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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLASP2
Full Name:
CLIP-associating protein 2
Alias:
CLAP2; Cytoplasmic linker associated protein 2; Cytoplasmic linker-associated protein 2; HOrbit2; KIAA0627; Protein Orbit homologue 2
Type:
Cytoskeletal protein
Mass (Da):
141133
Number AA:
1294
UniProt ID:
O75122
International Prot ID:
IPI00796485
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005938
GO:0005813
Uniprot
OncoNet
Molecular Function:
GO:0008107
GO:0051010
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007163
GO:0007067
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
M
G
D
D
K
S
F
D
D
E
E
S
V
Site 2
S14
K
S
F
D
D
E
E
S
V
D
G
N
R
P
S
Site 3
S21
S
V
D
G
N
R
P
S
S
A
A
S
A
F
K
Site 4
S22
V
D
G
N
R
P
S
S
A
A
S
A
F
K
V
Site 5
S25
N
R
P
S
S
A
A
S
A
F
K
V
P
A
P
Site 6
T34
F
K
V
P
A
P
K
T
S
G
N
P
A
N
S
Site 7
S35
K
V
P
A
P
K
T
S
G
N
P
A
N
S
A
Site 8
S41
T
S
G
N
P
A
N
S
A
R
K
P
G
S
A
Site 9
S47
N
S
A
R
K
P
G
S
A
G
G
P
K
V
G
Site 10
S57
G
P
K
V
G
G
A
S
K
E
G
G
A
G
A
Site 11
S79
K
A
F
T
D
V
P
S
I
Q
I
Y
S
S
R
Site 12
Y83
D
V
P
S
I
Q
I
Y
S
S
R
E
L
E
E
Site 13
S84
V
P
S
I
Q
I
Y
S
S
R
E
L
E
E
T
Site 14
S85
P
S
I
Q
I
Y
S
S
R
E
L
E
E
T
L
Site 15
T91
S
S
R
E
L
E
E
T
L
N
K
I
R
E
I
Site 16
S100
N
K
I
R
E
I
L
S
D
D
K
H
D
W
D
Site 17
S144
L
D
G
A
L
K
L
S
A
K
D
L
R
S
Q
Site 18
S150
L
S
A
K
D
L
R
S
Q
V
V
R
E
A
C
Site 19
T181
G
A
E
A
I
V
P
T
L
F
N
L
V
P
N
Site 20
S196
S
A
K
V
M
A
T
S
G
C
A
A
I
R
F
Site 21
T218
P
R
L
I
P
L
I
T
S
N
C
T
S
K
S
Site 22
S223
L
I
T
S
N
C
T
S
K
S
V
P
V
R
R
Site 23
S225
T
S
N
C
T
S
K
S
V
P
V
R
R
R
S
Site 24
S232
S
V
P
V
R
R
R
S
F
E
F
L
D
L
L
Site 25
S247
L
Q
E
W
Q
T
H
S
L
E
R
H
A
A
V
Site 26
T277
A
R
V
E
A
R
K
T
Y
M
G
L
R
N
H
Site 27
Y278
R
V
E
A
R
K
T
Y
M
G
L
R
N
H
F
Site 28
T291
H
F
P
G
E
A
E
T
L
Y
N
S
L
E
P
Site 29
Y293
P
G
E
A
E
T
L
Y
N
S
L
E
P
S
Y
Site 30
S295
E
A
E
T
L
Y
N
S
L
E
P
S
Y
Q
K
Site 31
S299
L
Y
N
S
L
E
P
S
Y
Q
K
S
L
Q
T
Site 32
Y300
Y
N
S
L
E
P
S
Y
Q
K
S
L
Q
T
Y
Site 33
S303
L
E
P
S
Y
Q
K
S
L
Q
T
Y
L
K
S
Site 34
T306
S
Y
Q
K
S
L
Q
T
Y
L
K
S
S
G
S
Site 35
Y307
Y
Q
K
S
L
Q
T
Y
L
K
S
S
G
S
V
Site 36
S310
S
L
Q
T
Y
L
K
S
S
G
S
V
A
S
L
Site 37
S313
T
Y
L
K
S
S
G
S
V
A
S
L
P
Q
S
Site 38
S316
K
S
S
G
S
V
A
S
L
P
Q
S
D
R
S
Site 39
S320
S
V
A
S
L
P
Q
S
D
R
S
S
S
S
S
Site 40
S323
S
L
P
Q
S
D
R
S
S
S
S
S
Q
E
S
Site 41
S324
L
P
Q
S
D
R
S
S
S
S
S
Q
E
S
L
Site 42
S325
P
Q
S
D
R
S
S
S
S
S
Q
E
S
L
N
Site 43
S326
Q
S
D
R
S
S
S
S
S
Q
E
S
L
N
R
Site 44
S327
S
D
R
S
S
S
S
S
Q
E
S
L
N
R
P
Site 45
S330
S
S
S
S
S
Q
E
S
L
N
R
P
F
S
S
Site 46
S336
E
S
L
N
R
P
F
S
S
K
W
S
T
A
N
Site 47
S337
S
L
N
R
P
F
S
S
K
W
S
T
A
N
P
Site 48
S340
R
P
F
S
S
K
W
S
T
A
N
P
S
T
V
Site 49
T341
P
F
S
S
K
W
S
T
A
N
P
S
T
V
A
Site 50
T346
W
S
T
A
N
P
S
T
V
A
G
R
V
S
A
Site 51
S352
S
T
V
A
G
R
V
S
A
G
S
S
K
A
S
Site 52
S355
A
G
R
V
S
A
G
S
S
K
A
S
S
L
P
Site 53
S356
G
R
V
S
A
G
S
S
K
A
S
S
L
P
G
Site 54
S359
S
A
G
S
S
K
A
S
S
L
P
G
S
L
Q
Site 55
S360
A
G
S
S
K
A
S
S
L
P
G
S
L
Q
R
Site 56
S364
K
A
S
S
L
P
G
S
L
Q
R
S
R
S
D
Site 57
S368
L
P
G
S
L
Q
R
S
R
S
D
I
D
V
N
Site 58
S370
G
S
L
Q
R
S
R
S
D
I
D
V
N
A
A
Site 59
S389
A
H
H
A
A
G
Q
S
V
R
R
G
R
L
G
Site 60
S404
A
G
A
L
N
A
G
S
Y
A
S
L
E
D
T
Site 61
S407
L
N
A
G
S
Y
A
S
L
E
D
T
S
D
K
Site 62
T411
S
Y
A
S
L
E
D
T
S
D
K
L
D
G
T
Site 63
S412
Y
A
S
L
E
D
T
S
D
K
L
D
G
T
A
Site 64
T418
T
S
D
K
L
D
G
T
A
S
E
D
G
R
V
Site 65
S420
D
K
L
D
G
T
A
S
E
D
G
R
V
R
A
Site 66
S430
G
R
V
R
A
K
L
S
A
P
L
A
G
M
G
Site 67
S443
M
G
N
A
K
A
D
S
R
G
R
S
R
T
K
Site 68
S447
K
A
D
S
R
G
R
S
R
T
K
M
V
S
Q
Site 69
T449
D
S
R
G
R
S
R
T
K
M
V
S
Q
S
Q
Site 70
S453
R
S
R
T
K
M
V
S
Q
S
Q
P
G
S
R
Site 71
S455
R
T
K
M
V
S
Q
S
Q
P
G
S
R
S
G
Site 72
S459
V
S
Q
S
Q
P
G
S
R
S
G
S
P
G
R
Site 73
S461
Q
S
Q
P
G
S
R
S
G
S
P
G
R
V
L
Site 74
S463
Q
P
G
S
R
S
G
S
P
G
R
V
L
T
T
Site 75
S477
T
T
A
L
S
T
V
S
S
G
V
Q
R
V
L
Site 76
S487
V
Q
R
V
L
V
N
S
A
S
A
Q
K
R
S
Site 77
S489
R
V
L
V
N
S
A
S
A
Q
K
R
S
K
I
Site 78
S494
S
A
S
A
Q
K
R
S
K
I
P
R
S
Q
G
Site 79
S499
K
R
S
K
I
P
R
S
Q
G
C
S
R
E
A
Site 80
S503
I
P
R
S
Q
G
C
S
R
E
A
S
P
S
R
Site 81
S507
Q
G
C
S
R
E
A
S
P
S
R
L
S
V
A
Site 82
S509
C
S
R
E
A
S
P
S
R
L
S
V
A
R
S
Site 83
S512
E
A
S
P
S
R
L
S
V
A
R
S
S
R
I
Site 84
S516
S
R
L
S
V
A
R
S
S
R
I
P
R
P
S
Site 85
S517
R
L
S
V
A
R
S
S
R
I
P
R
P
S
V
Site 86
S523
S
S
R
I
P
R
P
S
V
S
Q
G
C
S
R
Site 87
S525
R
I
P
R
P
S
V
S
Q
G
C
S
R
E
A
Site 88
S529
P
S
V
S
Q
G
C
S
R
E
A
S
R
E
S
Site 89
S533
Q
G
C
S
R
E
A
S
R
E
S
S
R
D
T
Site 90
S536
S
R
E
A
S
R
E
S
S
R
D
T
S
P
V
Site 91
S537
R
E
A
S
R
E
S
S
R
D
T
S
P
V
R
Site 92
T540
S
R
E
S
S
R
D
T
S
P
V
R
S
F
Q
Site 93
S541
R
E
S
S
R
D
T
S
P
V
R
S
F
Q
P
Site 94
S545
R
D
T
S
P
V
R
S
F
Q
P
L
A
S
R
Site 95
S551
R
S
F
Q
P
L
A
S
R
H
H
S
R
S
T
Site 96
S555
P
L
A
S
R
H
H
S
R
S
T
G
A
L
Y
Site 97
S557
A
S
R
H
H
S
R
S
T
G
A
L
Y
A
P
Site 98
T558
S
R
H
H
S
R
S
T
G
A
L
Y
A
P
E
Site 99
Y562
S
R
S
T
G
A
L
Y
A
P
E
V
Y
G
A
Site 100
Y567
A
L
Y
A
P
E
V
Y
G
A
S
G
P
G
Y
Site 101
S570
A
P
E
V
Y
G
A
S
G
P
G
Y
G
I
S
Site 102
Y574
Y
G
A
S
G
P
G
Y
G
I
S
Q
S
S
R
Site 103
S577
S
G
P
G
Y
G
I
S
Q
S
S
R
L
S
S
Site 104
S579
P
G
Y
G
I
S
Q
S
S
R
L
S
S
S
V
Site 105
S580
G
Y
G
I
S
Q
S
S
R
L
S
S
S
V
S
Site 106
S583
I
S
Q
S
S
R
L
S
S
S
V
S
A
M
R
Site 107
S584
S
Q
S
S
R
L
S
S
S
V
S
A
M
R
V
Site 108
S585
Q
S
S
R
L
S
S
S
V
S
A
M
R
V
L
Site 109
S587
S
R
L
S
S
S
V
S
A
M
R
V
L
N
T
Site 110
T594
S
A
M
R
V
L
N
T
G
S
D
V
E
E
A
Site 111
S596
M
R
V
L
N
T
G
S
D
V
E
E
A
V
A
Site 112
Y614
K
K
P
A
R
R
R
Y
E
S
Y
G
M
H
S
Site 113
S616
P
A
R
R
R
Y
E
S
Y
G
M
H
S
D
D
Site 114
Y617
A
R
R
R
Y
E
S
Y
G
M
H
S
D
D
D
Site 115
S621
Y
E
S
Y
G
M
H
S
D
D
D
A
N
S
D
Site 116
S627
H
S
D
D
D
A
N
S
D
A
S
S
A
C
S
Site 117
S630
D
D
A
N
S
D
A
S
S
A
C
S
E
R
S
Site 118
S631
D
A
N
S
D
A
S
S
A
C
S
E
R
S
Y
Site 119
S634
S
D
A
S
S
A
C
S
E
R
S
Y
S
S
R
Site 120
S637
S
S
A
C
S
E
R
S
Y
S
S
R
N
G
S
Site 121
Y638
S
A
C
S
E
R
S
Y
S
S
R
N
G
S
I
Site 122
S639
A
C
S
E
R
S
Y
S
S
R
N
G
S
I
P
Site 123
S640
C
S
E
R
S
Y
S
S
R
N
G
S
I
P
T
Site 124
S644
S
Y
S
S
R
N
G
S
I
P
T
Y
M
R
Q
Site 125
T647
S
R
N
G
S
I
P
T
Y
M
R
Q
T
E
D
Site 126
Y648
R
N
G
S
I
P
T
Y
M
R
Q
T
E
D
V
Site 127
T652
I
P
T
Y
M
R
Q
T
E
D
V
A
E
V
L
Site 128
S664
E
V
L
N
R
C
A
S
S
N
W
S
E
R
K
Site 129
S668
R
C
A
S
S
N
W
S
E
R
K
E
G
L
L
Site 130
T686
N
L
L
K
N
Q
R
T
L
S
R
V
E
L
K
Site 131
S688
L
K
N
Q
R
T
L
S
R
V
E
L
K
R
L
Site 132
T764
V
Q
K
A
L
D
V
T
R
E
S
F
P
N
D
Site 133
S767
A
L
D
V
T
R
E
S
F
P
N
D
L
Q
F
Site 134
T781
F
N
I
L
M
R
F
T
V
D
Q
T
Q
T
P
Site 135
T785
M
R
F
T
V
D
Q
T
Q
T
P
S
L
K
V
Site 136
T787
F
T
V
D
Q
T
Q
T
P
S
L
K
V
K
V
Site 137
S789
V
D
Q
T
Q
T
P
S
L
K
V
K
V
A
I
Site 138
T802
A
I
L
K
Y
I
E
T
L
A
K
Q
M
D
P
Site 139
S816
P
G
D
F
I
N
S
S
E
T
R
L
A
V
S
Site 140
T827
L
A
V
S
R
V
I
T
W
T
T
E
P
K
S
Site 141
T829
V
S
R
V
I
T
W
T
T
E
P
K
S
S
D
Site 142
T830
S
R
V
I
T
W
T
T
E
P
K
S
S
D
V
Site 143
S834
T
W
T
T
E
P
K
S
S
D
V
R
K
A
A
Site 144
S835
W
T
T
E
P
K
S
S
D
V
R
K
A
A
Q
Site 145
T866
L
L
G
A
L
P
K
T
F
Q
D
G
A
T
K
Site 146
T882
L
H
N
H
L
R
N
T
G
N
G
T
Q
S
S
Site 147
T886
L
R
N
T
G
N
G
T
Q
S
S
M
G
S
P
Site 148
S888
N
T
G
N
G
T
Q
S
S
M
G
S
P
L
T
Site 149
S889
T
G
N
G
T
Q
S
S
M
G
S
P
L
T
R
Site 150
S892
G
T
Q
S
S
M
G
S
P
L
T
R
P
T
P
Site 151
T895
S
S
M
G
S
P
L
T
R
P
T
P
R
S
P
Site 152
T898
G
S
P
L
T
R
P
T
P
R
S
P
A
N
W
Site 153
S901
L
T
R
P
T
P
R
S
P
A
N
W
S
S
P
Site 154
S906
P
R
S
P
A
N
W
S
S
P
L
T
S
P
T
Site 155
S907
R
S
P
A
N
W
S
S
P
L
T
S
P
T
N
Site 156
T910
A
N
W
S
S
P
L
T
S
P
T
N
T
S
Q
Site 157
S911
N
W
S
S
P
L
T
S
P
T
N
T
S
Q
N
Site 158
T913
S
S
P
L
T
S
P
T
N
T
S
Q
N
T
L
Site 159
T915
P
L
T
S
P
T
N
T
S
Q
N
T
L
S
P
Site 160
S916
L
T
S
P
T
N
T
S
Q
N
T
L
S
P
S
Site 161
T919
P
T
N
T
S
Q
N
T
L
S
P
S
A
F
D
Site 162
S921
N
T
S
Q
N
T
L
S
P
S
A
F
D
Y
D
Site 163
Y927
L
S
P
S
A
F
D
Y
D
T
E
N
M
N
S
Site 164
T929
P
S
A
F
D
Y
D
T
E
N
M
N
S
E
D
Site 165
S934
Y
D
T
E
N
M
N
S
E
D
I
Y
S
S
L
Site 166
Y938
N
M
N
S
E
D
I
Y
S
S
L
R
G
V
T
Site 167
S939
M
N
S
E
D
I
Y
S
S
L
R
G
V
T
E
Site 168
S940
N
S
E
D
I
Y
S
S
L
R
G
V
T
E
A
Site 169
T945
Y
S
S
L
R
G
V
T
E
A
I
Q
N
F
S
Site 170
S952
T
E
A
I
Q
N
F
S
F
R
S
Q
E
D
M
Site 171
S955
I
Q
N
F
S
F
R
S
Q
E
D
M
N
E
P
Site 172
S967
N
E
P
L
K
R
D
S
K
K
D
D
G
D
S
Site 173
S974
S
K
K
D
D
G
D
S
M
C
G
G
P
G
M
Site 174
S982
M
C
G
G
P
G
M
S
D
P
R
A
G
G
D
Site 175
T991
P
R
A
G
G
D
A
T
D
S
S
Q
T
A
L
Site 176
S993
A
G
G
D
A
T
D
S
S
Q
T
A
L
D
N
Site 177
S994
G
G
D
A
T
D
S
S
Q
T
A
L
D
N
K
Site 178
S1003
T
A
L
D
N
K
A
S
L
L
H
S
M
P
T
Site 179
S1007
N
K
A
S
L
L
H
S
M
P
T
H
S
S
P
Site 180
T1010
S
L
L
H
S
M
P
T
H
S
S
P
R
S
R
Site 181
S1012
L
H
S
M
P
T
H
S
S
P
R
S
R
D
Y
Site 182
S1013
H
S
M
P
T
H
S
S
P
R
S
R
D
Y
N
Site 183
S1016
P
T
H
S
S
P
R
S
R
D
Y
N
P
Y
N
Site 184
Y1019
S
S
P
R
S
R
D
Y
N
P
Y
N
Y
S
D
Site 185
Y1022
R
S
R
D
Y
N
P
Y
N
Y
S
D
S
I
S
Site 186
Y1024
R
D
Y
N
P
Y
N
Y
S
D
S
I
S
P
F
Site 187
S1025
D
Y
N
P
Y
N
Y
S
D
S
I
S
P
F
N
Site 188
S1027
N
P
Y
N
Y
S
D
S
I
S
P
F
N
K
S
Site 189
S1029
Y
N
Y
S
D
S
I
S
P
F
N
K
S
A
L
Site 190
S1034
S
I
S
P
F
N
K
S
A
L
K
E
A
M
F
Site 191
S1053
D
Q
F
P
D
D
L
S
L
D
H
S
D
L
V
Site 192
S1057
D
D
L
S
L
D
H
S
D
L
V
A
E
L
L
Site 193
S1068
A
E
L
L
K
E
L
S
N
H
N
E
R
V
E
Site 194
Y1082
E
E
R
K
I
A
L
Y
E
L
M
K
L
T
Q
Site 195
T1088
L
Y
E
L
M
K
L
T
Q
E
E
S
F
S
V
Site 196
S1092
M
K
L
T
Q
E
E
S
F
S
V
W
D
E
H
Site 197
S1094
L
T
Q
E
E
S
F
S
V
W
D
E
H
F
K
Site 198
T1110
I
L
L
L
L
L
E
T
L
G
D
K
E
P
T
Site 199
Y1140
Q
P
A
R
F
K
N
Y
A
E
L
T
V
M
K
Site 200
T1144
F
K
N
Y
A
E
L
T
V
M
K
T
L
E
A
Site 201
T1148
A
E
L
T
V
M
K
T
L
E
A
H
K
D
P
Site 202
S1162
P
H
K
E
V
V
R
S
A
E
E
A
A
S
V
Site 203
S1210
T
K
V
I
E
R
V
S
K
E
T
L
N
L
L
Site 204
T1213
I
E
R
V
S
K
E
T
L
N
L
L
L
P
E
Site 205
Y1229
M
P
G
L
I
Q
G
Y
D
N
S
E
S
S
V
Site 206
S1232
L
I
Q
G
Y
D
N
S
E
S
S
V
R
K
A
Site 207
S1234
Q
G
Y
D
N
S
E
S
S
V
R
K
A
C
V
Site 208
S1235
G
Y
D
N
S
E
S
S
V
R
K
A
C
V
F
Site 209
S1260
D
E
L
K
P
H
L
S
Q
L
T
G
S
K
M
Site 210
Y1273
K
M
K
L
L
N
L
Y
I
K
R
A
Q
T
G
Site 211
T1279
L
Y
I
K
R
A
Q
T
G
S
G
G
A
D
P
Site 212
S1281
I
K
R
A
Q
T
G
S
G
G
A
D
P
T
T
Site 213
T1287
G
S
G
G
A
D
P
T
T
D
V
S
G
Q
S
Site 214
T1288
S
G
G
A
D
P
T
T
D
V
S
G
Q
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation