:
727
UniProt ID:
O75112
International Prot ID:
IPI00165263
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030018
GO:0005856
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
Y
S
V
T
L
T
G
Site 2
T6
_
_
M
S
Y
S
V
T
L
T
G
P
G
P
W
Site 3
T28
K
D
F
N
M
P
L
T
I
S
R
I
T
P
G
Site 4
T33
P
L
T
I
S
R
I
T
P
G
S
K
A
A
Q
Site 5
S36
I
S
R
I
T
P
G
S
K
A
A
Q
S
Q
L
Site 6
S41
P
G
S
K
A
A
Q
S
Q
L
S
Q
G
D
L
Site 7
S44
K
A
A
Q
S
Q
L
S
Q
G
D
L
V
V
A
Site 8
T59
I
D
G
V
N
T
D
T
M
T
H
L
E
A
Q
Site 9
S71
E
A
Q
N
K
I
K
S
A
S
Y
N
L
S
L
Site 10
S73
Q
N
K
I
K
S
A
S
Y
N
L
S
L
T
L
Site 11
Y74
N
K
I
K
S
A
S
Y
N
L
S
L
T
L
Q
Site 12
S77
K
S
A
S
Y
N
L
S
L
T
L
Q
K
S
K
Site 13
T79
A
S
Y
N
L
S
L
T
L
Q
K
S
K
R
P
Site 14
S83
L
S
L
T
L
Q
K
S
K
R
P
I
P
I
S
Site 15
S90
S
K
R
P
I
P
I
S
T
T
A
P
P
V
Q
Site 16
T92
R
P
I
P
I
S
T
T
A
P
P
V
Q
T
P
Site 17
T98
T
T
A
P
P
V
Q
T
P
L
P
V
I
P
H
Site 18
T113
Q
K
D
P
A
L
D
T
N
G
S
L
V
A
P
Site 19
S116
P
A
L
D
T
N
G
S
L
V
A
P
S
P
S
Site 20
S121
N
G
S
L
V
A
P
S
P
S
P
E
A
R
A
Site 21
S123
S
L
V
A
P
S
P
S
P
E
A
R
A
S
P
Site 22
S129
P
S
P
E
A
R
A
S
P
G
T
P
G
T
P
Site 23
T132
E
A
R
A
S
P
G
T
P
G
T
P
E
L
R
Site 24
T135
A
S
P
G
T
P
G
T
P
E
L
R
P
T
F
Site 25
T141
G
T
P
E
L
R
P
T
F
S
P
A
F
S
R
Site 26
S143
P
E
L
R
P
T
F
S
P
A
F
S
R
P
S
Site 27
S147
P
T
F
S
P
A
F
S
R
P
S
A
F
S
S
Site 28
S150
S
P
A
F
S
R
P
S
A
F
S
S
L
A
E
Site 29
S153
F
S
R
P
S
A
F
S
S
L
A
E
A
S
D
Site 30
S154
S
R
P
S
A
F
S
S
L
A
E
A
S
D
P
Site 31
S159
F
S
S
L
A
E
A
S
D
P
G
P
P
R
A
Site 32
S167
D
P
G
P
P
R
A
S
L
R
A
K
T
S
P
Site 33
T172
R
A
S
L
R
A
K
T
S
P
E
G
A
R
D
Site 34
S173
A
S
L
R
A
K
T
S
P
E
G
A
R
D
L
Site 35
S189
G
P
K
A
L
P
G
S
S
Q
P
R
Q
Y
N
Site 36
S190
P
K
A
L
P
G
S
S
Q
P
R
Q
Y
N
N
Site 37
Y195
G
S
S
Q
P
R
Q
Y
N
N
P
I
G
L
Y
Site 38
T206
I
G
L
Y
S
A
E
T
L
R
E
M
A
Q
M
Site 39
Y214
L
R
E
M
A
Q
M
Y
Q
M
S
L
R
G
K
Site 40
S217
M
A
Q
M
Y
Q
M
S
L
R
G
K
A
S
G
Site 41
S223
M
S
L
R
G
K
A
S
G
V
G
L
P
G
G
Site 42
S243
D
L
A
V
D
S
A
S
P
V
Y
Q
A
V
I
Site 43
Y246
V
D
S
A
S
P
V
Y
Q
A
V
I
K
S
Q
Site 44
S252
V
Y
Q
A
V
I
K
S
Q
N
K
P
E
D
E
Site 45
S267
A
D
E
W
A
R
R
S
S
N
L
Q
S
R
S
Site 46
S268
D
E
W
A
R
R
S
S
N
L
Q
S
R
S
F
Site 47
S272
R
R
S
S
N
L
Q
S
R
S
F
R
I
L
A
Site 48
S274
S
S
N
L
Q
S
R
S
F
R
I
L
A
Q
M
Site 49
T282
F
R
I
L
A
Q
M
T
G
T
E
F
M
Q
D
Site 50
S298
D
E
E
A
L
R
R
S
S
T
P
I
E
H
A
Site 51
S299
E
E
A
L
R
R
S
S
T
P
I
E
H
A
P
Site 52
T300
E
A
L
R
R
S
S
T
P
I
E
H
A
P
V
Site 53
S328
A
Q
P
P
A
A
A
S
P
S
A
A
S
P
P
Site 54
S355
A
S
T
T
A
P
A
S
S
P
A
D
S
P
R
Site 55
S356
S
T
T
A
P
A
S
S
P
A
D
S
P
R
P
Site 56
S360
P
A
S
S
P
A
D
S
P
R
P
Q
A
S
S
Site 57
S367
S
P
R
P
Q
A
S
S
Y
S
P
A
V
A
A
Site 58
S369
R
P
Q
A
S
S
Y
S
P
A
V
A
A
S
S
Site 59
S375
Y
S
P
A
V
A
A
S
S
A
P
A
T
H
T
Site 60
S376
S
P
A
V
A
A
S
S
A
P
A
T
H
T
S
Site 61
T380
A
A
S
S
A
P
A
T
H
T
S
Y
S
E
G
Site 62
S383
S
A
P
A
T
H
T
S
Y
S
E
G
P
A
A
Site 63
S385
P
A
T
H
T
S
Y
S
E
G
P
A
A
P
A
Site 64
T399
A
P
K
P
R
V
V
T
T
A
S
I
R
P
S
Site 65
T400
P
K
P
R
V
V
T
T
A
S
I
R
P
S
V
Site 66
S402
P
R
V
V
T
T
A
S
I
R
P
S
V
Y
Q
Site 67
S406
T
T
A
S
I
R
P
S
V
Y
Q
P
V
P
A
Site 68
S414
V
Y
Q
P
V
P
A
S
T
Y
S
P
S
P
G
Site 69
T415
Y
Q
P
V
P
A
S
T
Y
S
P
S
P
G
A
Site 70
S417
P
V
P
A
S
T
Y
S
P
S
P
G
A
N
Y
Site 71
S419
P
A
S
T
Y
S
P
S
P
G
A
N
Y
S
P
Site 72
S425
P
S
P
G
A
N
Y
S
P
T
P
Y
T
P
S
Site 73
T427
P
G
A
N
Y
S
P
T
P
Y
T
P
S
P
A
Site 74
T430
N
Y
S
P
T
P
Y
T
P
S
P
A
P
A
Y
Site 75
S432
S
P
T
P
Y
T
P
S
P
A
P
A
Y
T
P
Site 76
Y437
T
P
S
P
A
P
A
Y
T
P
S
P
A
P
A
Site 77
T438
P
S
P
A
P
A
Y
T
P
S
P
A
P
A
Y
Site 78
S440
P
A
P
A
Y
T
P
S
P
A
P
A
Y
T
P
Site 79
Y445
T
P
S
P
A
P
A
Y
T
P
S
P
V
P
T
Site 80
T446
P
S
P
A
P
A
Y
T
P
S
P
V
P
T
Y
Site 81
S448
P
A
P
A
Y
T
P
S
P
V
P
T
Y
T
P
Site 82
T452
Y
T
P
S
P
V
P
T
Y
T
P
S
P
A
P
Site 83
Y453
T
P
S
P
V
P
T
Y
T
P
S
P
A
P
A
Site 84
T454
P
S
P
V
P
T
Y
T
P
S
P
A
P
A
Y
Site 85
S456
P
V
P
T
Y
T
P
S
P
A
P
A
Y
T
P
Site 86
Y461
T
P
S
P
A
P
A
Y
T
P
S
P
A
P
N
Site 87
T462
P
S
P
A
P
A
Y
T
P
S
P
A
P
N
Y
Site 88
S464
P
A
P
A
Y
T
P
S
P
A
P
N
Y
N
P
Site 89
Y469
T
P
S
P
A
P
N
Y
N
P
A
P
S
V
A
Site 90
S474
P
N
Y
N
P
A
P
S
V
A
Y
S
G
G
P
Site 91
S478
P
A
P
S
V
A
Y
S
G
G
P
A
E
P
A
Site 92
S486
G
G
P
A
E
P
A
S
R
P
P
W
V
T
D
Site 93
T492
A
S
R
P
P
W
V
T
D
D
S
F
S
Q
K
Site 94
S495
P
P
W
V
T
D
D
S
F
S
Q
K
F
A
P
Site 95
S497
W
V
T
D
D
S
F
S
Q
K
F
A
P
G
K
Site 96
S505
Q
K
F
A
P
G
K
S
T
T
S
I
S
K
Q
Site 97
T506
K
F
A
P
G
K
S
T
T
S
I
S
K
Q
T
Site 98
S510
G
K
S
T
T
S
I
S
K
Q
T
L
P
R
G
Site 99
T513
T
T
S
I
S
K
Q
T
L
P
R
G
G
P
A
Site 100
Y521
L
P
R
G
G
P
A
Y
T
P
A
G
P
Q
V
Site 101
T522
P
R
G
G
P
A
Y
T
P
A
G
P
Q
V
P
Site 102
T535
V
P
P
L
A
R
G
T
V
Q
R
A
E
R
F
Site 103
S545
R
A
E
R
F
P
A
S
S
R
T
P
L
C
G
Site 104
S546
A
E
R
F
P
A
S
S
R
T
P
L
C
G
H
Site 105
T548
R
F
P
A
S
S
R
T
P
L
C
G
H
C
N
Site 106
Y579
P
E
E
F
T
C
A
Y
C
K
T
S
L
A
D
Site 107
Y597
V
E
E
Q
N
N
V
Y
C
E
R
C
Y
E
Q
Site 108
Y602
N
V
Y
C
E
R
C
Y
E
Q
F
F
A
P
L
Site 109
Y656
H
M
E
D
G
E
P
Y
C
E
K
D
Y
I
N
Site 110
Y661
E
P
Y
C
E
K
D
Y
I
N
L
F
S
T
K
Site 111
S666
K
D
Y
I
N
L
F
S
T
K
C
H
G
C
D
Site 112
T667
D
Y
I
N
L
F
S
T
K
C
H
G
C
D
F
Site 113
S711
L
E
G
Q
P
F
Y
S
K
K
D
R
P
L
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation